Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2018 from OUS - Division of Head, Neck and Reconstructive Surgery

66 publications found

Akhtar S, Petrovski G, Albert R, Alkanaan A, Kirat O, Khan AD, Almubrad T (2018)
Ultrastructure and 3D transmission electron tomography of collagen fibrils and proteoglycans of swollen human corneal stroma
Histol Histopathol, 18029 (in press)
DOI 10.14670/HH-18-029, PubMed 30019745

Anisimova NS, Arbisser LB, Petrovski G, Petrichuk SV, Sobolev NP, Petrovski B, Borsenok SA, Komah YA, Malyugin BE (2018)
Effect of NSAIDs on Pupil Diameter and Expression of Aqueous Humor Cytokines in FLACS Versus Conventional Phacoemulsification
J Refract Surg, 34 (10), 646-652
DOI 10.3928/1081597X-20180814-02, PubMed 30296325

Anniko M (2018)
Koskinen et al. Long-term follow-up after ESS and balloon sinoplasty: comparison of symptom reduction and patient satisfaction. Acta Oto-Laryngol 2016; 136: 532-536
Acta Otolaryngol, 138 (3), 339-344
DOI 10.1080/00016489.2018.1438163, PubMed 29532720

Aqrawi LA, Chen X, Jensen JL, Morthen MK, Thiede B, Utheim ØA, Palm Ø, Tashbayev B, Utheim TP, Galtung HK (2018)
Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome
PLoS One, 13 (10), e0205762
DOI 10.1371/journal.pone.0205762, PubMed 30312344

Azqueta A, Rundén-Pran E, Elje E, Nicolaissen B, Berg KH, Smeringaiova I, Jirsova K, Collins AR (2018)
The comet assay applied to cells of the eye
Mutagenesis, 33 (1), 21-24
DOI 10.1093/mutage/gex025, PubMed 29077953

Bjaerke HB, Bjark TH, Berg T (2018)
Reconstruction with facial paresis
Tidsskr. Nor. Laegeforen., 138 (18), 1733-1736

Bjærke HB, Bjark TH, Berg T (2018)
Rekonstruksjon ved facialisparese
Tidsskr Nor Laegeforen, 138 (18)
DOI 10.4045/tidsskr.17.1023, PubMed 30421736

Brejchova K, Trosan P, Studeny P, Skalicka P, Utheim TP, Bednar J, Jirsova K (2018)
Characterization and comparison of human limbal explant cultures grown under defined and xeno-free conditions
Exp Eye Res, 176, 20-28
DOI 10.1016/j.exer.2018.06.019, PubMed 29928900

Colijn JM, den Hollander AI, Demirkan A, Cougnard-Grégoire A, Verzijden T, Kersten E, Meester-Smoor MA, Merle BMJ, Papageorgiou G, Ahmad S, Mulder MT, Costa MA, Benlian P, Bertelsen G, Bron AM, Claes B, Creuzot-Garcher C, Erke MG, Fauser S, Foster PJ, Hammond CJ, Hense HW, Hoyng CB, Khawaja AP, Korobelnik JF et al. (2018)
Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia
Ophthalmology (in press)
DOI 10.1016/j.ophtha.2018.09.045, PubMed 30315903

de la Rosa Carrillo D, Vindenes H, Kinsler VA, Rønnestad A, Ringstad G, Müller LO, Tafjord S, Tønseth KA, Kvamme B, Clausen OPF (2018)
Aggressive melanoma in an infant with congenital melanocytic nevus syndrome and multiple, NRAS and BRAF mutation-negative nodules
Pediatr Dermatol, 35 (5), e281-e285
DOI 10.1111/pde.13595, PubMed 29999207

Djirackor L, Shakir D, Kalirai H, Petrovski G, Coupland SE (2018)
Nestin expression in primary and metastatic uveal melanoma - possible biomarker for high-risk uveal melanoma
Acta Ophthalmol, 96 (5), 503-509
DOI 10.1111/aos.13645, PubMed 29338117

Eguíluz-Gracia I, Malmstrom K, Dheyauldeen SA, Lohi J, Sajantila A, Aaløkken R, Sundaram AYM, Gilfillan GD, Makela M, Baekkevold ES, Jahnsen FL (2018)
Monocytes accumulate in the airways of children with fatal asthma
Clin Exp Allergy, 48 (12), 1631-1639
DOI 10.1111/cea.13265, PubMed 30184280

Falkenberg-Jensen B, Heimdal KR, Høgevold HE, Jablonski GE, Due-Tønnessen BJ, Hopp E (2018)
Abnormally wide eustachian tubes involving the sphenoid bone: A collection
Laryngoscope Investig Otolaryngol, 3 (3), 214-217
DOI 10.1002/lio2.158, PubMed 30062137

Falkenberg-Jensen B, Hopp E, Jablonski GE, Pripp AH, Silvola JT (2018)
The cartilaginous Eustachian tube: Reliable CT measurement and impact of the length
Am J Otolaryngol, 39 (4), 436-440
DOI 10.1016/j.amjoto.2018.04.010, PubMed 29685379

Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G et al. (2018)
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Redox Biol, 20, 1-12 (in press)
DOI 10.1016/j.redox.2018.09.011, PubMed 30253279

Fowler P, Bellardie H, Shaw B, Eyres P, Semb G, Thompson J (2018)
Reliability of a Categorical Scale (GOSLON) and a Continuous Scale (10-cm Visual Analog Scale) for Assessing Dental Arch Relationships Using Conventional Plaster and 3D Digital Orthodontic Study Models of Children With Complete Unilateral Cleft Lip and Palate
Cleft Palate Craniofac J, 56 (1), 84-89
DOI 10.1177/1055665618770054, PubMed 29698112

Hagem AM, Thorsrud A, Sandvik GF, Drolsum L (2018)
Randomized Study of Collagen Cross-Linking With Conventional Versus Accelerated UVA Irradiation Using Riboflavin With Hydroxypropyl Methylcellulose: Two-Year Results
Cornea (in press)
DOI 10.1097/ICO.0000000000001791, PubMed 30365412

Haukedal CL, von Koss Torkildsen J, Lyxell B, Wie OB (2018)
Parents' Perception of Health-Related Quality of Life in Children With Cochlear Implants: The Impact of Language Skills and Hearing
J Speech Lang Hear Res, 61 (8), 2084-2098
DOI 10.1044/2018_JSLHR-H-17-0278, PubMed 30046806

He M, Lippestad M, Li D, Hodges RR, Utheim TP, Dartt DA (2018)
Activation of the EGF Receptor by Histamine Receptor Subtypes Stimulates Mucin Secretion in Conjunctival Goblet Cells
Invest Ophthalmol Vis Sci, 59 (8), 3543-3553
DOI 10.1167/iovs.18-2476, PubMed 30025103

Herlofson BB, Kjølle GK, Westgaard KL, Løndalen AM, Bruland ØS (2018)
Osteonecrosis of the Jaw in a Patient With Bone Metastatic Prostate Cancer After Long-term Bisphosphonate Treatment With Severe Deterioration Following Radium-223
Clin Genitourin Cancer, 16 (5), 328-331
DOI 10.1016/j.clgc.2018.05.003, PubMed 29861164

Impieri D, Tønseth KA, Hide Ø, Brinck EL, Høgevold HE, Filip C (2018)
Impact of orthognathic surgery on velopharyngeal function by evaluating speech and cephalometric radiographs
J Plast Reconstr Aesthet Surg, 71 (12), 1786-1795
DOI 10.1016/j.bjps.2018.07.018, PubMed 30172730

Ingvaldsen CA, Tindholdt TT, Tønseth KA (2018)
DIEAP Flap Patients Equally as Satisfied with the Abdomen as Abdominoplasty Patients
Plast Reconstr Surg Glob Open, 6 (8), e1876
DOI 10.1097/GOX.0000000000001876, PubMed 30324061

Jelin E, Wisløff T, Moe MC, Heiberg T (2018)
Development and testing of a patient-derived questionnaire for treatment of neovascular age-related macular degeneration: dimensions of importance in treatment of neovascular age-related macular degeneration
Acta Ophthalmol, 96 (8), 804-811
DOI 10.1111/aos.13847, PubMed 30198182

Jørstad ØK, Wigers AR, Marthinsen PB, Moe MC, Evang JA (2018)
Loss of horizontal macular ganglion cell complex asymmetry: an optical coherence tomography indicator of chiasmal compression
BMJ Open Ophthalmol, 3 (1), e000195
DOI 10.1136/bmjophth-2018-000195, PubMed 30519642

Katta K, Sembajwe LF, Kusche-Gullberg M (2018)
Potential role for Ext1-dependent heparan sulfate in regulating P311 gene expression in A549 carcinoma cells
Biochim Biophys Acta Gen Subj, 1862 (6), 1472-1481
DOI 10.1016/j.bbagen.2018.03.024, PubMed 29580921

Khan AZ, Utheim TP, Reppe S, Sandvik L, Lyberg T, Roald BB, Ibrahim IB, Eidet JR (2018)
Cultured Human Retinal Pigment Epithelial (hRPE) Sheets: A Search for Suitable Storage Conditions
Microsc Microanal, 24 (2), 147-155
DOI 10.1017/S1431927618000144, PubMed 29637873

König M, Osnes T, Jebsen P, Meling TR (2018)
Craniofacial resection of malignant tumors of the anterior skull base: a case series and a systematic review
Acta Neurochir (Wien), 160 (12), 2339-2348
DOI 10.1007/s00701-018-3716-4, PubMed 30402666

Landsend ECS, Pedersen HR, Utheim ØA, Xiao J, Adil MY, Tashbayev B, Lagali N, Dartt DA, Baraas RC, Utheim TP (2018)
Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia
Br J Ophthalmol, 103 (1), 119-124
DOI 10.1136/bjophthalmol-2017-310927, PubMed 29519880

Landsend ECS, Utheim ØA, Pedersen HR, Aass HCD, Lagali N, Dartt DA, Baraas RC, Utheim TP (2018)
The Level of Inflammatory Tear Cytokines is Elevated in Congenital Aniridia and Associated with Meibomian Gland Dysfunction
Invest Ophthalmol Vis Sci, 59 (5), 2197-2204
DOI 10.1167/iovs.18-24027, PubMed 29801153

Lorenzo Y, Haug Berg K, Ringvold A, Petrovski G, Moe MC, Collins A, Nicolaissen B (2018)
Levels of oxidative DNA damage are low in ex vivo engineered human limbal epithelial tissue
Acta Ophthalmol, 96 (8), 834-840
DOI 10.1111/aos.13811, PubMed 30239138

Lång E, Połeć A, Lång A, Valk M, Blicher P, Rowe AD, Tønseth KA, Jackson CJ, Utheim TP, Janssen LMC, Eriksson J, Bøe SO (2018)
Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding
Nat Commun, 9 (1), 3665
DOI 10.1038/s41467-018-05578-7, PubMed 30202009

Mariathasan AB, Boye K, Giercksky KE, Brennhovd B, Gullestad HP, Emblemsvåg HL, Grøholt KK, Dueland S, Flatmark K, Larsen SG (2018)
Beyond total mesorectal excision in locally advanced rectal cancer with organ or pelvic side-wall involvement
Eur J Surg Oncol, 44 (8), 1226-1232
DOI 10.1016/j.ejso.2018.03.029, PubMed 29691115

Moberg IO, Schou Bredal I, Schneider MR, Tønseth KA, Schlichting E (2018)
Complications, risk factors, and patients-reported outcomes after skin-sparing mastectomy followed by breast reconstruction in women with BRCA mutations
J Plast Surg Hand Surg, 52 (4), 234-239
DOI 10.1080/2000656X.2018.1470093, PubMed 29741462

Momtazi L, Dartt DA, Nilsen O, Eidet JR (2018)
Molecular layer deposition builds biocompatible substrates for epithelial cells
J Biomed Mater Res A, 106 (12), 3090-3098
DOI 10.1002/jbm.a.36499, PubMed 30194710

Navaratnam J, Dedi L, Tjølsen AM, Bragadóttir R (2018)
Identification of Dietzia Species in a Patient with Endophthalmitis following Penetrating Injury with Retained Intraocular Metallic Foreign Body
Case Rep Infect Dis, 2018, 3027846
DOI 10.1155/2018/3027846, PubMed 30356339

Nirvani M, Khuu C, Tulek A, Utheim TP, Sand LP, Snead ML, Sehic A (2018)
Transcriptomic analysis of MicroRNA expression in enamel-producing cells
Gene (in press)
DOI 10.1016/j.gene.2018.11.089, PubMed 30529249

Odegaard EM, Jorstad OK, Kerty E (2018)
A teenager with acute bilateral vision loss
Tidsskr. Nor. Laegeforen., 138 (12), 1144-1147

Pasovic L, Utheim TP, Reppe S, Khan AZ, Jackson CJ, Thiede B, Berg JP, Messelt EB, Eidet JR (2018)
Improvement of Storage Medium for Cultured Human Retinal Pigment Epithelial Cells Using Factorial Design
Sci Rep, 8 (1), 5688
DOI 10.1038/s41598-018-24121-8, PubMed 29632395

Pathak M, Diep PP, Lai X, Brinch L, Ruud E, Drolsum L (2018)
Ocular findings and ocular graft-versus-host disease after allogeneic stem cell transplantation without total body irradiation
Bone Marrow Transplant, 53 (7), 863-872
DOI 10.1038/s41409-018-0090-z, PubMed 29382955

Pedersen HR, Hagen LA, Landsend ECS, Gilson SJ, Utheim ØA, Utheim TP, Neitz M, Baraas RC (2018)
Color Vision in Aniridia
Invest Ophthalmol Vis Sci, 59 (5), 2142-2152
DOI 10.1167/iovs.17-23047, PubMed 29801149

Piippo N, Korhonen E, Hytti M, Skottman H, Kinnunen K, Josifovska N, Petrovski G, Kaarniranta K, Kauppinen A (2018)
Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
Sci Rep, 8 (1), 6720
DOI 10.1038/s41598-018-25123-2, PubMed 29712950

Reppe S, Jackson CJ, Ringstad H, Tonseth KA, Bakke H, Eidet JR, Utheim TP (2018)
High Throughput Screening of Additives Using Factorial Design to Promote Survival of Stored Cultured Epithelial Sheets
Stem Cells Int., 6545876

Riise N, Lindberg BR, Kulseth MA, Fredwall SO, Lundby R, Estensen ME, Drolsum L, Merckoll E, Krohg-Sørensen K, Paus B (2018)
Clinical diagnosis of Larsen syndrome, Stickler syndrome and Loeys-Dietz syndrome in a 19-year old male: a case report
BMC Med Genet, 19 (1), 155
DOI 10.1186/s12881-018-0671-0, PubMed 30170566

Rødvik AK, von Koss Torkildsen J, Wie OB, Storaker MA, Silvola JT (2018)
Consonant and Vowel Identification in Cochlear Implant Users Measured by Nonsense Words: A Systematic Review and Meta-Analysis
J Speech Lang Hear Res, 61 (4), 1023-1050
DOI 10.1044/2018_JSLHR-H-16-0463, PubMed 29623340

Salvanos P, Moe MC, Utheim TP, Bragadóttir R, Kerty E (2018)
ULTRA-WIDE-FIELD FUNDUS IMAGING IN THE DIAGNOSIS AND FOLLOW-UP OF SUSAC SYNDROME
Retin Cases Brief Rep, 12 (3), 234-239
DOI 10.1097/ICB.0000000000000470, PubMed 27828899

Sandvik GF, Vanem TT, Rand-Hendriksen S, Cholidis S, Saethre M, Drolsum L (2018)
Ten-year reinvestigation of ocular manifestations in Marfan syndrome
Clin Exp Ophthalmol (in press)
DOI 10.1111/ceo.13408, PubMed 30260057

Schippert AC, Jelin E, Moe MC, Heiberg T, Grov EK (2018)
The Impact of Age-Related Macular Degeneration on Quality of Life and Its Association With Demographic Data: Results From the NEI VFQ-25 Questionnaire in a Norwegian Population
Gerontol Geriatr Med, 4, 2333721418801601
DOI 10.1177/2333721418801601, PubMed 30263908

Sembajwe LF, Katta K, Grønning M, Kusche-Gullberg M (2018)
The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulphate structure in human breast carcinoma cell lines
Biosci Rep, 38 (4)
DOI 10.1042/BSR20180770, PubMed 30054430

Senti G, Freiburghaus AU, Larenas-Linnemann D, Hoffmann HJ, Patterson AM, Klimek L, Di Bona D, Pfaar O, Ahlbeck L, Akdis M, Weinfeld D, Contreras-Verduzco FA, Pedroza-Melendez A, Skaarup SH, Lee SM, Cardell LO, Schmid JM, Westin U, Dollner R, Kündig TM (2018)
Intralymphatic Immunotherapy: Update and Unmet Needs
Int Arch Allergy Immunol, 1-9 (in press)
DOI 10.1159/000493647, PubMed 30391954

Seys SF, Bousquet J, Bachert C, Fokkens WJ, Agache I, Bernal-Sprekelsen M, Callebaut I, Cardel LO, Carrie S, Castelnuovo P, Cathcart R, Constantinidis J, Cools L, Cornet M, Clement G, de Sousa JC, Cox T, Doulaptsi M, Gevaert P, Hopkins C, Hox V, Hummel T, Hosemann W, Jacobs R, Jorissen M et al. (2018)
mySinusitisCoach: patient empowerment in chronic rhinosinusitis using mobile technology
Rhinology, 56 (3), 209-215
DOI 10.4193/Rhin17.253, PubMed 29466477

Sivertsen MS, Jørstad ØK, Grevys A, Foss S, Moe MC, Andersen JT (2018)
Pharmaceutical compounding of aflibercept in prefilled syringes does not affect structural integrity, stability or VEGF and Fc binding properties
Sci Rep, 8 (1), 2101
DOI 10.1038/s41598-018-20525-8, PubMed 29391560

Skogseid IM, Røsby O, Konglund A, Connelly JP, Nedregaard B, Jablonski GE, Kvernmo N, Stray-Pedersen A, Glover JC (2018)
Dystonia-deafness syndrome caused by ACTB p.Arg183Trp heterozygosity shows striatal dopaminergic dysfunction and response to pallidal stimulation
J Neurodev Disord, 10 (1), 17
DOI 10.1186/s11689-018-9235-z, PubMed 29788902

Slettedal JK, Sandvik L, Ringvold A (2018)
Lifespan reduction due to neoplasia is nullified by pseudoexfoliation syndrome
Heliyon, 4 (10), e00832
DOI 10.1016/j.heliyon.2018.e00832, PubMed 30302411

Smeland AH, Twycross A, Lundeberg S, Rustøen T (2018)
Nurses' Knowledge, Attitudes and Clinical Practice in Pediatric Postoperative Pain Management
Pain Manag Nurs, 19 (6), 585-598
DOI 10.1016/j.pmn.2018.04.006, PubMed 29778756

Solheim O, Skalleberg J, Warncke T, Ørstavik K, Tropé C, Fosså SD (2018)
Long-term neurotoxicity and raynaud's phenomenon in patients treated with cisplatin-based chemotherapy for malignant ovarian germ cell tumor
Acta Obstet Gynecol Scand (in press)
DOI 10.1111/aogs.13477, PubMed 30289161

Spasojevic M, Mariathasan AB, Goscinski M, Thorgersen EB, Solbakken AM, Gullestad HP, Ryder T, Flatmark K, Larsen SG (2018)
Vertical Rectus Abdominis Musculocutaneous Flap Repair Improves Perineal Wound Healing after Abdominoperineal Resection for Irradiated Locally Advanced Rectal Cancer
Ann Surg Oncol, 25 (5), 1357-1365
DOI 10.1245/s10434-018-6363-3, PubMed 29497909

Steineger J, Osnes T, Heimdal K, Dheyauldeen S (2018)
Long-term experience with intranasal bevacizumab therapy
Laryngoscope, 128 (10), 2237-2244
DOI 10.1002/lary.27147, PubMed 29469958

Steineger J, Ueland T, Aukrust P, Michelsen A, Osnes T, Heimdal K, Dheyauldeen S (2018)
Pentraxin 3 level is elevated in hereditary hemorrhagic telangiectasia and reflects the severity of disease-associated epistaxis
Laryngoscope (in press)
DOI 10.1002/lary.27548, PubMed 30329172

Svee A, Mani M, Sandquist K, Audolfsson T, Folkvaljon Y, Isern AE, Ringberg A, Manjer J, Falk-Delgado A, Wärnberg F (2018)
Survival and risk of breast cancer recurrence after breast reconstruction with deep inferior epigastric perforator flap
Br J Surg, 105 (11), 1446-1453
DOI 10.1002/bjs.10888, PubMed 29999520

Talsma DT, Katta K, Ettema MAB, Kel B, Kusche-Gullberg M, Daha MR, Stegeman CA, van den Born J, Wang L (2018)
Endothelial heparan sulfate deficiency reduces inflammation and fibrosis in murine diabetic nephropathy
Lab Invest, 98 (4), 427-438
DOI 10.1038/s41374-017-0015-2, PubMed 29330473

Thorsrud A, Hagem AM, Sandvik GF, Drolsum L (2018)
Superior outcome of corneal collagen cross-linking using riboflavin with methylcellulose than riboflavin with dextran as the main supplement
Acta Ophthalmol (in press)
DOI 10.1111/aos.13928, PubMed 30284383

Tulek A, Saeed M, Mulic A, Stenhagen KR, Utheim TP, Galtung HK, Khuu C, Nirvani M, Kristiansen MS, Sehic A (2018)
New animal model of extrinsic dental erosion-Erosive effect on the mouse molar teeth
Arch Oral Biol, 96, 137-145
DOI 10.1016/j.archoralbio.2018.08.013, PubMed 30241000

Utheim OA, Lyberg T, Eidet JR, Raeder S, Sehic A, Roald B, Messelt E, de la Paz MF, Dartt DA, Utheim TP (2018)
Effect of Transportation on Cultured Limbal Epithelial Sheets for Worldwide Treatment of Limbal Stem Cell Deficiency
Sci Rep, 8 (1), 10502
DOI 10.1038/s41598-018-28553-0, PubMed 30002380

Utheim TP, Aass Utheim Ø, Salvanos P, Jackson CJ, Schrader S, Geerling G, Sehic A (2018)
Concise Review: Altered Versus Unaltered Amniotic Membrane as a Substrate for Limbal Epithelial Cells
Stem Cells Transl Med, 7 (5), 415-427
DOI 10.1002/sctm.17-0257, PubMed 29573222

Wankel VD, Bondø G, Jørstad ØK (2018)
Visual requirements for driving licences
Tidsskr Nor Laegeforen, 138 (16)
DOI 10.4045/tidsskr.18.0559, PubMed 30344329

Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Lagli N, Stojanovic A, Dartt DA, Utheim TP (2018)
Tear Production Levels and Dry Eye Disease Severity in a Large Norwegian Cohort
Curr Eye Res, 43 (12), 1465-1470
DOI 10.1080/02713683.2018.1514055, PubMed 30183390

 
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