NPI Vaccines publication: A light-controlled vaccine technology based on PCI can significantly enhance immune responses
In a paper published as open access in NPJ Vaccines, Pål Kristian Selbo and coworkers demonstrate how a light-controlled vaccine technology based on photochemical internalization (PCI) can significantly enhance immune responses to both peptide- and protein-based vaccines when combined with synthetic dsRNA adjuvants. The findings support further exploration of PCI as an approach to improve therapeutic cancer vaccines and other immunotherapies.
The work has also been highlighted in a popular science article at forskning.no.
Selbo is head of the Photochemical internalisation (PCI) research group at the Department of Radiation Biology at the Institute for Cancer Research.
Links:
Popular science article (in Norwegian) from forskning.no:
Norske forskere bak ny metode som kan gjøre kreftvaksiner mer effektive
First author Selbo about the work, from LinkedIn
The paper:
Photochemical internalization enhances in vivo immunity to peptide‑ and protein‑based vaccines with synthetic dsRNA adjuvants
Pål Kristian Selbo, Arno Bruel, Monika Håkerud, Anne Grete Nedberg, Victoria Tudor Edwards, Gustav Gaudernack, Pål Johansen, Kristian Berg & Anders Høgset
npj Vaccines (2026) Open access Published: 09 August 2026
Photochemical internalisation (PCI) research group, headed by Pål Kristian Selbo