Sascha Pust
Position: Project Leader, Senior Scientist
Phone: +47 22 78 18 04

Sascha is in charge of the project Membrane-associated proteins in intracellular trafficking and disease


Publications 2017

Manna D, Pust S, Torgersen ML, Cordara G, Künzler M, Krengel U, Sandvig K (2017)
Polyporus squamosus Lectin 1a (PSL1a) Exhibits Cytotoxicity in Mammalian Cells by Disruption of Focal Adhesions, Inhibition of Protein Synthesis and Induction of Apoptosis
PLoS One, 12 (1), e0170716
PubMed 28114329

Publications 2016

Asp N, Kvalvaag A, Sandvig K, Pust S (2016)
Regulation of ErbB2 localization and function in breast cancer cells by ERM proteins
Oncotarget, 7 (18), 25443-60
PubMed 27029001

Publications 2014

Asp N, Pust S, Sandvig K (2014)
Flotillin depletion affects ErbB protein levels in different human breast cancer cells
Biochim Biophys Acta, 1843 (9), 1987-96
PubMed 24747692

Kvalvaag AS, Pust S, Sandvig K (2014)
Vps11, a subunit of the tethering complexes HOPS and CORVET, is involved in regulation of glycolipid degradation and retrograde toxin transport
Commun Integr Biol, 7 (1), e28129
PubMed 24778763

Publications 2013

Kvalvaag AS, Pust S, Sundet KI, Engedal N, Simm R, Sandvig K (2013)
The ERM proteins ezrin and moesin regulate retrograde Shiga toxin transport
Traffic, 14 (7), 839-52
PubMed 23593995

Publications 2012

Pust S, Klokk TI, Musa N, Jenstad M, Risberg B, Erikstein B, Tcatchoff L, Liestøl K, Danielsen HE, van Deurs B, Sandvig K (2012)
Flotillins as regulators of ErbB2 levels in breast cancer
Oncogene, 32 (29), 3443-51
PubMed 22869152

Tcatchoff L, Andersson S, Utskarpen A, Klokk TI, Skånland SS, Pust S, Gerke V, Sandvig K (2012)
Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin
PLoS One, 7 (7), e40429
PubMed 22792315

Publications 2011

Haugsten EM, Zakrzewska M, Brech A, Pust S, Olsnes S, Sandvig K, Wesche J (2011)
Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling
PLoS One, 6 (7), e21708
PubMed 21779335

Sandvig K, Pust S, Skotland T, van Deurs B (2011)
Clathrin-independent endocytosis: mechanisms and function
Curr Opin Cell Biol, 23 (4), 413-20
PubMed 21466956

Publications 2010

Pust S, Barth H, Sandvig K (2010)
Clostridium botulinum C2 toxin is internalized by clathrin- and Rho-dependent mechanisms
Cell Microbiol, 12 (12), 1809-20
PubMed 20690924

Pust S, Dyve AB, Torgersen ML, van Deurs B, Sandvig K (2010)
Interplay between toxin transport and flotillin localization
PLoS One, 5 (1), e8844
PubMed 20107503

Publications 2009

Hilger H, Pust S, von Figura G, Kaiser E, Stiles BG, Popoff MR, Barth H (2009)
The long-lived nature of clostridium perfringens iota toxin in mammalian cells induces delayed apoptosis
Infect Immun, 77 (12), 5593-601
PubMed 19805536

Kaiser E, Pust S, Kroll C, Barth H (2009)
Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells
Cell Microbiol, 11 (5), 780-95
PubMed 19159389

Publications 2008

Heine K, Pust S, Enzenmüller S, Barth H (2008)
ADP-ribosylation of actin by the Clostridium botulinum C2 toxin in mammalian cells results in delayed caspase-dependent apoptotic cell death
Infect Immun, 76 (10), 4600-8
PubMed 18710868

Publications 2007

Pust S, Hochmann H, Kaiser E, von Figura G, Heine K, Aktories K, Barth H (2007)
A cell-permeable fusion toxin as a tool to study the consequences of actin-ADP-ribosylation caused by the salmonella enterica virulence factor SpvB in intact cells
J Biol Chem, 282 (14), 10272-82
PubMed 17283073

Publications 2006

Hochmann H, Pust S, von Figura G, Aktories K, Barth H (2006)
Salmonella enterica SpvB ADP-ribosylates actin at position arginine-177-characterization of the catalytic domain within the SpvB protein and a comparison to binary clostridial actin-ADP-ribosylating toxins
Biochemistry, 45 (4), 1271-7
PubMed 16430223

Publications 2005

Pust S, Morrison H, Wehland J, Sechi AS, Herrlich P (2005)
Listeria monocytogenes exploits ERM protein functions to efficiently spread from cell to cell
EMBO J, 24 (6), 1287-300
PubMed 15729356