Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2014 from OUS - Institute for Experimental Medical Research IEMR

36 publications found

Aronsen JM, Skogestad J, Lewalle A, Louch WE, Hougen K, Stokke MK, Swift F, Niederer S, Smith NP, Sejersted OM, Sjaastad I (2014)
Hypokalaemia induces Ca²⁺ overload and Ca²⁺ waves in ventricular myocytes by reducing Na⁺,K⁺-ATPase α₂ activity
J Physiol, 593 (6), 1509-21
DOI 10.1113/jphysiol.2014.279893, PubMed 25772299

Askevold ET, Aukrust P, Nymo SH, Lunde IG, Kaasbøll OJ, Aakhus S, Florholmen G, Ohm IK, Strand ME, Attramadal H, Fiane A, Dahl CP, Finsen AV, Vinge LE, Christensen G, Yndestad A, Gullestad L, Latini R, Masson S, Tavazzi L, GISSI-HF Investigators, Ueland T (2014)
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure
J Intern Med, 275 (6), 621-30
DOI 10.1111/joim.12175, PubMed 24330105

Aspelin T, Eriksen M, Ilebekk A, Cataliotti A, Carlson CR, Lyberg T (2014)
β-blockade abolishes the augmented cardiac tPA release induced by transactivation of heterodimerised bradykinin receptor-2 and β2-adrenergic receptor in vivo
Thromb Haemost, 112 (5), 951-9
DOI 10.1160/TH14-01-0059, PubMed 25078038

Ayala U, Irusta U, Ruiz J, Alonso-Atienza F, Alonso E, Gonzalez-Otero D, Kramer-Johansen J, Naas H, Eftestol T (2014)
Filtering Chest Compression Artifacts Improves the Performance of VF-detection Parameters
COMPUT CARDIOL, 41, 1109-1112

Berk JM, Simon DN, Jenkins-Houk CR, Westerbeck JW, Grønning-Wang LM, Carlson CR, Wilson KL (2014)
The molecular basis of emerin-emerin and emerin-BAF interactions
J Cell Sci, 127 (Pt 18), 3956-69
DOI 10.1242/jcs.148247, PubMed 25052089

Bjerregaard-Andersen K, Sommer T, Jensen JK, Jochimsen B, Etzerodt M, Morth JP (2014)
A proton wire and water channel revealed in the crystal structure of isatin hydrolase
J Biol Chem, 289 (31), 21351-9
DOI 10.1074/jbc.M114.568824, PubMed 24917679

Boardman NT, Aronsen JM, Louch WE, Sjaastad I, Willoch F, Christensen G, Sejersted O, Aasum E (2014)
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2
Am J Physiol Heart Circ Physiol, 306 (7), H1018-24
DOI 10.1152/ajpheart.00741.2013, PubMed 24486508

Engebretsen KV, Skårdal K, Bjørnstad S, Marstein HS, Skrbic B, Sjaastad I, Christensen G, Bjørnstad JL, Tønnessen T (2014)
Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5
J Mol Cell Cardiol, 76, 148-57
DOI 10.1016/j.yjmcc.2014.08.008, PubMed 25169971

Finsen AV, Ueland T, Sjaastad I, Ranheim T, Ahmed MS, Dahl CP, Askevold ET, Aakhus S, Husberg C, Fiane AE, Lipp M, Gullestad L, Christensen G, Aukrust P, Yndestad A (2014)
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling
PLoS One, 9 (11), e112172
DOI 10.1371/journal.pone.0112172, PubMed 25398010

Frisk M, Koivumäki JT, Norseng PA, Maleckar MM, Sejersted OM, Louch WE (2014)
Variable t-tubule organization and Ca2+ homeostasis across the atria
Am J Physiol Heart Circ Physiol, 307 (4), H609-20
DOI 10.1152/ajpheart.00295.2014, PubMed 24951751

Furenes EB, Opstad TB, Solheim S, Lunde K, Arnesen H, Seljeflot I (2014)
The influence of autologous bone marrow stem cell transplantation on matrix metalloproteinases in patients treated for acute ST-elevation myocardial infarction
Mediators Inflamm, 2014, 385901
DOI 10.1155/2014/385901, PubMed 25294955

Hardeland C, Olasveengen TM, Lawrence R, Garrison D, Lorem T, Farstad G, Wik L (2014)
Comparison of Medical Priority Dispatch (MPD) and Criteria Based Dispatch (CBD) relating to cardiac arrest calls
Resuscitation, 85 (5), 612-6
DOI 10.1016/j.resuscitation.2014.01.029, PubMed 24525117

Hillestad V, Espe EK, Cero F, Larsen KO, Sjaastad I, Nygård S, Skjønsberg OH, Christensen G (2014)
IL-18 neutralization during alveolar hypoxia improves left ventricular diastolic function in mice
Acta Physiol (Oxf), 213 (2), 492-504
DOI 10.1111/apha.12376, PubMed 25182570

Kong XY, Nesset CK, Damme M, Løberg EM, Lübke T, Mæhlen J, Andersson KB, Lorenzo PI, Roos N, Thoresen GH, Rustan AC, Kase ET, Eskild W (2014)
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells
Dis Model Mech, 7 (3), 351-62
DOI 10.1242/dmm.014050, PubMed 24487409

Kudryavtseva O, Herum KM, Dam VS, Straarup MS, Kamaev D, Briggs Boedtkjer DM, Matchkov VV, Aalkjær C (2014)
Downregulation of L-type Ca2+ channel in rat mesenteric arteries leads to loss of smooth muscle contractile phenotype and inward hypertrophic remodeling
Am J Physiol Heart Circ Physiol, 306 (9), H1287-301
DOI 10.1152/ajpheart.00503.2013, PubMed 24561864

Land S, Niederer SA, Louch WE, Røe ÅT, Aronsen JM, Stuckey DJ, Sikkel MB, Tranter MH, Lyon AR, Harding SE, Smith NP (2014)
Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle
Am J Physiol Heart Circ Physiol, 307 (10), H1487-96
DOI 10.1152/ajpheart.00443.2014, PubMed 25239804

Majak P, Lunde IG, Hasic AK, Husebye T, Christensen G, Tønnessen T, Bjørnstad JL (2014)
Reduced visfatin levels in aortic stenosis increase after aortic valve replacement and may contribute to reverse left ventricular remodelling
J Cardiovasc Surg (Torino), 56 (3), 483-92
PubMed 24429804

Manotheepan R, Saberniak J, Danielsen TK, Edvardsen T, Sjaastad I, Haugaa KH, Stokke MK (2014)
Effects of individualized exercise training in patients with catecholaminergic polymorphic ventricular tachycardia type 1
Am J Cardiol, 113 (11), 1829-33
DOI 10.1016/j.amjcard.2014.03.012, PubMed 24837260

McKie PM, Cataliotti A, Ichiki T, Sangaralingham SJ, Chen HH, Burnett JC (2014)
M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure: differential actions of 2 cGMP activating therapeutics
J Am Heart Assoc, 3 (1), e000206
DOI 10.1161/JAHA.113.000206, PubMed 24385449

Melsom CB, Hussain RI, Ørstavik Ø, Aronsen JM, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Krobert KA (2014)
Non-classical regulation of β1- and β 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi
Naunyn Schmiedebergs Arch Pharmacol, 387 (12), 1177-86
DOI 10.1007/s00210-014-1036-7, PubMed 25216690

Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De Paula AM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, Tjønnfjord GE, Frengen E (2014)
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
DOI 10.1002/humu.22544, PubMed 24619930

Moltzau LR, Aronsen JM, Meier S, Skogestad J, Ørstavik Ø, Lothe GB, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle
J Pharmacol Exp Ther, 350 (3), 681-90
DOI 10.1124/jpet.114.214882, PubMed 25022512

Moltzau LR, Meier S, Aronsen JM, Afzal F, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium
Naunyn Schmiedebergs Arch Pharmacol, 387 (5), 407-17
DOI 10.1007/s00210-013-0953-1, PubMed 24424715

Nishiyama C, Brown SP, May S, Iwami T, Koster RW, Beesems SG, Kuisma M, Salo A, Jacobs I, Finn J, Sterz F, Nürnberger A, Smith K, Morrison L, Olasveengen TM, Callaway CW, Shin SD, Gräsner JT, Daya M, Ma MH, Herlitz J, Strömsöe A, Aufderheide TP, Masterson S, Wang H et al. (2014)
Apples to apples or apples to oranges? International variation in reporting of process and outcome of care for out-of-hospital cardiac arrest
Resuscitation, 85 (11), 1599-609
DOI 10.1016/j.resuscitation.2014.06.031, PubMed 25010784

Nordbø O, Lamata P, Land S, Niederer S, Aronsen JM, Louch WE, Sjaastad I, Martens H, Gjuvsland AB, Tøndel K, Torp H, Lohezic M, Schneider JE, Remme EW, Smith N, Omholt SW, Vik JO (2014)
A computational pipeline for quantification of mouse myocardial stiffness parameters
Comput Biol Med, 53, 65-75
DOI 10.1016/j.compbiomed.2014.07.013, PubMed 25129018

Nygård S, Reitan T, Clancy T, Nygaard V, Bjørnstad J, Skrbic B, Tønnessen T, Christensen G, Hovig E (2014)
Identifying pathogenic processes by integrating microarray data with prior knowledge
BMC Bioinformatics, 15, 115
DOI 10.1186/1471-2105-15-115, PubMed 24758699

Rad AB, Ejtestol T, Kvaloy JT, Ayala U, Kramer-Johansen J, Engan K (2014)
NEAREST-MANIFOLD CLASSIFICATION APPROACH FOR CARDIAC ARREST RHYTHM INTERPRETATION DURING RESUSCITATION
INT CONF ACOUST SPEE

Røsjø H, Dahl MB, Bye A, Andreassen J, Jørgensen M, Wisløff U, Christensen G, Edvardsen T, Omland T (2014)
Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis
PLoS One, 9 (3), e91812
DOI 10.1371/journal.pone.0091812, PubMed 24626394

Sandvik GK, Hodne K, Haug TM, Okubo K, Weltzien FA (2014)
RFamide Peptides in Early Vertebrate Development
Front Endocrinol (Lausanne), 5, 203
DOI 10.3389/fendo.2014.00203, PubMed 25538682

Sanner H, Schwartz T, Flatø B, Vistnes M, Christensen G, Sjaastad I (2014)
Increased levels of eotaxin and MCP-1 in juvenile dermatomyositis median 16.8 years after disease onset; associations with disease activity, duration and organ damage
PLoS One, 9 (3), e92171
DOI 10.1371/journal.pone.0092171, PubMed 24647150

Sanner H, Sjaastad I, Flatø B (2014)
Disease activity and prognostic factors in juvenile dermatomyositis: a long-term follow-up study applying the Paediatric Rheumatology International Trials Organization criteria for inactive disease and the myositis disease activity assessment tool
Rheumatology (Oxford), 53 (9), 1578-85
DOI 10.1093/rheumatology/keu146, PubMed 24692575

Schwartz T, Sjaastad I, Flatø B, Vistnes M, Christensen G, Sanner H (2014)
In active juvenile dermatomyositis, elevated eotaxin and MCP-1 and cholesterol levels in the upper normal range are associated with cardiac dysfunction
Rheumatology (Oxford), 53 (12), 2214-22
DOI 10.1093/rheumatology/keu256, PubMed 24996906

Stær-Jensen H, Sunde K, Olasveengen TM, Jacobsen D, Drægni T, Nakstad ER, Eritsland J, Andersen GØ (2014)
Bradycardia during therapeutic hypothermia is associated with good neurologic outcome in comatose survivors of out-of-hospital cardiac arrest
Crit Care Med, 42 (11), 2401-8
DOI 10.1097/CCM.0000000000000515, PubMed 25072762

Sunde K, Olasveengen TM (2014)
Towards cardiopulmonary resuscitation without vasoactive drugs
Curr Opin Crit Care, 20 (3), 234-41
DOI 10.1097/MCC.0000000000000082, PubMed 24739267

Vistnes M, Aronsen JM, Lunde IG, Sjaastad I, Carlson CR, Christensen G (2014)
Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding
PLoS One, 9 (3), e89621
DOI 10.1371/journal.pone.0089621, PubMed 24595230

Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR (2014)
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645

 
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