Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2017 from OUS - Dept. of Microbiology (MIK), Section for Research (former CMBN)

41 publications found

Alsøe L, Sarno A, Carracedo S, Domanska D, Dingler F, Lirussi L, SenGupta T, Tekin NB, Jobert L, Alexandrov LB, Galashevskaya A, Rada C, Sandve GK, Rognes T, Krokan HE, Nilsen H (2017)
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1
Sci Rep, 7 (1), 7199
DOI 10.1038/s41598-017-07314-5, PubMed 28775312

Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M (2017)
Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach
J Med Chem, 60 (24), 10013-10025
DOI 10.1021/acs.jmedchem.7b00883, PubMed 29155568

Batmanov K, Wang W, Bjørås M, Delabie J, Wang J (2017)
Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma
Sci Rep, 7 (1), 7040
DOI 10.1038/s41598-017-07226-4, PubMed 28765546

Beyene GT, Kalayou S, Riaz T, Tonjum T (2017)
Comparative proteomic analysis of Neisseria meningitidis wildtype and dprA null mutant strains links DNA processing to pilus biogenesis
BMC Microbiol, 17 (1), 96
DOI 10.1186/s12866-017-1004-8, PubMed 28431522

Birhanu AG, Yimer SA, Holm-Hansen C, Norheim G, Aseffa A, Abebe M, Tønjum T (2017)
Nε- and O-Acetylation in Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains: Proteins Involved in Bioenergetics, Virulence, and Antimicrobial Resistance Are Acetylated
J Proteome Res, 16 (11), 4045-4059
DOI 10.1021/acs.jproteome.7b00429, PubMed 28920697

Bj Rås KØ, Sousa MML, Sharma A, Fonseca DM, S Gaard CK, Bj Rås M, Otterlei M (2017)
Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication
Nucleic Acids Res, 45 (14), 8291-8301
DOI 10.1093/nar/gkx476, PubMed 28575236

Castañeda-García A, Prieto AI, Rodríguez-Beltrán J, Alonso N, Cantillon D, Costas C, Pérez-Lago L, Zegeye ED, Herranz M, Plociński P, Tonjum T, García de Viedma D, Paget M, Waddell SJ, Rojas AM, Doherty AJ, Blázquez J (2017)
A non-canonical mismatch repair pathway in prokaryotes
Nat Commun, 8, 14246
DOI 10.1038/ncomms14246, PubMed 28128207

Chymkowitch P, Enserink JM (2017)
Regulation of tRNA synthesis by posttranslational modifications of RNA polymerase III subunits
Biochim Biophys Acta Gene Regul Mech, 1861 (4), 310-319
DOI 10.1016/j.bbagrm.2017.11.001, PubMed 29127063

Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM (2017)
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity
Proc Natl Acad Sci U S A, 114 (5), 1039-1044
DOI 10.1073/pnas.1615093114, PubMed 28096404

Desler C, Lillenes MS, Tønjum T, Rasmussen LJ (2017)
The role of mitochondrial dysfunction in the progression of Alzheimer's disease
Curr Med Chem (in press)
DOI 10.2174/0929867324666170616110111, PubMed 28618998

Flåtten I, Helgesen E, Pedersen IB, Waldminghaus T, Rothe C, Taipale R, Johnsen L, Skarstad K (2017)
Phenotypes of dnaXE145A Mutant Cells Indicate that the Escherichia coli Clamp Loader Has a Role in the Restart of Stalled Replication Forks
J Bacteriol, 199 (24)
DOI 10.1128/JB.00412-17, PubMed 28947673

Forsberg Z, Bissaro B, Gullesen J, Dalhus B, Vaaje-Kolstad G, Eijsink VGH (2017)
Structural determinants of bacterial lytic polysaccharide monooxygenase functionality
J Biol Chem, 293 (4), 1397-1412
DOI 10.1074/jbc.M117.817130, PubMed 29222333

Frye SA, Beyene GT, Namouchi A, Gómez-Muñoz M, Homberset H, Kalayou S, Riaz T, Tønjum T, Balasingham SV (2017)
The helicase DinG responds to stress due to DNA double strand breaks
PLoS One, 12 (11), e0187900
DOI 10.1371/journal.pone.0187900, PubMed 29121674

Gunnarsen KS, Høydahl LS, Risnes LF, Dahal-Koirala S, Neumann RS, Bergseng E, Frigstad T, Frick R, du Pré MF, Dalhus B, Lundin KE, Qiao SW, Sollid LM, Sandlie I, Løset GÅ (2017)
A TCRα framework-centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions
JCI Insight, 2 (17), e95193
DOI 10.1172/jci.insight.95193, PubMed 28878121

Hovland E, Beyene GT, Frye SA, Homberset H, Balasingham SV, Gómez-Muñoz M, Derrick JP, Tønjum T, Ambur OH (2017)
DprA from Neisseria meningitidis: properties and role in natural competence for transformation
Microbiology, 163 (7), 1016-1029
DOI 10.1099/mic.0.000489, PubMed 28696187

Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D (2017)
ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage
Cell Death Dis, 8 (7), e2947
DOI 10.1038/cddis.2017.343, PubMed 28726787

Kalikstad B, Kultima HG, Andersstuen TK, Klungland A, Isaksson A (2017)
Gene expression profiles in preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia
Mol Med Rep, 15 (4), 1513-1526
DOI 10.3892/mmr.2017.6185, PubMed 28259955

Khelik K, Lagesen K, Sandve GK, Rognes T, Nederbragt AJ (2017)
NucDiff: in-depth characterization and annotation of differences between two sets of DNA sequences
BMC Bioinformatics, 18 (1), 338
DOI 10.1186/s12859-017-1748-z, PubMed 28701187

Kvisvik B, Morkrid L, Rosjo H, Cvancarova M, Rowe AD, Eek C, Bendz B, Edvardsen T, Gravning J (2017)
High-Sensitivity Troponin T vs I in Acute Coronary Syndrome: Prediction of Significant Coronary Lesions and Long-term Prognosis
Acta Bioquim. Clin. Latinoam., 51 (3), 395-407

Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A (2017)
Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation
Cell Discov, 3, 17013
DOI 10.1038/celldisc.2017.13, PubMed 28529766

Lillenes MS, Støen M, Günther CC, Selnes P, Stenset VT, Espeseth T, Reinvang I, Fladby T, Tønjum T (2017)
Mitochondrial transcription factor A (TFAM) rs1937 and AP endonuclease 1 (APE1) rs1130409 alleles are associated with reduced cognitive performance
Neurosci Lett, 645, 46-52
DOI 10.1016/j.neulet.2017.02.062, PubMed 28242328

Lund K, Olsen CE, Wong JJW, Olsen PA, Solberg NT, Høgset A, Krauss S, Selbo PK (2017)
5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin
J Exp Clin Cancer Res, 36 (1), 187
DOI 10.1186/s13046-017-0662-6, PubMed 29258566

Malachin G, Reiten MR, Salvesen Ø, Aanes H, Kamstra JH, Skovgaard K, Heegaard PMH, Ersdal C, Espenes A, Tranulis MA, Bakkebø MK (2017)
Loss of prion protein induces a primed state of type I interferon-responsive genes
PLoS One, 12 (6), e0179881
DOI 10.1371/journal.pone.0179881, PubMed 28651013

Norheim G, Seterelv S, Arnesen TM, Mengshoel AT, Tønjum T, Rønning JO, Eldholm V (2017)
Tuberculosis Outbreak in an Educational Institution in Norway
J Clin Microbiol, 55 (5), 1327-1333
DOI 10.1128/JCM.01152-16, PubMed 28202795

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262

Pawar T, Bjørås M, Klungland A, Eide L (2017)
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
Mitochondrion, 40, 16-28
DOI 10.1016/j.mito.2017.09.002, PubMed 28893634

Pedersen IB, Helgesen E, Flåtten I, Fossum-Raunehaug S, Skarstad K (2017)
SeqA structures behind Escherichia coli replication forks affect replication elongation and restart mechanisms
Nucleic Acids Res, 45 (11), 6471-6485
DOI 10.1093/nar/gkx263, PubMed 28407100

Robertson J, Humphries JD, Paul NR, Warwood S, Knight D, Byron A, Humphries MJ (2017)
Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics
Methods Mol Biol, 1636, 235-251
DOI 10.1007/978-1-4939-7154-1_15, PubMed 28730483

Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M (2017)
No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice
Sci Rep, 7 (1), 4384
DOI 10.1038/s41598-017-04472-4, PubMed 28663564

Rydning SL, Backe PH, Sousa MML, Iqbal Z, Øye AM, Sheng Y, Yang M, Lin X, Slupphaug G, Nordenmark TH, Vigeland MD, Bjørås M, Tallaksen CM, Selmer KK (2017)
Novel UCHL1 mutations reveal new insights into ubiquitin processing
Hum Mol Genet, 26 (6), 1031-1040
DOI 10.1093/hmg/ddw391, PubMed 28007905

Scheffler K, Rachek L, You P, Rowe AD, Wang W, Kuśnierczyk A, Kittelsen L, Bjørås M, Eide L (2017)
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
DNA Repair (Amst), 61, 56-62
DOI 10.1016/j.dnarep.2017.11.008, PubMed 29207315

Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B (2017)
Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes
DNA Repair (Amst), 58, 13-20
DOI 10.1016/j.dnarep.2017.08.005, PubMed 28843610

Solberg NT, Waaler J, Lund K, Mygland L, Olsen PA, Krauss S (2017)
TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal Cancer
Mol Cancer Res, 16 (3), 543-553
DOI 10.1158/1541-7786.MCR-17-0362, PubMed 29222171

Strøm TB, Laerdahl JK, Leren TP (2017)
Mutations affecting the transmembrane domain of the LDL receptor: impact of charged residues on the membrane insertion
Hum Mol Genet, 26 (9), 1634-1642
DOI 10.1093/hmg/ddx068, PubMed 28334946

Søberg K, Moen LV, Skålhegg BS, Laerdahl JK (2017)
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms
PLoS One, 12 (7), e0181091
DOI 10.1371/journal.pone.0181091, PubMed 28742821

Tang C, Klukovich R, Peng H, Wang Z, Yu T, Zhang Y, Zheng H, Klungland A, Yan W (2017)
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells
Proc Natl Acad Sci U S A, 115 (2), E325-E333
DOI 10.1073/pnas.1717794115, PubMed 29279410

Vehus T, Waaler J, Krauss S, Lundanes E, Wilson SR (2017)
Combining HIC, SEC, and IEX with Fluorescence Polarization for Drug Target Discovery
LC GC Eur., 30 (5), 232-239

Yan L, Zhang W, Zhang B, Xuan C, Wang D (2017)
BIIB021: A novel inhibitor to heat shock protein 90-addicted oncology
Tumour Biol, 39 (4), 1010428317698355
DOI 10.1177/1010428317698355, PubMed 28443462

Yimer SA, Birhanu AG, Kalayou S, Riaz T, Zegeye ED, Beyene GT, Holm-Hansen C, Norheim G, Abebe M, Aseffa A, Tønjum T (2017)
Comparative Proteomic Analysis of Mycobacterium tuberculosis Lineage 7 and Lineage 4 Strains Reveals Differentially Abundant Proteins Linked to Slow Growth and Virulence
Front Microbiol, 8, 795
DOI 10.3389/fmicb.2017.00795, PubMed 28536560

Zhang B, Zhang W, Yan L, Wang D (2017)
The association between MTHFR gene C677T polymorphism and ALL risk based on a meta-analysis involving 17,469 subjects
Clin Chim Acta, 466, 85-92
DOI 10.1016/j.cca.2017.01.001, PubMed 28062297

Aas A, Isakson P, Bindesbøll C, Alemu EA, Klungland A, Simonsen A (2017)
Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy
PLoS One, 12 (3), e0168182
DOI 10.1371/journal.pone.0168182, PubMed 28288181

 
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