Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

Click here to see hierarchical division and subunit overview

Summary of publications:

Publications (original articles or review articles) published in 2018 from OUS - Institute for Cancer Genetics and Informatics

36 publications found

Agostini A, Brunetti M, Davidson B, Göran Tropé C, Heim S, Panagopoulos I, Micci F (2018)
Identification of novel cyclin gene fusion transcripts in endometrioid ovarian carcinomas
Int J Cancer, 143 (6), 1379-1387
DOI 10.1002/ijc.31418, PubMed 29633253

Agostini A, Brunetti M, Davidson B, Tropé CG, Eriksson AGZ, Heim S, Panagopoulos I, Micci F (2018)
The microRNA miR-192/215 family is upregulated in mucinous ovarian carcinomas
Sci Rep, 8 (1), 11069
DOI 10.1038/s41598-018-29332-7, PubMed 30038317

Andreassen BK, Grimsrud TK, Haug ES (2018)
Bladder cancer survival: Women better off in the long run
Eur J Cancer, 95, 52-58
DOI 10.1016/j.ejca.2018.03.001, PubMed 29635144

Batman S, Morgan T, Brunetti M, Strandabø RAU, Micci F, Moffitt M, Pejovic T (2018)
Primary mediastinal choriocarcinoma in a female patient: Case report and review of the literature
Gynecol Oncol Rep, 26, 99-101
DOI 10.1016/j.gore.2018.10.013, PubMed 30456287

Birkeland E, Zhang S, Poduval D, Geisler J, Nakken S, Vodak D, Meza-Zepeda LA, Hovig E, Myklebost O, Knappskog S, Lønning PE (2018)
Patterns of genomic evolution in advanced melanoma
Nat Commun, 9 (1), 2665
DOI 10.1038/s41467-018-05063-1, PubMed 29991680

Brunetti M, Gorunova L, Davidson B, Heim S, Panagopoulos I, Micci F (2018)
Identification of an EPC2-PHF1 fusion transcript in low-grade endometrial stromal sarcoma
Oncotarget, 9 (27), 19203-19208
DOI 10.18632/oncotarget.24969, PubMed 29721194

Brunetti M, Holth A, Panagopoulos I, Staff AC, Micci F, Davidson B (2018)
Expression and clinical role of the dipeptidyl peptidases DPP8 and DPP9 in ovarian carcinoma
Virchows Arch (in press)
DOI 10.1007/s00428-018-2487-x, PubMed 30467600

Brynildsen J, Petäjä L, Pettilä V, Nygård S, Vaara ST, Linko R, Okkonen M, Hagve TA, Soininen L, Suojaranta-Ylinen R, Lyngbakken MN, Omland T, Røsjø H (2018)
The predictive value of NT-proBNP and hs-TnT for risk of death in cardiac surgical patients
Clin Biochem, 53, 65-71
DOI 10.1016/j.clinbiochem.2018.01.012, PubMed 29371002

Danielsen HE, Hveem TS, Domingo E, Pradhan M, Kleppe A, Syvertsen RA, Kostolomov I, Nesheim JA, Askautrud HA, Nesbakken A, Lothe RA, Svindland A, Shepherd N, Novelli M, Johnstone E, Tomlinson I, Kerr R, Kerr DJ (2018)
Prognostic markers for colorectal cancer: estimating ploidy and stroma
Ann Oncol, 29 (3), 616-623
DOI 10.1093/annonc/mdx794, PubMed 29293881

Domingo E, Camps C, Kaisaki PJ, Parsons MJ, Mouradov D, Pentony MM, Makino S, Palmieri M, Ward RL, Hawkins NJ, Gibbs P, Askautrud H, Oukrif D, Wang H, Wood J, Tomlinson E, Bark Y, Kaur K, Johnstone EC, Palles C, Church DN, Novelli M, Danielsen HE, Sherlock J, Kerr D et al. (2018)
Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series
Lancet Gastroenterol Hepatol, 3 (9), 635-643
DOI 10.1016/S2468-1253(18)30117-1, PubMed 30042065

Dominguez-Valentin M, Evans DGR, Nakken S, Tubeuf H, Vodak D, Ekstrøm PO, Nissen AM, Morak M, Holinski-Feder E, Martins A, Møller P, Hovig E (2018)
Genetic variants of prospectively demonstrated phenocopies in BRCA1/2 kindreds
Hered Cancer Clin Pract, 16, 4
DOI 10.1186/s13053-018-0086-0, PubMed 29371908

Dominguez-Valentin M, Nakken S, Tubeuf H, Vodak D, Ekstrøm PO, Nissen AM, Morak M, Holinski-Feder E, Martins A, Møller P, Hovig E (2018)
Identification of genetic variants for clinical management of familial colorectal tumors
BMC Med Genet, 19 (1), 26
DOI 10.1186/s12881-018-0533-9, PubMed 29458332

Dominguez-Valentin M, Nakken S, Tubeuf H, Vodak D, Ekstrøm PO, Nissen AM, Morak M, Holinski-Feder E, Martins A, Møller P, Hovig E (2018)
Potentially pathogenic germline CHEK2 c.319+2T>A among multiple early-onset cancer families
Fam Cancer, 17 (1), 141-153
DOI 10.1007/s10689-017-0011-0, PubMed 28608266

Ebenesersdóttir SS, Sandoval-Velasco M, Gunnarsdóttir ED, Jagadeesan A, Guðmundsdóttir VB, Thordardóttir EL, Einarsdóttir MS, Moore KHS, Sigurðsson Á, Magnúsdóttir DN, Jónsson H, Snorradóttir S, Hovig E, Møller P, Kockum I, Olsson T, Alfredsson L, Hansen TF, Werge T, Cavalleri GL, Gilbert E, Lalueza-Fox C, Walser JW, Kristjánsdóttir S, Gopalakrishnan S et al. (2018)
Ancient genomes from Iceland reveal the making of a human population
Science, 360 (6392), 1028-1032
DOI 10.1126/science.aar2625, PubMed 29853688

Fusser M, Øverbye A, Pandya AD, Mørch Ý, Borgos SE, Kildal W, Snipstad S, Sulheim E, Fleten KG, Askautrud HA, Engebraaten O, Flatmark K, Iversen TG, Sandvig K, Skotland T, Mælandsmo GM (2018)
Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft
J Control Release, 293, 183-192 (in press)
DOI 10.1016/j.jconrel.2018.11.029, PubMed 30529259

Georgakopoulos N, Diamantopoulos P, Micci F, Giannakopoulou N, Zervakis K, Dimitrakopoulou A, Viniou NA (2018)
An Adult Patient with Early Pre-B Acute Lymphoblastic Leukemia with t(12;17)(p13;q21)/ZNF384-TAF15
In Vivo, 32 (5), 1241-1245
DOI 10.21873/invivo.11371, PubMed 30150451

Gerhauser C, Favero F, Risch T, Simon R, Feuerbach L, Assenov Y, Heckmann D, Sidiropoulos N, Waszak SM, Hübschmann D, Urbanucci A, Girma EG, Kuryshev V, Klimczak LJ, Saini N, Stütz AM, Weichenhan D, Böttcher LM, Toth R, Hendriksen JD, Koop C, Lutsik P, Matzk S, Warnatz HJ, Amstislavskiy V et al. (2018)
Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories
Cancer Cell, 34 (6), 996-1011.e8
DOI 10.1016/j.ccell.2018.10.016, PubMed 30537516

González Martín A, Oza AM, Embleton AC, Pfisterer J, Ledermann JA, Pujade-Lauraine E, Kristensen G, Bertrand MA, Beale P, Cervantes A, Kent E, Kaplan RS, Parmar MKB, Scotto N, Perren TJ, ICON7 investigators (2018)
Exploratory outcome analyses according to stage and/or residual disease in the ICON7 trial of carboplatin and paclitaxel with or without bevacizumab for newly diagnosed ovarian cancer
Gynecol Oncol (in press)
DOI 10.1016/j.ygyno.2018.08.036, PubMed 30449719

Johannessen LE, Brandal P, Myklebust TÅ, Heim S, Micci F, Panagopoulos I (2018)
MGMT Gene Promoter Methylation Status - Assessment of Two Pyrosequencing Kits and Three Methylation-specific PCR Methods for their Predictive Capacity in Glioblastomas
Cancer Genomics Proteomics, 15 (6), 437-446
DOI 10.21873/cgp.20102, PubMed 30343277

Kanduri C, Bock C, Gundersen S, Hovig E, Sandve GK (2018)
Colocalization analyses of genomic elements: approaches, recommendations and challenges
Bioinformatics (in press)
DOI 10.1093/bioinformatics/bty835, PubMed 30307532

Kleppe A, Albregtsen F, Vlatkovic L, Pradhan M, Nielsen B, Hveem TS, Askautrud HA, Kristensen GB, Nesbakken A, Trovik J, Wæhre H, Tomlinson I, Shepherd NA, Novelli M, Kerr DJ, Danielsen HE (2018)
Chromatin organisation and cancer prognosis: a pan-cancer study
Lancet Oncol, 19 (3), 356-369
DOI 10.1016/S1470-2045(17)30899-9, PubMed 29402700

Kumar RP, Barkhatov L, Edwin B, Albregtsen F, Elle OJ (2018)
Portal and Hepatic Vein Segmentation with Leak Restriction: A Pilot Study
IFMBE PROC, 65, 823-826

Møller P, Hovig E (2018)
Our genes, our selves: hereditary breast cancer and biological citizenship in Norway
Med Health Care Philos, 21 (2), 239-242
DOI 10.1007/s11019-017-9803-0, PubMed 28939999

Nakken S, Fournous G, Vodák D, Aasheim LB, Myklebost O, Hovig E (2018)
Personal Cancer Genome Reporter: variant interpretation report for precision oncology
Bioinformatics, 34 (10), 1778-1780
DOI 10.1093/bioinformatics/btx817, PubMed 29272339

Nielsen B, Kleppe A, Hveem TS, Pradhan M, Syvertsen RA, Nesheim JA, Kristensen GB, Trovik J, Kerr DJ, Albregtsen F, Danielsen HE (2018)
Association Between Proportion of Nuclei With High Chromatin Entropy and Prognosis in Gynecological Cancers
J Natl Cancer Inst, 110 (12), 1400-1408
DOI 10.1093/jnci/djy063, PubMed 29684152

Panagopoulos I, Gorunova L, Andersen HK, Bergrem A, Dahm A, Andersen K, Micci F, Heim S (2018)
PAN3-PSMA2 fusion resulting from a novel t(7;13)(p14;q12) chromosome translocation in a myelodysplastic syndrome that evolved into acute myeloid leukemia
Exp Hematol Oncol, 7, 7
DOI 10.1186/s40164-018-0099-4, PubMed 29560286

Panagopoulos I, Gorunova L, Andersen K, Lobmaier I, Bjerkehagen B, Heim S (2018)
Consistent Involvement of Chromosome 13 in Angiolipoma
Cancer Genomics Proteomics, 15 (1), 61-65
DOI 10.21873/cgp.20065, PubMed 29275363

Panagopoulos I, Gorunova L, Jacobsen EM, Andersen K, Micci F, Heim S (2018)
RUNX1-PDCD6 fusion resulting from a novel t(5;21)(p15;q22) chromosome translocation in myelodysplastic syndrome secondary to chronic lymphocytic leukemia
PLoS One, 13 (4), e0196181
DOI 10.1371/journal.pone.0196181, PubMed 29672642

Panagopoulos I, Gorunova L, Leske H, Niehusmann P, Johannessen LE, Staurseth J, Øino N, Meling TR, Heim S, Micci F, Brandal P (2018)
Pyrosequencing Analysis of MGMT Promoter Methylation in Meningioma
Cancer Genomics Proteomics, 15 (5), 379-385
DOI 10.21873/cgp.20096, PubMed 30194078

Panagopoulos I, Gorunova L, Lund-Iversen M, Andersen K, Andersen HK, Lobmaier I, Bjerkehagen B, Heim S (2018)
Cytogenetics of Spindle Cell/Pleomorphic Lipomas: Karyotyping and FISH Analysis of 31 Tumors
Cancer Genomics Proteomics, 15 (3), 193-200
DOI 10.21873/cgp.20077, PubMed 29695401

Simonsen TG, Lund KV, Hompland T, Kristensen GB, Rofstad EK (2018)
DCE-MRI-Derived Measures of Tumor Hypoxia and Interstitial Fluid Pressure Predict Outcomes in Cervical Carcinoma
Int J Radiat Oncol Biol Phys, 102 (4), 1193-1201
DOI 10.1016/j.ijrobp.2018.04.035, PubMed 29859790

Smogeli E, Cvancarova M, Wang Y, Davidson B, Kristensen G, Lindemann K (2018)
Clinical Outcome of Patients With High-Risk Endometrial Carcinoma After Treatment With Chemotherapy Only
Int J Gynecol Cancer, 28 (9), 1789-1795
DOI 10.1097/IGC.0000000000001356, PubMed 30365455

Vaccaro CA, López-Kostner F, Adriana DV, Palmero EI, Rossi BM, Antelo M, Solano A, Carraro DM, Forones NM, Bohorquez M, Lino-Silva LS, Buleje J, Spirandelli F, Abe-Sandes K, Nascimento I, Sullcahuaman Y, Sarroca C, Gonzalez ML, Herrando AI, Alvarez K, Neffa F, Galvão HC, Esperon P, Golubicki M, Cisterna D et al. (2018)
From colorectal cancer pattern to the characterization of individuals at risk: Picture for genetic research in Latin America
Int J Cancer (in press)
DOI 10.1002/ijc.31920, PubMed 30303536

Vergote I, Coens C, Nankivell M, Kristensen GB, Parmar MKB, Ehlen T, Jayson GC, Johnson N, Swart AM, Verheijen R, McCluggage WG, Perren T, Panici PB, Kenter G, Casado A, Mendiola C, Stuart G, Reed NS, Kehoe S, EORTC, MRC CHORUS study investigators (2018)
Neoadjuvant chemotherapy versus debulking surgery in advanced tubo-ovarian cancers: pooled analysis of individual patient data from the EORTC 55971 and CHORUS trials
Lancet Oncol, 19 (12), 1680-1687
DOI 10.1016/S1470-2045(18)30566-7, PubMed 30413383

Winje IM, Sheng X, Hansson KA, Solbrå A, Tennøe S, Saatcioglu F, Bruusgaard JC, Gundersen K (2018)
Cachexia does not induce loss of myonuclei or muscle fibres during xenografted prostate cancer in mice
Acta Physiol (Oxf), e13204 (in press)
DOI 10.1111/apha.13204, PubMed 30325108

Xu C, Wang Y, Tu Q, Zhang Z, Chen M, Mwangi J, Li Y, Jin Y, Zhao X, Lai R (2018)
Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation
Oncogene (in press)
DOI 10.1038/s41388-018-0556-x, PubMed 30356139

 
Page visits: 72976