New sequencing technologies allow extensive sequencing to be carried out to analyse sequence variation, transcription, epigenetics and other phenomena. Complete genome sequences from thousands of organisms as well as data from large-scale protein structure determination projects are also publicly available. Microbiotic diversity and composition can be analysed in detail by sequencing patient or environmental samples. The main challenge in computational biology is to integrate and make sense of all of this data.
Publika - the scientific publication database for Oslo University Hospital has been developed in the group.
We also work in structural bioinformatics, for instance by modelling the structure of proteins and predicting the effect of mutations. An example of this is the work by Jon K. Lærdahl et al. on the PCSK9 protein shown above (see publication for details).
Characterization of the mechanisms by which missense mutations in the lysosomal acid lipase gene disrupt enzymatic activity
Hum Mol Genet (in press)
Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
Philos Trans R Soc Lond B Biol Sci, 373 (1748)
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1
Sci Rep, 7 (1), 7199