Publications published since 1976 by Einar K. Rofstad

283 publications found

Publications 2019

  1. Gaustad JV, Simonsen TG, Wegner CS, Rofstad EK (2019)
    Vascularization, Oxygenation, and the Effect of Sunitinib Treatment in Pancreatic Ductal Adenocarcinoma Xenografts
    Front. Oncol., 9, 845
  2. Hansem LMK, Huang R, Wegner CS, Simonsen TG, Gaustad JV, Hauge A, Rofstad EK (2019)
    Intratumor Heterogeneity in Interstitial Fluid Pressure in Cervical and Pancreatic Carcinoma Xenografts
    Transl Oncol, 12 (8), 1079-1085
    DOI 10.1016/j.tranon.2019.05.012, PubMed 31174058
  3. Hauge A, Gaustad JV, Huang R, Simonsen TG, Wegner CS, Andersen LMK, Rofstad EK (2019)
    DCE-MRI and Quantitative Histology Reveal Enhanced Vessel Maturation but Impaired Perfusion and Increased Hypoxia in Bevacizumab-Treated Cervical Carcinoma
    Int J Radiat Oncol Biol Phys, 104 (3), 666-676
    DOI 10.1016/j.ijrobp.2019.03.002, PubMed 30858145
  4. Lund KV, Simonsen TG, Kristensen GB, Rofstad EK (2019)
    Pharmacokinetic analysis of DCE-MRI data of locally advanced cervical carcinoma with the Brix model
    Acta Oncol, 58 (6), 828-837
    DOI 10.1080/0284186X.2019.1580386, PubMed 30810443

Publications 2018

  1. Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2018)
    Diffusion-Weighted MRI Is Insensitive to Changes in the Tumor Microenvironment Induced by Antiangiogenic Therapy
    Transl Oncol, 11 (5), 1128-1136
    DOI 10.1016/j.tranon.2018.07.005, PubMed 30036782
  2. Huang R, Rofstad EK (2018)
    Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma
    J Exp Clin Cancer Res, 37 (1), 92
    DOI 10.1186/s13046-018-0763-x, PubMed 29703238
  3. Simonsen TG, Lund KV, Hompland T, Kristensen GB, Rofstad EK (2018)
    DCE-MRI-Derived Measures of Tumor Hypoxia and Interstitial Fluid Pressure Predict Outcomes in Cervical Carcinoma
    Int J Radiat Oncol Biol Phys, 102 (4), 1193-1201
    DOI 10.1016/j.ijrobp.2018.04.035, PubMed 29859790
  4. Wegner CS, Hauge A, Andersen LMK, Huang R, Simonsen TG, Gaustad JV, Rofstad EK (2018)
    Increasing aggressiveness of patient-derived xenograft models of cervix carcinoma during serial transplantation
    Oncotarget, 9 (30), 21036-21051
    DOI 10.18632/oncotarget.24783, PubMed 29765518
  5. Wegner CS, Hauge A, Simonsen TG, Gaustad JV, Andersen LMK, Rofstad EK (2018)
    DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts
    Neoplasia, 20 (7), 734-744
    DOI 10.1016/j.neo.2018.05.006, PubMed 29886124

Publications 2017

  1. Andersen LMK, Wegner CS, Simonsen TG, Huang R, Gaustad JV, Hauge A, Galappathi K, Rofstad EK (2017)
    Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts
    Oncotarget, 8 (29), 48060-48074
    DOI 10.18632/oncotarget.18231, PubMed 28624797
  2. Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2017)
    The Effect of Sunitinib Treatment in Human Melanoma Xenografts: Associations with Angiogenic Profiles
    Transl Oncol, 10 (2), 158-167
    DOI 10.1016/j.tranon.2016.12.007, PubMed 28167241
  3. Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
    Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts
    BMC Cancer, 17 (1), 411
    DOI 10.1186/s12885-017-3404-4, PubMed 28606060
  4. Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
    Vascular abnormalities and development of hypoxia in microscopic melanoma xenografts
    J Transl Med, 15 (1), 241
    DOI 10.1186/s12967-017-1347-9, PubMed 29183378
  5. Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
    DCE-MRI of patient-derived xenograft models of uterine cervix carcinoma: associations with parameters of the tumor microenvironment
    J Transl Med, 15 (1), 225
    DOI 10.1186/s12967-017-1331-4, PubMed 29100521
  6. Hauge A, Wegner CS, Gaustad JV, Simonsen TG, Andersen LMK, Rofstad EK (2017)
    Diffusion-weighted MRI-derived ADC values reflect collagen I content in PDX models of uterine cervical cancer
    Oncotarget, 8 (62), 105682-105691
    DOI 10.18632/oncotarget.22388, PubMed 29285283
  7. Huang R, Andersen LMK, Rofstad EK (2017)
    Metastatic pathway and the microvascular and physicochemical microenvironments of human melanoma xenografts
    J Transl Med, 15 (1), 203
    DOI 10.1186/s12967-017-1307-4, PubMed 29017512
  8. Huang R, Rofstad EK (2017)
    Cancer stem cells (CSCs), cervical CSCs and targeted therapies
    Oncotarget, 8 (21), 35351-35367
    DOI 10.18632/oncotarget.10169, PubMed 27343550
  9. Lund KV, Simonsen TG, Kristensen GB, Rofstad EK (2017)
    Pretreatment late-phase DCE-MRI predicts outcome in locally advanced cervix cancer
    Acta Oncol, 56 (5), 675-681
    DOI 10.1080/0284186X.2017.1294762, PubMed 28447564
  10. Wegner CS, Hauge A, Gaustad JV, Andersen LMK, Simonsen TG, Galappathi K, Rofstad EK (2017)
    Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts
    Acta Oncol, 56 (12), 1754-1762
    DOI 10.1080/0284186X.2017.1343494, PubMed 28661213

Publications 2016

  1. Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2016)
    Properdistatin inhibits angiogenesis and improves vascular function in human melanoma xenografts with low thrombospondin-1 expression
    Oncotarget, 7 (47), 76806-76815
    DOI 10.18632/oncotarget.12695, PubMed 27756886
  2. Rofstad EK, Huang R, Galappathi K, Andersen LM, Wegner CS, Hauge A, Gaustad JV, Simonsen TG (2016)
    Functional intratumoral lymphatics in patient-derived xenograft models of squamous cell carcinoma of the uterine cervix: implications for lymph node metastasis
    Oncotarget, 7 (35), 56986-56997
    DOI 10.18632/oncotarget.10931, PubMed 27486768
  3. Rofstad EK, Simonsen TG, Huang R, Andersen LM, Galappathi K, Ellingsen C, Wegner CS, Hauge A, Gaustad JV (2016)
    Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix
    Cancer Lett, 373 (2), 147-55
    DOI 10.1016/j.canlet.2016.01.047, PubMed 26828134
  4. Simonsen TG, Gaustad JV, Rofstad EK (2016)
    Intracranial Tumor Cell Migration and the Development of Multiple Brain Metastases in Malignant Melanoma
    Transl Oncol, 9 (3), 211-8
    DOI 10.1016/j.tranon.2016.04.003, PubMed 27267839
  5. Wegner CS, Gaustad JV, Andersen LM, Simonsen TG, Rofstad EK (2016)
    Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content
    J Transl Med, 14 (1), 161
    DOI 10.1186/s12967-016-0920-y, PubMed 27268062

Publications 2015

  1. Ellingsen C, Andersen LM, Galappathi K, Rofstad EK (2015)
    Hypoxia biomarkers in squamous cell carcinoma of the uterine cervix
    BMC Cancer, 15, 805
    DOI 10.1186/s12885-015-1828-2, PubMed 26502718
  2. Gaustad JV, Simonsen TG, Smistad R, Wegner CS, Andersen LM, Rofstad EK (2015)
    Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging
    BMC Cancer, 15, 900
    DOI 10.1186/s12885-015-1918-1, PubMed 26573613
  3. Gorad SS, Ellingsen C, Bathen TF, Mathiesen BS, Moestue SA, Rofstad EK (2015)
    Identification of Metastasis-Associated Metabolic Profiles of Tumors by (1)H-HR-MAS-MRS
    Neoplasia, 17 (10), 767-75
    DOI 10.1016/j.neo.2015.10.001, PubMed 26585232
  4. Lund KV, Simonsen TG, Hompland T, Kristensen GB, Rofstad EK (2015)
    Short-term pretreatment DCE-MRI in prediction of outcome in locally advanced cervical cancer
    Radiother Oncol, 115 (3), 379-85
    DOI 10.1016/j.radonc.2015.05.001, PubMed 25998804
  5. Simonsen TG, Gaustad JV, Rofstad EK (2015)
    Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases
    J Exp Clin Cancer Res, 34, 150
    DOI 10.1186/s13046-015-0264-0, PubMed 26667022

Publications 2014

  1. Gaustad JV, Simonsen TG, Andersen LM, Rofstad EK (2014)
    Thrombospondin-1 domain-containing peptide properdistatin improves vascular function in human melanoma xenografts
    Microvasc Res, 98, 159-65
    DOI 10.1016/j.mvr.2014.02.005, PubMed 24555949
  2. Hompland T, Ellingsen C, Galappathi K, Rofstad EK (2014)
    DW-MRI in assessment of the hypoxic fraction, interstitial fluid pressure, and metastatic propensity of melanoma xenografts
    BMC Cancer, 14, 92
    DOI 10.1186/1471-2407-14-92, PubMed 24528854
  3. Hompland T, Lund KV, Ellingsen C, Kristensen GB, Rofstad EK (2014)
    Peritumoral interstitial fluid flow velocity predicts survival in cervical carcinoma
    Radiother Oncol, 113 (1), 132-8
    DOI 10.1016/j.radonc.2014.09.011, PubMed 25443501
  4. Rofstad EK, Galappathi K, Mathiesen BS (2014)
    Tumor interstitial fluid pressure-a link between tumor hypoxia, microvascular density, and lymph node metastasis
    Neoplasia, 16 (7), 586-94
    DOI 10.1016/j.neo.2014.07.003, PubMed 25117980

Publications 2013

  1. Ellingsen C, Hompland T, Galappathi K, Mathiesen B, Rofstad EK (2013)
    DCE-MRI of the hypoxic fraction, radioresponsiveness, and metastatic propensity of cervical carcinoma xenografts
    Radiother Oncol, 110 (2), 335-41
    DOI 10.1016/j.radonc.2013.10.018, PubMed 24231244
  2. Ellingsen C, Walenta S, Hompland T, Mueller-Klieser W, Rofstad EK (2013)
    The Microenvironment of Cervical Carcinoma Xenografts: Associations with Lymph Node Metastasis and Its Assessment by DCE-MRI
    Transl Oncol, 6 (5), 607-17
    DOI 10.1593/tlo.13313, PubMed 24151541
  3. Gaustad JV, Pozdniakova V, Hompland T, Simonsen TG, Rofstad EK (2013)
    Magnetic resonance imaging identifies early effects of sunitinib treatment in human melanoma xenografts
    J Exp Clin Cancer Res, 32, 93
    DOI 10.1186/1756-9966-32-93, PubMed 24245934
  4. Hasvold G, Nähse-Kumpf V, Tkacz-Stachowska K, Rofstad EK, Syljuåsen RG (2013)
    The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation
    Mol Cancer Ther, 12 (5), 705-16
    DOI 10.1158/1535-7163.MCT-12-0879, PubMed 23635654
  5. Hompland T, Ellingsen C, Galappathi K, Rofstad EK (2013)
    Connective tissue of cervical carcinoma xenografts: associations with tumor hypoxia and interstitial fluid pressure and its assessment by DCE-MRI and DW-MRI
    Acta Oncol, 53 (1), 6-15
    DOI 10.3109/0284186X.2013.773073, PubMed 23445339

Publications 2012

  1. Ellingsen C, Hompland T, Mathiesen B, Rofstad EK (2012)
    Microenvironment-associated lymph node metastasis of human cervical carcinoma xenografts
    Acta Oncol, 51 (4), 465-72
    DOI 10.3109/0284186X.2011.636751, PubMed 22292610
  2. Ellingsen C, Ovrebø KM, Galappathi K, Mathiesen B, Rofstad EK (2012)
    pO₂ fluctuation pattern and cycling hypoxia in human cervical carcinoma and melanoma xenografts
    Int J Radiat Oncol Biol Phys, 83 (4), 1317-23
    DOI 10.1016/j.ijrobp.2011.09.037, PubMed 22270159
  3. Gaustad JV, Simonsen TG, Leinaas MN, Rofstad EK (2012)
    A novel application of dorsal window chambers: repetitive imaging of tumor-associated lymphatics
    Microvasc Res, 83 (3), 360-5
    DOI 10.1016/j.mvr.2012.02.003, PubMed 22342351
  4. Gaustad JV, Simonsen TG, Leinaas MN, Rofstad EK (2012)
    Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts
    BMC Cancer, 12, 388
    DOI 10.1186/1471-2407-12-388, PubMed 22947392
  5. Gaustad JV, Simonsen TG, Roa AM, Rofstad EK (2012)
    Tumors exposed to acute cyclic hypoxia show increased vessel density and delayed blood supply
    Microvasc Res, 85, 10-5
    DOI 10.1016/j.mvr.2012.11.002, PubMed 23154277
  6. Hompland T, Ellingsen C, Rofstad EK (2012)
    Preclinical evaluation of Gd-DTPA and gadomelitol as contrast agents in DCE-MRI of cervical carcinoma interstitial fluid pressure
    BMC Cancer, 12, 544
    DOI 10.1186/1471-2407-12-544, PubMed 23173554
  7. Hompland T, Ellingsen C, Øvrebø KM, Rofstad EK (2012)
    Interstitial fluid pressure and associated lymph node metastasis revealed in tumors by dynamic contrast-enhanced MRI
    Cancer Res, 72 (19), 4899-908
    DOI 10.1158/0008-5472.CAN-12-0903, PubMed 23027087
  8. Hompland T, Gulliksrud K, Ellingsen C, Rofstad EK (2012)
    Assessment of the interstitial fluid pressure of tumors by dynamic contrast-enhanced magnetic resonance imaging with contrast agents of different molecular weights
    Acta Oncol, 52 (3), 627-35
    DOI 10.3109/0284186X.2012.737931, PubMed 23126523
  9. Ovrebø KM, Ellingsen C, Galappathi K, Rofstad EK (2012)
    Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of melanoma xenografts
    Int J Radiat Oncol Biol Phys, 83 (1), e121-7
    DOI 10.1016/j.ijrobp.2011.12.019, PubMed 22381901
  10. Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
    Tumor-line specific causes of intertumor heterogeneity in blood supply in human melanoma xenografts
    Microvasc Res, 85, 16-23
    DOI 10.1016/j.mvr.2012.11.001, PubMed 23149341
  11. Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
    Vascular abnormalities associated with acute hypoxia in human melanoma xenografts
    Radiother Oncol, 105 (1), 72-8
    DOI 10.1016/j.radonc.2012.08.018, PubMed 23022175
  12. Simonsen TG, Gaustad JV, Leinaas MN, Rofstad EK (2012)
    High interstitial fluid pressure is associated with tumor-line specific vascular abnormalities in human melanoma xenografts
    PLoS One, 7 (6), e40006
    DOI 10.1371/journal.pone.0040006, PubMed 22768196
  13. Øvrebø KM, Ellingsen C, Hompland T, Rofstad EK (2012)
    Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of tumors: a preclinical study of cervical carcinoma and melanoma xenografts
    Acta Oncol, 52 (3), 604-11
    DOI 10.3109/0284186X.2012.689851, PubMed 22671573

Publications 2011

  1. Egeland TA, Gulliksrud K, Gaustad JV, Mathiesen B, Rofstad EK (2011)
    Dynamic contrast-enhanced-MRI of tumor hypoxia
    Magn Reson Med, 67 (2), 519-30
    DOI 10.1002/mrm.23014, PubMed 21661044
  2. Gulliksrud K, Galappathi K, Rofstad EK (2011)
    Interstitial fluid pressure and vascularity of intradermal and intramuscular human tumor xenografts
    Int J Radiat Oncol Biol Phys, 80 (1), 258-64
    DOI 10.1016/j.ijrobp.2010.11.042, PubMed 21255944
  3. Gulliksrud K, Hompland T, Galappathi K, Rofstad EK (2011)
    Assessment of tumor hypoxia and interstitial fluid pressure by gadomelitol-based dynamic contrast-enhanced magnetic resonance imaging
    Radiother Oncol, 101 (1), 217-22
    DOI 10.1016/j.radonc.2011.06.036, PubMed 21840612
  4. Gulliksrud K, Øvrebø KM, Mathiesen B, Rofstad EK (2011)
    Differentiation between hypoxic and non-hypoxic experimental tumors by dynamic contrast-enhanced magnetic resonance imaging
    Radiother Oncol, 98 (3), 360-4
    DOI 10.1016/j.radonc.2010.12.016, PubMed 21262548
  5. Øvrebø KM, Gulliksrud K, Mathiesen B, Rofstad EK (2011)
    Assessment of tumor radioresponsiveness and metastatic potential by dynamic contrast-enhanced magnetic resonance imaging
    Int J Radiat Oncol Biol Phys, 81 (1), 255-61
    DOI 10.1016/j.ijrobp.2011.04.008, PubMed 21816291
  6. Øvrebø KM, Hompland T, Mathiesen B, Rofstad EK (2011)
    Assessment of hypoxia and radiation response in intramuscular experimental tumors by dynamic contrast-enhanced magnetic resonance imaging
    Radiother Oncol, 102 (3), 429-35
    DOI 10.1016/j.radonc.2011.11.013, PubMed 22197352

Publications 2010

  1. Egeland TA, Gaustad JV, Galappathi K, Rofstad EK (2010)
    Magnetic resonance imaging of tumor necrosis
    Acta Oncol, 50 (3), 427-34
    DOI 10.3109/0284186X.2010.526633, PubMed 20950229
  2. Ellingsen C, Egeland TA, Galappathi K, Rofstad EK (2010)
    Dynamic contrast-enhanced magnetic resonance imaging of human cervical carcinoma xenografts: pharmacokinetic analysis and correlation to tumor histomorphology
    Radiother Oncol, 97 (2), 217-24
    DOI 10.1016/j.radonc.2010.06.011, PubMed 20656365
  3. Gulliksrud K, Egeland TAM, Gaustad JV, Rofstad EK (2010)
    Interstitial fluid pressure of tumors as a function of parameters derived by dynamic contrast-enhanced magnetic resonance imaging: Response to letter by Farace and Boschi
    Radiother. Oncol., 94 (3), 385-386
  4. Gulliksrud K, Mathiesen B, Galappathi K, Rofstad EK (2010)
    Quantitative assessment of hypoxia in melanoma xenografts by dynamic contrast-enhanced magnetic resonance imaging: intradermal versus intramuscular tumors
    Radiother Oncol, 97 (2), 233-8
    DOI 10.1016/j.radonc.2010.09.005, PubMed 20934767
  5. Rofstad EK, Gaustad JV, Egeland TA, Mathiesen B, Galappathi K (2010)
    Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination
    Int J Cancer, 127 (7), 1535-46
    DOI 10.1002/ijc.25176, PubMed 20091868
  6. Rofstad EK, Mathiesen B (2010)
    Metastasis in melanoma xenografts is associated with tumor microvascular density rather than extent of hypoxia
    Neoplasia, 12 (11), 889-98
    DOI 10.1593/neo.10712, PubMed 21076614
  7. Rofstad EK, Ruud EB, Mathiesen B, Galappathi K (2010)
    Associations between radiocurability and interstitial fluid pressure in human tumor xenografts without hypoxic tissue
    Clin Cancer Res, 16 (3), 936-45
    DOI 10.1158/1078-0432.CCR-09-2718, PubMed 20103667
  8. Simonsen TG, Gaustad JV, Rofstad EK (2010)
    Development of hypoxia in a preclinical model of tumor micrometastases
    Int J Radiat Oncol Biol Phys, 76 (3), 879-88
    DOI 10.1016/j.ijrobp.2009.09.045, PubMed 20159362

Publications 2009

  1. Egeland TA, Simonsen TG, Gaustad JV, Gulliksrud K, Ellingsen C, Rofstad EK (2009)
    Dynamic contrast-enhanced magnetic resonance imaging of tumors: preclinical validation of parametric images
    Radiat Res, 172 (3), 339-47
    DOI 10.1667/RR1787.1, PubMed 19708783
  2. Ellingsen C, Egeland TA, Gulliksrud K, Gaustad JV, Mathiesen B, Rofstad EK (2009)
    Assessment of hypoxia in human cervical carcinoma xenografts by dynamic contrast-enhanced magnetic resonance imaging
    Int J Radiat Oncol Biol Phys, 73 (3), 838-45
    DOI 10.1016/j.ijrobp.2008.10.062, PubMed 19215820
  3. Ellingsen C, Natvig I, Gaustad JV, Gulliksrud K, Egeland TA, Rofstad EK (2009)
    Human cervical carcinoma xenograft models for studies of the physiological microenvironment of tumors
    J Cancer Res Clin Oncol, 135 (9), 1177-84
    DOI 10.1007/s00432-009-0558-8, PubMed 19214568
  4. Gaustad JV, Simonsen TG, Brurberg KG, Huuse EM, Rofstad EK (2009)
    Blood supply in melanoma xenografts is governed by the morphology of the supplying arteries
    Neoplasia, 11 (3), 277-85
    DOI 10.1593/neo.81400, PubMed 19242609
  5. Rofstad EK, Gaustad JV, Brurberg KG, Mathiesen B, Galappathi K, Simonsen TG (2009)
    Radiocurability is associated with interstitial fluid pressure in human tumor xenografts
    Neoplasia, 11 (11), 1243-51
    DOI 10.1593/neo.91152, PubMed 19881960

Publications 2008

  1. Benjaminsen IC, Melås EA, Mathiesen BS, Rofstad EK (2008)
    Limitations of dynamic contrast-enhanced MRI in monitoring radiation-induced changes in the fraction of radiobiologically hypoxic cells in human melanoma xenografts
    J Magn Reson Imaging, 28 (5), 1209-18
    DOI 10.1002/jmri.21602, PubMed 18972344
  2. Brurberg KG, Gaustad JV, Mollatt CS, Rofstad EK (2008)
    Temporal heterogeneity in blood supply in human tumor xenografts
    Neoplasia, 10 (7), 727-35
    DOI 10.1593/neo.08388, PubMed 18592011
  3. Egeland TA, Gaustad JV, Benjaminsen IC, Hedalen K, Mathiesen B, Rofstad EK (2008)
    Assessment of fraction of hypoxic cells in human tumor xenografts with necrotic regions by dynamic contrast-enhanced MRI
    Radiat Res, 169 (6), 689-99
    DOI 10.1667/RR1311.1, PubMed 18494552
  4. Gaustad JV, Brurberg KG, Simonsen TG, Mollatt CS, Rofstad EK (2008)
    Tumor vascularity assessed by magnetic resonance imaging and intravital microscopy imaging
    Neoplasia, 10 (4), 354-62
    DOI 10.1593/neo.08162, PubMed 18392132
  5. Gulliksrud K, Brurberg KG, Rofstad EK (2008)
    Dynamic contrast-enhanced magnetic resonance imaging of tumor interstitial fluid pressure
    Radiother Oncol, 91 (1), 107-13
    DOI 10.1016/j.radonc.2008.08.015, PubMed 18973959
  6. Gulliksrud K, Vestvik IK, Galappathi K, Mathiesen B, Rofstad EK (2008)
    Detection of different hypoxic cell subpopulations in human melanoma xenografts by pimonidazole immunohistochemistry
    Radiat Res, 170 (5), 638-50
    DOI 10.1667/RR1400.1, PubMed 18959463
  7. Norum OJ, Gaustad JV, Angell-Petersen E, Rofstad EK, Peng Q, Giercksky KE, Berg K (2008)
    Photochemical internalization of bleomycin is superior to photodynamic therapy due to the therapeutic effect in the tumor periphery
    Photochem Photobiol, 85 (3), 740-9
    DOI 10.1111/j.1751-1097.2008.00477.x, PubMed 19076314

Publications 2007

  1. Benjaminsen IC, Brurberg KG, Ruud EB, Rofstad EK (2007)
    Assessment of extravascular extracellular space fraction in human melanoma xenografts by DCE-MRI and kinetic modeling
    Magn Reson Imaging, 26 (2), 160-70
    DOI 10.1016/j.mri.2007.06.003, PubMed 17692490
  2. Brurberg KG, Benjaminsen IC, Dørum LM, Rofstad EK (2007)
    Fluctuations in tumor blood perfusion assessed by dynamic contrast-enhanced MRI
    Magn Reson Med, 58 (3), 473-81
    DOI 10.1002/mrm.21367, PubMed 17763357
  3. Gaustad JV, Benjaminsen IC, Ruud EB, Rofstad EK (2007)
    Dynamic contrast-enhanced magnetic resonance imaging of human melanoma xenografts with necrotic regions
    J Magn Reson Imaging, 26 (1), 133-43
    DOI 10.1002/jmri.20939, PubMed 17659570
  4. Rofstad EK, Galappathi K, Mathiesen B, Ruud EB (2007)
    Fluctuating and diffusion-limited hypoxia in hypoxia-induced metastasis
    Clin Cancer Res, 13 (7), 1971-8
    DOI 10.1158/1078-0432.CCR-06-1967, PubMed 17360973
  5. Vestvik IK, Egeland TA, Gaustad JV, Mathiesen B, Rofstad EK (2007)
    Assessment of microvascular density, extracellular volume fraction, and radiobiological hypoxia in human melanoma xenografts by dynamic contrast-enhanced MRI
    J Magn Reson Imaging, 26 (4), 1033-42
    DOI 10.1002/jmri.21110, PubMed 17896373
  6. Øye KS, Gulati G, Graff BA, Gaustad JV, Brurberg KG, Rofstad EK (2007)
    A novel method for mapping the heterogeneity in blood supply to normal and malignant tissues in the mouse dorsal window chamber
    Microvasc Res, 75 (2), 179-87
    DOI 10.1016/j.mvr.2007.06.009, PubMed 17688890

Publications 2006

  1. Brurberg KG, Thuen M, Ruud EB, Rofstad EK (2006)
    Fluctuations in pO2 in irradiated human melanoma xenografts
    Radiat Res, 165 (1), 16-25
    DOI 10.1667/rr3491.1, PubMed 16392958
  2. Egeland TA, Gaustad JV, Vestvik IK, Benjaminsen IC, Mathiesen B, Rofstad EK (2006)
    Assessment of fraction of radiobiologically hypoxic cells in human melanoma xenografts by dynamic contrast-enhanced MRI
    Magn Reson Med, 55 (4), 874-82
    DOI 10.1002/mrm.20852, PubMed 16506163
  3. Rofstad EK, Mathiesen B, Kindem K, Galappathi K (2006)
    Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
    Cancer Res, 66 (13), 6699-707
    DOI 10.1158/0008-5472.CAN-06-0983, PubMed 16818644

Publications 2005

  1. Brurberg KG, Skogmo HK, Graff BA, Olsen DR, Rofstad EK (2005)
    Fluctuations in pO2 in poorly and well-oxygenated spontaneous canine tumors before and during fractionated radiation therapy
    Radiother Oncol, 77 (2), 220-6
    DOI 10.1016/j.radonc.2005.09.009, PubMed 16257074
  2. Gaustad JV, Benjaminsen IC, Graff BA, Brurberg KG, Ruud EB, Rofstad EK (2005)
    Intratumor heterogeneity in blood perfusion in orthotopic human melanoma xenografts assessed by dynamic contrast-enhanced magnetic resonance imaging
    J Magn Reson Imaging, 21 (6), 792-800
    DOI 10.1002/jmri.20321, PubMed 15906326
  3. Graff BA, Benjaminsen IC, Brurberg KG, Ruud EB, Rofstad EK (2005)
    Comparison of tumor blood perfusion assessed by dynamic contrast-enhanced MRI with tumor blood supply assessed by invasive imaging
    J Magn Reson Imaging, 21 (3), 272-81
    DOI 10.1002/jmri.20265, PubMed 15723369
  4. Graff BA, Benjaminsen IC, Melås EA, Brurberg KG, Rofstad EK (2005)
    Changes in intratumor heterogeneity in blood perfusion in intradermal human melanoma xenografts during tumor growth assessed by DCE-MRI
    Magn Reson Imaging, 23 (9), 961-6
    DOI 10.1016/j.mri.2005.09.006, PubMed 16310112
  5. Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T (2005)
    Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms
    Cancer Res, 65 (5), 1877-86
    DOI 10.1158/0008-5472.CAN-04-2828, PubMed 15753386
  6. Rofstad EK, Mathiesen B, Henriksen K, Kindem K, Galappathi K (2005)
    The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products
    Cancer Res, 65 (6), 2387-96
    DOI 10.1158/0008-5472.CAN-04-3039, PubMed 15781654

Publications 2004

  1. Barth RF, Grecula JC, Yang W, Rotaru JH, Nawrocky M, Gupta N, Albertson BJ, Ferketich AK, Moeschberger ML, Coderre JA, Rofstad EK (2004)
    Combination of boron neutron capture therapy and external beam radiotherapy for brain tumors
    Int J Radiat Oncol Biol Phys, 58 (1), 267-77
    DOI 10.1016/s0360-3016(03)01613-4, PubMed 14697448
  2. Benjaminsen IC, Graff BA, Brurberg KG, Rofstad EK (2004)
    Assessment of tumor blood perfusion by high-resolution dynamic contrast-enhanced MRI: a preclinical study of human melanoma xenografts
    Magn Reson Med, 52 (2), 269-76
    DOI 10.1002/mrm.20149, PubMed 15282808
  3. Brurberg KG, Graff BA, Olsen DR, Rofstad EK (2004)
    Tumor-line specific pO(2) fluctuations in human melanoma xenografts
    Int J Radiat Oncol Biol Phys, 58 (2), 403-9
    DOI 10.1016/j.ijrobp.2003.09.049, PubMed 14751509
  4. Graff BA, Vangberg L, Rofstad EK (2004)
    Quantitative assessment of uptake and distribution of iron oxide particles (NC100150) in human melanoma xenografts by contrast-enhanced MRI
    Magn Reson Med, 51 (4), 727-35
    DOI 10.1002/mrm.20028, PubMed 15065245
  5. Rofstad EK, Galappathi K, Mathiesen B (2004)
    Thrombospondin-1 treatment prevents growth of dormant lung micrometastases after surgical resection and curative radiation therapy of the primary tumor in human melanoma xenografts
    Int J Radiat Oncol Biol Phys, 58 (2), 493-9
    DOI 10.1016/j.ijrobp.2003.09.030, PubMed 14751520
  6. Rofstad EK, Mathiesen B, Galappathi K (2004)
    Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor
    Cancer Res, 64 (1), 13-8
    DOI 10.1158/0008-5472.CAN-03-2658, PubMed 14729600

Publications 2003

  1. Brurberg KG, Graff BA, Rofstad EK (2003)
    Temporal heterogeneity in oxygen tension in human melanoma xenografts
    Br J Cancer, 89 (2), 350-6
    DOI 10.1038/sj.bjc.6601047, PubMed 12865929
  2. Graff BA, Kvinnsland Y, Skretting A, Rofstad EK (2003)
    Intratumour heterogeneity in the uptake of macromolecular therapeutic agents in human melanoma xenografts
    Br J Cancer, 88 (2), 291-7
    DOI 10.1038/sj.bjc.6600680, PubMed 12610516
  3. Rofstad EK, Henriksen K, Galappathi K, Mathiesen B (2003)
    Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts
    Cancer Res, 63 (14), 4055-61
    PubMed 12874006

Publications 2002

  1. Barth RF, Yang W, Bartus RT, Rotaru JH, Ferketich AK, Moeschberger ML, Nawrocky MM, Coderre JA, Rofstad EK (2002)
    Neutron capture therapy of intracerebral melanoma: enhanced survival and cure after blood-brain barrier opening to improve delivery of boronophenylalanine
    Int J Radiat Oncol Biol Phys, 52 (3), 858-68
    DOI 10.1016/s0360-3016(01)02734-1, PubMed 11849812
  2. Hatzi E, Murphy C, Zoephel A, Rasmussen H, Morbidelli L, Ahorn H, Kunisada K, Tontsch U, Klenk M, Yamauchi-Takihara K, Ziche M, Rofstad EK, Schweigerer L, Fotsis T (2002)
    N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth
    Oncogene, 21 (22), 3552-61
    DOI 10.1038/sj.onc.1205440, PubMed 12032857
  3. Rofstad EK, Halsør EF (2002)
    Hypoxia-associated spontaneous pulmonary metastasis in human melanoma xenografts: involvement of microvascular hot spots induced in hypoxic foci by interleukin 8
    Br J Cancer, 86 (2), 301-8
    DOI 10.1038/sj.bjc.6600052, PubMed 11870523
  4. Rofstad EK, Rasmussen H, Galappathi K, Mathiesen B, Nilsen K, Graff BA (2002)
    Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor
    Cancer Res, 62 (6), 1847-53
    PubMed 11912164
  5. Rofstad EK, Tunheim SH, Mathiesen B, Graff BA, Halsør EF, Nilsen K, Galappathi K (2002)
    Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts
    Cancer Res, 62 (3), 661-4
    PubMed 11830516

Publications 2001

  1. Bjørnaes I, Rofstad EK (2001)
    Microvascular permeability to macromolecules in human melanoma xenografts assessed by contrast-enhanced MRI--intertumor and intratumor heterogeneity
    Magn Reson Imaging, 19 (5), 723-30
    DOI 10.1016/s0730-725x(01)00377-0, PubMed 11672631
  2. Bjørnaes I, Rofstad EK (2001)
    Transvascular and interstitial transport of a 19 kDa linear molecule in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging
    J Magn Reson Imaging, 14 (5), 608-16
    DOI 10.1002/jmri.1226, PubMed 11747014
  3. Graff BA, Bjørnaes I, Rofstad EK (2001)
    Microvascular permeability of human melanoma xenografts to macromolecules: relationships to tumor volumetric growth rate, tumor angiogenesis, and VEGF expression
    Microvasc Res, 61 (2), 187-98
    DOI 10.1006/mvre.2001.2303, PubMed 11254398
  4. Lyng H, Vorren AO, Sundfør K, Taksdal I, Lien HH, Kaalhus O, Rofstad EK (2001)
    Intra- and intertumor heterogeneity in blood perfusion of human cervical cancer before treatment and after radiotherapy
    Int J Cancer, 96 (3), 182-90
    DOI 10.1002/ijc.1019, PubMed 11410887
  5. Lyng H, Vorren AO, Sundfør K, Taksdal I, Lien HH, Kaalhus O, Rofstad EK (2001)
    Assessment of tumor oxygenation in human cervical carcinoma by use of dynamic Gd-DTPA-enhanced MR imaging
    J Magn Reson Imaging, 14 (6), 750-6
    DOI 10.1002/jmri.10016, PubMed 11747032
  6. Måseide K, Lyng H, Rofstad EK (2001)
    Microvessel oxyhemoglobin saturation does not reflect tissue oxygen tension in human melanoma xenografts
    Microvasc Res, 61 (2), 199-202
    DOI 10.1006/mvre.2000.2294, PubMed 11254399
  7. Måseide K, Rofstad EK (2001)
    Intratumour heterogeneity in microvessel oxyhaemoglobin saturations
    Cancer Lett, 162 (2), 245-51
    DOI 10.1016/s0304-3835(00)00670-4, PubMed 11146232
  8. Rofstad EK, Graff BA (2001)
    Thrombospondin-1-mediated metastasis suppression by the primary tumor in human melanoma xenografts
    J Invest Dermatol, 117 (5), 1042-9
    DOI 10.1046/j.0022-202x.2001.01552.x, PubMed 11710911

Publications 2000

  1. Bjørnaes I, Halsør EF, Skretting A, Rofstad EK (2000)
    Measurement of the extracellular volume of human melanoma xenografts by contrast enhanced magnetic resonance imaging
    Magn Reson Imaging, 18 (1), 41-8
    DOI 10.1016/s0730-725x(99)00109-5, PubMed 10642101
  2. Bjørnaes I, Lyng H, Dahle GA, Kaalhus O, Rofstad EK (2000)
    Intratumor heterogeneity in perfusion in human melanoma xenografts measured by contrast-enhanced magnetic resonance imaging
    Magn Reson Imaging, 18 (8), 997-1002
    DOI 10.1016/s0730-725x(00)00188-0, PubMed 11121704
  3. Danielsen T, Rofstad EK (2000)
    The constitutive level of vascular endothelial growth factor (VEGF) is more important than hypoxia-induced VEGF up-regulation in the angiogenesis of human melanoma xenografts
    Br J Cancer, 82 (9), 1528-34
    DOI 10.1054/bjoc.2000.1173, PubMed 10789719
  4. Graff BA, Bjornaes I, Rofstad EK (2000)
    Macromolecule uptake in human melanoma xenografts. relationships to blood supply, vascular density, microvessel permeability and extracellular volume fraction
    Eur J Cancer, 36 (11), 1433-40
    DOI 10.1016/s0959-8049(00)00120-9, PubMed 10899658
  5. Lyng H, Haraldseth O, Rofstad EK (2000)
    Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging
    Magn Reson Med, 43 (6), 828-36
    DOI 10.1002/1522-2594(200006)43:6<828::aid-mrm8>3.0.co;2-p, PubMed 10861877
  6. Lyng H, Sundfør K, Rofstad EK (2000)
    Changes in tumor oxygen tension during radiotherapy of uterine cervical cancer: relationships to changes in vascular density, cell density, and frequency of mitosis and apoptosis
    Int J Radiat Oncol Biol Phys, 46 (4), 935-46
    DOI 10.1016/s0360-3016(99)00497-6, PubMed 10705016
  7. Lyng H, Sundfør K, Tropé C, Rofstad EK (2000)
    Disease control of uterine cervical cancer: relationships to tumor oxygen tension, vascular density, cell density, and frequency of mitosis and apoptosis measured before treatment and during radiotherapy
    Clin Cancer Res, 6 (3), 1104-12
    PubMed 10741740
  8. Måseide K, Rofstad EK (2000)
    Mathematical modeling of chronical hypoxia in tumors considering potential doubling time and hypoxic cell lifetime
    Radiother Oncol, 54 (2), 171-7
    DOI 10.1016/s0167-8140(99)00154-1, PubMed 10699481
  9. Rofstad EK (2000)
    Microenvironment-induced cancer metastasis
    Int J Radiat Biol, 76 (5), 589-605
    DOI 10.1080/095530000138259, PubMed 10866281
  10. Rofstad EK, Halsør EF (2000)
    Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts
    Cancer Res, 60 (17), 4932-8
    PubMed 10987309
  11. Rofstad EK, Sundfør K, Lyng H, Tropé CG (2000)
    Hypoxia-induced treatment failure in advanced squamous cell carcinoma of the uterine cervix is primarily due to hypoxia-induced radiation resistance rather than hypoxia-induced metastasis
    Br J Cancer, 83 (3), 354-9
    DOI 10.1054/bjoc.2000.1266, PubMed 10917551
  12. Sundfør K, Lyng H, Tropé CG, Rofstad EK (2000)
    Treatment outcome in advanced squamous cell carcinoma of the uterine cervix: relationships to pretreatment tumor oxygenation and vascularization
    Radiother Oncol, 54 (2), 101-7
    DOI 10.1016/s0167-8140(99)00175-9, PubMed 10699471
  13. Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfør K, Rofstad EK, Mueller-Klieser W (2000)
    High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    Cancer Res, 60 (4), 916-21
    PubMed 10706105

Publications 1999

  1. Danielsen T, Smith-Sørensen B, Grønlund HA, Hvidsten M, Børresen-Dale AL, Rofstad EK (1999)
    No association between radiosensitivity and TP53 status, G1 arrest or protein levels of p53, myc, ras or raf in human melanoma lines
    Int J Radiat Biol, 75 (9), 1149-60
    DOI 10.1080/095530099139629, PubMed 10528923
  2. Lyng H, Tanum G, Evensen JF, Rofstad EK (1999)
    Changes in oxygen tension during radiotherapy of head and neck tumours
    Acta Oncol, 38 (8), 1037-42
    DOI 10.1080/028418699432329, PubMed 10665759
  3. Olsen DR, Rofstad EK (1999)
    Monitoring of tumor reoxygenation following irradiation by 31P magnetic resonance spectroscopy: an experimental study of human melanoma xenografts
    Radiother Oncol, 52 (3), 261-7
    DOI 10.1016/s0167-8140(99)00075-4, PubMed 10580874
  4. Olsen DR, Singstad TE, Rofstad EK (1999)
    Effects of hyperthermia on bioenergetic status and phosphorus T1S in human melanoma xenografts monitored by 31P-MRS
    Magn Reson Imaging, 17 (7), 1049-56
    DOI 10.1016/s0730-725x(99)00032-6, PubMed 10463656
  5. Olsen G, Lyng H, Tufto I, Solberg K, Bjørnaes I, Rofstad EK (1999)
    Measurement of proliferation activity in human melanoma xenografts by magnetic resonance imaging
    Magn Reson Imaging, 17 (3), 393-402
    DOI 10.1016/s0730-725x(98)00175-1, PubMed 10195582
  6. Rofstad EK, Danielsen T (1999)
    Hypoxia-induced metastasis of human melanoma cells: involvement of vascular endothelial growth factor-mediated angiogenesis
    Br J Cancer, 80 (11), 1697-707
    DOI 10.1038/sj.bjc.6690586, PubMed 10468285
  7. Rofstad EK, Måseide K (1999)
    Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours
    Int J Radiat Biol, 75 (11), 1377-93
    DOI 10.1080/095530099139250, PubMed 10597912
  8. Tufto I, Rofstad EK (1999)
    Interstitial fluid pressure and capillary diameter distribution in human melanoma xenografts
    Microvasc Res, 58 (3), 205-14
    DOI 10.1006/mvre.1999.2184, PubMed 10527764

Publications 1998

  1. Danielsen T, Hvidsten M, Stokke T, Solberg K, Rofstad EK (1998)
    Hypoxia induces p53 accumulation in the S-phase and accumulation of hypophosphorylated retinoblastoma protein in all cell cycle phases of human melanoma cells
    Br J Cancer, 78 (12), 1547-58
    DOI 10.1038/bjc.1998.722, PubMed 9862563
  2. Danielsen T, Rofstad EK (1998)
    VEGF, bFGF and EGF in the angiogenesis of human melanoma xenografts
    Int J Cancer, 76 (6), 836-41
    DOI 10.1002/(sici)1097-0215(19980610)76:6<836::aid-ijc12>3.0.co;2-0, PubMed 9626350
  3. Lyng H, Dahle GA, Kaalhus O, Skretting A, Rofstad EK (1998)
    Measurement of perfusion rate in human melanoma xenografts by contrast-enhanced magnetic resonance imaging
    Magn Reson Med, 40 (1), 89-98
    DOI 10.1002/mrm.1910400113, PubMed 9660558
  4. Lyng H, Sundfør K, Rofstad EK (1998)
    Oxygen tension in human squamous cell carcinoma and adenocarcinoma of the uterine cervix
    Adv Exp Med Biol, 454, 635-41
    DOI 10.1007/978-1-4615-4863-8_75, PubMed 9889944
  5. Rofstad EK, Danielsen T (1998)
    Hypoxia-induced angiogenesis and vascular endothelial growth factor secretion in human melanoma
    Br J Cancer, 77 (6), 897-902
    DOI 10.1038/bjc.1998.148, PubMed 9528831
  6. Rofstad EK, Måseide K (1998)
    Fraction of radiobiologically hypoxic cells in human melanoma xenografts measured by using single-cell survival, tumour growth delay and local tumour control as end points
    Br J Cancer, 78 (7), 893-8
    DOI 10.1038/bjc.1998.598, PubMed 9764580
  7. Sundfør K, Lyng H, Rofstad EK (1998)
    Tumour hypoxia and vascular density as predictors of metastasis in squamous cell carcinoma of the uterine cervix
    Br J Cancer, 78 (6), 822-7
    DOI 10.1038/bjc.1998.586, PubMed 9743308
  8. Sundfør K, Lyng H, Rofstad EK (1998)
    Oxygen tension and vascular density in adenocarcinoma and squamous cell carcinoma of the uterine cervix
    Acta Oncol, 37 (7-8), 665-70
    DOI 10.1080/028418698430016, PubMed 10050984
  9. Tufto I, Lyng H, Rofstad EK (1998)
    Vascular density in human melanoma xenografts: relationship to angiogenesis, perfusion and necrosis
    Cancer Lett, 123 (2), 159-65
    DOI 10.1016/s0304-3835(97)00424-2, PubMed 9489483
  10. Tufto I, Rofstad EK (1998)
    Interstitial fluid pressure, fraction of necrotic tumor tissue, and tumor cell density in human melanoma xenografts
    Acta Oncol, 37 (3), 291-7
    DOI 10.1080/028418698429603, PubMed 9677102

Publications 1997

  1. Blomlie V, Rofstad EK, Tropé C, Lien HH (1997)
    Critical soft tissues of the female pelvis: serial MR imaging before, during, and after radiation therapy
    Radiology, 203 (2), 391-7
    DOI 10.1148/radiology.203.2.9114093, PubMed 9114093
  2. Danielsen T, Skøyum R, Rofstad EK (1997)
    Hypoxia-induced changes in radiation sensitivity in human melanoma cells: importance of oxygen-regulated proteins, adenylate energy charge and cell cycle distribution
    Radiother Oncol, 44 (2), 177-82
    DOI 10.1016/s0167-8140(97)01929-4, PubMed 9288847
  3. Lyng H, Sundfør K, Rofstad EK (1997)
    Oxygen tension in human tumours measured with polarographic needle electrodes and its relationship to vascular density, necrosis and hypoxia
    Radiother Oncol, 44 (2), 163-9
    DOI 10.1016/s0167-8140(97)01920-8, PubMed 9288845
  4. Lyng H, Sundfør K, Tanum G, Rofstad EK (1997)
    Oxygen tension in primary tumours of the uterine cervix and lymph node metastases of the head and neck
    Adv Exp Med Biol, 428, 55-60
    DOI 10.1007/978-1-4615-5399-1_9, PubMed 9500029
  5. Lyng H, Tufto I, Skretting A, Rofstad EK (1997)
    Proton relaxation times and interstitial fluid pressure in human melanoma xenografts
    Br J Cancer, 75 (2), 180-3
    DOI 10.1038/bjc.1997.30, PubMed 9010023
  6. Måseide K, Rofstad EK (1997)
    CCD imaging in cryospectrophotometric determination of microvascular oxyhemoglobin saturations
    Am J Physiol, 273 (6), H2910-8
    DOI 10.1152/ajpheart.1997.273.6.H2910, PubMed 9435631
  7. Olsen DR, Petersen SB, Rofstad EK (1997)
    Radiation-induced changes in phosphorus T1 values in human melanoma xenografts studied by 31P-MRS
    Magn Reson Imaging, 15 (10), 1187-92
    DOI 10.1016/s0730-725x(97)00181-1, PubMed 9408139
  8. Skøyum R, Eide K, Berg K, Rofstad EK (1997)
    Energy metabolism in human melanoma cells under hypoxic and acidic conditions in vitro
    Br J Cancer, 76 (4), 421-8
    DOI 10.1038/bjc.1997.405, PubMed 9275017
  9. Sundfør K, Lyng H, Kongsgård UL, Tropé C, Rofstad EK (1997)
    Polarographic measurement of pO2 in cervix carcinoma
    Gynecol Oncol, 64 (2), 230-6
    DOI 10.1006/gyno.1996.4571, PubMed 9038268
  10. Walenta S, Salameh A, Lyng H, Evensen JF, Mitze M, Rofstad EK, Mueller-Klieser W (1997)
    Correlation of high lactate levels in head and neck tumors with incidence of metastasis
    Am J Pathol, 150 (2), 409-15
    PubMed 9033256

Publications 1996

  1. Blomlie V, Rofstad EK, Talle K, Sundfør K, Winderen M, Lien HH (1996)
    Incidence of radiation-induced insufficiency fractures of the female pelvis: evaluation with MR imaging
    AJR Am J Roentgenol, 167 (5), 1205-10
    DOI 10.2214/ajr.167.5.8911181, PubMed 8911181
  2. Blomlie V, Rofstad EK, Tverå K, Lien HH (1996)
    Noncritical soft tissues of the female pelvis: serial MR imaging before, during, and after radiation therapy
    Radiology, 199 (2), 461-8
    DOI 10.1148/radiology.199.2.8668795, PubMed 8668795
  3. Lyng H, Sundfør K, Tropé C, Rofstad EK (1996)
    Oxygen tension and vascular density in human cervix carcinoma
    Br J Cancer, 74 (10), 1559-63
    DOI 10.1038/bjc.1996.589, PubMed 8932335
  4. Rofstad EK, Eide K, Skøyum R, Hystad ME, Lyng H (1996)
    Apoptosis, energy metabolism, and fraction of radiobiologically hypoxic cells: a study of human melanoma multicellular spheroids
    Int J Radiat Biol, 70 (3), 241-9
    DOI 10.1080/095530096144978, PubMed 8800195
  5. Rofstad EK, Johnsen NM, Lyng H (1996)
    Hypoxia-induced tetraploidisation of a diploid human melanoma cell line in vitro
    Br J Cancer Suppl, 27, S136-9
    PubMed 8763866
  6. Rofstad EK, Lyng H (1996)
    Xenograft model systems for human melanoma
    Mol Med Today, 2 (9), 394-403
    DOI 10.1016/S1357-4310(96)10035-6, PubMed 8885259
  7. Tufto I, Lyng H, Rofstad EK (1996)
    Interstitial fluid pressure, perfusion rate and oxygen tension in human melanoma xenografts
    Br J Cancer Suppl, 27, S252-5
    PubMed 8763891

Publications 1995

  1. Blomlie V, Rofstad EK, Skjønsberg A, Tverå K, Lien HH (1995)
    Female pelvic bone marrow: serial MR imaging before, during, and after radiation therapy
    Radiology, 194 (2), 537-43
    DOI 10.1148/radiology.194.2.7824737, PubMed 7824737
  2. Jakobsen I, Kaalhus O, Lyng H, Rofstad EK (1995)
    Detection of necrosis in human tumour xenografts by proton magnetic resonance imaging
    Br J Cancer, 71 (3), 456-61
    DOI 10.1038/bjc.1995.93, PubMed 7880724
  3. Jakobsen I, Lyng H, Kaalhus O, Rofstad EK (1995)
    MRI of human tumor xenografts in vivo: proton relaxation times and extracellular tumor volume
    Magn Reson Imaging, 13 (5), 693-700
    DOI 10.1016/0730-725x(95)00019-d, PubMed 8569443
  4. Kroeger M, Walenta S, Rofstad EK, Mueller-Klieser W (1995)
    Growth rates or radiobiological hypoxia are not correlated with local metabolite content in human melanoma xenografts with similar vascular network
    Br J Cancer, 72 (4), 912-6
    DOI 10.1038/bjc.1995.432, PubMed 7547239
  5. Lyng H, Olsen DR, Petersen SB, Rofstad EK (1995)
    31P NMR spectroscopy studies of phospholipid metabolism in human melanoma xenograft lines differing in rate of tumour cell proliferation
    NMR Biomed, 8 (2), 65-71
    DOI 10.1002/nbm.1940080204, PubMed 7547188
  6. Lyng H, Rofstad EK (1995)
    Treatment failure following sequential thermoradiotherapy of locally advanced breast carcinoma occurs primarily in poorly vascularized tumors
    Oncology, 52 (6), 443-7
    DOI 10.1159/000227508, PubMed 7478428
  7. Olsen DR, Lyng H, Petersen S, Rofstad EK (1995)
    Spin-lattice relaxation time of inorganic phosphate in human tumor xenografts measured in vivo by 31P-magnetic resonance spectroscopy. Influence of oxygen tension
    Acta Oncol, 34 (3), 339-43
    DOI 10.3109/02841869509093986, PubMed 7779420
  8. Olsen DR, Lyng H, Petersen SB, Rofstad EK (1995)
    Effect of melanin on phosphorus T1S in human melanoma xenografts studied by 31P MRS
    Magn Reson Imaging, 13 (6), 847-52
    DOI 10.1016/0730-725x(95)00054-k, PubMed 8544656
  9. Rofstad EK (1995)
    Metastatic behavior of human tumors in congenitally athymic nude mice: intrinsic properties of the tumor cells and host immune reactivity
    Int J Cancer, 63 (5), 744-9
    DOI 10.1002/ijc.2910630523, PubMed 7591295
  10. Schwickert G, Walenta S, Sundfør K, Rofstad EK, Mueller-Klieser W (1995)
    Correlation of high lactate levels in human cervical cancer with incidence of metastasis
    Cancer Res, 55 (21), 4757-9
    PubMed 7585499
  11. Tufto I, Rofstad EK (1995)
    Transient perfusion in human melanoma xenografts
    Br J Cancer, 71 (4), 789-93
    DOI 10.1038/bjc.1995.153, PubMed 7536022
  12. Tufto I, Rofstad EK (1995)
    Interstitial fluid pressure in human melanoma xenografts. Relationship to fractional tumor water content, tumor size, and tumor volume-doubling time
    Acta Oncol, 34 (3), 361-5
    DOI 10.3109/02841869509093990, PubMed 7779424

Publications 1994

  1. Barth RF, Matalka KZ, Bailey MQ, Staubus AE, Soloway AH, Moeschberger ML, Coderre JA, Rofstad EK (1994)
    A nude rat model for neutron capture therapy of human intracerebral melanoma
    Int J Radiat Oncol Biol Phys, 28 (5), 1079-88
    DOI 10.1016/0360-3016(94)90481-2, PubMed 8175392
  2. Hystad ME, Rofstad EK (1994)
    Oxygen consumption rate and mitochondrial density in human melanoma monolayer cultures and multicellular spheroids
    Int J Cancer, 57 (4), 532-7
    DOI 10.1002/ijc.2910570416, PubMed 8181856
  3. Larsen RH, Bruland OS, Hoff P, Alstad J, Lindmo T, Rofstad EK (1994)
    Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody: comparison with astatine-211-labeled bovine serum albumin, free astatine-211 and external-beam X rays
    Radiat Res, 139 (2), 178-84
    DOI 10.2307/3578662, PubMed 8052693
  4. Larsen RH, Bruland OS, Hoff P, Alstad J, Rofstad EK (1994)
    Analysis of the therapeutic gain in the treatment of human osteosarcoma microcolonies in vitro with 211At-labelled monoclonal antibody
    Br J Cancer, 69 (6), 1000-5
    DOI 10.1038/bjc.1994.196, PubMed 8198960
  5. Olsen DR, Lyng H, Southon TE, Rofstad EK (1994)
    31P-nuclear magnetic resonance spectroscopy in vivo of four human melanoma xenograft lines: spin-lattice relaxation times
    Radiother Oncol, 32 (1), 54-62
    DOI 10.1016/0167-8140(94)90449-9, PubMed 7938679
  6. Rofstad EK (1994)
    Fractionation sensitivity (alpha/beta ratio) of human melanoma xenografts
    Radiother Oncol, 33 (2), 133-8
    DOI 10.1016/0167-8140(94)90067-1, PubMed 7708956
  7. Rofstad EK (1994)
    Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern
    Br J Cancer, 70 (5), 804-12
    DOI 10.1038/bjc.1994.403, PubMed 7947084
  8. Rofstad EK (1994)
    Step-down heating of human melanoma xenografts: effects of the tumour microenvironment
    Br J Cancer, 70 (3), 453-8
    DOI 10.1038/bjc.1994.327, PubMed 8080730
  9. Rofstad EK, Lyng H, Olsen DR, Steinsland E (1994)
    Non-invasive assessment of tumor oxygenation status by integrated 31P NMR spectroscopy and 1H NMR imaging
    Adv Exp Med Biol, 345, 531-8
    DOI 10.1007/978-1-4615-2468-7_71, PubMed 8079755
  10. Rofstad EK, Steinsland E, Kaalhus O, Chang YB, Høvik B, Lyng H (1994)
    Magnetic resonance imaging of human melanoma xenografts in vivo: proton spin-lattice and spin-spin relaxation times versus fractional tumour water content and fraction of necrotic tumour tissue
    Int J Radiat Biol, 65 (3), 387-401
    DOI 10.1080/09553009414550451, PubMed 7908318
  11. Sanna K, Rofstad EK (1994)
    Hypoxia-induced resistance to doxorubicin and methotrexate in human melanoma cell lines in vitro
    Int J Cancer, 58 (2), 258-62
    DOI 10.1002/ijc.2910580219, PubMed 8026888
  12. Zaffaroni N, Orlandi L, Villa R, Bearzatto A, Rofstad EK, Silvestrini R (1994)
    DNA double-strand break repair and radiation response in human tumour primary cultures
    Int J Radiat Biol, 66 (3), 279-85
    DOI 10.1080/09553009414551211, PubMed 7930830

Publications 1993

  1. Lyng H, Monge OR, Sager EM, Rofstad EK (1993)
    Prediction of treatment temperatures in clinical hyperthermia of locally advanced breast carcinoma: the use of contrast enhanced computed tomography
    Int J Radiat Oncol Biol Phys, 26 (3), 451-7
    DOI 10.1016/0360-3016(93)90963-v, PubMed 8390419
  2. Lyng H, Olsen DR, Southon TE, Rofstad EK (1993)
    31P-nuclear magnetic resonance spectroscopy in vivo of six human melanoma xenograft lines: tumour bioenergetic status and blood supply
    Br J Cancer, 68 (6), 1061-70
    DOI 10.1038/bjc.1993.483, PubMed 8260356
  3. Lyng H, Rofstad EK (1993)
    Thermal dose and secondary tumour cell death
    Int J Hyperthermia, 9 (5), 755-61
    DOI 10.3109/02656739309032062, PubMed 8245585
  4. Matalka KZ, Bailey MQ, Barth RF, Staubus AE, Soloway AH, Moeschberger ML, Coderre JA, Rofstad EK (1993)
    Boron neutron capture therapy of intracerebral melanoma using boronophenylalanine as a capture agent
    Cancer Res, 53 (14), 3308-13
    PubMed 8324742
  5. Nagelhus TA, Rofstad EK (1993)
    Expression of the chondroitin sulphate proteoglycan molecular complex in six human melanoma xenograft lines studied by flow cytometry and immunohistochemistry
    Melanoma Res, 3 (3), 187-94
    DOI 10.1097/00008390-199306000-00007, PubMed 7691291
  6. Pettersen EO, Larsen RO, Dornish JM, Børretzen B, Juul ME, Aastveit TE, Nesland JM, Rofstad EK, Oftebro R (1993)
    Tumour necrotisation in nude mice xenografts by the reversible protein synthesis inhibitor zilascorb(2H)
    Br J Cancer, 67 (4), 650-6
    DOI 10.1038/bjc.1993.121, PubMed 8471421

Publications 1992

  1. Lyng H, Skretting A, Rofstad EK (1992)
    Blood flow in six human melanoma xenograft lines with different growth characteristics
    Cancer Res, 52 (3), 584-92
    PubMed 1732046
  2. Rofstad EK (1992)
    Retention of cellular radiation sensitivity in cell and xenograft lines established from human melanoma surgical specimens
    Cancer Res, 52 (7), 1764-9
    PubMed 1551106
  3. Rofstad EK (1992)
    Repopulation between radiation fractions in human melanoma xenografts
    Int J Radiat Oncol Biol Phys, 23 (1), 63-8
    DOI 10.1016/0360-3016(92)90544-r, PubMed 1572831
  4. Rofstad EK (1992)
    Radiation sensitivity in vitro of primary tumors and metastatic lesions of malignant melanoma
    Cancer Res, 52 (16), 4453-7
    PubMed 1643637
  5. Rofstad EK (1992)
    Comparative sensitivity of cells from human tumors and derivative tumor xenografts to radiation and heat treatments
    J Natl Cancer Inst, 84 (19), 1517-24
    DOI 10.1093/jnci/84.19.1517, PubMed 1433336

Publications 1991

  1. Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
    Changes in temperatures and thermal doses with fraction number during hyperthermic treatment of locally advanced breast carcinoma
    Int J Hyperthermia, 7 (6), 815-25
    DOI 10.3109/02656739109056450, PubMed 1666900
  2. Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
    Temperature distribution in locally advanced breast carcinoma during hyperthermic treatment: relationship to perfusion, vascular density, and histology
    Int J Radiat Oncol Biol Phys, 21 (2), 423-30
    DOI 10.1016/0360-3016(91)90791-2, PubMed 1648045
  3. Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
    The relevance of tumour and surrounding normal tissue vascular density in clinical hyperthermia of locally advanced breast carcinoma
    Int J Radiat Biol, 60 (1-2), 189-93
    DOI 10.1080/09553009114551821, PubMed 1677970
  4. Lyng H, Monge OR, Bøhler PJ, Rofstad EK (1991)
    Relationships between thermal dose and heat-induced tissue and vascular damage after thermoradiotherapy of locally advanced breast carcinoma
    Int J Hyperthermia, 7 (3), 403-15
    DOI 10.3109/02656739109005006, PubMed 1919137
  5. Monge OR, Rofstad EK (1991)
    Fractionated thermochemotherapy in vivo of a C3H mouse mammary carcinoma
    Radiother Oncol, 21 (3), 171-8
    DOI 10.1016/0167-8140(91)90034-e, PubMed 1924852
  6. Mueller-Klieser W, Kroeger M, Walenta S, Rofstad EK (1991)
    Comparative imaging of structure and metabolites in tumours
    Int J Radiat Biol, 60 (1-2), 147-59
    DOI 10.1080/09553009114551741, PubMed 1677963
  7. Rofstad EK (1991)
    Heterogeneity in vascular architecture and heat-induced vascular damage of human melanoma xenograft lines established from different lesions in the same patient
    Int J Radiat Biol, 60 (1-2), 183-7
    DOI 10.1080/09553009114551801, PubMed 1677969
  8. Rofstad EK (1991)
    Influence of cellular radiation sensitivity on local tumor control of human melanoma xenografts given fractionated radiation treatment
    Cancer Res, 51 (17), 4609-12
    PubMed 1873806
  9. Rofstad EK, Wahl A, Hystad ME, Nesland JM, Stokke T (1991)
    Establishment in monolayer culture and characterization of four human melanoma cell lines
    Virchows Arch B Cell Pathol Incl Mol Pathol, 60 (3), 189-97
    DOI 10.1007/BF02899546, PubMed 1679270

Publications 1990

  1. Mueller-Klieser W, Schaefer C, Walenta S, Rofstad EK, Fenton BM, Sutherland RM (1990)
    Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry
    Cancer Res, 50 (6), 1681-5
    PubMed 2306721
  2. Rofstad EK (1990)
    Heat sensitivity and thermotolerance in vitro of human breast carcinoma, malignant melanoma and squamous cell carcinoma of the head and neck
    Br J Cancer, 61 (1), 22-8
    DOI 10.1038/bjc.1990.6, PubMed 2297488
  3. Rofstad EK (1990)
    NMR spectroscopy in prediction and monitoring of radiation response of tumours in vivo
    Int J Radiat Biol, 57 (1), 1-5
    DOI 10.1080/09553009014550281, PubMed 1967281
  4. Rofstad EK (1990)
    PLD-repair in human melanoma xenografts following single dose and fractionated irradiation
    Br J Cancer, 61 (6), 856-60
    DOI 10.1038/bjc.1990.191, PubMed 2372487
  5. Rofstad EK, Wahl A, Stokke T, Nesland JM (1990)
    Establishment and characterization of six human melanoma xenograft lines
    APMIS, 98 (10), 945-53
    DOI 10.1111/j.1699-0463.1990.tb05019.x, PubMed 2245014
  6. Rofstad EK, Zaffaroni N, Hystad ME (1990)
    Heterogeneous radiation and heat sensitivity in vitro of human melanoma xenograft lines established from different lesions in the same patient. Comparisons with the radiation and heat sensitivity of cells isolated from the donor patient's surgical specimens
    Int J Radiat Biol, 57 (6), 1113-22
    DOI 10.1080/09553009014551231, PubMed 1971838

Publications 1989

  1. Lee FY, Vessey A, Rofstad E, Siemann DW, Sutherland RM (1989)
    Heterogeneity of glutathione content in human ovarian cancer
    Cancer Res, 49 (19), 5244-8
    PubMed 2766292
  2. Monge OR, Rofstad EK (1989)
    Thermochemotherapy in vivo of a C3H mouse mammary carcinoma: thermotolerant tumours
    Int J Hyperthermia, 5 (5), 579-87
    DOI 10.3109/02656738909140482, PubMed 2504842
  3. Rofstad EK (1989)
    Radiation biology of human tumour xenografts
    Int J Radiat Biol, 56 (5), 573-81
    DOI 10.1080/09553008914551761, PubMed 2573649
  4. Rofstad EK (1989)
    Local tumor control following single dose irradiation of human melanoma xenografts: relationship to cellular radiosensitivity and influence of an immune response by the athymic mouse
    Cancer Res, 49 (12), 3163-7
    PubMed 2655893
  5. Rofstad EK (1989)
    Influence of cellular, microenvironmental, and growth parameters on thermotolerance kinetics in vivo in human melanoma xenografts
    Cancer Res, 49 (18), 5027-32
    PubMed 2766273
  6. Rofstad EK (1989)
    Hypoxia and reoxygenation in human melanoma xenografts
    Int J Radiat Oncol Biol Phys, 17 (1), 81-9
    DOI 10.1016/0360-3016(89)90374-x, PubMed 2745212
  7. Rofstad EK, DeMuth P, Fenton BM, Ceckler TL, Sutherland RM (1989)
    31P NMR spectroscopy and HbO2 cryospectrophotometry in prediction of tumor radioresistance caused by hypoxia
    Int J Radiat Oncol Biol Phys, 16 (4), 919-23
    DOI 10.1016/0360-3016(89)90887-0, PubMed 2703397
  8. Rofstad EK, Sutherland RM (1989)
    Growth and radiation sensitivity of the MLS human ovarian carcinoma cell line grown as multicellular spheroids and xenografted tumours
    Br J Cancer, 59 (1), 28-35
    DOI 10.1038/bjc.1989.7, PubMed 2757922

Publications 1988

  1. Brustad T, Rofstad EK (1988)
    Effects of heat treatment in vitro and in vivo on human melanoma xenografts
    Recent Results Cancer Res, 109, 183-97
    DOI 10.1007/978-3-642-83263-5_21, PubMed 3175290
  2. Davies CL, Ranheim T, Malik Z, Rofstad EK, Moan J, Lindmo T (1988)
    Relationship between changes in antigen expression and protein synthesis in human melanoma cells after hyperthermia and photodynamic treatment
    Br J Cancer, 58 (3), 306-13
    DOI 10.1038/bjc.1988.209, PubMed 3179182
  3. Fenton BM, Rofstad EK, Degner FL, Sutherland RM (1988)
    Cryospectrophotometric determination of tumor intravascular oxyhemoglobin saturations: dependence on vascular geometry and tumor growth
    J Natl Cancer Inst, 80 (20), 1612-9
    DOI 10.1093/jnci/80.20.1612, PubMed 3193479
  4. Monge OR, Rofstad EK, Kaalhus O (1988)
    Thermochemotherapy in vivo of a C3H mouse mammary carcinoma: single fraction heat and drug treatment
    Eur J Cancer Clin Oncol, 24 (10), 1661-9
    DOI 10.1016/0277-5379(88)90060-0, PubMed 3145205
  5. Rofstad EK, DeMuth P, Fenton BM, Sutherland RM (1988)
    31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia
    Cancer Res, 48 (19), 5440-6
    PubMed 3416301
  6. Rofstad EK, DeMuth P, Sutherland RM (1988)
    31P NMR spectroscopy measurements of human ovarian carcinoma xenografts: relationship to tumour volume, growth rate, necrotic fraction and differentiation status
    Radiother Oncol, 12 (4), 315-26
    DOI 10.1016/0167-8140(88)90021-7, PubMed 3187070
  7. Rofstad EK, Fenton BM, Sutherland RM (1988)
    Intracapillary HbO2 saturations in murine tumours and human tumour xenografts measured by cryospectrophotometry: relationship to tumour volume, tumour pH and fraction of radiobiologically hypoxic cells
    Br J Cancer, 57 (5), 494-502
    DOI 10.1038/bjc.1988.113, PubMed 3395554
  8. Rofstad EK, Howell RL, DeMuth P, Ceckler TL, Sutherland RM (1988)
    31P NMR spectroscopy in vivo of two murine tumor lines with widely different fractions of radiobiologically hypoxic cells
    Int J Radiat Biol, 54 (4), 635-49
    DOI 10.1080/09553008814552071, PubMed 2902161
  9. Rofstad EK, Sutherland RM (1988)
    Radiation sensitivity of human ovarian carcinoma cell lines in vitro: effects of growth factors and hormones, basement membrane, and intercellular contact
    Int J Radiat Oncol Biol Phys, 15 (4), 921-9
    DOI 10.1016/0360-3016(88)90127-7, PubMed 3182331

Publications 1987

  1. Rofstad EK, Brustad T (1987)
    Radioresponsiveness of human melanoma xenografts given fractionated irradiation in vivo--relationship to the initial slope of the cell survival curves in vitro
    Radiother Oncol, 9 (1), 45-56
    DOI 10.1016/s0167-8140(87)80218-9, PubMed 3602429
  2. Rofstad EK, Wahl A, Brustad T (1987)
    Radiation sensitivity in vitro of cells isolated from human tumor surgical specimens
    Cancer Res, 47 (1), 106-10
    PubMed 3791195

Publications 1986

  1. Rofstad EK (1986)
    Radiation biology of malignant melanoma
    Acta Radiol Oncol, 25 (1), 1-10
    PubMed 3010642
  2. Rofstad EK (1986)
    Growth and radiosensitivity of malignant melanoma multicellular spheroids initiated directly from surgical specimens of tumours in man
    Br J Cancer, 54 (4), 569-78
    DOI 10.1038/bjc.1986.211, PubMed 3778801
  3. Rofstad EK, Brustad T (1986)
    Differences in thermosensitization among cloned cell lines isolated from a single human melanoma xenograft
    Radiat Res, 106 (2), 147-55
    DOI 10.2307/3576788, PubMed 3704108
  4. Rofstad EK, Brustad T (1986)
    Primary and secondary cell death in human melanoma xenografts following hyperthermic treatment
    Cancer Res, 46 (1), 355-61
    PubMed 3940201
  5. Rofstad EK, Brustad T (1986)
    Heterogeneity in radiosensitization by heat of cloned cell lines derived from a single human melanoma xenograft
    Int J Radiat Biol Relat Stud Phys Chem Med, 50 (1), 93-102
    DOI 10.1080/09553008614550471, PubMed 3487528
  6. Rofstad EK, Brustad T (1986)
    Arrhenius analysis of the heat response in vivo and in vitro of human melanoma xenografts
    Int J Hyperthermia, 2 (4), 359-68
    PubMed 3805805
  7. Rofstad EK, Wahl A, Brustad T (1986)
    Radiation response of human melanoma multicellular spheroids measured as single cell survival, growth delay, and spheroid cure: comparisons with the parent tumor xenograft
    Int J Radiat Oncol Biol Phys, 12 (6), 975-82
    DOI 10.1016/0360-3016(86)90394-9, PubMed 3721939
  8. Rofstad EK, Wahl A, Brustad T (1986)
    Radiation response of multicellular spheroids initiated from five human melanoma xenograft lines. Relationship to the radioresponsiveness in vivo
    Br J Radiol, 59 (706), 1023-9
    DOI 10.1259/0007-1285-59-706-1023, PubMed 3768626
  9. Rofstad EK, Wahl A, Davies Cde L, Brustad T (1986)
    Growth characteristics of human melanoma multicellular spheroids in liquid-overlay culture: comparisons with the parent tumour xenografts
    Cell Tissue Kinet, 19 (2), 205-16
    DOI 10.1111/j.1365-2184.1986.tb00731.x, PubMed 3698078

Publications 1985

  1. Davies Cde L, Rofstad EK, Lindmo T (1985)
    Hyperthermia-induced changes in antigen expression on human FME melanoma cells
    Cancer Res, 45 (9), 4109-14
    PubMed 3896477
  2. Rofstad EK (1985)
    Human tumour xenografts in radiotherapeutic research
    Radiother Oncol, 3 (1), 35-46
    DOI 10.1016/s0167-8140(85)80007-4, PubMed 3975440
  3. Rofstad EK, Brustad T (1985)
    Tumour growth delay following single dose irradiation of human melanoma xenografts. Correlations with tumour growth parameters, vascular structure and cellular radiosensitivity
    Br J Cancer, 51 (2), 201-10
    DOI 10.1038/bjc.1985.30, PubMed 3966977
  4. Rofstad EK, Brustad T (1985)
    Heterogeneity in heat sensitivity and development of thermotolerance of cloned cell lines derived from a single human melanoma xenograft
    Int J Hyperthermia, 1 (1), 85-96
    PubMed 3837083
  5. Rofstad EK, Wahl A, Brustad T (1985)
    Heat response of human melanoma multicellular spheroids: comparisons with single cells and xenografted tumors
    Radiat Res, 102 (3), 324-35
    DOI 10.2307/3576708, PubMed 4070547
  6. Rofstad EK, Wahl A, Tveit KM, Monge OR, Brustad T (1985)
    Survival curves after X-ray and heat treatments for melanoma cells derived directly from surgical specimens of tumours in man
    Radiother Oncol, 4 (1), 33-44
    DOI 10.1016/s0167-8140(85)80060-8, PubMed 4035001
  7. Solesvik OV, Rofstad EK, Brustad T (1985)
    Vascular structure of the C3H mammary carcinoma, the B16 melanoma and the Lewis lung carcinoma in syngeneic, conventional mice and congenitally athymic mice
    Eur J Cancer Clin Oncol, 21 (4), 499-505
    DOI 10.1016/0277-5379(85)90044-6, PubMed 4007018

Publications 1984

  1. Falkvoll KH, Rofstad EK, Brustad T, Marton P (1984)
    A transparent chamber for the dorsal skin fold of athymic mice
    Exp Cell Biol, 52 (4), 260-8
    PubMed 6734890
  2. Lindmo T, Davies C, Rofstad EK, Fodstad O, Sundan A (1984)
    Antigen expression in human melanoma cells in relation to growth conditions and cell-cycle distribution
    Int J Cancer, 33 (2), 167-71
    DOI 10.1002/ijc.2910330203, PubMed 6693198
  3. Rofstad EK (1984)
    Growth and vascular structure of human melanoma xenografts
    Cell Tissue Kinet, 17 (1), 91-101
    DOI 10.1111/j.1365-2184.1984.tb00571.x, PubMed 6692466
  4. Rofstad EK, Brustad T (1984)
    Development of thermotolerance in a human melanoma xenograft
    Cancer Res, 44 (2), 525-30
    PubMed 6692358
  5. Rofstad EK, Brustad T (1984)
    Hyperthermic radiosensitization of cells from a human melanoma xenograft
    Radiat Res, 99 (1), 59-72
    DOI 10.2307/3576447, PubMed 6739727
  6. Rofstad EK, Brustad T (1984)
    Response to heat treatment (42.5 degrees C) in vivo and in vitro of five human melanoma xenografts
    Br J Radiol, 57 (683), 1023-32
    DOI 10.1259/0007-1285-57-683-1023, PubMed 6535617
  7. Rofstad EK, Brustad T (1984)
    Differential responses to radiation and hyperthermia of cloned cell lines derived from a single human melanoma xenograft
    Int J Radiat Oncol Biol Phys, 10 (6), 857-64
    DOI 10.1016/0360-3016(84)90388-2, PubMed 6735769
  8. Rofstad EK, Falkvoll KH, Oftedal P (1984)
    Micronucleus formation in human melanoma xenografts following exposure to hyperthermia
    Radiat Environ Biophys, 23 (1), 51-60
    DOI 10.1007/BF01326736, PubMed 6709827
  9. Rofstad EK, Midthjell H, Brustad T (1984)
    Heat sensitivity and thermotolerance in cells from five human melanoma xenografts
    Cancer Res, 44 (10), 4347-54
    PubMed 6467196
  10. Rofstad EK, Solesvik OV, Brustad T (1984)
    Tumour growth delay, cell inactivation and vascular damage following hyperthermic treatment of a human melanoma xenograft
    Eur J Cancer Clin Oncol, 20 (10), 1295-1305
    DOI 10.1016/0277-5379(84)90259-1, PubMed 6541585
  11. Rofstad EK, Wahl A, Brustad T (1984)
    Radiation and heat sensitivity of cells from two slowly growing human melanoma xenografts
    Br J Cancer, 49 (6), 745-52
    DOI 10.1038/bjc.1984.117, PubMed 6733021
  12. Solesvik OV, Rofstad EK, Brustad T (1984)
    Vascular changes in a human malignant melanoma xenograft following single-dose irradiation
    Radiat Res, 98 (1), 115-28
    DOI 10.2307/3576056, PubMed 6718687

Publications 1983

  1. Fodstad O, Rofstad EK, Tveit KM, Pihl A (1983)
    Spontaneous alteration in growth rates of two human melanoma xenografts. Concurrent changes in chemosensitivity
    Eur J Cancer Clin Oncol, 19 (8), 1175-8
    DOI 10.1016/0277-5379(83)90046-9, PubMed 6684563
  2. Rofstad EK, Brustad T (1983)
    Radiosensitivity of the cells of an established human melanoma cell line and the parent melanoma xenograft
    Int J Radiat Biol Relat Stud Phys Chem Med, 44 (5), 447-54
    DOI 10.1080/09553008314551431, PubMed 6605949
  3. Rofstad EK, Brustad T (1983)
    Radiation and heat sensitivity of cells from human melanoma xenografts. Lack of correlations with tumour growth parameters
    Eur J Cancer Clin Oncol, 19 (3), 427-32
    DOI 10.1016/0277-5379(83)90142-6, PubMed 6683180
  4. Rofstad EK, Brustad T (1983)
    Intercellular contact and the radiation response of cells of human melanoma xenografts
    Int J Radiat Oncol Biol Phys, 9 (2), 191-5
    DOI 10.1016/0360-3016(83)90098-6, PubMed 6833022
  5. Rofstad EK, Brustad T (1983)
    Tumour control following single-dose irradiation of a human melanoma xenograft
    Eur J Cancer Clin Oncol, 19 (8), 1127-31
    DOI 10.1016/0277-5379(83)90038-x, PubMed 6684558

Publications 1982

  1. Rofstad EK, Brustad T (1982)
    Effect of hyperthermia on human melanoma cells heated either as solid tumors in athymic nude mice or in vitro
    Cancer, 50 (7), 1304-8
    DOI 10.1002/1097-0142(19821001)50:7<1304::aid-cncr2820500715>3.0.co;2-h, PubMed 7104974
  2. Rofstad EK, Fodstad O, Lindmo T (1982)
    Growth characteristics of human melanoma xenografts
    Cell Tissue Kinet, 15 (5), 545-54
    DOI 10.1111/j.1365-2184.1982.tb01576.x, PubMed 7127402
  3. Solesvik OV, Rofstad EK, Brustad T (1982)
    Vascular structure of five human malignant melanomas grown in athymic nude mice
    Br J Cancer, 46 (4), 557-67
    DOI 10.1038/bjc.1982.240, PubMed 7138764

Publications 1981

  1. Flaten TP, Rofstad EK, Brustad T (1981)
    Radiation response of two human malignant melanomas grown in athymic nude mice
    Eur J Cancer, 17 (5), 527-32
    DOI 10.1016/0014-2964(81)90054-2, PubMed 7297592
  2. Pettersen EO, Rofstad EK, Brustad T (1981)
    Sensitising effect of misonidazole on NHIK 1922 cells irradiated in vitro or as solid tumour in athymic nude mice
    Acta Radiol Oncol, 20 (2), 101-8
    PubMed 6270961
  3. Rofstad EK (1981)
    Radiation response of the cells of a human malignant melanoma xenograft. Effect of hypoxic cell radiosensitizers
    Radiat Res, 87 (3), 670-83
    DOI 10.2307/3575529, PubMed 7280191
  4. Rofstad EK, Brustad T (1981)
    Broad-shouldered survival curves of a human melanoma xenograft. Implications for radiation therapy in the absence and presence of misonidazole
    Acta Radiol Oncol, 20 (4), 261-5
    DOI 10.3109/02841868109130204, PubMed 6277155
  5. Rofstad EK, Brustad T (1981)
    Response of human malignant melanoma xenografts to hyperthermia: effect of vascular occlusion
    Int J Radiat Oncol Biol Phys, 7 (12), 1685-7
    DOI 10.1016/0360-3016(81)90193-0, PubMed 7333910
  6. Rofstad EK, Brustad T (1981)
    Radiation response in vitro of cells from five human malignant melanoma xenografts
    Int J Radiat Biol Relat Stud Phys Chem Med, 40 (6), 677-80
    DOI 10.1080/09553008114551671, PubMed 6978304

Publications 1980

  1. Rofstad EK, Brustad T (1980)
    Radiosensitizing effect of misonidazole in acute and fractionated irradiation of a human osteosarcoma xenograft
    Int J Radiat Oncol Biol Phys, 6 (9), 1163-7
    DOI 10.1016/0360-3016(80)90169-8, PubMed 6936394
  2. Rofstad EK, Brustad T (1980)
    Radiosensitization by misonidazole of a human malignant melanoma grown in athymic nude mice
    Br J Radiol, 53 (631), 678-86
    DOI 10.1259/0007-1285-53-631-678, PubMed 7426890
  3. Rofstad EK, Lindmo T, Brustad T (1980)
    Effect of single dose irradiation on the proliferation kinetics in a human malignant melanoma in athymic nude mice
    Acta Radiol Oncol, 19 (4), 261-9
    DOI 10.3109/02841868009130163, PubMed 6257048
  4. Rofstad EK, Pettersen EO, Lindmo T, Oftebro R (1980)
    The proliferation kinetics of NHIK 1922 cells in vitro and in solid tumours in athymic mice
    Cell Tissue Kinet, 13 (2), 163-71
    PubMed 7363302

Publications 1979

  1. Rofstad EK, Brustad T (1979)
    Radiosensitizing effect of misonidazole in fractionated gamma-ray treatment of a human malignant melanoma grown in athymic nude mice
    Br J Radiol, 52 (617), 393-7
    DOI 10.1259/0007-1285-52-617-393, PubMed 444837

Publications 1978

  1. Rofstad EK, Brustad T (1978)
    The radiosensitizing effect of metronidazole and misonidazole (Ro-07-0582) on a human malignant melanoma grown in the athymic mutant nude mouse
    Br J Radiol, 51 (605), 381-6
    DOI 10.1259/0007-1285-51-605-381, PubMed 638410

Publications 1977

  1. Rofstad EK, Brustad T, Johannessen JV (1977)
    Effect of clinically relevant irradiation regimes on human malignant melanomas grown in athymic nude mice
    Acta Radiol Ther Phys Biol, 16 (3), 273-80
    PubMed 906896
  2. Rofstad EK, Brustad T, Johannessen JV, Mossige J (1977)
    Effect of cobalt-60 gamma rays and DTIC (5-(3,3 dimethyl-1-triazeno)-imidazole-r-carboxamide) on human malignant melanomas grown in athymic nude mice
    Br J Radiol, 50 (593), 314-20
    DOI 10.1259/0007-1285-50-593-314, PubMed 861450
  3. Rofstad EK, Brustad T, Kaalhus O (1977)
    Cell proliferation kinetics in two human tumors grown in athymic nude mice
    Virchows Arch B Cell Pathol, 24 (3), 219-25
    PubMed 410153

Publications 1976

  1. Brustad T, Rofstad EK, Davy M, Mossige J (1976)
    A pilot experiment to compare regression of transplants of two different human tumors in athymic nude mice following single exposures to 60co radiation
    Strahlentherapie, 152 (5), 477-81
    PubMed 996892

 
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