Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Haematology

56 publications found

Andersen NG, Mowinckel MC, Sunde K, Sandset PM, Beitland S (2020)
Utility of coagulation analyses to assess thromboprophylaxis with dalteparin in intensive care unit patients
Acta Anaesthesiol Scand
DOI 10.1111/aas.13748, PubMed 33205407

Andresen MS, Stavik B, Sletten M, Tinholt M, Sandset PM, Iversen N, Skretting G (2020)
Indirect regulation of TFPI-2 expression by miR-494 in breast cancer cells
Sci Rep, 10 (1), 4036
DOI 10.1038/s41598-020-61018-x, PubMed 32132611

Atukunda P, Muhoozi GK, Diep LM, Berg JP, Westerberg AC, Iversen PO (2020)
The association of urine markers of iodine intake with development and growth among children in rural Uganda: a secondary analysis of a randomised education trial
Public Health Nutr, 1-10 (in press)
DOI 10.1017/S1368980020001603, PubMed 32654677

Bazarbachi A, Bug G, Baron F, Brissot E, Ciceri F, Dalle IA, Döhner H, Esteve J, Floisand Y, Giebel S, Gilleece M, Gorin NC, Jabbour E, Aljurf M, Kantarjian H, Kharfan-Dabaja M, Labopin M, Lanza F, Malard F, Peric Z, Prebet T, Ravandi F, Ruggeri A, Sanz J, Schmid C et al. (2020)
Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3-internal tandem duplication: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Haematologica, 105 (6), 1507-1516
DOI 10.3324/haematol.2019.243410, PubMed 32241850

Berentsen S, Barcellini W, D'Sa S, Randen U, Tvedt THA, Fattizzo B, Haukås E, Kell M, Brudevold R, Dahm AEA, Dalgaard J, Frøen H, Hallstensen RF, Jæger PH, Hjorth-Hansen H, Małecka A, Oksman M, Rolke J, Sekhar M, Sørbø JH, Tjønnfjord E, Tsykunova G, Tjønnfjord GE (2020)
Cold agglutinin disease revisited: a multinational, observational study of 232 patients
Blood, 136 (4), 480-488
DOI 10.1182/blood.2020005674, PubMed 32374875

Berentsen S, Malecka A, Randen U, Tjønnfjord GE (2020)
Cold agglutinin disease: where do we stand, and where are we going?
Clin Adv Hematol Oncol, 18 (1), 35-44
PubMed 32511221

Berishvili E, Kaiser L, Cohen M, Berney T, Scholz H, Floisand Y, Mattsson J (2020)
Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy
Stem Cell Rev Rep
DOI 10.1007/s12015-020-10004-x, PubMed 32696426

Caglayan S, Hashim A, Cieslar-Pobuda A, Jensen V, Behringer S, Talug B, Chu DT, Pecquet C, Rogne M, Brech A, Brorson SH, Nagelhus EA, Hannibal L, Boschi A, Taskén K, Staerk J (2020)
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation
iScience, 23 (6), 101154
DOI 10.1016/j.isci.2020.101154, PubMed 32450518

Cieslar-Pobuda A, Ahrens TD, Caglayan S, Behringer S, Hannibal L, Staerk J (2020)
DNMT3B deficiency alters mitochondrial biogenesis and α-ketoglutarate levels in human embryonic stem cells
Stem Cells, 38 (11), 1409-1422
DOI 10.1002/stem.3256, PubMed 32652733

Divito SJ, Aasebø AT, Matos TR, Hsieh PC, Collin M, Elco CP, O'Malley JT, Bækkevold ES, Reims H, Gedde-Dahl T, Hagerstrom M, Hilaire J, Lian JW, Milford EL, Pinkus GS, Ho VT, Soiffer RJ, Kim HT, Mihm MC, Ritz J, Guleria I, Cutler CS, Clark RA, Jahnsen FL, Kupper TS (2020)
Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease
J Clin Invest, 130 (9), 4624-4636
DOI 10.1172/JCI129965, PubMed 32516138

Dusingizimana T, Weber JL, Ramilan T, Iversen PO, Brough L (2020)
An empirical study of factors associated with height-for-age z-scores of children aged 6-23 months in northwest Rwanda: the role of care practices related to child feeding and health
Br J Nutr, 1-12 (in press)
DOI 10.1017/S0007114520004961, PubMed 33298231

Dusingizimana T, Weber JL, Ramilan T, Iversen PO, Brough L (2020)
A qualitative analysis of infant and young child feeding practices in rural Rwanda
Public Health Nutr, 1-10 (in press)
DOI 10.1017/S1368980020001081, PubMed 32611464

Fronas SG, Dahm AEA, Wik HS, Jørgensen CT, Gleditsch J, Raouf N, Holst R, Klok FA, Ghanima W (2020)
Safety and feasibility of rivaroxaban in deferred workup of patients with suspected deep vein thrombosis
Blood Adv, 4 (11), 2468-2476
DOI 10.1182/bloodadvances.2020001556, PubMed 32502267

Fronas SG, Jørgensen CT, Dahm AEA, Wik HS, Gleditsch J, Raouf N, Holst R, Klok FA, Ghanima W (2020)
Safety of a strategy combining D-dimer testing and whole-leg ultrasonography to rule out deep vein thrombosis
Blood Adv, 4 (20), 5002-5010
DOI 10.1182/bloodadvances.2020002173, PubMed 33057634

Godolphin PJ, Bath PM, Partlett C, Berge E, Brown MM, Eliasziw M, Sandset PM, Serena J, Montgomery AA (2020)
Outcome assessment by central adjudicators in randomised stroke trials: Simulation of differential and non-differential misclassification
Eur Stroke J, 5 (2), 174-183
DOI 10.1177/2396987320910047, PubMed 32637651

Gorkom BL, Holme PA, Joch C, Rogosch T, Feussner A, McKeand W, Roberts J, van Heerde W (2020)
Pharmacokinetics and pharmacodynamics of a recombinant fusion protein linking activated coagulation factor VII with human albumin (rVIIa-FP) in patients with congenital FVII deficiency
Hematology, 25 (1), 17-25
DOI 10.1080/16078454.2019.1700329, PubMed 31852380

Hagestande S, Kvam AK, Lothe IMB, Gjelberg HK, Bruserud O, Tvedt THA (2020)
Aplastic anaemia
Tidsskr. Nor. Laegeforen., 140 (18), 1897-1900

Hannevik TL, Brekke J, Enden T, Frøen H, Garresori H, Jacobsen EM, Paulsen PQ, Porojnicu AC, Ree AH, Torfoss D, Velle EO, Wik HS, Ghanima W, Sandset PM, Dahm AEA (2020)
Thrombosis and bleedings in a cohort of cancer patients treated with apixaban for venous thromboembolism
Thromb Res, 196, 238-244
DOI 10.1016/j.thromres.2020.08.042, PubMed 32919178

Hasanaliyeva G, Chatzidimitrou E, Wang J, Baranski M, Volakakis N, Seal C, Rosa EAS, Iversen PO, Vigar V, Barkla B, Leifert C, Rempelos L (2020)
Effects of Production Region, Production Systems and Grape Type/Variety on Nutritional Quality Parameters of Table Grapes; Results from a UK Retail Survey
Foods, 9 (12)
DOI 10.3390/foods9121874, PubMed 33339243

Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E (2020)
Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifolafrondosa: A Review of Preclinical and Clinical Studies
Nutrients, 12 (5)
DOI 10.3390/nu12051339, PubMed 32397163

Iversen PO, Sioud M (2020)
Harnessing the Antiviral-Type Responses Induced by Immunostimulatory siRNAs for Cancer Immunotherapy
Methods Mol Biol, 2115, 281-287
DOI 10.1007/978-1-0716-0290-4_16, PubMed 32006407

Iversen PO, von Lueder TG, Kardel KR, Lien K (2020)
Cardiac Dimensions and Function Are Not Altered among Females with the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Healthcare (Basel), 8 (4)
DOI 10.3390/healthcare8040406, PubMed 33081294

Kaiser M, Beksaç M, Gulbrandsen N, Schjesvold F, Hájek R, Moreau P, de Arriba de la Fuente F, Mateos MV, West S, Spencer A, Rajkumar SV, Suryanarayan K, Czorniak M, Li C, Teng Z, Labotka R, Dimopoulos MA (2020)
Adverse event management in the TOURMALINE-MM3 study of post-transplant ixazomib maintenance in multiple myeloma
Ann Hematol, 99 (8), 1793-1804
DOI 10.1007/s00277-020-04149-5, PubMed 32613281

Kakkos SK, Gohel M, Baekgaard N, Bauersachs R, Bellmunt-Montoya S, Black SA, Ten Cate-Hoek AJ, Elalamy I, Enzmann FK, Geroulakos G, Gottsäter A, Hunt BJ, Mansilha A, Nicolaides AN, Sandset PM, Stansby G, Esvs Guidelines Committee, de Borst GJ, Bastos Gonçalves F, Chakfé N, Hinchliffe R, Kolh P, Koncar I, Lindholt JS, Tulamo R et al. (2020)
Editor's Choice - European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis
Eur J Vasc Endovasc Surg, 61 (1), 9-82
DOI 10.1016/j.ejvs.2020.09.023, PubMed 33334670

Kara E, Nielsen NV, Eggertsdottir B, Thiede B, Kanse SM, Løset GÅ (2020)
Design and Characterization of a New pVII Combinatorial Phage Display Peptide Library for Protease Substrate Mining Using Factor VII Activating Protease (FSAP) as Model
Chembiochem, 21 (13), 1875-1884
DOI 10.1002/cbic.201900705, PubMed 32180321

Kaufman JL, Gasparetto C, Schjesvold FH, Moreau P, Touzeau C, Facon T, Boise LH, Jiang Y, Yang X, Dunbar F, Vishwamitra D, Unger S, Macartney T, Pesko J, Yu Y, Salem AH, Ross JA, Hong WJ, Maciag PC, Pauff JM, Kumar S (2020)
Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma
Am J Hematol (in press)
DOI 10.1002/ajh.26083, PubMed 33368455

Kempton CL, Makris M, Holme PA (2020)
Management of comorbidities in haemophilia
Haemophilia
DOI 10.1111/hae.14013, PubMed 32476243

Kuijlaars IAR, van der Net J, Feldman BM, Aspdahl M, Bladen M, de Boer W, Cuesta-Barriuso R, Matlary RED, Funk SM, Hilliard P, John JA, Kempton CL, de Kleijn P, Manco-Johnson M, Petrini P, Poonnoose P, St-Louis J, Thomas S, Timmer MA, Trakymiene SS, van Vlimmeren L, Fischer K (2020)
Evaluating international Haemophilia Joint Health Score (HJHS) results combined with expert opinion: Options for a shorter HJHS
Haemophilia, 26 (6), 1072-1080
DOI 10.1111/hae.14180, PubMed 33058441

Laubach JP, Schjesvold F, Mariz M, Dimopoulos MA, Lech-Maranda E, Spicka I, Hungria VTM, Shelekhova T, Abdo A, Jacobasch L, Polprasert C, Hájek R, Illés Á, Wróbel T, Sureda A, Beksac M, Gonçalves IZ, Bladé J, Rajkumar SV, Chari A, Lonial S, Spencer A, Maison-Blanche P, Moreau P, San-Miguel JF et al. (2020)
Efficacy and safety of oral panobinostat plus subcutaneous bortezomib and oral dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma (PANORAMA 3): an open-label, randomised, phase 2 study
Lancet Oncol, 22 (1), 142-154
DOI 10.1016/S1470-2045(20)30680-X, PubMed 33301738

Lenartova A, Johannesen TB, Tjønnfjord GE (2020)
Chronic lymphocytic leukemia and secondary hematological malignancies: A nation-wide cancer registry study
Eur J Haematol, 104 (6), 546-553
DOI 10.1111/ejh.13396, PubMed 32058605

Marvyin K, Tjønnfjord EB, Breland UM, Tjønnfjord GE (2020)
Transformation to plasmablastic lymphoma in CLL upon ibrutinib treatment
BMJ Case Rep, 13 (9)
DOI 10.1136/bcr-2020-235816, PubMed 32994268

Måseide RJ, Berntorp E, Astermark J, Olsson A, Bruzelius M, Frisk T, Nummi V, Lassila R, Tjønnfjord GE, Holme PA (2020)
Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B - The MoHem study
Haemophilia, 26 (5), 891-897
DOI 10.1111/hae.14114, PubMed 33021747

Massey RJ, Diep PP, Ruud E, Burman MM, Kvaslerud AB, Brinch L, Aakhus S, Gullestad LL, Beitnes JO (2020)
Left Ventricular Systolic Function in Long-Term Survivors of Allogeneic Hematopoietic Stem Cell Transplantation
JACC CardioOncol, 2 (3), 460-471
DOI 10.1016/j.jaccao.2020.06.011, PublikaID 352

Molteberg E, Thorsby PM, Kverneland M, Iversen PO, Selmer KK, Nakken KO, Taubøll E (2020)
Effects of modified Atkins diet on thyroid function in adult patients with pharmacoresistant epilepsy
Epilepsy Behav, 111, 107285
DOI 10.1016/j.yebeh.2020.107285, PubMed 32698106

Mpinganzima C, Haaland A, Holm AGV, Thein SL, Tjønnfjord GE, Iversen PO (2020)
Two Consecutive Episodes of Severe Delayed Hemolytic Transfusion Reaction in a Sickle Cell Disease Patient
Case Rep Hematol, 2020, 2765012
DOI 10.1155/2020/2765012, PubMed 32351743

Mwaiswelo RO, Mawala W, Iversen PO, de Montalembert M, Luzzatto L, Makani J (2020)
Sickle cell disease and malaria: decreased exposure and asplenia can modulate the risk from Plasmodium falciparum
Malar J, 19 (1), 165
DOI 10.1186/s12936-020-03212-w, PubMed 32334583

Myrdal OH, Diep PP, Ruud E, Brinch L, Massey RJ, Edvardsen E, Kongerud J, Lund MB, Sikkeland LI (2020)
Determinants of cardiorespiratory fitness in very long-term survivors of allogeneic hematopoietic stem cell transplantation: a national cohort study
Support Care Cancer
DOI 10.1007/s00520-020-05644-1, PubMed 32827056

Qvigstad C, Sørensen LQ, Tait RC, de Moerloose P, Holme PA, ADVANCE Working Group (2020)
Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension
Medicine (Baltimore), 99 (9), e19339
DOI 10.1097/MD.0000000000019339, PubMed 32118768

Qvigstad C, Tait RC, de Moerloose P, Holme PA, ADVANCE Working Group (2020)
Hematuria in aging men with hemophilia: Association with factor prophylaxis
Res Pract Thromb Haemost, 4 (2), 309-317
DOI 10.1002/rth2.12298, PubMed 32110762

Schjesvold F (2020)
Evolution of diagnostic workup and treatment for multiple myeloma 2013-2019
Eur J Haematol, 105 (4), 434-448
DOI 10.1111/ejh.13464, PubMed 32557833

Schjesvold F, Goldschmidt H, Maisnar V, Spicka I, Abildgaard N, Rowlings P, Cain L, Romanus D, Suryanarayan K, Rajkumar V, Odom D, Gnanasakthy A, Dimopoulos M (2020)
Quality of life is maintained with ixazomib maintenance in post-transplant newly diagnosed multiple myeloma: The TOURMALINE-MM3 trial
Eur J Haematol, 104 (5), 443-458
DOI 10.1111/ejh.13379, PubMed 31880006

Schjesvold F, Robak P, Pour L, Aschan J, Sonneveld P (2020)
OCEAN: a randomized Phase III study of melflufen + dexamethasone to treat relapsed refractory multiple myeloma
Future Oncol, 16 (11), 631-641
DOI 10.2217/fon-2020-0024, PubMed 32141766

Schjesvold FH, Richardson PG, Facon T, Alegre A, Spencer A, Jurczyszyn A, Sunami K, Frenzel L, Min CK, Guillonneau S, Lin PL, Le-Guennec S, Campana F, van de Velde H, Bensfia S, Bringhen S (2020)
Isatuximab plus pomalidomide and dexamethasone in elderly patients with relapsed/refractory multiple myeloma: ICARIA-MM subgroup analysis
Haematologica (in press)
DOI 10.3324/haematol.2020.253450, PubMed 32586908

Spyridonidis A, Labopin M, Savani BN, Niittyvuopio R, Blaise D, Craddock C, Socié G, Platzbecker U, Beelen D, Milpied N, Cornelissen JJ, Ganser A, Huynh A, Griskevicius L, Giebel S, Aljurf M, Brissot E, Malard F, Esteve J, Peric Z, Baron F, Ruggeri A, Schmid C, Gilleece M, Gorin NC et al. (2020)
Redefining and measuring transplant conditioning intensity in current era: a study in acute myeloid leukemia patients
Bone Marrow Transplant, 55 (6), 1114-1125
DOI 10.1200/JCO.2014.59.1339, PubMed 31996792

Tadele DS, Robertson J, Crispin R, Herrera MC, Chlubnova M, Piechaczyk L, Ayuda-Durán P, Singh SK, Gedde-Dahl T, Floisand Y, Skavland J, Wesche J, Gjertsen BT, Enserink JM (2020)
A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation
J Biol Chem (in press)
DOI 10.1074/jbc.RA120.015285, PubMed 33303632

Terrell DR, Neunert CE, Cooper N, Heitink-Pollé KM, Kruse C, Imbach P, Kühne T, Ghanima W (2020)
Immune Thrombocytopenia (ITP): Current Limitations in Patient Management
Medicina (Kaunas), 56 (12)
DOI 10.3390/medicina56120667, PubMed 33266286

Thorsen L, Haugnes HS, Fosså SD, Brydøy M, Tandstad T, Wisløff T, Gjerset GM, Edvardsen E, Larsen KO, Sandset PM, Henriksson CE, Raastad T, Negaard HFS (2020)
Thromboembolic events after high-intensity training during cisplatin-based chemotherapy for testicular cancer: Case reports and review of the literature
Int J Cancer, 147 (11), 3189-3198
DOI 10.1002/ijc.33151, PubMed 32525564

Tinholt M, Stavik B, Tekpli X, Garred Ø, Borgen E, Kristensen V, Sahlberg KK, Sandset PM, Iversen N (2020)
Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer
Oncoimmunology, 9 (1), 1824644
DOI 10.1080/2162402X.2020.1824644, PubMed 33457104

Tjønnfjord E, Holme PA, Darne B, Khelif A, Waage A, Michel M, Ben Romdhan N, Ghanima W (2020)
Long-term outcomes of patients treated with rituximab as second-line treatment for adult immune thrombocytopenia - Follow-up of the RITP study
Br J Haematol, 191 (3), 460-465
DOI 10.1111/bjh.16672, PubMed 32342497

Tritschler T, Mathieu ME, Skeith L, Rodger M, Middeldorp S, Brighton T, Sandset PM, Kahn SR, Angus DC, Blondon M, Bonten MJ, Cattaneo M, Cushman M, Derde LPG, DeSancho MT, Diehl JL, Goligher E, Jilma B, Jüni P, Lawler PR, Marietta M, Marshall JC, McArthur C, Miranda CH, Mirault T et al. (2020)
Anticoagulant interventions in hospitalized patients with COVID-19: A scoping review of randomized controlled trials and call for international collaboration
J Thromb Haemost, 18 (11), 2958-2967
DOI 10.1111/jth.15094, PubMed 32888372

Wacoo AP, Atukunda P, Muhoozi G, Braster M, Wagner M, Broek TJVD, Sybesma W, Westerberg AC, Iversen PO, Kort R (2020)
Aflatoxins: Occurrence, Exposure, and Binding to Lactobacillus Species from the Gut Microbiota of Rural Ugandan Children
Microorganisms, 8 (3)
DOI 10.3390/microorganisms8030347, PubMed 32121365

Wang J, Chatzidimitriou E, Wood L, Hasanalieva G, Markelou E, Iversen PO, Seal C, Baranski M, Vigar V, Ernst L, Willson A, Thapa M, Barkla BJ, Leifert C, Rempelos L (2020)
Effect of wheat species (Triticum aestivum vs T. spelta), farming system (organic vs conventional) and flour type (wholegrain vs white) on composition of wheat flour - Results of a retail survey in the UK and Germany - 2. Antioxidant activity, and phenolic and mineral content
Food Chem X, 6, 100091
DOI 10.1016/j.fochx.2020.100091, PubMed 32420543

Wang J, Hasanalieva G, Wood L, Anagnostopoulos C, Ampadogiannis G, Bempelou E, Kiousi M, Markellou E, Iversen PO, Seal C, Baranski M, Vigar V, Leifert C, Rempelos L (2020)
Effect of wheat species (Triticum aestivum vs T. spelta), farming system (organic vs conventional) and flour type (wholegrain vs white) on composition of wheat flour - Results of a retail survey in the UK and Germany - 3. Pesticide residue content
Food Chem X, 7, 100089
DOI 10.1016/j.fochx.2020.100089, PubMed 32637911

Wang J, Hasanalieva G, Wood L, Markellou E, Iversen PO, Bernhoft A, Seal C, Baranski M, Vigar V, Ernst L, Willson A, Barkla BJ, Leifert C, Rempelos L (2020)
Effect of wheat species (Triticum aestivum vs T. spelta), farming system (organic vs conventional) and flour type (wholegrain vs white) on composition of wheat flour; results of a retail survey in the UK and Germany - 1. Mycotoxin content
Food Chem, 327, 127011
DOI 10.1016/j.foodchem.2020.127011, PubMed 32438263

Weum Abrahamsen I, Grønvold BC, Inderberg EM, Mensali N, Mattsson J, Gedde-Dahl T (2020)
Posttransplantation Lymphoproliferative Disease Treated by Retransplantation
Case Reports Immunol, 2020, 9403123
DOI 10.1155/2020/9403123, PubMed 32158568

Ziyenda Katenga-Kaunda L, Iversen PO, Holmboe-Ottesen G, Fjeld H, Mdala I, Kamudoni PR (2020)
Dietary intake and processes of behaviour change in a nutrition education intervention for pregnant women in rural Malawi: a cluster-randomised controlled trial
Public Health Nutr, 23 (13), 2345-2354
DOI 10.1017/S1368980020000294, PubMed 32419688

 
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