Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2015 from OUS - Department of Gastrointestinal and Paediatric Surgery

57 publications found

Andresen K, Boberg KM, Vedeld HM, Honne H, Jebsen P, Hektoen M, Wadsworth CA, Clausen OP, Lundin KE, Paulsen V, Foss A, Mathisen Ø, Aabakken L, Schrumpf E, Lothe RA, Lind GE (2015)
Four DNA methylation biomarkers in biliary brush samples accurately identify the presence of cholangiocarcinoma
Hepatology, 61 (5), 1651-9
DOI 10.1002/hep.27707, PubMed 25644509

Anonsen KV, Buanes T, Rosok BI, Hauge T, Edwin B (2015)
Outcome of Laparoscopic Surgery in Patients with Cystic Lesions in the Distal Pancreas
J. Pancreas, 16 (3), 266-270

Baekelandt BM, Hjermstad MJ, Nordby T, Fagerland MW, Kure EH, Heiberg T, Buanes T, Labori KJ (2015)
Preoperative cognitive function predicts survival in patients with resectable pancreatic ductal adenocarcinoma
HPB (Oxford), 18 (3), 247-54
DOI 10.1016/j.hpb.2015.09.004, PubMed 27017164

Barkhatov L, Kazaryan AM, Aasen S, Edwin B (2015)
Endoscopic clipping of the Z-line (CMZL) helps recognize anatomical failures after Nissen fundoplication: technical report of a new method
Wideochir Inne Tech Maloinwazyjne, 10 (3), 363-7
DOI 10.5114/wiitm.2015.54315, PubMed 26649081

Brudvik KW, Seeberg LT, Hugenschmidt H, Renolen A, Schirmer CB, Brunborg C, Bjørnbeth BA, Borgen E, Naume B, Waage A, Wiedswang G (2015)
Detection of Circulating Tumor Cells at Surgery and at Follow-Up Assessment to Predict Survival After Two-Stage Liver Resection of Colorectal Liver Metastases
Ann Surg Oncol, 22 (12), 4029-37
DOI 10.1245/s10434-015-4482-7, PubMed 25801354

Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA (2015)
Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer
Clin Cancer Res, 21 (16), 3759-70
DOI 10.1158/1078-0432.CCR-14-3294, PubMed 25910952

Carling U, Dorenberg EJ, Haugvik SP, Eide NA, Berntzen DT, Edwin B, Dueland S, Røsok B (2015)
Transarterial Chemoembolization of Liver Metastases from Uveal Melanoma Using Irinotecan-Loaded Beads: Treatment Response and Complications
Cardiovasc Intervent Radiol, 38 (6), 1532-41
DOI 10.1007/s00270-015-1093-4, PubMed 25832764

Chellappa S, Hugenschmidt H, Hagness M, Line PD, Labori KJ, Wiedswang G, Taskén K, Aandahl EM (2015)
Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer
Oncoimmunology, 5 (4), e1102828
DOI 10.1080/2162402X.2015.1102828, PubMed 27141387

Costa-Silva B, Aiello NM, Ocean AJ, Singh S, Zhang H, Thakur BK, Becker A, Hoshino A, Mark MT, Molina H, Xiang J, Zhang T, Theilen TM, García-Santos G, Williams C, Ararso Y, Huang Y, Rodrigues G, Shen TL, Labori KJ, Lothe IM, Kure EH, Hernandez J, Doussot A, Ebbesen SH et al. (2015)
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Nat Cell Biol, 17 (6), 816-26
DOI 10.1038/ncb3169, PubMed 25985394

de Rooij T, Besselink MG, Shamali A, Butturini G, Busch OR, Edwin B, Troisi R, Fernández-Cruz L, Dagher I, Bassi C, Abu Hilal M, DIPLOMA trial group (2015)
Pan-European survey on the implementation of minimally invasive pancreatic surgery with emphasis on cancer
HPB (Oxford), 18 (2), 170-176
DOI 10.1016/j.hpb.2015.08.005, PubMed 26902136

Egeland EV, Boye K, Pettersen SJ, Haugen MH, Øyjord T, Malerød L, Flatmark K, Mælandsmo GM (2015)
Enrichment of nuclear S100A4 during G2/M in colorectal cancer cells: possible association with cyclin B1 and centrosomes
Clin Exp Metastasis, 32 (8), 755-67
DOI 10.1007/s10585-015-9742-1, PubMed 26349943

Engström M, Forsberg A, Søvik TT, Olbers T, Lönroth H, Karlsson J (2015)
Perception of control over eating after bariatric surgery for super-obesity--a 2-year follow-up study
Obes Surg, 25 (6), 1086-93
DOI 10.1007/s11695-015-1652-4, PubMed 25812530

Fretland AA, Sokolov A, Postriganova N, Kazaryan AM, Pischke SE, Nilsson PH, Rognes IN, Bjornbeth BA, Fagerland MW, Mollnes TE, Edwin B (2015)
Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial
Medicine (Baltimore), 94 (42), e1786
DOI 10.1097/MD.0000000000001786, PubMed 26496309

Fretland ÅA, Kazaryan AM, Bjørnbeth BA, Flatmark K, Andersen MH, Tønnessen TI, Bjørnelv GM, Fagerland MW, Kristiansen R, Øyri K, Edwin B (2015)
Open versus laparoscopic liver resection for colorectal liver metastases (the Oslo-CoMet Study): study protocol for a randomized controlled trial
Trials, 16, 73
DOI 10.1186/s13063-015-0577-5, PubMed 25872027

Fromm B, Billipp T, Peck LE, Johansen M, Tarver JE, King BL, Newcomb JM, Sempere LF, Flatmark K, Hovig E, Peterson KJ (2015)
A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome
Annu Rev Genet, 49, 213-42
DOI 10.1146/annurev-genet-120213-092023, PubMed 26473382

Fyhn TJ, Knatten CK, Edwin B, Schistad O, Aabakken L, Kjosbakken H, Pripp AH, Emblem R, Bjørnland K (2015)
Randomized Controlled Trial of Laparoscopic and Open Nissen Fundoplication in Children
Ann Surg, 261 (6), 1061-7
DOI 10.1097/SLA.0000000000001045, PubMed 26291953

Goscinski MA, Larsen SG, Giercksky KE, Nesland JM, Suo Z (2015)
PDGFR-α and CD117 Expression Pattern in Esophageal Carcinomas
Anticancer Res, 35 (7), 3793-9
PubMed 26124324

Goscinski MA, Larsen SG, Giercksky KE, Nesland JM, Suo ZH (2015)
PDGFR-alpha and CD117 Expression Pattern in Esophageal Carcinomas
Anticancer Res., 35 (7), 3793-3799

Goscinski MA, Xu R, Zhou F, Wang J, Yang H, Huang R, Li Y, Larsen SG, Giercksky KE, Nesland JM, Suo Z (2015)
Nuclear, cytoplasmic, and stromal expression of ZEB1 in squamous and small cell carcinoma of the esophagus
APMIS, 123 (12), 1040-7
DOI 10.1111/apm.12473, PubMed 26547370

Guren MG, Kørner H, Pfeffer F, Myklebust TÅ, Eriksen MT, Edna TH, Larsen SG, Knudsen KO, Nesbakken A, Wasmuth HH, Vonen B, Hofsli E, Færden AE, Brændengen M, Dahl O, Steigen SE, Johansen MJ, Lindsetmo RO, Drolsum A, Tollåli G, Dørum LM, Møller B, Wibe A (2015)
Nationwide improvement of rectal cancer treatment outcomes in Norway, 1993-2010
Acta Oncol, 54 (10), 1714-22
DOI 10.3109/0284186X.2015.1034876, PubMed 25924970

Hamfjord J, Saldova R, Stöckmann H, Sandhu V, Bowitz Lothe IM, Buanes T, Lingjærde OC, Labori KJ, Rudd PM, Kure EH (2015)
Serum N-Glycome Characterization in Patients with Resectable Periampullary Adenocarcinoma
J Proteome Res, 14 (12), 5144-56
DOI 10.1021/acs.jproteome.5b00395, PubMed 26515733

Hauge T, Hauge PW, Warloe T, Drolsum A, Johansen C, Viktil E, Aabakken L, Buanes T, Konopski Z (2015)
Randomised controlled trial of temoporfin photodynamic therapy plus chemotherapy in nonresectable biliary carcinoma--PCS Nordic study
Photodiagnosis Photodyn Ther, 13, 330-333
DOI 10.1016/j.pdpdt.2015.09.004, PubMed 26415549

Haugvik SP, Hedenström P, Korsæth E, Valente R, Hayes A, Siuka D, Maisonneuve P, Gladhaug IP, Lindkvist B, Capurso G (2015)
Diabetes, smoking, alcohol use, and family history of cancer as risk factors for pancreatic neuroendocrine tumors: a systematic review and meta-analysis
Neuroendocrinology, 101 (2), 133-42
DOI 10.1159/000375164, PubMed 25613442

Haugvik SP, Janson ET, Österlund P, Langer SW, Falk RS, Labori KJ, Vestermark LW, Grønbæk H, Gladhaug IP, Sorbye H (2015)
Surgical Treatment as a Principle for Patients with High-Grade Pancreatic Neuroendocrine Carcinoma: A Nordic Multicenter Comparative Study
Ann Surg Oncol, 23 (5), 1721-8
DOI 10.1245/s10434-015-5013-2, PubMed 26678407

Hektoen HH, Flatmark K, Andersson Y, Dueland S, Redalen KR, Ree AH (2015)
Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer
BMC Cancer, 15, 543
DOI 10.1186/s12885-015-1557-6, PubMed 26205955

Hektoen HH, Ree AH, Redalen KR, Flatmark K (2015)
Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells
J Enzyme Inhib Med Chem, 31 (5), 779-86
DOI 10.3109/14756366.2015.1069286, PubMed 26244271

Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K et al. (2015)
Tumour exosome integrins determine organotropic metastasis
Nature, 527 (7578), 329-35
DOI 10.1038/nature15756, PubMed 26524530

Klevebro F, Johnsen G, Johnson E, Viste A, Myrnäs T, Szabo E, Jacobsen AB, Friesland S, Tsai JA, Persson S, Lindblad M, Lundell L, Nilsson M (2015)
Morbidity and mortality after surgery for cancer of the oesophagus and gastro-oesophageal junction: A randomized clinical trial of neoadjuvant chemotherapy vs. neoadjuvant chemoradiation
Eur J Surg Oncol, 41 (7), 920-6
DOI 10.1016/j.ejso.2015.03.226, PubMed 25908010

Knatten CK, Kvello M, Fyhn TJ, Edwin B, Schistad O, Aabakken L, Pripp AH, Kjosbakken H, Emblem R, Bjørnland K (2015)
Nissen fundoplication in children with and without neurological impairment: A prospective cohort study
J Pediatr Surg, 51 (7), 1115-21
DOI 10.1016/j.jpedsurg.2015.12.007, PubMed 26787273

Krogvold L, Wiberg A, Edwin B, Buanes T, Jahnsen FL, Hanssen KF, Larsson E, Korsgren O, Skog O, Dahl-Jørgensen K (2015)
Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes
Diabetologia, 59 (3), 492-501
DOI 10.1007/s00125-015-3820-4, PubMed 26602422

Kvello M, Åvitsland TL, Knatten CK, Pripp AH, Aabakken L, Emblem R, Bjørnland K (2015)
Trends in the use of gastrostomies at a tertiary paediatric referral centre
Scand J Gastroenterol, 51 (5), 625-32
DOI 10.3109/00365521.2015.1123288, PubMed 26679498

Labori KJ, Katz MH, Tzeng CW, Bjørnbeth BA, Cvancarova M, Edwin B, Kure EH, Eide TJ, Dueland S, Buanes T, Gladhaug IP (2015)
Impact of early disease progression and surgical complications on adjuvant chemotherapy completion rates and survival in patients undergoing the surgery first approach for resectable pancreatic ductal adenocarcinoma - A population-based cohort study
Acta Oncol, 55 (3), 265-77
DOI 10.3109/0284186X.2015.1068445, PubMed 26213211

Labori KJ, Schulz A, Drolsum A, Guren MG, Kløw NE, Bjørnbeth BA (2015)
Radiofrequency ablation of unresectable colorectal liver metastases: trends in management and outcome during a decade at a single center
Acta Radiol Open, 4 (7), 2058460115580877
DOI 10.1177/2058460115580877, PubMed 26346740

Lambrecht JR, Larsen SG, Reiertsen O, Vaktskjold A, Julsrud L, Flatmark K (2015)
Prophylactic mesh at end-colostomy construction reduces parastomal hernia rate: a randomized trial
Colorectal Dis, 17 (10), O191-7
DOI 10.1111/codi.13065, PubMed 26179984

Mala T, Hewitt S, Høgestøl IK, Kjellevold K, Kristinsson JA, Risstad H (2015)
[Dumping syndrome following gastric surgery]
Tidsskr Nor Laegeforen, 135 (2), 137-41
DOI 10.4045/tidsskr.14.0550, PubMed 25625992

Monclair T, Mosseri V, Cecchetto G, De Bernardi B, Michon J, Holmes K (2015)
Influence of image-defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group
Pediatr Blood Cancer, 62 (9), 1536-42
DOI 10.1002/pbc.25460, PubMed 25663103

Monclair T, Ruud E, Holmstrom H, Aagenaes I, Asplin M, Beiske K (2015)
Extra-adrenal composite phaeochromocytoma/neuroblastoma in a 15-month-old child
J. Pediatr. Surg. Case Rep., 3 (8), 348-350

Næss PA, Wiborg J, Kjellevold K, Gaarder C (2015)
Tension gastrothorax: acute life-threatening manifestation of late onset congenital diaphragmatic hernia (CDH) in children
Scand J Trauma Resusc Emerg Med, 23, 49
DOI 10.1186/s13049-015-0129-8, PubMed 26104782

Otterdal K, Haukeland JW, Yndestad A, Dahl TB, Holm S, Segers FM, Gladhaug IP, Konopski Z, Damås JK, Halvorsen B, Aukrust P (2015)
Increased Serum Levels of LIGHT/TNFSF14 in Nonalcoholic Fatty Liver Disease: Possible Role in Hepatic Inflammation
Clin Transl Gastroenterol, 6, e95
DOI 10.1038/ctg.2015.23, PubMed 26133108

Ratti F, Barkhatov LI, Tomassini F, Cipriani F, Kazaryan AM, Edwin B, Abu Hilal M, Troisi RI, Aldrighetti L (2015)
Learning curve of self-taught laparoscopic liver surgeons in left lateral sectionectomy: results from an international multi-institutional analysis on 245 cases
Surg Endosc, 30 (8), 3618-29
DOI 10.1007/s00464-015-4665-0, PubMed 26572765

Redalen KR, Sitter B, Bathen TF, Grøholt KK, Hole KH, Dueland S, Flatmark K, Ree AH, Seierstad T (2015)
High tumor glycine concentration is an adverse prognostic factor in locally advanced rectal cancer
Radiother Oncol, 118 (2), 393-8
DOI 10.1016/j.radonc.2015.11.031, PubMed 26705680

Ree AH, Flatmark K, Saelen MG, Folkvord S, Dueland S, Geisler J, Redalen KR (2015)
Tumor phosphatidylinositol 3-kinase signaling in therapy resistance and metastatic dissemination of rectal cancer: opportunities for signaling-adapted therapies
Crit Rev Oncol Hematol, 95 (1), 114-24
DOI 10.1016/j.critrevonc.2015.01.003, PubMed 25624177

Risstad H, Søvik TT, Engström M, Aasheim ET, Fagerland MW, Olsén MF, Kristinsson JA, le Roux CW, Bøhmer T, Birkeland KI, Mala T, Olbers T (2015)
Five-year outcomes after laparoscopic gastric bypass and laparoscopic duodenal switch in patients with body mass index of 50 to 60: a randomized clinical trial
JAMA Surg, 150 (4), 352-61
DOI 10.1001/jamasurg.2014.3579, PubMed 25650964

Risstad H, Søvik TT, Hewitt S, Kristinsson JA, Fagerland MW, Bernklev T, Mala T (2015)
Changes in Health-Related Quality of Life After Gastric Bypass in Patients With and Without Obesity-Related Disease
Obes Surg, 25 (12), 2408-16
DOI 10.1007/s11695-015-1717-4, PubMed 26003550

Røsok BI, Björnsson B, Sparrelid E, Hasselgren K, Pomianowska E, Gasslander T, Bjørnbeth BA, Isaksson B, Sandström P (2015)
Scandinavian multicenter study on the safety and feasibility of the associating liver partition and portal vein ligation for staged hepatectomy procedure
Surgery, 159 (5), 1279-86
DOI 10.1016/j.surg.2015.10.004, PubMed 26606881

Sahakyan MA, Kazaryan AM, Rawashdeh M, Fuks D, Shmavonyan M, Haugvik SP, Labori KJ, Buanes T, Røsok BI, Ignjatovic D, Abu Hilal M, Gayet B, Kim SC, Edwin B (2015)
Laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: results of a multicenter cohort study on 196 patients
Surg Endosc, 30 (8), 3409-18
DOI 10.1007/s00464-015-4623-x, PubMed 26514135

Sandhu V, Bowitz Lothe IM, Labori KJ, Skrede ML, Hamfjord J, Dalsgaard AM, Buanes T, Dube G, Kale MM, Sawant S, Kulkarni-Kale U, Børresen-Dale AL, Lingjærde OC, Kure EH (2015)
Differential expression of miRNAs in pancreatobiliary type of periampullary adenocarcinoma and its associated stroma
Mol Oncol, 10 (2), 303-16
DOI 10.1016/j.molonc.2015.10.011, PubMed 26590090

Schultz JK, Yaqub S, Wallon C, Blecic L, Forsmo HM, Folkesson J, Buchwald P, Körner H, Dahl FA, Øresland T, SCANDIV Study Group (2015)
Laparoscopic Lavage vs Primary Resection for Acute Perforated Diverticulitis: The SCANDIV Randomized Clinical Trial
JAMA, 314 (13), 1364-75
DOI 10.1001/jama.2015.12076, PubMed 26441181

Schulz A, Godt JC, Dormagen JB, Holtedahl JE, Bogsrud TV, Labori KJ, Kløw NE, Bach-Gansmo T (2015)
Respiratory gated PET/CT of the liver: A novel method and its impact on the detection of colorectal liver metastases
Eur J Radiol, 84 (8), 1424-1431
DOI 10.1016/j.ejrad.2015.05.011, PubMed 26044293

Schulz A, Viktil E, Godt JC, Johansen CK, Dormagen JB, Holtedahl JE, Labori KJ, Bach-Gansmo T, Kløw NE (2015)
Diagnostic performance of CT, MRI and PET/CT in patients with suspected colorectal liver metastases: the superiority of MRI
Acta Radiol, 57 (9), 1040-8
DOI 10.1177/0284185115617349, PubMed 26622057

Seeberg LT, Waage A, Brunborg C, Hugenschmidt H, Renolen A, Stav I, Bjørnbeth BA, Brudvik KW, Borgen EF, Naume B, Wiedswang G (2015)
Circulating tumor cells in patients with colorectal liver metastasis predict impaired survival
Ann Surg, 261 (1), 164-71
DOI 10.1097/SLA.0000000000000580, PubMed 24509211

Seierstad T, Hole KH, Grøholt KK, Dueland S, Ree AH, Flatmark K, Redalen KR (2015)
MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer
Br J Radiol, 88 (1051), 20150097
DOI 10.1259/bjr.20150097, PubMed 25899892

Skog O, Korsgren S, Wiberg A, Danielsson A, Edwin B, Buanes T, Krogvold L, Korsgren O, Dahl-Jørgensen K (2015)
Expression of human leukocyte antigen class I in endocrine and exocrine pancreatic tissue at onset of type 1 diabetes
Am J Pathol, 185 (1), 129-38
DOI 10.1016/j.ajpath.2014.09.004, PubMed 25524212

Stensrud KJ, Emblem R, Bjørnland K (2015)
Anal endosonography and bowel function in patients undergoing different types of endorectal pull-through procedures for Hirschsprung disease
J Pediatr Surg, 50 (8), 1341-6
DOI 10.1016/j.jpedsurg.2014.12.024, PubMed 25783406

Svanevik M, Risstad H, Hofsø D, Schou CF, Solheim B, Søvik TT, Kristinsson J, Hjelmesæth J, Mala T, Sandbu R (2015)
Perioperative Outcomes of Proximal and Distal Gastric Bypass in Patients with BMI Ranged 50-60 kg/m(2)--A Double-Blind, Randomized Controlled Trial
Obes Surg, 25 (10), 1788-95
DOI 10.1007/s11695-015-1621-y, PubMed 25761943

Aarås AM, Reitan-Gjersøe TA, Waage A, Mala T, Edwin B, Løberg EM, Abildgaard A, Røsok BI (2015)
Laparoscopic resection of recurrent ectopic hepatocellular carcinoma: A case report with review of the literature and guidelines for follow-up
Int J Surg Case Rep, 17, 92-5
DOI 10.1016/j.ijscr.2015.10.014, PubMed 26590353

Aasrum M, Tjomsland V, Thoresen GH, De Angelis PM, Christoffersen T, Brusevold IJ (2015)
PI3K is required for both basal and LPA-induced DNA synthesis in oral carcinoma cells
J Oral Pathol Med, 45 (6), 425-32
DOI 10.1111/jop.12384, PubMed 26602326

 
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