Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2016 from OUS - Institute for Experimental Medical Research IEMR

28 publications found

Aronsen JM, Louch WE, Sjaastad I (2016)
Cardiomyocyte Ca2+ dynamics: clinical perspectives
Scand Cardiovasc J, 50 (2), 65-77
DOI 10.3109/14017431.2015.1136079, PubMed 26729487

Bauer J, Bakke O, Morth JP (2016)
Overview of the membrane-associated RING-CH (MARCH) E3 ligase family
N Biotechnol, 38 (Pt A), 7-15
DOI 10.1016/j.nbt.2016.12.002, PubMed 27988304

Buonacera A, Boukhris M, Tomasello SD, Campagna A, Cilia C, Tripepi G, Di Marca S, Terranova V, Pisano M, Mastrosimone G, Galassi AR, Stancanelli B, Cataliotti A, Malatino L (2016)
Impact of left ventricular remodeling and renal function on 24h-ECG recordings and cardiovascular outcome in elderly hypertensive patients
Eur J Intern Med, 29, 71-7
DOI 10.1016/j.ejim.2016.01.001, PubMed 26781517

Dhondup Y, Ueland T, Dahl CP, Askevold ET, Sandanger Ø, Fiane A, Ohm IK, Sjaastad I, Finsen AV, Wæhre A, Gullestad L, Aukrust P, Yndestad A, Vinge LE (2016)
Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure
J Card Fail, 22 (10), 823-8
DOI 10.1016/j.cardfail.2016.06.013, PubMed 27349571

Eftestøl E, Egner IM, Lunde IG, Ellefsen S, Andersen T, Sjåland C, Gundersen K, Bruusgaard JC (2016)
Increased hypertrophic response with increased mechanical load in skeletal muscles receiving identical activity patterns
Am J Physiol Cell Physiol, 311 (4), C616-C629
DOI 10.1152/ajpcell.00016.2016, PubMed 27488660

Espe EKS, Skårdal K, Aronsen JM, Zhang L, Sjaastad I (2016)
A semiautomatic method for rapid segmentation of velocity-encoded myocardial magnetic resonance imaging data
Magn Reson Med, 78 (3), 1199-1207
DOI 10.1002/mrm.26486, PubMed 27699840

Frisk M, Ruud M, Espe EK, Aronsen JM, Røe ÅT, Zhang L, Norseng PA, Sejersted OM, Christensen GA, Sjaastad I, Louch WE (2016)
Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis
Cardiovasc Res, 112 (1), 443-51
DOI 10.1093/cvr/cvw111, PubMed 27226008

Gattoni S, Røe ÅT, Frisk M, Louch WE, Niederer SA, Smith NP (2016)
The calcium-frequency response in the rat ventricular myocyte: an experimental and modelling study
J Physiol, 594 (15), 4193-224
DOI 10.1113/JP272011, PubMed 26916026

Gerner L, Munack S, Temmerman K, Lawrence-Dörner AM, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP (2016)
Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli
Data Brief, 8, 733-40
DOI 10.1016/j.dib.2016.06.033, PubMed 27508226

Gerner L, Munack S, Temmerman K, Lawrence-Dörner AM, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP (2016)
Using the fluorescent properties of STO-609 as a tool to assist structure-function analyses of recombinant CaMKK2
Biochem Biophys Res Commun, 476 (2), 102-7
DOI 10.1016/j.bbrc.2016.05.045, PubMed 27178209

Hortemo KH, Lunde PK, Anonsen JH, Kvaløy H, Munkvik M, Rehn TA, Sjaastad I, Lunde IG, Aronsen JM, Sejersted OM (2016)
Exercise training increases protein O-GlcNAcylation in rat skeletal muscle
Physiol Rep, 4 (18)
DOI 10.14814/phy2.12896, PubMed 27664189

Huisamen B, Hafver TL, Lumkwana D, Lochner A (2016)
The Impact of Chronic Glycogen Synthase Kinase-3 Inhibition on Remodeling of Normal and Pre-Diabetic Rat Hearts
Cardiovasc Drugs Ther, 30 (3), 237-46
DOI 10.1007/s10557-016-6665-2, PubMed 27180786

Høiseth AD, Brynildsen J, Hagve TA, Christensen G, Søyseth V, Omland T, Røsjø H (2016)
The influence of heart failure co-morbidity on high-sensitivity troponin T levels in COPD exacerbation in a prospective cohort study: data from the Akershus cardiac examination (ACE) 2 study
Biomarkers, 21 (2), 173-9
DOI 10.3109/1354750X.2015.1126645, PubMed 26754170

Kummen M, Holm K, Anmarkrud JA, Nygård S, Vesterhus M, Høivik ML, Trøseid M, Marschall HU, Schrumpf E, Moum B, Røsjø H, Aukrust P, Karlsen TH, Hov JR (2016)
The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls
Gut, 66 (4), 611-619
DOI 10.1136/gutjnl-2015-310500, PubMed 26887816

Logantha SJ, Stokke MK, Atkinson AJ, Kharche SR, Parveen S, Saeed Y, Sjaastad I, Sejersted OM, Dobrzynski H (2016)
Ca(2+)-Clock-Dependent Pacemaking in the Sinus Node Is Impaired in Mice with a Cardiac Specific Reduction in SERCA2 Abundance
Front Physiol, 7, 197
DOI 10.3389/fphys.2016.00197, PubMed 27313537

Lunde IG, Herum KM, Carlson CC, Christensen G (2016)
Syndecans in heart fibrosis
Cell Tissue Res, 365 (3), 539-52
DOI 10.1007/s00441-016-2454-2, PubMed 27411689

Manotheepan R, Danielsen TK, Sadredini M, Anderson ME, Carlson CR, Lehnart SE, Sjaastad I, Stokke MK (2016)
Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca2+ release
Cardiovasc Res, 111 (3), 295-306
DOI 10.1093/cvr/cvw095, PubMed 27161030

Melleby AO, Strand ME, Romaine A, Herum KM, Skrbic B, Dahl CP, Sjaastad I, Fiane AE, Filmus J, Christensen G, Lunde IG (2016)
The Heparan Sulfate Proteoglycan Glypican-6 Is Upregulated in the Failing Heart, and Regulates Cardiomyocyte Growth through ERK1/2 Signaling
PLoS One, 11 (10), e0165079
DOI 10.1371/journal.pone.0165079, PubMed 27768722

Myhre PL, Ottesen AH, Okkonen M, Linko R, Stridsberg M, Nygård S, Christensen G, Pettilä V, Omland T, Røsjø H, FINNALI Laboratory Study Group (2016)
Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study
Clin Chem, 62 (10), 1380-9
DOI 10.1373/clinchem.2016.258764, PubMed 27540029

Røsjø H, Stridsberg M, Ottesen AH, Nygård S, Christensen G, Pettilä V, Linko R, Karlsson S, Varpula T, Ruokonen E, Omland T, FINNSEPSIS and FINNALI Study Groups (2016)
Prognostic Value of Secretoneurin in Critically Ill Patients With Infections
Crit Care Med, 44 (10), 1882-90
DOI 10.1097/CCM.0000000000001832, PubMed 27414477

Sadredini M, Danielsen TK, Aronsen JM, Manotheepan R, Hougen K, Sjaastad I, Stokke MK (2016)
Beta-Adrenoceptor Stimulation Reveals Ca2+ Waves and Sarcoplasmic Reticulum Ca2+ Depletion in Left Ventricular Cardiomyocytes from Post-Infarction Rats with and without Heart Failure
PLoS One, 11 (4), e0153887
DOI 10.1371/journal.pone.0153887, PubMed 27096943

Schwartz T, Diederichsen LP, Lundberg IE, Sjaastad I, Sanner H (2016)
Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies
RMD Open, 2 (2), e000291
DOI 10.1136/rmdopen-2016-000291, PubMed 27752355

Skårdal K, Espe EK, Zhang L, Aronsen JM, Sjaastad I (2016)
Three-Directional Evaluation of Mitral Flow in the Rat Heart by Phase-Contrast Cardiovascular Magnetic Resonance
PLoS One, 11 (3), e0150536
DOI 10.1371/journal.pone.0150536, PubMed 26930073

Sousa AR, Staff AC, Johnsen GM, Weedon-Fekjær MS, Størvold GL (2016)
Evaluation of four commonly used normalizer genes for the study of decidual gene expression
Placenta, 43, 9-12
DOI 10.1016/j.placenta.2016.04.009, PubMed 27324093

Subramani S, Perdreau-Dahl H, Morth JP (2016)
The magnesium transporter A is activated by cardiolipin and is highly sensitive to free magnesium in vitro
Elife, 5
DOI 10.7554/eLife.11407, PubMed 26780187

Thienpont B, Aronsen JM, Robinson EL, Okkenhaug H, Loche E, Ferrini A, Brien P, Alkass K, Tomasso A, Agrawal A, Bergmann O, Sjaastad I, Reik W, Roderick HL (2016)
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy
J Clin Invest, 127 (1), 335-348
DOI 10.1172/JCI88353, PubMed 27893464

Wanichawan P, Hodne K, Hafver TL, Lunde M, Martinsen M, Louch WE, Sejersted OM, Carlson CR (2016)
Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1)
Biochem J, 473 (15), 2413-23
DOI 10.1042/BCJ20160465, PubMed 27247424

Winther JA, Brynildsen J, Høiseth AD, Følling I, Brekke PH, Christensen G, Hagve TA, Verbalis JG, Omland T, Røsjø H (2016)
Prevalence and Prognostic Significance of Hyponatremia in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Data from the Akershus Cardiac Examination (ACE) 2 Study
PLoS One, 11 (8), e0161232
DOI 10.1371/journal.pone.0161232, PubMed 27529844

 
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