Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Neurosurgery

59 publications found

Bakker MK, van der Spek RAA, van Rheenen W, Morel S, Bourcier R, Hostettler IC, Alg VS, van Eijk KR, Koido M, Akiyama M, Terao C, Matsuda K, Walters RG, Lin K, Li L, Millwood IY, Chen Z, Rouleau GA, Zhou S, Rannikmäe K, Sudlow CLM, Houlden H, van den Berg LH, Dina C, Naggara O et al. (2020)
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Nat Genet, 52 (12), 1303-1313
DOI 10.1038/s41588-020-00725-7, PubMed 33199917

Digernes I, Nilsen LB, Grøvik E, Bjørnerud A, Løvland G, Vik-Mo E, Meling TR, Saxhaug C, Helland Å, Jacobsen KD, Geier O, Emblem KE (2020)
Noise dependency in vascular parameters from combined gradient-echo and spin-echo DSC MRI
Phys Med Biol, 65 (22), 225020
DOI 10.1088/1361-6560/abb71a, PubMed 33200748

Døving M, Galteland P, Eken T, Sehic A, Utheim TP, Skaga NO, Helseth E, Ramm-Pettersen J (2020)
Dentoalveolar injuries, bicycling accidents and helmet use in patients referred to a Norwegian Trauma Centre: A 12-year prospective study
Dent Traumatol
DOI 10.1111/edt.12627, PubMed 33220164

Eide PK, Hasan-Olive MM, Hansson HA, Enger R (2020)
Increased occurrence of pathological mitochondria in astrocytic perivascular endfoot processes and neurons of idiopathic intracranial hypertension
J Neurosci Res, 99 (2), 467-480
DOI 10.1002/jnr.24743, PubMed 33105056

Eide PK, Pripp AH, Ringstad G (2020)
<b>Magnetic resonance imaging biomarkers of cerebrospinal fluid tracer dynamics</b> <b>in idiopathic normal pressure hydrocephalus</b>
Brain Commun, 2 (2), fcaa187
DOI 10.1093/braincomms/fcaa187, PubMed 33381757

Evensen KB, Eide PK (2020)
Mechanisms behind altered pulsatile intracranial pressure in idiopathic normal pressure hydrocephalus: role of vascular pulsatility and systemic hemodynamic variables
Acta Neurochir (Wien), 162 (8), 1803-1813
DOI 10.1007/s00701-020-04423-5, PubMed 32533412

Evensen KB, Eide PK (2020)
Measuring intracranial pressure by invasive, less invasive or non-invasive means: limitations and avenues for improvement
Fluids Barriers CNS, 17 (1), 34
DOI 10.1186/s12987-020-00195-3, PubMed 32375853

Fjermestad KW, Huster R, Thunberg C, Stokke S, Gravholt CH, Solbakk AK (2020)
Neuropsychological functions, sleep, and mental health in adults with Klinefelter syndrome
Am J Med Genet C Semin Med Genet, 184 (2), 482-492
DOI 10.1002/ajmg.c.31797, PubMed 32415904

Foldal MD, Blenkmann AO, Llorens A, Knight RT, Solbakk AK, Endestad T (2020)
The brain tracks auditory rhythm predictability independent of selective attention
Sci Rep, 10 (1), 7975
DOI 10.1038/s41598-020-64758-y, PubMed 32409738

Freidin MB, Tsepilov YA, Stanaway IB, Meng W, Hayward C, Smith BH, Khoury S, Parisien M, Bortsov A, Diatchenko L, Børte S, Winsvold BS, Brumpton BM, Zwart JA, Aulchenko YS, Suri P, Williams FMK, HUNT All-In Pain (2020)
Sex- and age-specific genetic analysis of chronic back pain
Pain (in press)
DOI 10.1097/j.pain.0000000000002100, PubMed 33021770

Frič R, Due-Tønnessen BJ, Lundar T, Egge A, Kronen Krossnes B, Due-Tønnessen P, Stensvold E, Brandal P (2020)
Long-term outcome of posterior fossa medulloblastoma in patients surviving more than 20 years following primary treatment in childhood
Sci Rep, 10 (1), 9371
DOI 10.1038/s41598-020-66328-8, PubMed 32523021

Fuster-Garcia E, Estelles DL, Alvarez-Torres MD, Juan-Albarracin J, Chelebian E, Rovira A, Acosta CA, Pineda J, Oleaga L, Molla-Olmos E, Filice S, Due-Tonnessen P, Meling TR, Emblem KE, Garcia-Gomez JM (2020)
MGMT methylation may benefit overall survival in patients with moderately vascularized glioblastomas
Eur. Radiol.

Habhab SF, Ulvin LB, Taubøll E, Svalheim S, Olsen KB, Horn MA, Heuser K (2020)
Influence of valproate-induced hyperammonemia on treatment decision in an adult status epilepticus cohort
Epilepsy Behav, 111, 107193
DOI 10.1016/j.yebeh.2020.107193, PubMed 32759060

Halvorsen M, Edeklev CS, Fraser-Green J, Løvland G, Vatnehol SAS, Gjertsen Ø, Nedregaard B, Sletteberg R, Ringstad G, Eide PK (2020)
Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols
Neuroradiology, 63 (1), 51-61
DOI 10.1007/s003300100881, PubMed 32803338

Halvorsen M, Edeklev CS, Fraser-Green J, Lovland G, Vatnehol SAS, Gjertsen O, Nedregaard B, Sletteberg R, Ringstad G, Eide PK (2020)
Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols
Neuroradiology

Hovden IT, Geier OM, Digernes I, Fuster-Garcia E, Løvland G, Vik-Mo E, Meling TR, Emblem KE (2020)
The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma
Eur J Radiol, 132, 109278
DOI 10.1016/j.ejrad.2020.109278, PubMed 33010685

Jacobsen HH, Sandell T, Jørstad ØK, Moe MC, Ringstad G, Eide PK (2020)
In Vivo Evidence for Impaired Glymphatic Function in the Visual Pathway of Patients With Normal Pressure Hydrocephalus
Invest Ophthalmol Vis Sci, 61 (13), 24
DOI 10.1167/iovs.61.13.24, PubMed 33201186

Jeanmougin M, Håvik AB, Cekaite L, Brandal P, Sveen A, Meling TR, Ågesen TH, Scheie D, Heim S, Lothe RA, Lind GE (2020)
Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
Mol Oncol, 14 (5), 1016-1027
DOI 10.1002/1878-0261.12668, PubMed 32171051

Johnsen MB, Magnusson K, Børte S, Gabrielsen ME, Winsvold BS, Skogholt AH, Thomas L, Storheim K, Hveem K, Zwart JA (2020)
Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study
Osteoarthritis Cartilage, 28 (7), 932-940
DOI 10.1016/j.joca.2020.04.005, PubMed 32360252

Juel BE, Romundstad L, Storm JF, Larsson PG (2020)
Validation of a new approach for distinguishing anesthetized from awake state in patients using directed transfer function applied to raw EEG
J Clin Monit Comput
DOI 10.1007/s10877-020-00603-x, PubMed 33064257

Kierulf-Vieira KS, Sandberg CJ, Waaler J, Lund K, Skaga E, Saberniak BM, Panagopoulos I, Brandal P, Krauss S, Langmoen IA, Vik-Mo EO (2020)
A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061630, PubMed 32575464

Kolnes AJ, Øystese KA, Dahlberg D, Berg-Johnsen J, Niehusmann P, Pahnke J, Bollerslev J, Jørgensen AP (2020)
Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma
Acta Neurochir (Wien), 162 (4), 845-852
DOI 10.1007/s00701-019-04068-z, PubMed 31907611

Kolnes AJ, Øystese KAB, Olarescu NC, Ringstad G, Berg-Johnsen J, Casar-Borota O, Bollerslev J, Jørgensen AP (2020)
FSH Levels Are Related to E-cadherin Expression and Subcellular Location in Nonfunctioning Pituitary Tumors
J Clin Endocrinol Metab, 105 (8)
DOI 10.1210/clinem/dgaa281, PubMed 32421791

König M, Osnes T, Bruland Ø, Sundby Hall K, Bratland Å, Meling TR (2020)
The Role of Adjuvant Treatment in Craniofacial Malignancy: A Critical Review
Front Oncol, 10, 1402
DOI 10.3389/fonc.2020.01402, PubMed 32850452

Kristoffersen ES, Børte S, Hagen K, Zwart JA, Winsvold BS (2020)
Migraine, obesity and body fat distribution - a population-based study
J Headache Pain, 21 (1), 97
DOI 10.1186/s10194-020-01163-w, PubMed 32762643

Kristoffersen ES, Børte S, Hagen K, Zwart JA, Winsvold BS (2020)
Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study
BMJ Open, 10 (11), e040685
DOI 10.1136/bmjopen-2020-040685, PubMed 33208331

Kristoffersen ES, Faiz KW, Sandset EC, Storstein AM, Stefansen S, Winsvold BS, Hansen JM (2020)
Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway
J Headache Pain, 21 (1), 128
DOI 10.1186/s10194-020-01195-2, PubMed 33121445

Kristoffersen ES, Sandset EC, Winsvold BS, Faiz KW, Storstein AM (2020)
Experiences of telemedicine in neurological out-patient clinics during the COVID-19 pandemic
Ann Clin Transl Neurol
DOI 10.1002/acn3.51293, PubMed 33377609

Kural MA, Duez L, Sejer Hansen V, Larsson PG, Rampp S, Schulz R, Tankisi H, Wennberg R, Bibby BM, Scherg M, Beniczky S (2020)
Criteria for defining interictal epileptiform discharges in EEG: A clinical validation study
Neurology, 94 (20), e2139-e2147
DOI 10.1212/WNL.0000000000009439, PubMed 32321764

Kural MA, Tankisi H, Duez L, Sejer Hansen V, Udupi A, Wennberg R, Rampp S, Larsson PG, Schulz R, Beniczky S (2020)
Optimized set of criteria for defining interictal epileptiform EEG discharges
Clin Neurophysiol, 131 (9), 2250-2254
DOI 10.1016/j.clinph.2020.06.026, PubMed 32731161

Larsson C, Groote I, Vardal J, Kleppestø M, Odland A, Brandal P, Due-Tønnessen P, Holme SS, Hope TR, Meling TR, Fosse E, Emblem KE, Bjørnerud A (2020)
Prediction of survival and progression in glioblastoma patients using temporal perfusion changes during radiochemotherapy
Magn Reson Imaging, 68, 106-112
DOI 10.1016/j.mri.2020.01.012, PubMed 32004711

Lashkarivand A, Ringstad G, Eide PK (2020)
Surgery for Brainstem Cavernous Malformations: Association between Preoperative Grade and Postoperative Quality of Life
Oper Neurosurg (Hagerstown), 18 (6), 590-598
DOI 10.1093/ons/opz337, PubMed 31768544

Lashkarivand A, Sorteberg W, Rosseland LA, Sorteberg A (2020)
Survival and outcome in patients with aneurysmal subarachnoid hemorrhage in Glasgow coma score 3-5
Acta Neurochir (Wien), 162 (3), 533-544
DOI 10.1007/s00701-019-04190-y, PubMed 31980948

Latysheva A, Geier OM, Hope TR, Brunetti M, Micci F, Vik-Mo EO, Emblem KE, Server A (2020)
Diagnostic utility of Restriction Spectrum Imaging in the characterization of the peritumoral brain zone in glioblastoma: Analysis of overall and progression-free survival
Eur J Radiol, 132, 109289
DOI 10.1016/j.ejrad.2020.109289, PubMed 33002815

Lemée JM, Corniola MV, Meling TR (2020)
Benefits of re-do surgery for recurrent intracranial meningiomas
Sci Rep, 10 (1), 303
DOI 10.1007/s00701-019-03862-z, PubMed 31941981

Lie MU, Winsvold B, Gjerstad J, Matre D, Pedersen LM, Heuch I, Zwart JA, Nilsen KB (2020)
The association between selected genetic variants and individual differences in experimental pain
Scand J Pain (in press)
DOI 10.1515/sjpain-2020-0091, PubMed 33108341

Llorens A, Funderud I, Blenkmann AO, Lubell J, Foldal M, Leske S, Huster R, Meling TR, Knight RT, Solbakk AK, Endestad T (2020)
Preservation of Interference Effects in Working Memory After Orbitofrontal Damage
Front Hum Neurosci, 13, 445
DOI 10.3389/fnhum.2019.00445, PubMed 31998097

Lundar T, Due-Tønnessen BJ, Frič R, Brandal P, Due-Tønnessen P (2020)
Adult outcome after treatment of pediatric posterior fossa ependymoma: long-term follow-up of a single consecutive institutional series of 22 patients with more than 5 years of survival
J Neurosurg Pediatr, 26 (1), 22-26
DOI 10.3171/2020.1.PEDS19700, PubMed 32217795

Lundar T, Due-Tønnessen BJ, Frič R, Brandal P, Stensvold E, Due-Tønnessen P (2020)
Outcomes in adulthood after neurosurgical treatment of brain tumors in the first 3 years of life: long-term follow-up of a single consecutive institutional series of 97 patients
Childs Nerv Syst
DOI 10.1007/s00381-020-04859-1, PubMed 32814984

Melin E, Eide PK, Ringstad G (2020)
In vivo assessment of cerebrospinal fluid efflux to nasal mucosa in humans
Sci Rep, 10 (1), 14974
DOI 10.1038/s41598-020-72031-5, PubMed 32917953

Mjåset C, Zwart JA, Goedmakers CMW, Smith TR, Solberg TK, Grotle M (2020)
Criteria for success after surgery for cervical radiculopathy-estimates for a substantial amount of improvement in core outcome measures
Spine J, 20 (9), 1413-1421
DOI 10.1016/j.spinee.2020.05.549, PubMed 32502657

Næss I, Galteland P, Skaga NO, Eken T, Helseth E, Ramm-Pettersen J (2020)
The number of patients hospitalized with bicycle injuries is increasing - A cry for better road safety
Accid Anal Prev, 148, 105836
DOI 10.1016/j.aap.2020.105836, PubMed 33171415

Nome T, Herrman H, Lehtimäki K, Egge A, Konglund A, Ramm-Pettersen J, Taubøll E, Dietrichs E (2020)
Direct visual targeting versus preset coordinates for ANT-DBS in epilepsy
Acta Neurol Scand, 142 (1), 23-29
DOI 10.1111/ane.13233, PubMed 32078161

Ringstad G, Eide PK (2020)
Cerebrospinal fluid tracer efflux to parasagittal dura in humans
Nat Commun, 11 (1), 354
DOI 10.3174/ajnr.A4893, PubMed 31953399

Rizvi SAM, Helseth E, Harr ME, Mirzamohammadi J, Rønning P, Mejlænder-Evjensvold M, Linnerud H (2020)
Management and long-term outcome of type II acute odontoid fractures: a population-based consecutive series of 282 patients
Spine J (in press)
DOI 10.1016/j.spinee.2020.11.012, PubMed 33346157

Rizvi SAM, Helseth E, Rønning P, Mirzamohammadi J, Harr ME, Brommeland T, Aarhus M, Høstmælingen CT, Ølstørn H, Rydning PNF, Mejlænder-Evjensvold M, Utheim NC, Linnerud H (2020)
Odontoid fractures: impact of age and comorbidities on surgical decision making
BMC Surg, 20 (1), 236
DOI 10.1186/s12893-020-00893-7, PubMed 33054819

Rogne AG, Müller EG, Udnaes E, Sigurdardottir S, Raudeberg R, Connelly JP, Revheim ME, Hassel B, Dahlberg D (2020)
β-Amyloid may accumulate in the human brain after focal bacterial infection: An 18 F-flutemetamol positron emission tomography study
Eur J Neurol
DOI 10.1111/ene.14622, PubMed 33131195

Skaansar O, Tverdal C, Rønning PA, Skogen K, Brommeland T, Røise O, Aarhus M, Andelic N, Helseth E (2020)
Traumatic brain injury-the effects of patient age on treatment intensity and mortality
BMC Neurol, 20 (1), 376
DOI 10.1186/s12883-020-01943-6, PubMed 33069218

Skodvin TØ, Kloster R, Sorteberg W, Isaksen JG (2020)
Survey of European neurosurgeons' management of unruptured intracranial aneurysms: inconsistent practice and organization
Acta Neurochir (Wien), 163 (1), 113-121
DOI 10.1007/s00701-020-04539-8, PubMed 32870423

Slettebø H, Karic T, Sorteberg A (2020)
Impact of smoking on course and outcome of aneurysmal subarachnoid hemorrhage
Acta Neurochir (Wien), 162 (12), 3117-3128
DOI 10.1007/s00701-020-04506-3, PubMed 32728905

Stensvold E, Stadskleiv K, Myklebust TÅ, Wesenberg F, Helseth E, Bechensteen AG, Brandal P (2020)
Unmet rehabilitation needs in 86% of Norwegian paediatric embryonal brain tumour survivors
Acta Paediatr, 109 (9), 1875-1886
DOI 10.1111/apa.15188, PubMed 31977119

Stubberud J, Løvstad M, Solbakk AK, Schanke AK, Tornås S (2020)
Emotional Regulation Following Acquired Brain Injury: Associations With Executive Functioning in Daily Life and Symptoms of Anxiety and Depression
Front Neurol, 11, 1011
DOI 10.3389/fneur.2020.01011, PubMed 33013668

Taso M, Sommernes JH, Kolstad F, Sundseth J, Bjorland S, Pripp AH, Zwart JA, Brox JI (2020)
A randomised controlled trial comparing the effectiveness of surgical and nonsurgical treatment for cervical radiculopathy
BMC Musculoskelet Disord, 21 (1), 171
DOI 10.1186/s12891-020-3188-6, PubMed 32178655

Tønne E, Due-Tønnessen BJ, Mero IL, Wiig US, Kulseth MA, Vigeland MD, Sheng Y, von der Lippe C, Tveten K, Meling TR, Helseth E, Heimdal KR (2020)
Benefits of clinical criteria and high-throughput sequencing for diagnosing children with syndromic craniosynostosis
Eur J Hum Genet
DOI 10.1038/s41431-020-00788-4, PubMed 33288889

Tønne E, Due-Tønnessen BJ, Wiig U, Stadheim BF, Meling TR, Helseth E, Heimdal KR (2020)
Epidemiology of craniosynostosis in Norway
J Neurosurg Pediatr, 26 (1), 68-75
DOI 10.3171/2020.1.PEDS2051, PubMed 32244202

Tverdal C, Aarhus M, Andelic N, Skaansar O, Skogen K, Helseth E (2020)
Characteristics of traumatic brain injury patients with abnormal neuroimaging in Southeast Norway
Inj Epidemiol, 7 (1), 45
DOI 10.1186/s40621-020-00269-8, PubMed 32867838

Valnes LM, Mitusch SK, Ringstad G, Eide PK, Funke SW, Mardal KA (2020)
Apparent diffusion coefficient estimates based on 24 hours tracer movement support glymphatic transport in human cerebral cortex
Sci Rep, 10 (1), 9176
DOI 10.1038/s41598-020-66042-5, PubMed 32514105

van Wijk RPJ, van Dijck JTJM, Timmers M, van Veen E, Citerio G, Lingsma HF, Maas AIR, Menon DK, Peul WC, Stocchetti N, Kompanje EJO, CENTER-TBI investigators and participants (2020)
Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study
J Crit Care, 59, 6-15
DOI 10.1016/j.jcrc.2020.05.004, PubMed 32485440

Western E, Sorteberg A, Brunborg C, Nordenmark TH (2020)
Prevalence and predictors of fatigue after aneurysmal subarachnoid hemorrhage
Acta Neurochir (Wien), 162 (12), 3107-3116
DOI 10.1007/s00701-020-04538-9, PubMed 32809068

 
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