Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2016 from OUS - Department of Haematology

44 publications found

Ali HO, Arroyo AB, González-Conejero R, Stavik B, Iversen N, Sandset PM, Martínez C, Skretting G (2016)
The role of microRNA-27a/b and microRNA-494 in estrogen-mediated downregulation of tissue factor pathway inhibitor α
J Thromb Haemost, 14 (6), 1226-37
DOI 10.1111/jth.13321, PubMed 26999003

Ali HO, Stavik B, Myklebust CF, Andersen E, Dahm AE, Iversen N, Sandset PM, Skretting G (2016)
Oestrogens Downregulate Tissue Factor Pathway Inhibitor through Oestrogen Response Elements in the 5'-Flanking Region
PLoS One, 11 (3), e0152114
DOI 10.1371/journal.pone.0152114, PubMed 26999742

Bates SM, Alonso-Coello P, Tikkinen KA, Ebrahim S, Lopes LC, McDonald SD, Zhou Q, Akl EA, Neumann I, Jacobsen AF, Zhang Y, Santamaría A, Annichino-Bizzacchi JM, Sandset PM, Bitar W, Eckman MH, Guyatt GH (2016)
Women's values and preferences and health state valuations for thromboprophylaxis during pregnancy: A cross-sectional interview
Thromb Res, 140, 22-9
DOI 10.1016/j.thromres.2015.12.015, PubMed 27500301

Berger K, Schopohl D, Lowe G, Holme PA, Tait RC, Combescure C, Rauchensteiner S, Klamroth R (2016)
How to compare cardiovascular disease and risk factors in elderly patients with haemophilia with the general population
Haemophilia, 22 (5), e406-16
DOI 10.1111/hae.13069, PubMed 27650262

Biegstraaten M, Cox TM, Belmatoug N, Berger MG, Collin-Histed T, Vom Dahl S, Di Rocco M, Fraga C, Giona F, Giraldo P, Hasanhodzic M, Hughes DA, Iversen PO, Kiewiet AI, Lukina E, Machaczka M, Marinakis T, Mengel E, Pastores GM, Plöckinger U, Rosenbaum H, Serratrice C, Symeonidis A, Szer J, Timmerman J et al. (2016)
Management goals for type 1 Gaucher disease: An expert consensus document from the European working group on Gaucher disease
Blood Cells Mol Dis, 68, 203-208
DOI 10.1016/j.bcmd.2016.10.008, PubMed 28274788

Bleker SM, Buchmüller A, Chauleur C, Ní Áinle F, Donnelly J, Verhamme P, Jacobsen AF, Ganzevoort W, Prins M, Beyer-Westendorf J, DeSancho M, Konstantinides S, Pabinger I, Rodger M, Decousus H, Middeldorp S (2016)
Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: Rationale and design of the Highlow study, a randomised trial of two doses
Thromb Res, 144, 62-8
DOI 10.1016/j.thromres.2016.06.001, PubMed 27289488

Broesby-Olsen S, Dybedal I, Gülen T, Kristensen TK, Møller MB, Ackermann L, Sääf M, Karlsson MA, Agertoft L, Brixen K, Hermann P, Stylianou E, Mortz CG, Torfing T, Havelund T, Sander B, Bergström A, Bendix M, Garvey LH, Bjerrum OW, Valent P, Bindslev-Jensen C, Nilsson G, Vestergaard H, Hägglund H (2016)
Multidisciplinary Management of Mastocytosis: Nordic Expert Group Consensus
Acta Derm Venereol, 96 (5), 602-12
DOI 10.2340/00015555-2325, PubMed 26694951

Bustamante A, Díaz-Fernández B, Giralt D, Boned S, Pagola J, Molina CA, García-Berrocoso T, Kanse SM, Montaner J (2016)
Factor seven activating protease (FSAP) predicts response to intravenous thrombolysis in acute ischemic stroke
Int J Stroke, 11 (6), 646-55
DOI 10.1177/1747493016641949, PubMed 27073188

Bye A, Wesseltoft-Rao N, Iversen PO, Skjegstad G, Holven KB, Ulven S, Hjermstad MJ (2016)
Alterations in inflammatory biomarkers and energy intake in cancer cachexia: a prospective study in patients with inoperable pancreatic cancer
Med Oncol, 33 (6), 54
DOI 10.1007/s12032-016-0768-2, PubMed 27119533

Cui XY, Tinholt M, Stavik B, Dahm AE, Kanse S, Jin Y, Seidl S, Sahlberg KK, Iversen N, Skretting G, Sandset PM (2016)
Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer
J Thromb Haemost, 14 (2), 387-96
DOI 10.1111/jth.13206, PubMed 26598923

Daniel JM, Reichel CA, Schmidt-Woell T, Dutzmann J, Zuchtriegel G, Krombach F, Herold J, Bauersachs J, Sedding DG, Kanse SM (2016)
Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation
J Thromb Haemost, 14 (10), 2058-2067
DOI 10.1111/jth.13417, PubMed 27431088

Fløisand Y, Lundin KEA, Lazarevic V, Kristiansen JD, Osnes LTN, Tjønnfjord GE, Reims HM, Gedde-Dahl T (2016)
Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease
Biol Blood Marrow Transplant, 23 (1), 172-175
DOI 10.1016/j.bbmt.2016.10.009, PubMed 27777142

Garabet L, Gilboe IM, Mowinckel MC, Jacobsen AF, Mollnes TE, Sandset PM, Jacobsen EM (2016)
Antiphospholipid Antibodies are Associated with Low Levels of Complement C3 and C4 in Patients with Systemic Lupus Erythematosus
Scand J Immunol, 84 (2), 95-9
DOI 10.1111/sji.12445, PubMed 27135178

Gervin K, Andreassen BK, Hjorthaug HS, Carlsen KCL, Carlsen KH, Undlien DE, Lyle R, Munthe-Kaas MC (2016)
Intra-individual changes in DNA methylation not mediated by cell-type composition are correlated with aging during childhood
Clin Epigenetics, 8, 110
DOI 10.1186/s13148-016-0277-3, PubMed 27785156

Haig Y, Enden T, Grøtta O, Kløw NE, Slagsvold CE, Ghanima W, Sandvik L, Hafsahl G, Holme PA, Holmen LO, Njaaastad AM, Sandbæk G, Sandset PM, CaVenT Study Group (2016)
Post-thrombotic syndrome after catheter-directed thrombolysis for deep vein thrombosis (CaVenT): 5-year follow-up results of an open-label, randomised controlled trial
Lancet Haematol, 3 (2), e64-71
DOI 10.1016/S2352-3026(15)00248-3, PubMed 26853645

Hjorth-Hansen H, Stentoft J, Richter J, Koskenvesa P, Höglund M, Dreimane A, Porkka K, Gedde-Dahl T, Gjertsen BT, Gruber FX, Stenke L, Eriksson KM, Markevärn B, Lübking A, Vestergaard H, Udby L, Bjerrum OW, Persson I, Mustjoki S, Olsson-Strömberg U (2016)
Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients
Leukemia, 30 (9), 1853-60
DOI 10.1038/leu.2016.121, PubMed 27133821

Holstein K, Batorova A, Carvalho M, Fijnvandraat K, Holme P, Kavakli K, Lambert T, Rocino A, Jiménez-Yuste V, Astermark J, European Haemophilia Therapy Strategy Board (EHTSB) (2016)
Current view and outcome of ITI therapy - A change over time?
Thromb Res, 148, 38-44
DOI 10.1016/j.thromres.2016.10.015, PubMed 27770665

Ilander M, Olsson-Strömberg U, Schlums H, Guilhot J, Brück O, Lähteenmäki H, Kasanen T, Koskenvesa P, Söderlund S, Höglund M, Markevärn B, Själander A, Lotfi K, Dreimane A, Lübking A, Holm E, Björeman M, Lehmann S, Stenke L, Ohm L, Gedde-Dahl T, Majeed W, Ehrencrona H, Koskela S, Saussele S et al. (2016)
Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia
Leukemia, 31 (5), 1108-1116
DOI 10.1038/leu.2016.360, PubMed 27890936

James PD, Mahlangu J, Bidlingmaier C, Mingot-Castellano ME, Chitlur M, Fogarty PF, Cuker A, Mancuso ME, Holme PA, Grabell J, Satkunam N, Hopman WM, Mathew P, Global Emerging HEmostasis Experts Panel (GEHEP) (2016)
Evaluation of the utility of the ISTH-BAT in haemophilia carriers: a multinational study
Haemophilia, 22 (6), 912-918
DOI 10.1111/hae.13089, PubMed 27868369

Johannsdottir IM, Karlstad Ø, Loge JH, Fosså SD, Kiserud C, Skurtveit S (2016)
Prescriptions of Antidepressants to Survivors of Cancer in Childhood, Adolescence, and Young Adulthood: A Population-Based Study
J Adolesc Young Adult Oncol, 6 (1), 120-126
DOI 10.1089/jayao.2016.0041, PubMed 27841952

Kaur P, Bergrem A, Gerlyng P, Reims HM, Leh S, Valeur J (2016)
A methadone user with anaemia, skeletal pain and altered appearance
Tidsskr Nor Laegeforen, 136 (10), 925-9
DOI 10.4045/tidsskr.15.0692, PubMed 27272371

Kontro M, Kumar A, Majumder MM, Eldfors S, Parsons A, Pemovska T, Saarela J, Yadav B, Malani D, Fløisand Y, Höglund M, Remes K, Gjertsen BT, Kallioniemi O, Wennerberg K, Heckman CA, Porkka K (2016)
HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia
Leukemia, 31 (2), 301-309
DOI 10.1038/leu.2016.222, PubMed 27499136

Leiting S, Seidl S, Martinez-Palacian A, Muhl L, Kanse SM (2016)
Transforming Growth Factor-β (TGF-β) Inhibits the Expression of Factor VII-activating Protease (FSAP) in Hepatocytes
J Biol Chem, 291 (40), 21020-21028
DOI 10.1074/jbc.M116.744631, PubMed 27462075

Lenartova A, Johannesen TB, Tjønnfjord GE (2016)
National trends in incidence and survival of chronic lymphocytic leukemia in Norway for 1953-2012: a systematic analysis of population-based data
Cancer Med, 5 (12), 3588-3595
DOI 10.1002/cam4.849, PubMed 27925456

Martin K, Beyer-Westendorf J, Davidson BL, Huisman MV, Sandset PM, Moll S (2016)
Use of the direct oral anticoagulants in obese patients: guidance from the SSC of the ISTH
J Thromb Haemost, 14 (6), 1308-13
DOI 10.1111/jth.13323, PubMed 27299806

Muhoozi GK, Atukunda P, Mwadime R, Iversen PO, Westerberg AC (2016)
Nutritional and developmental status among 6- to 8-month-old children in southwestern Uganda: a cross-sectional study
Food Nutr Res, 60, 30270
DOI 10.3402/fnr.v60.30270, PubMed 27238555

Mundal L, Veierød MB, Halvorsen T, Holven KB, Ose L, Iversen PO, Tell GS, Leren TP, Retterstøl K (2016)
Cardiovascular disease in patients with genotyped familial hypercholesterolemia in Norway during 1994-2009, a registry study
Eur J Prev Cardiol, 23 (18), 1962-1969
DOI 10.1177/2047487316666371, PubMed 27558979

Nordheim T, Rustøen T, Iversen PO, Nakstad B (2016)
Quality of life in parents of preterm infants in a randomized nutritional intervention trial
Food Nutr Res, 60, 32162
DOI 10.3402/fnr.v60.32162, PubMed 27839532

Panagopoulos I, Torkildsen S, Gorunova L, Ulvmoen A, Tierens A, Zeller B, Heim S (2016)
RUNX1 truncation resulting from a cryptic and novel t(6;21)(q25;q22) chromosome translocation in acute myeloid leukemia: A case report
Oncol Rep, 36 (5), 2481-2488
DOI 10.3892/or.2016.5119, PubMed 27667292

Robin M, Porcher R, Zinke-Cerwenka W, van Biezen A, Volin L, Mufti G, Craddock C, Finke J, Richard C, Passweg J, Peniket A, Maertens J, Sucak G, Gedde-Dahl T, Vitek A, Nagler A, Blaise D, Beelen D, Maillard N, Schwerdtfeger R, de Witte T, Kroger N (2016)
Allogeneic haematopoietic stem cell transplant in patients with lower risk myelodysplastic syndrome: a retrospective analysis on behalf of the Chronic Malignancy Working Party of the EBMT
Bone Marrow Transplant, 52 (2), 209-215
DOI 10.1038/bmt.2016.266, PubMed 27819688

Rukundo PM, Andreassen BA, Kikafunda J, Rukooko B, Oshaug A, Iversen PO (2016)
Household food insecurity and diet diversity after the major 2010 landslide disaster in Eastern Uganda: a cross-sectional survey
Br J Nutr, 115 (4), 718-29
DOI 10.1017/S0007114515004961, PubMed 26777212

Rukundo PM, Oshaug A, Andreassen BA, Kikafunda J, Rukooko B, Iversen PO (2016)
Food variety consumption and household food insecurity coping strategies after the 2010 landslide disaster - the case of Uganda
Public Health Nutr, 19 (17), 3197-3209
DOI 10.1017/S1368980016001397, PubMed 27278061

Skarpengland T, Holm S, Scheffler K, Gregersen I, Dahl TB, Suganthan R, Segers FM, Østlie I, Otten JJ, Luna L, Ketelhuth DF, Lundberg AM, Neurauter CG, Hildrestrand G, Skjelland M, Bjørndal B, Svardal AM, Iversen PO, Hedin U, Nygård S, Olstad OK, Krohg-Sørensen K, Slupphaug G, Eide L, Kuśnierczyk A et al. (2016)
Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice
Sci Rep, 6, 28337
DOI 10.1038/srep28337, PubMed 27328939

Stavik B, Espada S, Cui XY, Iversen N, Holm S, Mowinkel MC, Halvorsen B, Skretting G, Sandset PM (2016)
EPAS1/HIF-2 alpha-mediated downregulation of tissue factor pathway inhibitor leads to a pro-thrombotic potential in endothelial cells
Biochim Biophys Acta, 1862 (4), 670-678
DOI 10.1016/j.bbadis.2016.01.017, PubMed 26826018

Tavoly M, Utne KK, Jelsness-Jørgensen LP, Wik HS, Klok FA, Sandset PM, Ghanima W (2016)
Health-related quality of life after pulmonary embolism: a cross-sectional study
BMJ Open, 6 (11), e013086
DOI 10.1136/bmjopen-2016-013086, PubMed 27810979

Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J (2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
Epigenetics Chromatin, 9, 21
DOI 10.1186/s13072-016-0070-8, PubMed 27252783

Tinholt M, Sandset PM, Iversen N (2016)
Polymorphisms of the coagulation system and risk of cancer
Thromb Res, 140 Suppl 1, S49-54
DOI 10.1016/S0049-3848(16)30098-6, PubMed 27067978

Tinholt M, Sandset PM, Mowinckel MC, Garred Ø, Sahlberg KK, Kristensen VN, Børresen-Dale AL, Jacobsen AF, Skretting G, Iversen N (2016)
Determinants of acquired activated protein C resistance and D-dimer in breast cancer
Thromb Res, 145, 78-83
DOI 10.1016/j.thromres.2016.08.003, PubMed 27505249

Tiscia GL, Dørum E, Myklebust CF, Grandone E, Sandset PM, Skretting G (2016)
Functional characterization of annexin A5 gene promoter allelic variants
Thromb Res, 144, 93-9
DOI 10.1016/j.thromres.2016.06.009, PubMed 27318245

Torfoss D, Fladhagen T, Holte H, Brinch L, Schjesvold FH, Fløisand Y, Nyquist E, Dalgaard J, Meyer P, Lehmann AK, Hammerstrøm J, Skjelbakken T, Høiby EA, Sandvik L, Kvaløy S (2016)
Benzylpenicillin plus an aminoglycoside versus meropenem in neutropenic lymphoma and leukaemia patients with a suspected bacterial infection: a randomized, controlled trial
Clin Microbiol Infect, 23 (3), 179-187
DOI 10.1016/j.cmi.2016.10.019, PubMed 27793737

Utne KK, Tavoly M, Wik HS, Jelsness-Jørgensen LP, Holst R, Sandset PM, Ghanima W (2016)
Health-related quality of life after deep vein thrombosis
Springerplus, 5 (1), 1278
DOI 10.1186/s40064-016-2949-z, PubMed 27547653

Vandraas K, Tjønnfjord GE, Johannesen TB, Brandal P (2016)
Persistent bone marrow depression following short-term treatment with temozolomide
BMJ Case Rep, 2016
DOI 10.1136/bcr-2016-215797, PubMed 27130558

Vojdeman FJ, Van't Veer MB, Tjønnfjord GE, Itälä-Remes M, Kimby E, Polliack A, Wu KL, Doorduijn JK, Alemayehu WG, Wittebol S, Kozak T, Walewski J, Abrahamse-Testroote MC, van Oers MH, Geisler CH (2016)
The HOVON68 CLL trial revisited: performance status and comorbidity affect survival in elderly patients with chronic lymphocytic leukemia
Leuk Lymphoma, 58 (3), 594-600
DOI 10.1080/10428194.2016.1213831, PubMed 27484290

von Krogh AS, Quist-Paulsen P, Waage A, Langseth ØO, Thorstensen K, Brudevold R, Tjønnfjord GE, Largiadèr CR, Lämmle B, Kremer Hovinga JA (2016)
High prevalence of hereditary thrombotic thrombocytopenic purpura in central Norway: from clinical observation to evidence
J Thromb Haemost, 14 (1), 73-82
DOI 10.1111/jth.13186, PubMed 26566785

 
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