Genetic overlap between bipolar disorder and intelligence

Olav B. Smeland

A new study from NORMENT - Norwegian Centre for Mental Disorders Research -  shows an overlap in genes involved in mental illness and intelligence. Postdoctoral fellow Olav B. Smeland and colleagues found that risk genes for bipolar disorder were associated with higher intelligence.

The study is published in Molecular Psychiatry, and was covered by the Norwegian newspaper VG+

From the NORMENT home page at UiO:

Smeland and co-authors investigated DNA from more than 400.000 people, including 20.000 patients with bipolar disorder and 35.000 patients with schizophrenia.

They found that 12 risk genes for bipolar disorder were also linked to intelligence. In 75 % of these genes, bipolar disorder risk was associated with higher intelligence.

In schizophrenia, there was also a genetic overlap with intelligence, but a higher proportion of the genes was associated with cognitive impairment.

The study is published in Molecular Psychiatry, and was covered by the Norwegian newspaper VG+ on January 8 (behind paywall): Tonje (40) har bipolar lidelse: Sykdommen knyttes til høy IQ


Links:

The article:
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence.
Smeland OB, Bahrami S, Frei O, Shadrin A, O'Connell K, Savage J, Watanabe K, Krull F, Bettella F, Steen NE, Ueland T, Posthuma D, Djurovic S, Dale AM, Andreassen OA.
Mol Psychiatry. 2019 Jan 4. doi: 10.1038/s41380-018-0332-x. 
PMID: 30610197

The news article from the NORMENT home page:
Genetic overlap between bipolar disorder and intelligence

Norwegian version (more extensive text):
Genetisk sammenheng mellom bipolar lidelse og intelligens

VG article (major national newspaper), behind payment wall:
Tonje (40) har bipolar lidelse: Sykdommen knyttes til høy IQ


NORMENT home page 
The centre is based on a collaboration between three partners: The University of Oslo (host institution), the University of Bergen and Oslo University Hospital.

Division of Mental Health and Addiction, OUH

Olav B. Bjerkehagen's publications

 

 
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