Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2014 from OUS - Centre for Immune Regulation (CIR)

35 publications found

Amundsen SS, Viken MK, Sollid LM, Lie BA (2014)
Coeliac disease-associated polymorphisms influence thymic gene expression
Genes Immun, 15 (6), 355-60
DOI 10.1038/gene.2014.26, PubMed 24871462

Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J (2014)
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
DOI 10.1074/jbc.M114.549832, PubMed 24652290

Balan S, Ollion V, Colletti N, Chelbi R, Montanana-Sanchis F, Liu H, Vu Manh TP, Sanchez C, Savoret J, Perrot I, Doffin AC, Fossum E, Bechlian D, Chabannon C, Bogen B, Asselin-Paturel C, Shaw M, Soos T, Caux C, Valladeau-Guilemond J, Dalod M (2014)
Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells
J Immunol, 193 (4), 1622-35
DOI 10.4049/jimmunol.1401243, PubMed 25009205

Bergseng E, Dørum S, Arntzen MØ, Nielsen M, Nygård S, Buus S, de Souza GA, Sollid LM (2014)
Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires
Immunogenetics, 67 (2), 73-84
DOI 10.1007/s00251-014-0819-9, PubMed 25502872

Binsfeld M, Beguin Y, Belle L, Otjacques E, Hannon M, Briquet A, Heusschen R, Drion P, Zilberberg J, Bogen B, Baron F, Caers J (2014)
Establishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation
PLoS One, 9 (11), e113764
DOI 10.1371/journal.pone.0113764, PubMed 25415267

Bürgler S, Gimeno A, Parente-Ribes A, Wang D, Os A, Devereux S, Jebsen P, Bogen B, Tjønnfjord GE, Munthe LA (2014)
Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-γ by a T-bet-dependent mechanism
J Immunol, 194 (2), 827-35
DOI 10.4049/jimmunol.1401350, PubMed 25505279

Christophersen A, Ráki M, Bergseng E, Lundin KE, Jahnsen J, Sollid LM, Qiao SW (2014)
Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge
United European Gastroenterol J, 2 (4), 268-78
DOI 10.1177/2050640614540154, PubMed 25083284

Danilova E, Skrindo I, Gran E, Hales BJ, Smith WA, Jahnsen J, Johansen FE, Jahnsen FL, Baekkevold ES (2014)
A role for CCL28-CCR3 in T-cell homing to the human upper airway mucosa
Mucosal Immunol, 8 (1), 107-14
DOI 10.1038/mi.2014.46, PubMed 24917456

Dhanasekaran S, Jenum S, Stavrum R, Ritz C, Kenneth J, Vaz M, Doherty TM, Grewal HM, TB Trials Study Group (2014)
Concordant or discordant results by the tuberculin skin test and the quantiFERON-TB test in children reflect immune biomarker profiles
Genes Immun, 15 (5), 265-74
DOI 10.1038/gene.2014.13, PubMed 24739497

Dhanasekaran S, Jenum S, Stavrum R, Wiker HG, Kenneth J, Vaz M, Doherty TM, Grewal HM, TB Trials Study Group (2014)
Effect of non-tuberculous Mycobacteria on host biomarkers potentially relevant for tuberculosis management
PLoS Negl Trop Dis, 8 (10), e3243
DOI 10.1371/journal.pntd.0003243, PubMed 25329719

Dutertre CA, Jourdain JP, Rancez M, Amraoui S, Fossum E, Bogen B, Sanchez C, Couëdel-Courteille A, Richard Y, Dalod M, Feuillet V, Cheynier R, Hosmalin A (2014)
TLR3-responsive, XCR1+, CD141(BDCA-3)+/CD8α+-equivalent dendritic cells uncovered in healthy and simian immunodeficiency virus-infected rhesus macaques
J Immunol, 192 (10), 4697-708
DOI 10.4049/jimmunol.1302448, PubMed 24740505

Dørum S, Bodd M, Fallang LE, Bergseng E, Christophersen A, Johannesen MK, Qiao SW, Stamnaes J, de Souza GA, Sollid LM (2014)
HLA-DQ molecules as affinity matrix for identification of gluten T cell epitopes
J Immunol, 193 (9), 4497-506
DOI 10.4049/jimmunol.1301466, PubMed 25261484

Einarsdottir HK, Stapleton NM, Scherjon S, Andersen JT, Rispens T, van der Schoot CE, Vidarsson G (2014)
On the perplexingly low rate of transport of IgG2 across the human placenta
PLoS One, 9 (9), e108319
DOI 10.1371/journal.pone.0108319, PubMed 25251461

Hammerstad SS, Jahnsen FL, Tauriainen S, Hyöty H, Paulsen T, Norheim I, Dahl-Jørgensen K (2014)
Immunological changes and increased expression of myxovirus resistance protein a in thyroid tissue of patients with recent onset and untreated Graves' disease
Thyroid, 24 (3), 537-44
DOI 10.1089/thy.2013.0287, PubMed 24032645

Haabeth OA, Tveita AA, Fauskanger M, Schjesvold F, Lorvik KB, Hofgaard PO, Omholt H, Munthe LA, Dembic Z, Corthay A, Bogen B (2014)
How Do CD4(+) T Cells Detect and Eliminate Tumor Cells That Either Lack or Express MHC Class II Molecules?
Front Immunol, 5, 174
DOI 10.3389/fimmu.2014.00174, PubMed 24782871

Iversen R, Mysling S, Hnida K, Jørgensen TJ, Sollid LM (2014)
Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange
Proc Natl Acad Sci U S A, 111 (48), 17146-51
DOI 10.1073/pnas.1407457111, PubMed 25404341

Jacobsen J, Haabeth OA, Tveita AA, Schjetne KW, Munthe LA, Bogen B (2014)
Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells
J Immunol, 192 (9), 4174-83
DOI 10.4049/jimmunol.1302359, PubMed 24706724

Jenum S, Grewal HM, Hokey DA, Kenneth J, Vaz M, Doherty TM, Jahnsen FL, TB Trials Study Group (2014)
The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy indian adolescents
PLoS One, 9 (7), e101224
DOI 10.1371/journal.pone.0101224, PubMed 24992314

Jenum S, Selvam S, Mahelai D, Jesuraj N, Cárdenas V, Kenneth J, Hesseling AC, Doherty TM, Vaz M, Grewal HM (2014)
Influence of age and nutritional status on the performance of the tuberculin skin test and QuantiFERON-TB gold in-tube in young children evaluated for tuberculosis in Southern India
Pediatr Infect Dis J, 33 (10), e260-9
DOI 10.1097/INF.0000000000000399, PubMed 24797993

Kroll JE, de Souza SJ, de Souza GA (2014)
Identification of rare alternative splicing events in MS/MS data reveals a significant fraction of alternative translation initiation sites
PeerJ, 2, e673
DOI 10.7717/peerj.673, PubMed 25405079

Lundin KE, Sollid LM (2014)
Advances in coeliac disease
Curr Opin Gastroenterol, 30 (2), 154-62
DOI 10.1097/MOG.0000000000000041, PubMed 24457347

Løset GÅ, Berntzen G, Frigstad T, Pollmann S, Gunnarsen KS, Sandlie I (2014)
Phage Display Engineered T Cell Receptors as Tools for the Study of Tumor Peptide-MHC Interactions
Front Oncol, 4, 378
DOI 10.3389/fonc.2014.00378, PubMed 25629004

Melum GR, Farkas L, Scheel C, Van Dieren B, Gran E, Liu YJ, Johansen FE, Jahnsen FL, Baekkevold ES (2014)
A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa
J Allergy Clin Immunol, 134 (3), 613-621.e7
DOI 10.1016/j.jaci.2014.05.010, PubMed 24958565

Pieper J, Johansson S, Snir O, Linton L, Rieck M, Buckner JH, Winqvist O, van Vollenhoven R, Malmström V (2014)
Peripheral and site-specific CD4(+) CD28(null) T cells from rheumatoid arthritis patients show distinct characteristics
Scand J Immunol, 79 (2), 149-55
DOI 10.1111/sji.12139, PubMed 24313359

Ruffini PA, Os A, Dolcetti R, Tjønnfjord GE, Munthe LA, Bogen B (2014)
Targeted DNA vaccines eliciting crossreactive anti-idiotypic antibody responses against human B cell malignancies in mice
J Transl Med, 12, 207
DOI 10.1186/1479-5876-12-207, PubMed 25059102

Sand KM, Bern M, Nilsen J, Dalhus B, Gunnarsen KS, Cameron J, Grevys A, Bunting K, Sandlie I, Andersen JT (2014)
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)
J Biol Chem, 289 (50), 34583-94
DOI 10.1074/jbc.M114.587675, PubMed 25344603

Sand KM, Bern M, Nilsen J, Noordzij HT, Sandlie I, Andersen JT (2014)
Unraveling the Interaction between FcRn and Albumin: Opportunities for Design of Albumin-Based Therapeutics
Front Immunol, 5, 682
DOI 10.3389/fimmu.2014.00682, PubMed 25674083

Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT (2014)
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301

Schwarzer R, Nickel N, Godau J, Willie BM, Duda GN, Schwarzer R, Cirovic B, Leutz A, Manz R, Bogen B, Dörken B, Jundt F (2014)
Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model
Blood Cancer J, 4, e217
DOI 10.1038/bcj.2014.37, PubMed 24927406

Sollid LM, Pos W, Wucherpfennig KW (2014)
Molecular mechanisms for contribution of MHC molecules to autoimmune diseases
Curr Opin Immunol, 31, 24-30
DOI 10.1016/j.coi.2014.08.005, PubMed 25216261

Steinsbø Ø, Henry Dunand CJ, Huang M, Mesin L, Salgado-Ferrer M, Lundin KE, Jahnsen J, Wilson PC, Sollid LM (2014)
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells
Nat Commun, 5, 4041
DOI 10.1038/ncomms5041, PubMed 24909383

Tutturen AE, Fleckenstein B, de Souza GA (2014)
Assessing the citrullinome in rheumatoid arthritis synovial fluid with and without enrichment of citrullinated peptides
J Proteome Res, 13 (6), 2867-73
DOI 10.1021/pr500030x, PubMed 24724574

Tveita AA, Schjesvold FH, Sundnes O, Haabeth OA, Haraldsen G, Bogen B (2014)
Indirect CD4+ T-cell-mediated elimination of MHC II(NEG) tumor cells is spatially restricted and fails to prevent escape of antigen-negative cells
Eur J Immunol, 44 (9), 2625-37
DOI 10.1002/eji.201444659, PubMed 24846412

Wong D, Winter O, Hartig C, Siebels S, Szyska M, Tiburzy B, Meng L, Kulkarni U, Fähnrich A, Bommert K, Bargou R, Berek C, Chu VT, Bogen B, Jundt F, Manz RA (2014)
Eosinophils and megakaryocytes support the early growth of murine MOPC315 myeloma cells in their bone marrow niches
PLoS One, 9 (10), e109018
DOI 10.1371/journal.pone.0109018, PubMed 25272036

Aas-Hanssen K, Funderud A, Thompson KM, Bogen B, Munthe LA (2014)
Idiotype-specific Th cells support oligoclonal expansion of anti-dsDNA B cells in mice with lupus
J Immunol, 193 (6), 2691-8
DOI 10.4049/jimmunol.1400640, PubMed 25127856

 
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