Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2020 from OUS - Department of Neurosurgery
59 publications found
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Nat Genet, 52 (12), 1303-1313
DOI 10.1038/s41588-020-00725-7, PubMed 33199917
Noise dependency in vascular parameters from combined gradient-echo and spin-echo DSC MRI
Phys Med Biol, 65 (22), 225020
DOI 10.1088/1361-6560/abb71a, PubMed 33200748
Dentoalveolar injuries, bicycling accidents and helmet use in patients referred to a Norwegian Trauma Centre: A 12-year prospective study
Dent Traumatol
DOI 10.1111/edt.12627, PubMed 33220164
Increased occurrence of pathological mitochondria in astrocytic perivascular endfoot processes and neurons of idiopathic intracranial hypertension
J Neurosci Res, 99 (2), 467-480
DOI 10.1002/jnr.24743, PubMed 33105056
<b>Magnetic resonance imaging biomarkers of cerebrospinal fluid tracer dynamics</b> <b>in idiopathic normal pressure hydrocephalus</b>
Brain Commun, 2 (2), fcaa187
DOI 10.1093/braincomms/fcaa187, PubMed 33381757
Mechanisms behind altered pulsatile intracranial pressure in idiopathic normal pressure hydrocephalus: role of vascular pulsatility and systemic hemodynamic variables
Acta Neurochir (Wien), 162 (8), 1803-1813
DOI 10.1007/s00701-020-04423-5, PubMed 32533412
Measuring intracranial pressure by invasive, less invasive or non-invasive means: limitations and avenues for improvement
Fluids Barriers CNS, 17 (1), 34
DOI 10.1186/s12987-020-00195-3, PubMed 32375853
Neuropsychological functions, sleep, and mental health in adults with Klinefelter syndrome
Am J Med Genet C Semin Med Genet, 184 (2), 482-492
DOI 10.1002/ajmg.c.31797, PubMed 32415904
The brain tracks auditory rhythm predictability independent of selective attention
Sci Rep, 10 (1), 7975
DOI 10.1038/s41598-020-64758-y, PubMed 32409738
Sex- and age-specific genetic analysis of chronic back pain
Pain (in press)
DOI 10.1097/j.pain.0000000000002100, PubMed 33021770
Long-term outcome of posterior fossa medulloblastoma in patients surviving more than 20 years following primary treatment in childhood
Sci Rep, 10 (1), 9371
DOI 10.1038/s41598-020-66328-8, PubMed 32523021
MGMT methylation may benefit overall survival in patients with moderately vascularized glioblastomas
Eur. Radiol.
Influence of valproate-induced hyperammonemia on treatment decision in an adult status epilepticus cohort
Epilepsy Behav, 111, 107193
DOI 10.1016/j.yebeh.2020.107193, PubMed 32759060
Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols
Neuroradiology, 63 (1), 51-61
DOI 10.1007/s003300100881, PubMed 32803338
Off-label intrathecal use of gadobutrol: safety study and comparison of administration protocols
Neuroradiology
The impact of EPI-based distortion correction of dynamic susceptibility contrast MRI on cerebral blood volume estimation in patients with glioblastoma
Eur J Radiol, 132, 109278
DOI 10.1016/j.ejrad.2020.109278, PubMed 33010685
In Vivo Evidence for Impaired Glymphatic Function in the Visual Pathway of Patients With Normal Pressure Hydrocephalus
Invest Ophthalmol Vis Sci, 61 (13), 24
DOI 10.1167/iovs.61.13.24, PubMed 33201186
Improved prognostication of glioblastoma beyond molecular subtyping by transcriptional profiling of the tumor microenvironment
Mol Oncol, 14 (5), 1016-1027
DOI 10.1002/1878-0261.12668, PubMed 32171051
Development and validation of a prediction model for incident hand osteoarthritis in the HUNT study
Osteoarthritis Cartilage, 28 (7), 932-940
DOI 10.1016/j.joca.2020.04.005, PubMed 32360252
Validation of a new approach for distinguishing anesthetized from awake state in patients using directed transfer function applied to raw EEG
J Clin Monit Comput
DOI 10.1007/s10877-020-00603-x, PubMed 33064257
A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061630, PubMed 32575464
Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma
Acta Neurochir (Wien), 162 (4), 845-852
DOI 10.1007/s00701-019-04068-z, PubMed 31907611
FSH Levels Are Related to E-cadherin Expression and Subcellular Location in Nonfunctioning Pituitary Tumors
J Clin Endocrinol Metab, 105 (8)
DOI 10.1210/clinem/dgaa281, PubMed 32421791
The Role of Adjuvant Treatment in Craniofacial Malignancy: A Critical Review
Front Oncol, 10, 1402
DOI 10.3389/fonc.2020.01402, PubMed 32850452
Migraine, obesity and body fat distribution - a population-based study
J Headache Pain, 21 (1), 97
DOI 10.1186/s10194-020-01163-w, PubMed 32762643
Caesarean section and the association with migraine: a retrospective register-linked HUNT population cohort study
BMJ Open, 10 (11), e040685
DOI 10.1136/bmjopen-2020-040685, PubMed 33208331
Hospital-based headache care during the Covid-19 pandemic in Denmark and Norway
J Headache Pain, 21 (1), 128
DOI 10.1186/s10194-020-01195-2, PubMed 33121445
Experiences of telemedicine in neurological out-patient clinics during the COVID-19 pandemic
Ann Clin Transl Neurol
DOI 10.1002/acn3.51293, PubMed 33377609
Criteria for defining interictal epileptiform discharges in EEG: A clinical validation study
Neurology, 94 (20), e2139-e2147
DOI 10.1212/WNL.0000000000009439, PubMed 32321764
Optimized set of criteria for defining interictal epileptiform EEG discharges
Clin Neurophysiol, 131 (9), 2250-2254
DOI 10.1016/j.clinph.2020.06.026, PubMed 32731161
Prediction of survival and progression in glioblastoma patients using temporal perfusion changes during radiochemotherapy
Magn Reson Imaging, 68, 106-112
DOI 10.1016/j.mri.2020.01.012, PubMed 32004711
Surgery for Brainstem Cavernous Malformations: Association between Preoperative Grade and Postoperative Quality of Life
Oper Neurosurg (Hagerstown), 18 (6), 590-598
DOI 10.1093/ons/opz337, PubMed 31768544
Survival and outcome in patients with aneurysmal subarachnoid hemorrhage in Glasgow coma score 3-5
Acta Neurochir (Wien), 162 (3), 533-544
DOI 10.1007/s00701-019-04190-y, PubMed 31980948
Diagnostic utility of Restriction Spectrum Imaging in the characterization of the peritumoral brain zone in glioblastoma: Analysis of overall and progression-free survival
Eur J Radiol, 132, 109289
DOI 10.1016/j.ejrad.2020.109289, PubMed 33002815
Benefits of re-do surgery for recurrent intracranial meningiomas
Sci Rep, 10 (1), 303
DOI 10.1007/s00701-019-03862-z, PubMed 31941981
The association between selected genetic variants and individual differences in experimental pain
Scand J Pain (in press)
DOI 10.1515/sjpain-2020-0091, PubMed 33108341
Preservation of Interference Effects in Working Memory After Orbitofrontal Damage
Front Hum Neurosci, 13, 445
DOI 10.3389/fnhum.2019.00445, PubMed 31998097
Adult outcome after treatment of pediatric posterior fossa ependymoma: long-term follow-up of a single consecutive institutional series of 22 patients with more than 5 years of survival
J Neurosurg Pediatr, 26 (1), 22-26
DOI 10.3171/2020.1.PEDS19700, PubMed 32217795
Outcomes in adulthood after neurosurgical treatment of brain tumors in the first 3 years of life: long-term follow-up of a single consecutive institutional series of 97 patients
Childs Nerv Syst
DOI 10.1007/s00381-020-04859-1, PubMed 32814984
In vivo assessment of cerebrospinal fluid efflux to nasal mucosa in humans
Sci Rep, 10 (1), 14974
DOI 10.1038/s41598-020-72031-5, PubMed 32917953
Criteria for success after surgery for cervical radiculopathy-estimates for a substantial amount of improvement in core outcome measures
Spine J, 20 (9), 1413-1421
DOI 10.1016/j.spinee.2020.05.549, PubMed 32502657
The number of patients hospitalized with bicycle injuries is increasing - A cry for better road safety
Accid Anal Prev, 148, 105836
DOI 10.1016/j.aap.2020.105836, PubMed 33171415
Direct visual targeting versus preset coordinates for ANT-DBS in epilepsy
Acta Neurol Scand, 142 (1), 23-29
DOI 10.1111/ane.13233, PubMed 32078161
Cerebrospinal fluid tracer efflux to parasagittal dura in humans
Nat Commun, 11 (1), 354
DOI 10.3174/ajnr.A4893, PubMed 31953399
Management and long-term outcome of type II acute odontoid fractures: a population-based consecutive series of 282 patients
Spine J (in press)
DOI 10.1016/j.spinee.2020.11.012, PubMed 33346157
Odontoid fractures: impact of age and comorbidities on surgical decision making
BMC Surg, 20 (1), 236
DOI 10.1186/s12893-020-00893-7, PubMed 33054819
β-Amyloid may accumulate in the human brain after focal bacterial infection: An 18 F-flutemetamol positron emission tomography study
Eur J Neurol
DOI 10.1111/ene.14622, PubMed 33131195
Traumatic brain injury-the effects of patient age on treatment intensity and mortality
BMC Neurol, 20 (1), 376
DOI 10.1186/s12883-020-01943-6, PubMed 33069218
Survey of European neurosurgeons' management of unruptured intracranial aneurysms: inconsistent practice and organization
Acta Neurochir (Wien), 163 (1), 113-121
DOI 10.1007/s00701-020-04539-8, PubMed 32870423
Impact of smoking on course and outcome of aneurysmal subarachnoid hemorrhage
Acta Neurochir (Wien), 162 (12), 3117-3128
DOI 10.1007/s00701-020-04506-3, PubMed 32728905
Unmet rehabilitation needs in 86% of Norwegian paediatric embryonal brain tumour survivors
Acta Paediatr, 109 (9), 1875-1886
DOI 10.1111/apa.15188, PubMed 31977119
Emotional Regulation Following Acquired Brain Injury: Associations With Executive Functioning in Daily Life and Symptoms of Anxiety and Depression
Front Neurol, 11, 1011
DOI 10.3389/fneur.2020.01011, PubMed 33013668
A randomised controlled trial comparing the effectiveness of surgical and nonsurgical treatment for cervical radiculopathy
BMC Musculoskelet Disord, 21 (1), 171
DOI 10.1186/s12891-020-3188-6, PubMed 32178655
Benefits of clinical criteria and high-throughput sequencing for diagnosing children with syndromic craniosynostosis
Eur J Hum Genet
DOI 10.1038/s41431-020-00788-4, PubMed 33288889
Epidemiology of craniosynostosis in Norway
J Neurosurg Pediatr, 26 (1), 68-75
DOI 10.3171/2020.1.PEDS2051, PubMed 32244202
Characteristics of traumatic brain injury patients with abnormal neuroimaging in Southeast Norway
Inj Epidemiol, 7 (1), 45
DOI 10.1186/s40621-020-00269-8, PubMed 32867838
Apparent diffusion coefficient estimates based on 24 hours tracer movement support glymphatic transport in human cerebral cortex
Sci Rep, 10 (1), 9176
DOI 10.1038/s41598-020-66042-5, PubMed 32514105
Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study
J Crit Care, 59, 6-15
DOI 10.1016/j.jcrc.2020.05.004, PubMed 32485440
Prevalence and predictors of fatigue after aneurysmal subarachnoid hemorrhage
Acta Neurochir (Wien), 162 (12), 3107-3116
DOI 10.1007/s00701-020-04538-9, PubMed 32809068