Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2016 from OUS - Dept. of Microbiology (MIK), Section for Research (former CMBN)

42 publications found

A Alemu E, He C, Klungland A (2016)
ALKBHs-facilitated RNA modifications and de-modifications
DNA Repair (Amst), 44, 87-91
DOI 10.1016/j.dnarep.2016.05.026, PubMed 27237585

Benterud T, Ystgaard MB, Manueldas S, Pankratov L, Alfaro-Cervello C, Florholmen G, Ahmed MS, Sandvik L, Norgren S, Bjørås M, Baumbusch LO, Solberg R, Saugstad OD (2016)
N-Acetylcysteine Amide Exerts Possible Neuroprotective Effects in Newborn Pigs after Perinatal Asphyxia
Neonatology, 111 (1), 12-21
DOI 10.1159/000447255, PubMed 27497671

Beyene GT, Balasingham SV, Frye SA, Namouchi A, Homberset H, Kalayou S, Riaz T, Tønjum T (2016)
Characterization of the Neisseria meningitidis Helicase RecG
PLoS One, 11 (10), e0164588
DOI 10.1371/journal.pone.0164588, PubMed 27736945

Dahl JA, Jung I, Aanes H, Greggains GD, Manaf A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjørås M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A (2016)
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition
Nature, 537 (7621), 548-552
DOI 10.1038/nature19360, PubMed 27626377

Forsberg Z, Nelson CE, Dalhus B, Mekasha S, Loose JS, Crouch LI, Røhr ÅK, Gardner JG, Eijsink VG, Vaaje-Kolstad G (2016)
Structural and Functional Analysis of a Lytic Polysaccharide Monooxygenase Important for Efficient Utilization of Chitin in Cellvibrio japonicus
J Biol Chem, 291 (14), 7300-12
DOI 10.1074/jbc.M115.700161, PubMed 26858252

Foss S, Watkinson RE, Grevys A, McAdam MB, Bern M, Høydahl LS, Dalhus B, Michaelsen TE, Sandlie I, James LC, Andersen JT (2016)
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
DOI 10.4049/jimmunol.1502601, PubMed 26962230

Jalland CM, Scheffler K, Benestad SL, Moldal T, Ersdal C, Gunnes G, Suganthan R, Bjørås M, Tranulis MA (2016)
Neil3 induced neurogenesis protects against prion disease during the clinical phase
Sci Rep, 6, 37844
DOI 10.1038/srep37844, PubMed 27886261

Klungland A, Dahl JA, Greggains G, Fedorcsak P, Filipczyk A (2016)
Reversible RNA modifications in meiosis and pluripotency
Nat Methods, 14 (1), 18-22
DOI 10.1038/nmeth.4111, PubMed 28032624

Klungland A, Robertson AB (2016)
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine
Free Radic Biol Med, 107, 62-68
DOI 10.1016/j.freeradbiomed.2016.11.038, PubMed 27890639

Kopylova E, Navas-Molina JA, Mercier C, Xu ZZ, Mahé F, He Y, Zhou HW, Rognes T, Caporaso JG, Knight R (2016)
Open-Source Sequence Clustering Methods Improve the State Of the Art
mSystems, 1 (1)
DOI 10.1128/mSystems.00003-15, PubMed 27822515

Kristiansen KI, Weel-Sneve R, Booth JA, Bjørås M (2016)
Mutually exclusive RNA secondary structures regulate translation initiation of DinQ in Escherichia coli
RNA, 22 (11), 1739-1749
DOI 10.1261/rna.058461.116, PubMed 27651528

Landfors M, Nakken S, Fusser M, Dahl JA, Klungland A, Fedorcsak P (2016)
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations
Fertil Steril, 105 (5), 1170-1179.e5
DOI 10.1016/j.fertnstert.2016.01.002, PubMed 26820768

Lauritzen KH, Hasan-Olive MM, Regnell CE, Kleppa L, Scheibye-Knudsen M, Gjedde A, Klungland A, Bohr VA, Storm-Mathisen J, Bergersen LH (2016)
A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
Neurobiol Aging, 48, 34-47
DOI 10.1016/j.neurobiolaging.2016.08.005, PubMed 27639119

Lillenes MS, Rabano A, Støen M, Riaz T, Misaghian D, Møllersen L, Esbensen Y, Günther CC, Selnes P, Stenset VT, Fladby T, Tønjum T (2016)
Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease
Mol Brain, 9 (1), 61
DOI 10.1186/s13041-016-0237-z, PubMed 27234294

Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C (2016)
ALKBH1-Mediated tRNA Demethylation Regulates Translation
Cell, 167 (7), 1897
DOI 10.1016/j.cell.2016.11.045, PubMed 27984735

Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C (2016)
ALKBH1-Mediated tRNA Demethylation Regulates Translation
Cell, 167 (3), 816-828.e16
DOI 10.1016/j.cell.2016.09.038, PubMed 27745969

Moen MN, Fjær R, Hamdani EH, Laerdahl JK, Menchini RJ, Vigeland MD, Sheng Y, Undlien DE, Hassel B, Salih MA, El Khashab HY, Selmer KK, Chaudhry FA (2016)
Pathogenic variants in KCTD7 perturb neuronal K+ fluxes and glutamine transport
Brain, 139 (Pt 12), 3109-3120
DOI 10.1093/brain/aww244, PubMed 27742667

Møllersen L, Moldestad O, Rowe AD, Bjølgerud A, Holm I, Tveterås L, Klungland A, Retterstøl L (2016)
Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice
PLoS Curr, 8
DOI 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67, PubMed 27540492

Namouchi A, Gómez-Muñoz M, Frye SA, Moen LV, Rognes T, Tønjum T, Balasingham SV (2016)
The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress
BMC Genomics, 17 (1), 791
DOI 10.1186/s12864-016-3132-1, PubMed 27724857

Nawaz MS, Vik ES, Berges N, Fladeby C, Bjørås M, Dalhus B, Alseth I (2016)
Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules
J Biol Chem, 291 (41), 21786-21801
DOI 10.1074/jbc.M116.730911, PubMed 27573237

Nawaz MS, Vik ES, Ronander ME, Solvoll AM, Blicher P, Bjørås M, Alseth I, Dalhus B (2016)
Crystal structure and MD simulation of mouse EndoV reveal wedge motif plasticity in this inosine-specific endonuclease
Sci Rep, 6, 24979
DOI 10.1038/srep24979, PubMed 27108838

Ougland R, Jonson I, Moen MN, Nesse G, Asker G, Klungland A, Larsen E (2016)
Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells
Cell Physiol Biochem, 38 (1), 173-84
DOI 10.1159/000438619, PubMed 26765775

Palibrk V, Suganthan R, Scheffler K, Wang W, Bjørås M, Bøe SO (2016)
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic-ischemic encephalopathy model
Cell Death Dis, 7 (7), e2320
DOI 10.1038/cddis.2016.223, PubMed 27468695

Petrova L, Gran C, Bjoras M, Doetsch PW (2016)
Efficient and Reliable Production of Vectors for the Study of the Repair, Mutagenesis, and Phenotypic Consequences of Defined DNA Damage Lesions in Mammalian Cells
PLoS One, 11 (6), e0158581
DOI 10.1371/journal.pone.0158581, PubMed 27362559

Qu Y, Gharbi N, Yuan X, Olsen JR, Blicher P, Dalhus B, Brokstad KA, Lin B, Øyan AM, Zhang W, Kalland KH, Ke X (2016)
Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer
Proc Natl Acad Sci U S A, 113 (33), 9339-44
DOI 10.1073/pnas.1604520113, PubMed 27482107

Rasmussen EMK, Vågbø CB, Münch D, Krokan HE, Klungland A, Amdam GV, Dahl JA (2016)
DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates
Biochem Biophys Rep, 6, 9-15
DOI 10.1016/j.bbrep.2016.02.011, PubMed 28955859

Roberg-Larsen H, Lund K, Seterdal KE, Solheim S, Vehus T, Solberg N, Krauss S, Lundanes E, Wilson SR (2016)
Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes
J Steroid Biochem Mol Biol, 169, 22-28
DOI 10.1016/j.jsbmb.2016.02.006, PubMed 26877254

Rognes T, Flouri T, Nichols B, Quince C, Mahé F (2016)
VSEARCH: a versatile open source tool for metagenomics
PeerJ, 4, e2584
DOI 10.7717/peerj.2584, PubMed 27781170

Samarakoon PS, Sorte HS, Stray-Pedersen A, Rødningen OK, Rognes T, Lyle R (2016)
cnvScan: a CNV screening and annotation tool to improve the clinical utility of computational CNV prediction from exome sequencing data
BMC Genomics, 17, 51
DOI 10.1186/s12864-016-2374-2, PubMed 26764020

Schuermann D, Scheidegger SP, Weber AR, Bjørås M, Leumann CJ, Schär P (2016)
3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair
Nucleic Acids Res, 44 (5), 2187-98
DOI 10.1093/nar/gkv1520, PubMed 26733580

Skarpengland T, Dahl TB, Skjelland M, Scheffler K, de Sousa MML, Gregersen I, Kuśnierczyk A, Sharma A, Slupphaug G, Eide L, Segers FM, Skagen KR, Dahl CP, Russell D, Folkersen L, Krohg-Sørensen K, Holm S, Bjørås M, Aukrust P, Halvorsen B (2016)
Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA
Free Radic Biol Med, 97, 386-397
DOI 10.1016/j.freeradbiomed.2016.07.001, PubMed 27381496

Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Østlie I, Otten JJ, Luna L, Ketelhuth DF, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjørndal B, Svardal AM, Iversen PO, Hedin U, Nygård S, Olstad OK, Krohg-Sørensen K, Slupphaug G, Eide L, Kuśnierczyk A et al. (2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939

Skjærven KH, Jakt LM, Dahl JA, Espe M, Aanes H, Hamre K, Fernandes JM (2016)
Parental vitamin deficiency affects the embryonic gene expression of immune-, lipid transport- and apolipoprotein genes
Sci Rep, 6, 34535
DOI 10.1038/srep34535, PubMed 27731423

Sorte HS, Osnes LT, Fevang B, Aukrust P, Erichsen HC, Backe PH, Abrahamsen TG, Kittang OB, Øverland T, Jhangiani SN, Muzny DM, Vigeland MD, Samarakoon P, Gambin T, Akdemir ZH, Gibbs RA, Rødningen OK, Lyle R, Lupski JR, Stray-Pedersen A (2016)
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction
Mol Genet Genomic Med, 4 (6), 604-616
DOI 10.1002/mgg3.237, PubMed 27896283

Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J (2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
Epigenetics Chromatin, 9, 21
DOI 10.1186/s13072-016-0070-8, PubMed 27252783

Vander Zanden CM, Rowe RK, Broad AJ, Robertson AB, Ho PS (2016)
Effect of Hydroxymethylcytosine on the Structure and Stability of Holliday Junctions
Biochemistry, 55 (41), 5781-5789
DOI 10.1021/acs.biochem.6b00801, PubMed 27653243

Vehus T, Roberg-Larsen H, Waaler J, Aslaksen S, Krauss S, Wilson SR, Lundanes E (2016)
Versatile, sensitive liquid chromatography mass spectrometry - Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins
Sci Rep, 6, 37507
DOI 10.1038/srep37507, PubMed 27897190

Vehus T, Seterdal KE, Krauss S, Lundanes E, Wilson SR (2016)
Comparison of commercial nanoliquid chromatography columns for fast, targeted mass spectrometry-based proteomics
Future Sci OA, 2 (2), FSO119
DOI 10.4155/fsoa-2016-0014, PubMed 28031966

Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA (2016)
Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation
Mol Cell Neurosci, 77, 47-52
DOI 10.1016/j.mcn.2016.10.004, PubMed 27751903

Weber AR, Krawczyk C, Robertson AB, Kuśnierczyk A, Vågbø CB, Schuermann D, Klungland A, Schär P (2016)
Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism
Nat Commun, 7, 10806
DOI 10.1038/ncomms10806, PubMed 26932196

Yimer SA, Namouchi A, Zegeye ED, Holm-Hansen C, Norheim G, Abebe M, Aseffa A, Tønjum T (2016)
Deciphering the recent phylogenetic expansion of the originally deeply rooted Mycobacterium tuberculosis lineage 7
BMC Evol Biol, 16 (1), 146
DOI 10.1186/s12862-016-0715-z, PubMed 27363525

Zegeye N, Asrat D, Woldeamanuel Y, Habte A, Gedlu E, Tønjum T, Aseffa A (2016)
Throat culture positivity rate and antibiotic susceptibility pattern of beta-hemolytic streptococci in children on secondary prophylaxis for rheumatic heart disease
BMC Infect Dis, 16 (1), 510
DOI 10.1186/s12879-016-1841-3, PubMed 27663649

 
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