Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2017 from OUS - Department of Cardiothoracic Surgery

31 publications found

Abraityte A, Lunde IG, Askevold ET, Michelsen AE, Christensen G, Aukrust P, Yndestad A, Fiane A, Andreassen A, Aakhus S, Dahl CP, Gullestad L, Broch K, Ueland T (2017)
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
Sci Rep, 7 (1), 3490
DOI 10.1038/s41598-017-03625-9, PubMed 28615692

Abraityte A, Vinge LE, Askevold ET, Lekva T, Michelsen AE, Ranheim T, Alfsnes K, Fiane A, Aakhus S, Lunde IG, Dahl CP, Aukrust P, Christensen G, Gullestad L, Yndestad A, Ueland T (2017)
Wnt5a is elevated in heart failure and affects cardiac fibroblast function
J Mol Med (Berl), 95 (7), 767-777
DOI 10.1007/s00109-017-1529-1, PubMed 28357477

Andresen B, Mishra V, Lewandowska M, Andersen JG, Andersen MH, Lindberg H, Døhlen G, Fosse E (2017)
In-hospital cost comparison between percutaneous pulmonary valve implantation and surgery
Eur J Cardiothorac Surg, 51 (4), 747-753
DOI 10.1093/ejcts/ezw378, PubMed 28007875

Auensen A, Hussain AI, Bendz B, Aaberge L, Falk RS, Walle-Hansen MM, Bye J, Andreassen J, Beitnes JO, Rein KA, Pettersen KI, Gullestad L (2017)
Morbidity outcomes after surgical aortic valve replacement
Open Heart, 4 (1), e000588
DOI 10.1136/openhrt-2017-000588, PubMed 28674629

Bjørnnes AK, Parry M, Falk R, Watt-Watson J, Lie I, Leegaard M (2017)
Impact of marital status and comorbid disorders on health-related quality of life after cardiac surgery
Qual Life Res, 26 (9), 2421-2434
DOI 10.1007/s11136-017-1589-2, PubMed 28484915

Bonaros N, Kofler M, Frank D, Cocchieri R, Jagielak D, Aiello M, Lapeze J, Laine M, Chocron S, Muir D, Eichinger W, Thielmann M, Labrousse L, Bapat V, Rein KA, Verhoye JP, Gerosa G, Baumbach H, Deutsch C, Bramlage P, Thoenes M, Romano M (2017)
Balloon-expandable transaortic transcatheter aortic valve implantation with or without predilation
J Thorac Cardiovasc Surg, 155 (3), 915-923
DOI 10.1016/j.jtcvs.2017.10.071, PubMed 29221741

Bonaros N, Petzina R, Cocchieri R, Jagielak D, Aiello M, Lapeze J, Laine M, Chocron S, Muir D, Eichinger W, Thielmann M, Labrousse L, Bapat V, Arne Rein K, Verhoye JP, Gerosa G, Baumbach H, Kofler M, Bramlage P, Deutsch C, Thoenes M, Frank D, Romano M (2017)
Transaortic transcatheter aortic valve implantation as a first-line choice or as a last resort? An analysis based on the ROUTE registry
Eur J Cardiothorac Surg, 51 (5), 919-926
DOI 10.1093/ejcts/ezw406, PubMed 28369303

Bruton M, Hollan I, Xiao J, Lindroos E, Mikkelsen K, Rynning SE, Saatvedt K, Almdahl SM, Harris HE, Lundberg IE, Wick C (2017)
Expression of High Mobility Group Protein B1 in Cardiac Tissue of Elderly Patients with Coronary Artery Disease with or without Inflammatory Rheumatic Disease
Gerontology, 63 (4), 337-349
DOI 10.1159/000471763, PubMed 28427050

Bürker BS, Gude E, Gullestad L, Grov I, Relbo Authen A, Andreassen AK, Havik OE, Dew MA, Fiane AE, Haraldsen IR, Malt UF, Andersson S (2017)
Cognitive function among long-term survivors of heart transplantation
Clin Transplant, 31 (12)
DOI 10.1111/ctr.13143, PubMed 29055147

Bürker BS, Gullestad L, Gude E, Relbo Authen A, Grov I, Hol PK, Andreassen AK, Arora S, Dew MA, Fiane AE, Haraldsen IR, Malt UF, Andersson S (2017)
Cognitive function after heart transplantation: Comparing everolimus-based and calcineurin inhibitor-based regimens
Clin Transplant, 31 (4)
DOI 10.1111/ctr.12927, PubMed 28185318

Dahle G, Rein KA, Fiane AE (2017)
Single centre experience with transapical transcatheter mitral valve implantation
Interact Cardiovasc Thorac Surg, 25 (2), 177-184
DOI 10.1093/icvts/ivx038, PubMed 28444177

Fiane KKH, Dahle G, Bendz B, Halvorsen PS, Abdelnoor M, Mollnes TE, Fosse E (2017)
Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement
Scand Cardiovasc J, 52 (1), 43-50
DOI 10.1080/14017431.2017.1416157, PubMed 29233022

Gregersen I, Sandanger Ø, Askevold ET, Sagen EL, Yang K, Holm S, Pedersen TM, Skjelland M, Krohg-Sørensen K, Hansen TV, Dahl TB, Otterdal K, Espevik T, Aukrust P, Yndestad A, Halvorsen B (2017)
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation
PLoS One, 12 (11), e0188387
DOI 10.1371/journal.pone.0188387, PubMed 29176764

Grut H, Solberg S, Seierstad T, Revheim ME, Egge TS, Larsen SG, Line PD, Dueland S (2017)
Growth rates of pulmonary metastases after liver transplantation for unresectable colorectal liver metastases
Br J Surg, 105 (3), 295-301
DOI 10.1002/bjs.10651, PubMed 29168565

Grymyr OH, Beitnes JO, Eidet J, Tølløfsrud S, Fiane A, Skulstad H, Fosse E, Halvorsen PS (2017)
Detection of intraoperative myocardial dysfunction by accelerometer during aortic valve replacement
Interact Cardiovasc Thorac Surg, 24 (2), 188-195
DOI 10.1093/icvts/ivw326, PubMed 28364479

Helland Å, Brustugun OT, Nakken S, Halvorsen AR, Dønnem T, Bremnes R, Busund LT, Sun J, Lorenz S, Solberg SK, Jørgensen LH, Vodak D, Myklebost O, Hovig E, Meza-Zepeda LA (2017)
High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival
Int J Cancer, 141 (1), 184-190
DOI 10.1002/ijc.30726, PubMed 28387924

Husebråten IM, Fiane AE, Ringdal MIL, Thiara APS (2017)
Measurement of gaseous microemboli in the prime before the initiation of cardiopulmonary bypass
Perfusion, 33 (1), 30-35
DOI 10.1177/0267659117723454, PubMed 28784030

Hussain AI, Auensen A, Brunborg C, Aakhus S, Fiane A, Pettersen KI, Gullestad L (2017)
Determinants and Outcome of Decision Making Among Patients with Severe Aortic Stenosis
J Heart Valve Dis, 26 (4), 413-422
PubMed 29302940

Jortveit J, Klcovansky J, Døhlen G, Eskedal L, Birkeland S, Holmstrøm H (2017)
Out-of-hospital sudden cardiac arrest in children with congenital heart defects
Arch Dis Child, 103 (1), 57-60
DOI 10.1136/archdischild-2017-312621, PubMed 28838970

Krohg-Sørensen K, Lingaas PS, Lundblad R, Seem E, Paus B, Geiran OR (2017)
Cardiovascular surgery in Loeys-Dietz syndrome types 1-4
Eur J Cardiothorac Surg, 52 (6), 1125-1131
DOI 10.1093/ejcts/ezx147, PubMed 28541520

Lie I, Danielsen SO, Tønnessen T, Solheim S, Leegaard M, Sandvik L, Wisløff T, Vangen J, Røsstad TH, Moons P (2017)
Determining the impact of 24/7 phone support on hospital readmissions after aortic valve replacement surgery (the AVRre study): study protocol for a randomised controlled trial
Trials, 18 (1), 246
DOI 10.1186/s13063-017-1971-y, PubMed 28693599

Norum HM, Broch K, Michelsen AE, Lunde IG, Lekva T, Abraityte A, Dahl CP, Fiane AE, Andreassen AK, Christensen G, Aakhus S, Aukrust P, Gullestad L, Ueland T (2017)
The Notch Ligands DLL1 and Periostin Are Associated with Symptom Severity and Diastolic Function in Dilated Cardiomyopathy
J Cardiovasc Transl Res, 10 (4), 401-410
DOI 10.1007/s12265-017-9748-y, PubMed 28474304

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P et al. (2017)
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture
Cell Rep, 18 (1), 82-92
DOI 10.1016/j.celrep.2016.12.009, PubMed 28052262

Parikh SS, Blackwell DJ, Gomez-Hurtado N, Frisk M, Wang L, Kim K, Dahl CP, Fiane A, Tønnessen T, Kryshtal DO, Louch WE, Knollmann BC (2017)
Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Circ Res, 121 (12), 1323-1330
DOI 10.1161/CIRCRESAHA.117.311920, PubMed 28974554

Romano M, Frank D, Cocchieri R, Jagielak D, Bonaros N, Aiello M, Lapeze J, Laine M, Chocron S, Muir D, Eichinger W, Thielmann M, Labrousse L, Arne Rein K, Verhoye JP, Gerosa G, Baumbach H, Deutsch C, Bramlage P, Thoenes M, Bapat V (2017)
Transaortic transcatheter aortic valve implantation using SAPIEN XT or SAPIEN 3 valves in the ROUTE registry
Interact Cardiovasc Thorac Surg, 25 (5), 757-764
DOI 10.1093/icvts/ivx159, PubMed 28582580

Rutkovskiy A, Malashicheva A, Sullivan G, Bogdanova M, Kostareva A, Stensløkken KO, Fiane A, Vaage J (2017)
Valve Interstitial Cells: The Key to Understanding the Pathophysiology of Heart Valve Calcification
J Am Heart Assoc, 6 (9)
DOI 10.1161/JAHA.117.006339, PubMed 28912209

Rutkovskiy A, Sagave J, Czibik G, Baysa A, Zihlavnikova Enayati K, Hillestad V, Dahl CP, Fiane A, Gullestad L, Gravning J, Ahmed S, Attramadal H, Valen G, Vaage J (2017)
Connective tissue growth factor and bone morphogenetic protein 2 are induced following myocardial ischemia in mice and humans
Scand J Clin Lab Invest, 77 (5), 321-331
DOI 10.1080/00365513.2017.1318447, PubMed 28460577

Sundheim LK, Sporastøyl AH, Wester T, Salerud G, Kvernebo K (2017)
Acute skin trauma induces hyperemia, but superficial papillary nutritive perfusion remains unchanged
Microcirculation, 24 (7)
DOI 10.1111/micc.12389, PubMed 28632939

Thelle A, Gjerdevik M, SueChu M, Hagen OM, Bakke P (2017)
Randomised comparison of needle aspiration and chest tube drainage in spontaneous pneumothorax
Eur Respir J, 49 (4)
DOI 10.1183/13993003.01296-2016, PubMed 28404647

Tjønnfjord E, Vengen ØA, Berentsen S, Tjønnfjord GE (2017)
Prophylactic use of eculizumab during surgery in chronic cold agglutinin disease
BMJ Case Rep, 2017
DOI 10.1136/bcr-2016-219066, PubMed 28487302

Wendt K, Kristiansen R, Krohg-Sørensen K, Gregersen FA, Fosse E (2017)
Norwegian trends in numbers of lower extremity revascularisations and amputations including regional trends in endovascular treatments for peripheral arterial disease: a retrospective cross-sectional registry study from 2001 to 2014
BMJ Open, 7 (11), e016210
DOI 10.1136/bmjopen-2017-016210, PubMed 29138198

 
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