The Lancet article with statistical contribution from OUS: Avoiding unnecessary Caesarean sections

Inge C. Olsen
In a trial led by Stine Bernitz and Rebecka Dalbye at Østfold Hospital Trust, OUS statisticians Kathrine Frey Frøslie at the Norwegian National Advisory Unit on Women's Health and Inge Christoffer Olsen at Research Support Services CTU contributed with statistical analyses showing that a newly developed and widely applied guideline for labour progression is not better than a guideline developed almost 70 years ago in preventing unneccesary intrapartum Caesarean sections (ICS). An interesting observation was, however, that the overall frequency of ICS decreased in all the trial centres, indicating that close focus on assessing labour progression is more important than use of the guidelines. 

The trial was designed and completed as a cluster-randomised controlled trial where each of the 14 trial centres were randomised to either the new guideline proposed by Zhang et. al. or the control group adhering to the WHO partograph guideline. Due to  the design, standard statistical methods were no longer applicable, and the trial leaders turned to the statistical resources at OUS for advise and help with the analyses. 

«The statistical help we received at OECB has been invaluable. The statisticians, with their profound statistical knowledge, have entered the field of obstetrics in an impressive way. Several interdisciplinary discussions have enhanced the article.» says Rebecka Dalbye, one of the first authors. 

«It has been a wonderful experience to see how we as statisticians can contribute as part of a strong and well-organised trial. The analyses were far from trivial, and we are very happy to see that the statistical solutions we chose were well received by our peer reviewers.», says Inge Christoffer Olsen on behalf of the statisticians in the trial. 

The trial is an example on how a strong collaboration between dedicated and resourceful clinicians, and experienced statisticians may change clinical practice world wide. 

From left: Rebecka Dalbye, Pål Øian, Kathrine Frey Frøslie, Stine Bernitz, Inge Christoffer Olsen og Ellen Blix

 

Links:

The Lancet article:
Bernitz S, Dalbye R, Zhang J, Eggebø TM, Frøslie KF, Olsen IC, Blix E, Øian P (2018)
The frequency of intrapartum caesarean section use with the WHO partograph versus Zhang's guideline in the Labour Progression Study (LaPS): a multicentre, cluster-randomised controlled trial
Lancet (in press)
DOI 10.1016/S0140-6736(18)31991-3, PubMed 30581039

 
 
 
 
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