Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2018 from OUS - Institute for Experimental Medical Research IEMR

35 publications found

Altara R, Ghali R, Mallat Z, Cataliotti A, Booz GW, Zouein FA (2018)
Conflicting vascular and metabolic impact of the IL-33/sST2 axis
Cardiovasc Res, 114 (12), 1578-1594
DOI 10.1093/cvr/cvy166, PubMed 29982301

Altara R, Zouein FA, Brandão RD, Bajestani SN, Cataliotti A, Booz GW (2018)
In Silico Analysis of Differential Gene Expression in Three Common Rat Models of Diastolic Dysfunction
Front Cardiovasc Med, 5, 11
DOI 10.3389/fcvm.2018.00011, PubMed 29556499

Andenæs K, Lunde IG, Mohammadzadeh N, Dahl CP, Aronsen JM, Strand ME, Palmero S, Sjaastad I, Christensen G, Engebretsen KVT, Tønnessen T (2018)
The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling
PLoS One, 13 (7), e0201422
DOI 10.1371/journal.pone.0201422, PubMed 30052659

Barth Z, Schwartz T, Flatø B, Aaløkken TM, Koller A, Lund MB, Sjaastad I, Sanner H (2018)
The Association Between Nailfold Capillary Density and Pulmonary and Cardiac Involvement in Medium- to Long-standing Juvenile Dermatomyositis
Arthritis Care Res (Hoboken) (in press)
DOI 10.1002/acr.23687, PubMed 29953739

Berge K, Lyngbakken MN, Einvik G, Winther JA, Brynildsen J, Røysland R, Strand H, Christensen G, Høiseth AD, Omland T, Røsjø H (2018)
Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study
Clin Biochem, 59, 62-68
DOI 10.1016/j.clinbiochem.2018.07.006, PubMed 30028971

Berntsen KS, Edvardsen E, Hansen BH, Flatø B, Sjaastad I, Sanner H (2018)
Cardiorespiratory fitness in long-term juvenile dermatomyositis: a controlled, cross-sectional study of active/inactive disease
Rheumatology (Oxford) (in press)
DOI 10.1093/rheumatology/key342, PubMed 30508195

Borg Distefano M, Hofstad Haugen L, Wang Y, Perdreau-Dahl H, Kjos I, Jia D, Morth JP, Neefjes J, Bakke O, Progida C (2018)
TBC1D5 controls the GTPase cycle of Rab7b
J Cell Sci, 131 (17)
DOI 10.1242/jcs.216630, PubMed 30111580

Christensen G, Herum KM, Lunde IG (2018)
Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease
Matrix Biol (in press)
DOI 10.1016/j.matbio.2018.01.001, PubMed 29337052

Danielsen TK, Manotheepan R, Sadredini M, Leren IS, Edwards AG, Vincent KP, Lehnart SE, Sejersted OM, Sjaastad I, Haugaa KH, Stokke MK (2018)
Arrhythmia initiation in catecholaminergic polymorphic ventricular tachycardia type 1 depends on both heart rate and sympathetic stimulation
PLoS One, 13 (11), e0207100
DOI 10.1371/journal.pone.0207100, PubMed 30399185

Espeland T, Lunde IG, Amundsen BH, Gullestad L, Aakhus S (2018)
Espeland og medarbeidere svarer
Tidsskr Nor Laegeforen, 138 (19)
DOI 10.4045/tidsskr.18.0865, PubMed 30497251

Espeland T, Lunde IG, Amundsen BH, Gullestad L, Aakhus S (2018)
Myocardial Fibrosis
Tidsskr. Nor. Laegeforen., 138 (16), 1533-1539

Espeland T, Lunde IG, H Amundsen B, Gullestad L, Aakhus S (2018)
Myocardial fibrosis
Tidsskr Nor Laegeforen, 138 (16)
DOI 10.4045/tidsskr.17.1027, PubMed 30344312

Fan Q, Moen A, Anonsen JH, Bindesbøll C, Sæther T, Carlson CR, Grønning-Wang LM (2018)
O-GlcNAc site-mapping of liver X receptor-α and O-GlcNAc transferase
Biochem Biophys Res Commun, 499 (2), 354-360
DOI 10.1016/j.bbrc.2018.03.164, PubMed 29577901

Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR (2018)
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction
Mol Ther, 26 (7), 1644-1659
DOI 10.1016/j.ymthe.2018.02.012, PubMed 29606507

Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E (2018)
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
Cell Calcium, 76, 87-100
DOI 10.1016/j.ceca.2018.10.001, PubMed 30390422

Ghali R, Altara R, Louch WE, Cataliotti A, Mallat Z, Kaplan A, Zouein FA, Booz GW (2018)
IL-33 (Interleukin 33)/sST2 (Soluble Suppression of Tumorigenicity 2) Axis in Hypertension and Heart Failure
Hypertension, 72 (4), 818-828
DOI 10.1161/HYPERTENSIONAHA.118.11157, PubMed 30354724

Johnsen GM, Størvold GL, Drabbels JJM, Haasnoot GW, Eikmans M, Spruyt-Gerritse MJ, Alnæs-Katjavivi P, Scherjon SA, Redman CWG, Claas FHJ, Staff AC (2018)
The combination of maternal KIR-B and fetal HLA-C2 is associated with decidua basalis acute atherosis in pregnancies with preeclampsia
J Reprod Immunol, 129, 23-29
DOI 10.1016/j.jri.2018.07.005, PubMed 30055414

Kaplan A, Yabluchanskiy A, Ghali R, Altara R, Booz GW, Zouein FA (2018)
Cerebral blood flow alteration following acute myocardial infarction in mice
Biosci Rep, 38 (5)
DOI 10.1042/BSR20180382, PubMed 30061176

Kolstad TR, van den Brink J, MacQuaide N, Lunde PK, Frisk M, Aronsen JM, Norden ES, Cataliotti A, Sjaastad I, Sejersted OM, Edwards AG, Lines GT, Louch WE (2018)
Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes
Elife, 7
DOI 10.7554/eLife.39427, PubMed 30375974

Melleby AO, Romaine A, Aronsen JM, Veras I, Zhang L, Sjaastad I, Lunde IG, Christensen G (2018)
A novel method for high precision aortic constriction that allows for generation of specific cardiac phenotypes in mice
Cardiovasc Res, 114 (12), 1680-1690
DOI 10.1093/cvr/cvy141, PubMed 29878127

Moe K, Alnaes-Katjavivi P, Størvold GL, Sugulle M, Johnsen GM, Redman CWG, Dechend R, Staff AC (2018)
Classical Cardiovascular Risk Markers in Pregnancy and Associations to Uteroplacental Acute Atherosis
Hypertension, 72 (3), 695-702
DOI 10.1161/HYPERTENSIONAHA.118.10964, PubMed 30354752

Mughal AA, Zhang L, Fayzullin A, Server A, Li Y, Wu Y, Glass R, Meling T, Langmoen IA, Leergaard TB, Vik-Mo EO (2018)
Patterns of Invasive Growth in Malignant Gliomas-The Hippocampus Emerges as an Invasion-Spared Brain Region
Neoplasia, 20 (7), 643-656
DOI 10.1016/j.neo.2018.04.001, PubMed 29793116

Maack C, Lehrke M, Backs J, Heinzel FR, Hulot JS, Marx N, Paulus WJ, Rossignol P, Taegtmeyer H, Bauersachs J, Bayes-Genis A, Brutsaert D, Bugger H, Clarke K, Cosentino F, De Keulenaer G, Dei Cas A, González A, Huelsmann M, Iaccarino G, Lunde IG, Lyon AR, Pollesello P, Rena G, Riksen NP et al. (2018)
Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology
Eur Heart J (in press)
DOI 10.1093/eurheartj/ehy596, PubMed 30295797

Pervez MO, Winther JA, Brynildsen J, Strand H, Christensen G, Høiseth AD, Myhre PL, Røysland R, Lyngbakken MN, Omland T, Røsjø H (2018)
Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study
Biomarkers, 23 (7), 654-663
DOI 10.1080/1354750X.2018.1474258, PubMed 29733687

Rieber-Mohn AB, Sugulle M, Wallukat G, Alnæs-Katjavivi P, Leite Størvold G, Bolstad N, Redman CW, Dechend R, Staff AC (2018)
Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum
J Reprod Immunol, 128, 23-29
DOI 10.1016/j.jri.2018.05.008, PubMed 29843114

Røe ÅT, Ruud M, Espe EK, Manfra O, Longobardi S, Aronsen JM, Nordén ES, Husebye T, Kolstad TRS, Cataliotti A, Christensen G, Sejersted OM, Niederer SA, Øystein Andersen G, Sjaastad I, Louch WE (2018)
Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression
Cardiovasc Res (in press)
DOI 10.1093/cvr/cvy257, PubMed 30351410

Schjørring OL, Toft-Petersen AP, Kusk KH, Mouncey P, Sørensen EE, Berezowicz P, Bestle MH, Bülow HH, Bundgaard H, Christensen S, Iversen SA, Kirkeby-Garstad I, Krarup KB, Kruse M, Laake JH, Liboriussen L, Laebel RL, Okkonen M, Poulsen LM, Russell L, Sjövall F, Sunde K, Søreide E, Waldau T, Walli AR et al. (2018)
Intensive care doctors' preferences for arterial oxygen tension levels in mechanically ventilated patients
Acta Anaesthesiol Scand, 62 (10), 1443-1451
DOI 10.1111/aas.13171, PubMed 29926908

Shen X, van den Brink J, Hou Y, Colli D, Le C, Kolstad TR, MacQuaide N, Carlson CR, Kekenes-Huskey PM, Edwards AG, Soeller C, Louch WE (2018)
3D dSTORM imaging reveals novel detail of ryanodine receptor localization in rat cardiac myocytes
J Physiol (in press)
DOI 10.1113/JP277360, PubMed 30412283

Simon DN, Wriston A, Fan Q, Shabanowitz J, Florwick A, Dharmaraj T, Peterson SB, Gruenbaum Y, Carlson CR, Grønning-Wang LM, Hunt DF, Wilson KL (2018)
OGT (O-GlcNAc Transferase) Selectively Modifies Multiple Residues Unique to Lamin A
Cells, 7 (5)
DOI 10.3390/cells7050044, PubMed 29772801

Skogestad J, Aronsen JM (2018)
Hypokalemia-Induced Arrhythmias and Heart Failure: New Insights and Implications for Therapy
Front Physiol, 9, 1500
DOI 10.3389/fphys.2018.01500, PubMed 30464746

Smyrnias I, Goodwin N, Wachten D, Skogestad J, Aronsen JM, Robinson EL, Demydenko K, Segonds-Pichon A, Oxley D, Sadayappan S, Sipido K, Bootman MD, Roderick HL (2018)
Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes
J Mol Cell Cardiol, 117, 1-18
DOI 10.1016/j.yjmcc.2018.02.012, PubMed 29470978

Sommer T, Bjerregaard-Andersen K, Uribe L, Etzerodt M, Diezemann G, Gauss J, Cascella M, Morth JP (2018)
A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase
Sci Rep, 8 (1), 13104
DOI 10.1038/s41598-018-31259-y, PubMed 30166577

Steinberg MT, Olsen JA, Eriksen M, Neset A, Norseng PA, Kramer-Johansen J, Hardig BM, Wik L (2018)
Haemodynamic outcomes during piston-based mechanical CPR with or without active decompression in a porcine model of cardiac arrest
Scand J Trauma Resusc Emerg Med, 26 (1), 31
DOI 10.1186/s13049-018-0496-z, PubMed 29690910

Uribe L, Diezemann G, Gauss J, Morth JP, Cascella M (2018)
Structural Origin of Metal Specificity in Isatin Hydrolase from Labrenzia aggregata Investigated by Computer Simulations
Chemistry, 24 (20), 5074-5077
DOI 10.1002/chem.201705159, PubMed 29243856

Wollmann BM, Syversen SW, Vistnes M, Lie E, Mehus LL, Molden E (2018)
Associations between Cytokine Levels and CYP3A4 Phenotype in Patients with Rheumatoid Arthritis
Drug Metab Dispos, 46 (10), 1384-1389
DOI 10.1124/dmd.118.082065, PubMed 29991576

 
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