Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2015 from OUS - Department of Radiation Biology

35 publications found

Baglo Y, Peng Q, Hagen L, Berg K, Høgset A, Drabløs F, Gederaas OA (2015)
Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model
Photodiagnosis Photodyn Ther, 12 (1), 58-66
DOI 10.1016/j.pdpdt.2014.12.005, PubMed 25575731

Berstad MB, Cheung LH, Berg K, Peng Q, Fremstedal AS, Patzke S, Rosenblum MG, Weyergang A (2015)
Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy
Oncogene, 34 (44), 5582-92
DOI 10.1038/onc.2015.15, PubMed 25684137

Bostad M, Olsen CE, Peng Q, Berg K, Høgset A, Selbo PK (2015)
Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization - A minimally invasive cancer stem cell-targeting strategy
J Control Release, 206, 37-48
DOI 10.1016/j.jconrel.2015.03.008, PubMed 25758331

Bruno C, Waeckerle-Men Y, Håkerud M, Kündig TM, Gander B, Johansen P (2015)
Photosensitizer and Light Pave the Way for Cytosolic Targeting and Generation of Cytosolic CD8 T Cells Using PLGA Vaccine Particles
J Immunol, 195 (1), 166-73
DOI 10.4049/jimmunol.1500431, PubMed 26019274

Bull-Hansen B, Berstad MB, Berg K, Cao Y, Skarpen E, Fremstedal AS, Rosenblum MG, Peng Q, Weyergang A (2015)
Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer
Oncotarget, 6 (14), 12436-51
DOI 10.18632/oncotarget.3814, PubMed 26002552

Christie CE, Zamora G, Kwon YJ, Berg K, Madsen SJ, Hirschberg H (2015)
Macrophage mediated PCI enhanced gene-directed enzyme prodrug therapy
PROC SPIE, 9305

Coelho SC, Pereira MC, Juzeniene A, Juzenas P, Coelho MAN (2015)
Supramolecular nanoscale assemblies for cancer diagnosis and therapy
J Control Release, 213, 152-167
DOI 10.1016/j.jconrel.2015.06.034, PubMed 26160308

Dale Rein I, Solberg Landsverk K, Micci F, Patzke S, Stokke T (2015)
Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation
Cell Cycle, 14 (20), 3248-60
DOI 10.1080/15384101.2015.1085137, PubMed 26312527

Dale Rein I, Stokke C, Jalal M, Myklebust JH, Patzke S, Stokke T (2015)
New distinct compartments in the G2 phase of the cell cycle defined by the levels of γH2AX
Cell Cycle, 14 (20), 3261-9
DOI 10.1080/15384101.2015.1087617, PubMed 26317799

Edin NJ, Altaner Č, Altanerova V, Ebbesen P (2015)
TGF-B3 Dependent Modification of Radiosensitivity in Reporter Cells Exposed to Serum From Whole-Body Low Dose-Rate Irradiated Mice
Dose Response, 13 (1)
DOI 10.2203/dose-response.14-015.Edin, PubMed 26673923

Ellingsen C, Andersen LM, Galappathi K, Rofstad EK (2015)
Hypoxia biomarkers in squamous cell carcinoma of the uterine cervix
BMC Cancer, 15, 805
DOI 10.1186/s12885-015-1828-2, PubMed 26502718

Gaustad JV, Simonsen TG, Smistad R, Wegner CS, Andersen LM, Rofstad EK (2015)
Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging
BMC Cancer, 15, 900
DOI 10.1186/s12885-015-1918-1, PubMed 26573613

Gederaas OA, Hauge A, Ellingsen PG, Berg K, Altin D, Bardal T, Høgset A, Lindgren M (2015)
Photochemical internalization of bleomycin and temozolomide--in vitro studies on the glioma cell line F98
Photochem Photobiol Sci, 14 (7), 1357-66
DOI 10.1039/c5pp00144g, PubMed 26088711

Generalov R, Kuan WB, Chen W, Kristensen S, Juzenas P (2015)
Radiosensitizing effect of zinc oxide and silica nanocomposites on cancer cells
Colloids Surf B Biointerfaces, 129, 79-86
DOI 10.1016/j.colsurfb.2015.03.026, PubMed 25829130

Gorad SS, Ellingsen C, Bathen TF, Mathiesen BS, Moestue SA, Rofstad EK (2015)
Identification of Metastasis-Associated Metabolic Profiles of Tumors by (1)H-HR-MAS-MRS
Neoplasia, 17 (10), 767-75
DOI 10.1016/j.neo.2015.10.001, PubMed 26585232

Grigalavicius M, Moan J, Dahlback A, Juzeniene A (2015)
Vitamin D and ultraviolet phototherapy in Caucasians
J Photochem Photobiol B, 147, 69-74
DOI 10.1016/j.jphotobiol.2015.03.009, PubMed 25846579

Grigalavicius M, Moan J, Dahlback A, Juzeniene A (2015)
Daily, seasonal, and latitudinal variations in solar ultraviolet A and B radiation in relation to vitamin D production and risk for skin cancer
Int J Dermatol, 55 (1), e23-8
DOI 10.1111/ijd.13065, PubMed 26547141

Hirschberg H, Trinidad A, Christie CE, Kwon YJ, Peng Q, Madsen SJ (2015)
Combined concurrent nanoshell loaded macrophage-mediated photothermal and photodynamic therapies
PROC SPIE, 9303, 930322

Huang R, Wang J, Zhong Y, Liu Y, Stokke T, Trope CG, Nesland JM, Suo Z (2015)
Mitochondrial DNA Deficiency in Ovarian Cancer Cells and Cancer Stem Cell-like Properties
Anticancer Res, 35 (7), 3743-53
PubMed 26124317

Håland TW, Boye E, Stokke T, Grallert B, Syljuåsen RG (2015)
Simultaneous measurement of passage through the restriction point and MCM loading in single cells
Nucleic Acids Res, 43 (22), e150
DOI 10.1093/nar/gkv744, PubMed 26250117

Juzeniene A, Baturaite Z, Lagunova Z, Grigalavicius M, Porojnicu AC, Bruland ØS, Moan J (2015)
Influence of multiple UV exposures on serum cobalamin and vitamin D levels in healthy females
Scand J Public Health, 43 (3), 324-30
DOI 10.1177/1403494815572206, PubMed 25740614

Juzeniene A, Porojnicu AC, Baturaite Z, Lagunova Z, Aksnes L, Bruland ØS, Moan J (2015)
Vitamin D levels and dietary intake among patients with benign soft tissue tumors and sarcomas
Anticancer Res, 35 (2), 1171-80
PubMed 25667508

Knutsen JH, Rødland GE, Bøe CA, Håland TW, Sunnerhagen P, Grallert B, Boye E (2015)
Stress-induced inhibition of translation independently of eIF2α phosphorylation
J Cell Sci, 128 (23), 4420-7
DOI 10.1242/jcs.176545, PubMed 26493332

Lando M, Fjeldbo CS, Wilting SM, C Snoek B, Aarnes EK, Forsberg MF, Kristensen GB, Steenbergen RD, Lyng H (2015)
Interplay between promoter methylation and chromosomal loss in gene silencing at 3p11-p14 in cervical cancer
Epigenetics, 10 (10), 970-80
DOI 10.1080/15592294.2015.1085140, PubMed 26291246

Lund KV, Simonsen TG, Hompland T, Kristensen GB, Rofstad EK (2015)
Short-term pretreatment DCE-MRI in prediction of outcome in locally advanced cervical cancer
Radiother Oncol, 115 (3), 379-85
DOI 10.1016/j.radonc.2015.05.001, PubMed 25998804

Magnussen GI, Emilsen E, Giller Fleten K, Engesæter B, Nähse-Kumpf V, Fjær R, Slipicevic A, Flørenes VA (2015)
Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma
BMC Cancer, 15, 462
DOI 10.1186/s12885-015-1474-8, PubMed 26054341

Pefkianakis EK, Theodossiou TA, Toubanaki DK, Karagouni E, Falaras P, Papadopoulos K, Vougioukalakis GC (2015)
A Family of Potent Ru(II) Photosensitizers with Enhanced DNA Intercalation: Bimodal Photokillers
Photochem Photobiol, 91 (5), 1191-202
DOI 10.1111/php.12485, PubMed 26118404

Repetto-Llamazares AH, Larsen RH, Patzke S, Fleten KG, Didierlaurent D, Pichard A, Pouget JP, Dahle J (2015)
Targeted Cancer Therapy with a Novel Anti-CD37 Beta-Particle Emitting Radioimmunoconjugate for Treatment of Non-Hodgkin Lymphoma
PLoS One, 10 (6), e0128816
DOI 10.1371/journal.pone.0128816, PubMed 26066655

Seierstad T, Hole KH, Grøholt KK, Dueland S, Ree AH, Flatmark K, Redalen KR (2015)
MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer
Br J Radiol, 88 (1051), 20150097
DOI 10.1259/bjr.20150097, PubMed 25899892

Selbo PK, Bostad M, Olsen CE, Edwards VT, Høgset A, Weyergang A, Berg K (2015)
Photochemical internalisation, a minimally invasive strategy for light-controlled endosomal escape of cancer stem cell-targeting therapeutics
Photochem Photobiol Sci, 14 (8), 1433-50
DOI 10.1039/c5pp00027k, PubMed 25805311

Simonsen TG, Gaustad JV, Rofstad EK (2015)
Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases
J Exp Clin Cancer Res, 34, 150
DOI 10.1186/s13046-015-0264-0, PubMed 26667022

Sternemalm J, Geimer S, Frikstad KA, Schink KO, Stokke T, Patzke S (2015)
CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation
PLoS One, 10 (8), e0134789
DOI 10.1371/journal.pone.0134789, PubMed 26241740

Syljuåsen RG, Hasvold G, Hauge S, Helland Å (2015)
Targeting lung cancer through inhibition of checkpoint kinases
Front Genet, 6, 70
DOI 10.3389/fgene.2015.00070, PubMed 25774168

Theodossiou TA, Wälchli S, Olsen CE, Skarpen E, Berg K (2015)
Deciphering the Nongenomic, Mitochondrial Toxicity of Tamoxifens As Determined by Cell Metabolism and Redox Activity
ACS Chem Biol, 11 (1), 251-62
DOI 10.1021/acschembio.5b00734, PubMed 26569462

Weyergang A, Berstad ME, Bull-Hansen B, Olsen CE, Selbo PK, Berg K (2015)
Photochemical activation of drugs for the treatment of therapy-resistant cancers
Photochem Photobiol Sci, 14 (8), 1465-75
DOI 10.1039/c5pp00029g, PubMed 25849953

 
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