Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
Click here to see hierarchical division and subunit overview
Summary of publications:
Publications (original articles or review articles) published in 2020 from OUS - Department of Cancer Immunology
42 publications found
Gene Editing in B-Lymphoma Cell Lines Using CRISPR/Cas9 Technology
Methods Mol Biol, 2115, 445-454
DOI 10.1007/978-1-0716-0290-4_25, PubMed 32006416
Anti-tumour immunity induces aberrant peptide presentation in melanoma
Nature (in press)
DOI 10.1093/nar/gky1106, PubMed 33328638
Anti-tumour immunity induces aberrant peptide presentation in melanoma
Nature
CD4+ T cells persist for years in the human small intestine and display a TH1 cytokine profile
Mucosal Immunol
DOI 10.1038/s41385-020-0315-5, PubMed 32572129
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation
iScience, 23 (6), 101154
DOI 10.1016/j.isci.2020.101154, PubMed 32450518
Use of RNA Interference with TCR Transfer to Enhance Safety and Efficiency
Methods Mol Biol, 2115, 327-349
DOI 10.1007/978-1-0716-0290-4_18, PubMed 32006409
Leaky severe combined immunodeficiency in mice lacking non-homologous end joining factors XLF and MRI
Aging (Albany NY), 12 (23), 23578-23597
DOI 10.18632/aging.202346, PubMed 33289702
DNMT3B deficiency alters mitochondrial biogenesis and α-ketoglutarate levels in human embryonic stem cells
Stem Cells, 38 (11), 1409-1422
DOI 10.1002/stem.3256, PubMed 32652733
TRP Channels as Interior Designers: Remodeling the Endolysosomal Compartment in Natural Killer Cells
Front Immunol, 11, 753
DOI 10.3389/fimmu.2020.00753, PubMed 32411146
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020377, PubMed 32041351
Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy
Mol Ther (in press)
DOI 10.1016/j.ymthe.2020.11.019, PubMed 33212301
Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies
MAbs, 12 (1), 1795505
DOI 10.1080/19420862.2020.1795505, PubMed 32744145
Vasculitis as a Major Morbidity Factor in Patients With Partial RAG Deficiency
Front Immunol, 11, 574738
DOI 10.3389/fimmu.2020.574738, PubMed 33193364
Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles
Front Immunol, 11, 561553
DOI 10.3389/fimmu.2020.561553, PubMed 33178188
Harnessing the Antiviral-Type Responses Induced by Immunostimulatory siRNAs for Cancer Immunotherapy
Methods Mol Biol, 2115, 281-287
DOI 10.1007/978-1-0716-0290-4_16, PubMed 32006407
The Oncometabolite 5'-Deoxy-5'-Methylthioadenosine Blocks Multiple Signaling Pathways of NK Cell Activation
Front Immunol, 11, 2128
DOI 10.3389/fimmu.2020.02128, PubMed 33123121
Minimal relapse risk and early normalization of survival for patients with Burkitt lymphoma treated with intensive immunochemotherapy: an international study of 264 real-world patients
Br J Haematol, 189 (4), 661-671
DOI 10.1111/bjh.16425, PubMed 32017050
Machine learning derived input-function in a dynamic 18F-FDG PET study of mice
Biomed Phys Eng Express, 6 (1), 015020
DOI 10.1088/2057-1976/ab6496, PubMed 33438608
ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer
J Transl Med, 18 (1), 269
DOI 10.1186/s12967-020-02421-w, PubMed 32620163
ALICE: a randomized placebo-controlled phase II study evaluating atezolizumab combined with immunogenic chemotherapy in patients with metastatic triple-negative breast cancer
J Transl Med, 18 (1), 252
DOI 10.1186/s12967-020-02424-7, PubMed 32576225
Prospects for NK Cell Therapy of Sarcoma
Cancers (Basel), 12 (12)
DOI 10.3390/cancers12123719, PubMed 33322371
Tuning the Antigen Density Requirement for CAR T-cell Activity
Cancer Discov, 10 (5), 702-723
DOI 10.1158/2159-8290.CD-19-0945, PubMed 32193224
Outcomes of COVID-19 in patients with CLL: a multicenter international experience
Blood, 136 (10), 1134-1143
DOI 10.1182/blood.2020006965, PubMed 32688395
Natural killer cell immunotypes related to COVID-19 disease severity
Sci Immunol, 5 (50)
DOI 10.1126/sciimmunol.abd6832, PubMed 32826343
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
Nat Commun, 11 (1), 147
DOI 10.1038/s41467-019-13837-4, PubMed 31919342
HIV-infected immunological non-responders have colon-restricted gut mucosal immune dysfunction
J Infect Dis (in press)
DOI 10.1093/infdis/jiaa714, PubMed 33216130
Exploring 5'-Biotinylation of the Sense Strand to Improve siRNA Specificity and Potency
Methods Mol Biol, 2115, 163-170
DOI 10.1007/978-1-0716-0290-4_9, PubMed 32006400
Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis
Cell Calcium, 92, 102289
DOI 10.1016/j.ceca.2020.102289, PubMed 33027744
Deciphering Natural Killer Cell Homeostasis
Front Immunol, 11, 812
DOI 10.3389/fimmu.2020.00812, PubMed 32477340
Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors
Allergy, 75 (11), 2829-2845
DOI 10.1111/all.14429, PubMed 32496587
Cell Cycle Analysis and Relevance for Single-Cell Gating in Mass Cytometry
Cytometry A, 97 (8), 832-844
DOI 10.1002/cyto.a.23960, PubMed 31943748
Improving Dendritic Cell Cancer Vaccine Potency Using RNA Interference
Methods Mol Biol, 2115, 249-258
DOI 10.1007/978-1-0716-0290-4_14, PubMed 32006405
RNA and CRISPR Interferences: Past, Present, and Future Perspectives
Methods Mol Biol, 2115, 1-22
DOI 10.1007/978-1-0716-0290-4_1, PubMed 32006392
Optimized siRNA Delivery into Primary Immune Cells Using Electroporation
Methods Mol Biol, 2115, 119-131
DOI 10.1007/978-1-0716-0290-4_7, PubMed 32006398
Unleashing the Therapeutic Potential of Dendritic and T Cell Therapies Using RNA Interference
Methods Mol Biol, 2115, 259-280
DOI 10.1007/978-1-0716-0290-4_15, PubMed 32006406
Microbial sensing by haematopoietic stem and progenitor cells: Vigilance against infections and immune education of myeloid cells
Scand J Immunol, 92 (5), e12957
DOI 10.1111/sji.12957, PubMed 32767789
B cell signalling pathways-New targets for precision medicine in chronic lymphocytic leukaemia
Scand J Immunol, 92 (5), e12931
DOI 10.1111/sji.12931, PubMed 32640099
Reduced polyfunctional T cells and increased cellular activation markers in adult allergy patients reporting adverse reactions to food
BMC Immunol, 21 (1), 43
DOI 10.1186/s12865-020-00373-w, PubMed 32698761
Cellular immunotherapy with multiple infusions of in vitro-expanded haploidentical natural killer cells after autologous transplantation for patients with plasma cell myeloma
Cytotherapy (in press)
DOI 10.1016/j.jcyt.2020.09.009, PubMed 33268029
Next Generation of Adoptive T Cell Therapy Using CRISPR/Cas9 Technology: Universal or Boosted?
Methods Mol Biol, 2115, 407-417
DOI 10.1007/978-1-0716-0290-4_22, PubMed 32006413
Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series
Blood Adv, 4 (9), 1859-1866
DOI 10.1182/bloodadvances.2019001325, PubMed 32374878
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
Cell Stem Cell, 27 (2), 224-237.e6
DOI 10.1016/j.stem.2020.05.008, PubMed 32531207