Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Research and Development Mental Health

52 publications found

Alnæs D, Kaufmann T, van der Meer D, Córdova-Palomera A, Rokicki J, Moberget T, Bettella F, Agartz I, Barch DM, Bertolino A, Brandt CL, Cervenka S, Djurovic S, Doan NT, Eisenacher S, Fatouros-Bergman H, Flyckt L, Di Giorgio A, Haatveit B, Jönsson EG, Kirsch P, Lund MJ, Meyer-Lindenberg A, Pergola G, Schwarz E et al. (2019)
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
JAMA Psychiatry (in press)
DOI 10.1001/jamapsychiatry.2019.0257, PubMed 30969333

Aminihajibashi S, Hagen T, Foldal MD, Laeng B, Espeseth T (2019)
Individual differences in resting-state pupil size: Evidence for association between working memory capacity and pupil size variability
Int J Psychophysiol, 140, 1-7
DOI 10.1016/j.ijpsycho.2019.03.007, PubMed 30894328

Bauer M, Glenn T, Alda M, Andreassen OA, Angelopoulos E, Ardau R, Ayhan Y, Baethge C, Bauer R, Baune BT, Becerra-Palars C, Bellivier F, Belmaker RH, Berk M, Bersudsky Y, Bicakci Ş, Birabwa-Oketcho H, Bjella TD, Cabrera J, Wo Cheung EY, Del Zompo M, Dodd S, Donix M, Etain B, Fagiolini A et al. (2019)
Association between solar insolation and a history of suicide attempts in bipolar I disorder
J Psychiatr Res, 113, 1-9
DOI 10.1016/j.jpsychires.2019.03.001, PubMed 30878786

Bjørnebekk A, Westlye LT, Walhovd KB, Jørstad ML, Sundseth ØØ, Fjell AM (2019)
Cognitive performance and structural brain correlates in long-term anabolic-androgenic steroid exposed and nonexposed weightlifters
Neuropsychology, 33 (4), 547-559
DOI 10.1037/neu0000537, PubMed 31033318

Di Sero A, Jørgensen KN, Nerland S, Melle I, Andreassen OA, Jovicich J, Agartz I (2019)
Antipsychotic treatment and basal ganglia volumes: Exploring the role of receptor occupancy, dosage and remission status
Schizophr Res (in press)
DOI 10.1016/j.schres.2019.04.002, PubMed 31006616

Drange OK, Smeland OB, Shadrin AA, Finseth PI, Witoelar A, Frei O, Psychiatric Genomics Consortium Bipolar Disorder Working Group, Wang Y, Hassani S, Djurovic S, Dale AM, Andreassen OA (2019)
Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
Front Neurosci, 13, 220
DOI 10.3389/fnins.2019.00220, PubMed 30930738

Drover SSM, Villanger GD, Aase H, Skogheim TS, Longnecker MP, Zoeller RT, Reichborn-Kjennerud T, Knudsen GP, Zeiner P, Engel SM (2019)
Maternal Thyroid Function During Pregnancy or Neonatal Thyroid Function and Attention Deficit Hyperactivity Disorder: A Systematic Review
Epidemiology, 30 (1), 130-144
DOI 10.1097/EDE.0000000000000937, PubMed 30299402

Egeland J, Holmen TL, Bang-Kittilsen G, Bigseth TT, Vaskinn A, Engh JA (2019)
Body language reading of emotion and outcome in schizophrenia
Cogn Neuropsychiatry, 24 (1), 54-64
DOI 10.1080/13546805.2019.1568234, PubMed 30654697

Evensen S, Wisløff T, Lystad JU, Bull H, Martinsen EW, Ueland T, Falkum E (2019)
Exploring the potential cost-effectiveness of a vocational rehabilitation program for individuals with schizophrenia in a high-income welfare society
BMC Psychiatry, 19 (1), 140
DOI 10.1186/s12888-019-2130-7, PubMed 31064371

Fausiah F, Turnip SS, Hauff E (2019)
Community violence exposure and determinants of adolescent mental health: A school-based study of a post-conflict area in Indonesia
Asian J Psychiatr, 40, 49-54
DOI 10.1016/j.ajp.2019.01.020, PubMed 30738376

Gjerde PB, Simonsen CE, Lagerberg TV, Steen NE, Ueland T, Andreassen OA, Steen VM, Melle I (2019)
Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients
Eur Arch Psychiatry Clin Neurosci (in press)
DOI 10.1007/s00406-019-01017-w, PubMed 31028479

Gohar SM, Dieset I, Steen NE, Mørch RH, Vedal TSJ, Reponen EJ, Steen VM, Andreassen OA, Melle I (2019)
Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders
Acta Psychiatr Scand, 139 (5), 464-471
DOI 10.1111/acps.13019, PubMed 30848483

Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Christensen JH, Churchhouse C, Dellenvall K, Demontis D, De Rubeis S, Devlin B, Djurovic S et al. (2019)
Identification of common genetic risk variants for autism spectrum disorder
Nat Genet, 51 (3), 431-444
DOI 10.1038/s41588-019-0344-8, PubMed 30804558

Hauger LE, Sagoe D, Vaskinn A, Arnevik EA, Leknes S, Jørstad ML, Bjørnebekk A (2019)
Anabolic androgenic steroid dependence is associated with impaired emotion recognition
Psychopharmacology (Berl) (in press)
DOI 10.1007/s00213-019-05239-7, PubMed 30941469

Hauger LE, Westlye LT, Fjell AM, Walhovd KB, Bjørnebekk A (2019)
Structural brain characteristics of anabolic-androgenic steroid dependence in men
Addiction (in press)
DOI 10.1111/add.14629, PubMed 30955206

Hogestol EA, Kaufmann T, Nygaard G, Beyer MK, Sowa P, Nordvik JE, Kolskar K, Richard G, Andreassen OA, Harbo HF, Westlye LT (2019)
Cross-Sectional and Longitudinal MRI Brain Scans Reveal Accelerated Brain Aging in Multiple Sclerosis
Front. Neurol., 10, 450

Høgestøl EA, Nygaard GO, Alnæs D, Beyer MK, Westlye LT, Harbo HF (2019)
Symptoms of fatigue and depression is reflected in altered default mode network connectivity in multiple sclerosis
PLoS One, 14 (4), e0210375
DOI 10.1371/journal.pone.0210375, PubMed 30933977

Høyland AL, Nærland T, Engstrøm M, Torske T, Lydersen S, Andreassen OA (2019)
Atypical event-related potentials revealed during the passive parts of a Go-NoGo task in autism spectrum disorder: a case-control study
Mol Autism, 10, 10
DOI 10.1186/s13229-019-0259-3, PubMed 30873274

Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK, Hägg S, Athanasiu L, Voyle N, Proitsi P, Witoelar A, Stringer S, Aarsland D, Almdahl IS, Andersen F, Bergh S, Bettella F, Bjornsson S, Brækhus A, Bråthen G, de Leeuw C, Desikan RS, Djurovic S et al. (2019)
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Nat Genet, 51 (3), 404-413
DOI 10.1038/s41588-018-0311-9, PubMed 30617256

Jonassen R, Harmer CJ, Hilland E, Maglanoc LA, Kraft B, Browning M, Stiles TC, Haaland VØ, Berge T, Landrø NI (2019)
Effects of Attentional Bias Modification on residual symptoms in depression: a randomized controlled trial
BMC Psychiatry, 19 (1), 141
DOI 10.1186/s12888-019-2105-8, PubMed 31068158

Juvodden HT, Alnæs D, Lund MJ, Dietrichs E, Thorsby PM, Westlye LT, Knudsen S (2019)
Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing
Sleep (in press)
DOI 10.1093/sleep/zsz082, PubMed 30923809

Laskemoen JF, Simonsen C, Büchmann C, Barrett EA, Bjella T, Lagerberg TV, Vedal TJ, Andreassen OA, Melle I, Aas M (2019)
Sleep disturbances in schizophrenia spectrum and bipolar disorders - a transdiagnostic perspective
Compr Psychiatry, 91, 6-12
DOI 10.1016/j.comppsych.2019.02.006, PubMed 30856497

Løvgren A, Røssberg JI, Nilsen L, Engebretsen E, Ulberg R (2019)
How do adolescents with depression experience improvement in psychodynamic psychotherapy? A qualitative study
BMC Psychiatry, 19 (1), 95
DOI 10.1186/s12888-019-2080-0, PubMed 30898111

Melle I (2019)
Cognition in schizophrenia: a marker of underlying neurodevelopmental problems?
World Psychiatry, 18 (2), 164-165
DOI 10.1002/wps.20646, PubMed 31059634

Moberget T, Alnæs D, Kaufmann T, Doan NT, Córdova-Palomera A, Norbom LB, Rokicki J, van der Meer D, Andreassen OA, Westlye LT (2019)
Cerebellar Gray Matter Volume Is Associated With Cognitive Function and Psychopathology in Adolescence
Biol Psychiatry (in press)
DOI 10.1016/j.biopsych.2019.01.019, PubMed 30850129

Mäki-Marttunen T, Krull F, Bettella F, Hagen E, Næss S, Ness TV, Moberget T, Elvsåshagen T, Metzner C, Devor A, Edwards AG, Fyhn M, Djurovic S, Dale AM, Andreassen OA, Einevoll GT (2019)
Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations
Cereb Cortex, 29 (2), 875-891
DOI 10.1093/cercor/bhy291, PubMed 30475994

Mørch RH, Dieset I, Færden A, Reponen EJ, Hope S, Hoseth EZ, Gardsjord ES, Aas M, Iversen T, Joa I, Morken G, Agartz I, Melle I, Aukrust P, Djurovic S, Ueland T, Andreassen OA (2019)
Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors - inflammatory markers and immune activation in severe mental disorders
Psychol Med, 1-9 (in press)
DOI 10.1017/S0033291718004142, PubMed 30688187

Mørch RH, Dieset I, Færden A, Reponen EJ, Hope S, Hoseth EZ, Gardsjord ES, Aas M, Iversen T, Joa I, Morken G, Agartz I, Melle I, Aukrust P, Djurovic S, Ueland T, Andreassen OA (2019)
Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors - ERRATUM
Psychol Med, 1 (in press)
DOI 10.1017/S0033291719000291, PubMed 30803457

Njølstad PR, Andreassen OA, Brunak S, Børglum AD, Dillner J, Esko T, Franks PW, Freimer N, Groop L, Heimer H, Hougaard DM, Hovig E, Hveem K, Jalanko A, Kaprio J, Knudsen GP, Melbye M, Metspalu A, Mortensen PB, Palmgren J, Palotie A, Reed W, Stefánsson H, Stitziel NO, Sullivan PF et al. (2019)
Roadmap for a precision-medicine initiative in the Nordic region
Nat Genet (in press)
DOI 10.1038/s41588-019-0391-1, PubMed 30988515

Normann-Eide E, Antonsen BT, Kvarstein EH, Pedersen G, Vaskinn A, Wilberg T (2019)
Are Impairments in Theory of Mind Specific to Borderline Personality Disorder?
J Pers Disord, 1-15 (in press)
DOI 10.1521/pedi_2019_33_417, PubMed 30785865

Quintana DS, Rokicki J, van der Meer D, Alnæs D, Kaufmann T, Córdova-Palomera A, Dieset I, Andreassen OA, Westlye LT (2019)
Oxytocin pathway gene networks in the human brain
Nat Commun, 10 (1), 668
DOI 10.1038/s41467-019-08503-8, PubMed 30737392

Romm KL, Gardsjord ES, Gjermundsen K, Aguirre Ulloa M, Berentzen LC, Melle I (2019)
Designing easy access to care for first-episode psychosis in complex organizations
Early Interv Psychiatry (in press)
DOI 10.1111/eip.12802, PubMed 30919597

Rongve A, Witoelar A, Ruiz A, Athanasiu L, Abdelnour C, Clarimon J, Heilmann-Heimbach S, Hernández I, Moreno-Grau S, de Rojas I, Morenas-Rodríguez E, Fladby T, Sando SB, Bråthen G, Blanc F, Bousiges O, Lemstra AW, van Steenoven I, Londos E, Almdahl IS, Pålhaugen L, Eriksen JA, Djurovic S, Stordal E, Saltvedt I et al. (2019)
GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study
Sci Rep, 9 (1), 7013
DOI 10.1038/s41598-019-43458-2, PubMed 31065058

Rødevand L, Steen NE, Elvsåshagen T, Quintana DS, Reponen EJ, Mørch RH, Lunding SH, Vedal TSJ, Dieset I, Melle I, Lagerberg TV, Andreassen OA (2019)
Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade
Acta Psychiatr Scand, 139 (4), 348-360
DOI 10.1111/acps.13008, PubMed 30697685

Sanyal N, Lo MT, Kauppi K, Djurovic S, Andreassen OA, Johnson VE, Chen CH (2019)
GWASinlps: non-local prior based iterative SNP selection tool for genome-wide association studies
Bioinformatics, 35 (1), 1-11
DOI 10.1093/bioinformatics/bty472, PubMed 29931045

Simonsen S, Eikenaes IUM, Norgaard NL, Normann-Eide E, Juul S, Wilberg T (2019)
Specialized Treatment for Patients with Severe Avoidant Personality Disorder: Experiences from Scandinavia
J. Contemp. Psychother., 49 (1), 27-38

Siqveland J, Hauff E, Ruud T, Brennen TJ (2019)
Posttraumatic stress and autobiographical memory in chronic pain patients
Scand J Pain, 19 (2), 337-343
DOI 10.1515/sjpain-2018-0044, PubMed 30422805

Smeland OB, Bahrami S, Frei O, Shadrin A, O'Connell K, Savage J, Watanabe K, Krull F, Bettella F, Steen NE, Ueland T, Posthuma D, Djurovic S, Dale AM, Andreassen OA (2019)
Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence
Mol Psychiatry (in press)
DOI 10.1038/s41380-018-0332-x, PubMed 30610197

Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JRI, Gaspar HA, de Leeuw CA, Steinberg S, Pavlides JMW, Trzaskowski M, Byrne EM, Pers TH, Holmans PA, Richards AL, Abbott L, Agerbo E, Akil H, Albani D, Alliey-Rodriguez N, Als TD, Anjorin A et al. (2019)
Genome-wide association study identifies 30 loci associated with bipolar disorder
Nat Genet, 51 (5), 793-803
DOI 10.1038/s41588-019-0397-8, PubMed 31043756

Stavestrand SH, Sirevåg K, Nordhus IH, Sjøbø T, Endal TB, Nordahl HM, Specht K, Hammar Å, Halmøy A, Martinsen EW, Andersson E, Hjelmervik H, Mohlman J, Thayer JF, Hovland A (2019)
Physical exercise augmented cognitive behaviour therapy for older adults with generalised anxiety disorder (PEXACOG): study protocol for a randomized controlled trial
Trials, 20 (1), 174
DOI 10.1186/s13063-019-3268-9, PubMed 30885256

Steen NE, Dieset I, Hope S, Vedal TSJ, Smeland OB, Matson W, Kaddurah-Daouk R, Agartz I, Melle I, Djurovic S, Jönsson EG, Bogdanov M, Andreassen OA (2019)
Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders
Psychol Med, 1-12 (in press)
DOI 10.1017/S0033291719000400, PubMed 30867076

Storvestre GB, Valnes LM, Jensen A, Nerland S, Tesli N, Hymer KE, Rosaeg C, Server A, Ringen PA, Jacobsen M, Andreassen OA, Agartz I, Melle I, Haukvik UK (2019)
A preliminary study of cortical morphology in schizophrenia patients with a history of violence
Psychiatry Res Neuroimaging, 288, 29-36
DOI 10.1016/j.pscychresns.2019.04.013, PubMed 31071542

Støme LN, Moger T, Kidholm K, Kværner KJ (2019)
Early assessment of innovation in a healthcare setting
Int J Technol Assess Health Care, 35 (1), 17-26
DOI 10.1017/S0266462318003719, PubMed 30744712

Sørensen KD, Råbu M, Wilberg T, Berthelsen E (2019)
Struggling to be a person: Lived experience of avoidant personality disorder
J Clin Psychol, 75 (4), 664-680
DOI 10.1002/jclp.22740, PubMed 30609024

Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, Kukull WA, Tosun D, Weiner MW, Sperling RA, Bennett DA, Hyman BT, Andreassen OA, Dale AM, Desikan RS, Alzheimer’s Disease Neuroimaging Initiative (2019)
Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration
Brain, 142 (2), 460-470
DOI 10.1093/brain/awy327, PubMed 30689776

Tesli N, Westlye LT, Storvestre GB, Gurholt TP, Agartz I, Melle I, Andreassen OA, Haukvik UK (2019)
White matter microstructure in schizophrenia patients with a history of violence
Eur Arch Psychiatry Clin Neurosci (in press)
DOI 10.1007/s00406-019-00988-0, PubMed 30694361

Vaskinn A, Løvgren A, Egeland MK, Feyer FK, Østefjells T, Andreassen OA, Melle I, Sundet K (2019)
A randomized controlled trial of training of affect recognition (TAR) in schizophrenia shows lasting effects for theory of mind
Eur Arch Psychiatry Clin Neurosci (in press)
DOI 10.1007/s00406-019-00997-z, PubMed 30826974

Vedal TSJ, Steen NE, Birkeland KI, Dieset I, Reponen EJ, Laskemoen JF, Rødevand L, Melle I, Andreassen OA, Molden E, Jönsson EG (2019)
Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI
Psychoneuroendocrinology, 103, 87-95
DOI 10.1016/j.psyneuen.2019.01.001, PubMed 30659986

Wikenius E, Myhre AM, Page CM, Moe V, Smith L, Heiervang ER, Undlien DE, LeBlanc M (2019)
Prenatal maternal depressive symptoms and infant DNA methylation: a longitudinal epigenome-wide study
Nord J Psychiatry, 1-7 (in press)
DOI 10.1080/08039488.2019.1613446, PubMed 31070508

Zak N, Bøen E, Boye B, Andreassen OA, Doan NT, Malt UF, Westlye LT, Elvsåshagen T (2019)
Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II
Bipolar Disord (in press)
DOI 10.1111/bdi.12771, PubMed 30864260

Aas M, Elvsåshagen T, Westlye LT, Kaufmann T, Athanasiu L, Djurovic S, Melle I, van der Meer D, Martin-Ruiz C, Steen NE, Agartz I, Andreassen OA (2019)
Telomere length is associated with childhood trauma in patients with severe mental disorders
Transl Psychiatry, 9 (1), 97
DOI 10.1038/s41398-019-0432-7, PubMed 30898995

Aas M, Pizzagalli DA, Laskemoen JF, Reponen EJ, Ueland T, Melle I, Agartz I, Steen NE, Andreassen OA (2019)
Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders
Schizophr Res (in press)
DOI 10.1016/j.schres.2019.01.011, PubMed 30660575

 
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