Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2020 from OUS - Department of Rheumatology, Dermatology and Infectious Diseases
88 publications found
Decreased IL-1β-induced CCL20 response in human iPSC-astrocytes in schizophrenia: Potential attenuating effects on recruitment of regulatory T cells
Brain Behav Immun, 87, 634-644
DOI 10.1016/j.bbi.2020.02.008, PubMed 32109548
Skin bioengineering in the diagnosis of occupational protein contact dermatitis
Occup Med (Lond), 70 (4), 282-285
DOI 10.1093/occmed/kqaa005, PubMed 32009172
Occupation and cutaneous melanoma: a 45-year historical cohort study of 14·9 million people in five Nordic countries
Br J Dermatol
DOI 10.1111/bjd.19379, PubMed 33026672
De novo species identification using 16S rRNA gene nanopore sequencing
PeerJ, 8, e10029
DOI 10.7717/peerj.10029, PubMed 33150059
The power of the EUSTAR cohort: key findings to date and implications for management of systemic sclerosis patients
Expert Rev Clin Immunol, 16 (11), 1065-1074
DOI 10.1080/1744666X.2021.1836962, PubMed 33076716
Excision of skin lesions
Tidsskr. Nor. Laegeforen., 140 (10), 1034-1037
Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection
Infection, 48 (3), 367-373
DOI 10.1007/s15010-020-01399-3, PubMed 32077073
Use of Antidepressants and Risk of Cutaneous Melanoma: A Prospective Registry-Based Case-Control Study
Clin Epidemiol, 12, 193-202
DOI 10.2147/CLEP.S241249, PubMed 32110111
Birt-Hogg-Dube-syndrome
Tidsskr. Nor. Laegeforen., 140 (6), 565-569
Functional and Structural Adaptations of Skeletal Muscle in Long-Term Juvenile Dermatomyositis: A Controlled Cross-Sectional Study
Arthritis Rheumatol, 72 (5), 837-848
DOI 10.1002/art.41174, PubMed 31746550
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases
J Clin Invest, 130 (4), 1669-1682
DOI 10.1172/JCI129301, PubMed 31874111
Predictors of progression in systemic sclerosis patients with interstitial lung disease
Eur Respir J, 55 (5)
DOI 10.1183/13993003.02026-2019, PubMed 32079645
ILD-specific health-related quality of life in systemic sclerosis-associated ILD compared with IPF
BMJ Open Respir Res, 7 (1)
DOI 10.1136/bmjresp-2020-000598, PubMed 32576559
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739, PubMed 32437393
Multidimensional tracking of phenotypes and organ involvement in a complete nationwide systemic sclerosis cohort
Rheumatology (Oxford), 59 (10), 2920-2929
DOI 10.1093/rheumatology/keaa026, PubMed 32097470
Efficacy and safety of intraarticular corticosteroid injections in adolescents with juvenile idiopathic arthritis in the temporomandibular joint: a Norwegian 2-year prospective multicenter pilot study
Pediatr Rheumatol Online J, 18 (1), 75
DOI 10.1186/s12969-020-00464-3, PubMed 32998740
Salivary Oral Microbiome of Children With Juvenile Idiopathic Arthritis: A Norwegian Cross-Sectional Study
Front Cell Infect Microbiol, 10, 602239
DOI 10.3389/fcimb.2020.602239, PubMed 33251163
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus
J Infect Dis, 221 (3), 419-427
DOI 10.1093/infdis/jiz465, PubMed 31538186
Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform
J Am Heart Assoc, 9 (12), e015628
DOI 10.1161/JAHA.119.015628, PubMed 32515246
Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
Arthritis Res Ther, 22 (1), 71
DOI 10.1186/s13075-020-02167-2, PubMed 32264969
Legumain in Acute Coronary Syndromes: A Substudy of the PLATO (Platelet Inhibition and Patient Outcomes) Trial
J Am Heart Assoc, 9 (17), e016360
DOI 10.1161/JAHA.120.016360, PubMed 32809893
Plasma levels of growth differentiation factor 15 are associated with future risk of venous thromboembolism
Blood, 136 (16), 1863-1870
DOI 10.1182/blood.2019004572, PubMed 32645137
Factors increasing the risk of inappropriate vancomycin therapy in ICU patients: A prospective observational study
Acta Anaesthesiol Scand, 64 (9), 1295-1304
DOI 10.1111/aas.13658, PubMed 32578201
Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement
J Intern Med
DOI 10.1111/joim.13178, PubMed 32976665
Soluble T-Cell Immunoglobulin Mucin Domain-3 Is Associated With Hepatitis C Virus Coinfection and Low-Grade Inflammation During Chronic Human Immunodeficiency Virus Infection
Open Forum Infect Dis, 7 (2), ofaa033
DOI 10.1093/ofid/ofaa033, PubMed 32055642
Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals
J Infect Dis, 221 (4), 506-509
DOI 10.1093/infdis/jiz253, PubMed 31077280
Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database
Ann Rheum Dis, 80 (2), 219-227
DOI 10.1136/annrheumdis-2020-217455, PubMed 32988845
The need for a holistic approach for SSc-ILD - achievements and ambiguity in a devastating disease
Respir Res, 21 (1), 197
DOI 10.1186/s12931-020-01459-0, PubMed 32703199
Circulating biomarkers of systemic sclerosis - interstitial lung disease
J. Scleroderma Relat. Disord., 5 (2_SUPPL 2_), 2397198319894851-47
The identification and management of interstitial lung disease in systemic sclerosis: evidence-based European consensus statements
Lancet Rheumatol., 2 (2), E71-E83
Detection, screening, and classification of interstitial lung disease in patients with systemic sclerosis
Curr Opin Rheumatol, 32 (6), 497-504
DOI 10.1097/BOR.0000000000000741, PubMed 32890027
Impact of Paranasal Sinus Surgery in Granulomatosis With Polyangiitis: A Longitudinal Computed Tomography Study
Laryngoscope, 130 (8), E460-E468
DOI 10.1002/lary.28639, PubMed 32243590
Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients
Proc Natl Acad Sci U S A, 117 (40), 25018-25025
DOI 10.1073/pnas.2010540117, PubMed 32943538
No evidence of a synergistic effect of HIV infection and diabetes mellitus type 2 on fat distribution, plasma adiponectin or inflammatory markers
BMC Infect Dis, 20 (1), 882
DOI 10.1186/s12879-020-05594-3, PubMed 33238950
Subjects with familial hypercholesterolemia have lower aortic valve area and higher levels of inflammatory biomarkers
J Clin Lipidol (in press)
DOI 10.1016/j.jacl.2020.12.006, PubMed 33358307
Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
Scand Cardiovasc J, 54 (5), 274-279
DOI 10.1080/14017431.2020.1775878, PubMed 32500743
Virus, allergic sensitisation and cortisol in infant bronchiolitis and risk of early asthma
ERJ Open Res, 6 (1)
DOI 10.1183/23120541.00268-2019, PubMed 32201686
A man in his 30s with right-sided heart failure, jaundice and abdominal pain
Tidsskr. Nor. Laegeforen., 140 (17), 1776-1779
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
Sci Rep, 10 (1), 21697
DOI 10.1038/s41598-020-78710-7, PubMed 33303843
Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma
Nucleic Acids Res, 48 (8), 4463-4479
DOI 10.1093/nar/gkaa115, PubMed 32083667
Rosuvastatin alters the genetic composition of the human gut microbiome
Sci Rep, 10 (1), 5397
DOI 10.1038/s41598-020-62261-y, PubMed 32214138
Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis
Gastroenterology (in press)
DOI 10.1053/j.gastro.2020.12.058, PubMed 33387530
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
Nat Genet, 52 (5), 494-504
DOI 10.1038/s41588-020-0611-8, PubMed 32341527
Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension
Sci Rep, 10 (1), 18540
DOI 10.1038/s41598-020-75654-w, PubMed 33122779
Selexipag treatment in patients with systemic sclerosis-associated pulmonary arterial hypertension in clinical practice, a case series
J. Scleroderma Relat. Disord., 5 (3), 2397198320916082-NP11
Early transcriptional changes after UVB treatment in atopic dermatitis includes inverse regulation of IL-36γ and IL-37
Exp Dermatol
DOI 10.1111/exd.14217, PubMed 33067891
Contact allergy in patients with chronic venous leg ulcers
Contact Dermatitis (in press)
DOI 10.1111/cod.13770, PubMed 33368388
Absence of NLRP3 Inflammasome in Hematopoietic Cells Reduces Adverse Remodeling After Experimental Myocardial Infarction
JACC Basic Transl Sci, 5 (12), 1210-1224
DOI 10.1016/j.jacbts.2020.09.013, PubMed 33426377
Multidisciplinary educational programme for caregivers of children with atopic dermatitis- in South East Norway - an observational study
BMC Dermatol, 20 (1), 20
DOI 10.1186/s12895-020-00119-6, PubMed 33298043
Gut Microbiota-Dependent Trimethylamine N-Oxide Associates With Inflammation in Common Variable Immunodeficiency
Front Immunol, 11, 574500
DOI 10.3389/fimmu.2020.574500, PubMed 33042155
Tocilizumab may slow radiographic progression in patients with systemic or polyarticular-course juvenile idiopathic arthritis: post hoc radiographic analysis from two randomized controlled trials
Arthritis Res Ther, 22 (1), 211
DOI 10.1186/s13075-020-02303-y, PubMed 32912276
Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis - a cross-sectional study of long-term disease
Rheumatology (Oxford), 59 (8), 1862-1870
DOI 10.1093/rheumatology/kez531, PubMed 31740970
Low fibre intake is associated with gut microbiota alterations in chronic heart failure
ESC Heart Fail, 7 (2), 456-466
DOI 10.1002/ehf2.12596, PubMed 31978943
Interleukin 18 (IL-18) and its binding protein (IL-18BP) are increased in patients with epilepsy suggesting low-grade systemic inflammation
Seizure, 80, 221-225
DOI 10.1016/j.seizure.2020.05.018, PubMed 32659652
EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 1: treatment and monitoring recommendations
J Eur Acad Dermatol Venereol, 34 (11), 2461-2498
DOI 10.1111/jdv.16915, PubMed 33349983
Butyrate Levels in the Transition from an Infant- to an Adult-Like Gut Microbiota Correlate with Bacterial Networks Associated with Eubacterium Rectale and Ruminococcus Gnavus
Genes (Basel), 11 (11)
DOI 10.3390/genes11111245, PubMed 33105702
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
EBioMedicine, 60, 102985
DOI 10.1016/j.ebiom.2020.102985, PubMed 32927275
Maternal use of nicotine products and breastfeeding 3 months postpartum
Acta Paediatr, 109 (12), 2594-2603
DOI 10.1111/apa.15299, PubMed 32274823
Estimation of the Prevalence of Progressive Fibrosing Interstitial Lung Diseases: Systematic Literature Review and Data from a Physician Survey
Adv. Ther.
The Impact of Spondyloarthritis and Joint Symptoms on Health-Related Quality of Life and Fatigue in IBD Patients. Results From a Population-Based Inception Cohort (20-Year Follow-up in the Ibsen Study)
Inflamm Bowel Dis, 26 (1), 114-124
DOI 10.1093/ibd/izz105, PubMed 31127829
Plasma levels of interleukin 27 in falciparum malaria is increased independently of co-infection with HIV: potential immune-regulatory role during malaria
BMC Infect Dis, 20 (1), 65
DOI 10.1186/s12879-020-4783-8, PubMed 31964363
Chronic nodular prurigo: clinical profile and burden. A European cross-sectional study
J Eur Acad Dermatol Venereol, 34 (10), 2373-2383
DOI 10.1111/jdv.16309, PubMed 32078192
Google Search Trends for Itch In Europe: A Retrospective Longitudinal Study
J Eur Acad Dermatol Venereol (in press)
DOI 10.1111/jdv.17077, PubMed 33295009
Lack of interleukin-33 and its receptor does not prevent calcipotriol-induced atopic dermatitis-like inflammation in mice
Sci Rep, 10 (1), 6451
DOI 10.1038/s41598-020-63410-z, PubMed 32296080
Exploring the potential effect of paricalcitol on markers of inflammation in de novo renal transplant recipients
PLoS One, 15 (12), e0243759
DOI 10.1371/journal.pone.0243759, PubMed 33326471
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis
Biochem Biophys Res Commun, 533 (4), 631-637
DOI 10.1016/j.bbrc.2020.09.057, PubMed 33004177
Probiotics to manage inflammation in HIV infection
Curr Opin Infect Dis, 33 (1), 34-43
DOI 10.1097/QCO.0000000000000612, PubMed 31789692
Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders
Front Psychiatry, 11, 672
DOI 10.3389/fpsyt.2020.00672, PubMed 32754070
Teledermatology in Norway using a mobile phone app
PLoS One, 15 (4), e0232131
DOI 10.1371/journal.pone.0232131, PubMed 32339203
Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing
Ann Rheum Dis, 80 (1), 109-117
DOI 10.1136/annrheumdis-2020-218636, PubMed 33037003
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
Biochem Biophys Res Commun, 523 (4), 867-873
DOI 10.1016/j.bbrc.2020.01.018, PubMed 31955888
Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial
Lancet, 395 (10228), 951-961
DOI 10.1016/S0140-6736(19)32983-6, PubMed 32087121
NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet
Sci Rep, 10 (1), 21006
DOI 10.1038/s41598-020-76497-1, PubMed 33273482
Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs)
Ann Rheum Dis, 80 (2), 143-150
DOI 10.1136/annrheumdis-2020-217230, PubMed 33037004
Therapeutic drug monitoring of infliximab compared to standard clinical treatment with infliximab: study protocol for a randomised, controlled, open, parallel-group, phase IV study (the NOR-DRUM study)
Trials, 21 (1), 13
DOI 10.1186/s13063-019-3734-4, PubMed 31907007
Cannabis Use Is Associated With Increased Levels of Soluble gp130 in Schizophrenia but Not in Bipolar Disorder
Front Psychiatry, 11, 642
DOI 10.3389/fpsyt.2020.00642, PubMed 32714224
Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study
Sci Rep, 10 (1), 2063
DOI 10.1038/s41598-020-59078-0, PubMed 32034249
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Nature, 583 (7814), 90-95
DOI 10.1038/s41586-020-2265-1, PubMed 32499645
Hemophagocytic lymphohistiocytosis in a patient with COVID-19 treated with tocilizumab: a case report
J Med Case Rep, 14 (1), 187
DOI 10.1186/s13256-020-02503-9, PubMed 33054818
Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome
Rheumatology (Oxford) (in press)
DOI 10.1093/rheumatology/keaa367, PubMed 32889544
Clinical Management of Atopic Dermatitis in Adults: Mapping of Expert Opinion in 4 Nordic Countries using a Modified Delphi Process
Acta Derm Venereol, 100 (1), adv00015
DOI 10.2340/00015555-3369, PubMed 31709450
A man in his forties with increasing shortness of breath
Tidsskr. Nor. Laegeforen., 140 (6), 578-581
Elevated plasma sTIM-3 levels in patients with severe COVID-19
J Allergy Clin Immunol, 147 (1), 92-98
DOI 10.1016/j.jaci.2020.09.007, PubMed 32971109
Elevated Cholesteryl Ester Transfer Protein Activity Early in Pregnancy Predicts Prediabetes 5 Years Later
J Clin Endocrinol Metab, 105 (3)
DOI 10.1210/clinem/dgz119, PubMed 31665383
Managing Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders: e-GLILDnet International Clinicians Survey
Front Immunol, 11, 606333
DOI 10.3389/fimmu.2020.606333, PubMed 33324422
Reduced levels of circulating adhesion molecules in adolescents with early-onset psychosis
NPJ Schizophr, 6 (1), 20
DOI 10.1038/s41537-020-00112-5, PubMed 32811840
Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results
N Engl J Med (in press)
DOI 10.1056/NEJMoa2023184, PubMed 33264556
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476