Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2016 from OUS - Department of Cardiology B (Div Med)
69 publications found
Latitude of the study place and age of the patient are associated with incidence of mediastinitis and microbiology in open-heart surgery: a systematic review and meta-analysis
Clin Epidemiol, 8, 151-63
DOI 10.2147/CLEP.S96107, PubMed 27330329
Predictors of cardiac morbidity in diabetic, new-onset diabetic and non-diabetic high-risk hypertensive patients: The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial
Blood Press, 25 (4), 235-40
DOI 10.3109/08037051.2015.1134071, PubMed 26808585
Apixaban 5 mg Twice Daily and Clinical Outcomes in Patients With Atrial Fibrillation and Advanced Age, Low Body Weight, or High Creatinine: A Secondary Analysis of a Randomized Clinical Trial
JAMA Cardiol, 1 (6), 673-81
DOI 10.1001/jamacardio.2016.1829, PubMed 27463942
Traditional and new composite endpoints in heart failure clinical trials: facilitating comprehensive efficacy assessments and improving trial efficiency
Eur J Heart Fail, 18 (5), 482-9
DOI 10.1002/ejhf.516, PubMed 27071916
Implications of ischaemic area at risk and mode of reperfusion in ST-elevation myocardial infarction
Heart, 102 (7), 527-33
DOI 10.1136/heartjnl-2015-308075, PubMed 26783237
Impact of acute kidney injury on patient outcome in out-of-hospital cardiac arrest: a prospective observational study
Acta Anaesthesiol Scand, 60 (8), 1170-81
DOI 10.1111/aas.12753, PubMed 27306254
Urine biomarkers give early prediction of acute kidney injury and outcome after out-of-hospital cardiac arrest
Crit Care, 20 (1), 314
DOI 10.1186/s13054-016-1503-2, PubMed 27716377
Methods to improve patient recruitment and retention in stroke trials
Int J Stroke, 11 (6), 663-76
DOI 10.1177/1747493016641963, PubMed 27118766
Evaluation of Adherence Should Become an Integral Part of Assessment of Patients With Apparently Treatment-Resistant Hypertension
Hypertension, 68 (2), 297-306
DOI 10.1161/HYPERTENSIONAHA.116.07464, PubMed 27296995
Extracellular mtDNA activates NF-κB via toll-like receptor 9 and induces cell death in cardiomyocytes
Basic Res Cardiol, 111 (4), 42
DOI 10.1007/s00395-016-0553-6, PubMed 27164906
Increased hsCRP is associated with higher risk of aortic valve replacement in patients with aortic stenosis
Scand Cardiovasc J, 50 (3), 138-45
DOI 10.3109/14017431.2016.1151928, PubMed 26911132
Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease
N Engl J Med, 375 (13), 1242-52
DOI 10.1056/NEJMoa1607991, PubMed 27572953
Effects of exercise training on carotid intima-media thickness in patients with type 2 diabetes and coronary artery disease. Influence of carotid plaques
Cardiovasc Diabetol, 15, 13
DOI 10.1186/s12933-016-0336-2, PubMed 26801098
Evolving antithrombotic treatment patterns for patients with newly diagnosed atrial fibrillation
Heart, 103 (4), 307-314
DOI 10.1136/heartjnl-2016-309832, PubMed 27647168
Monocyte-derived circulating microparticles (CD14+, CD14+/CD11b+ and CD14+/CD142+) are related to long-term prognosis for cardiovascular mortality in STEMI patients
Int J Cardiol, 227, 876-881
DOI 10.1016/j.ijcard.2016.11.302, PubMed 27915085
Sample Size in Clinical Cardioprotection Trials Using Myocardial Salvage Index, Infarct Size, or Biochemical Markers as Endpoint
J Am Heart Assoc, 5 (3), e002708
DOI 10.1161/JAHA.115.002708, PubMed 26961520
A new automatic algorithm for quantification of myocardial infarction imaged by late gadolinium enhancement cardiovascular magnetic resonance: experimental validation and comparison to expert delineations in multi-center, multi-vendor patient data
J Cardiovasc Magn Reson, 18 (1), 27
DOI 10.1186/s12968-016-0242-5, PubMed 27145749
Temporal Reduction in Chronotropic Index Predicts Risk of Cardiovascular Death Among Healthy Middle-Aged Men: a 28-Year Follow-Up Study
J Am Heart Assoc, 5 (12)
DOI 10.1161/JAHA.116.004555, PubMed 27881424
Hyperemesis gravidarum and long-term mortality: a population-based cohort study
BJOG, 124 (7), 1080-1087
DOI 10.1111/1471-0528.14454, PubMed 27981734
Radial versus femoral access for percutaneous coronary intervention in ST-elevation myocardial infarction patients treated with fibrinolysis: Results from the randomized routine early invasive clinical trials
Cardiovasc Revasc Med, 17 (5), 295-301
DOI 10.1016/j.carrev.2016.03.008, PubMed 27116940
Troponin and exercise
Int J Cardiol, 221, 609-21
DOI 10.1016/j.ijcard.2016.06.243, PubMed 27420587
Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 × 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol
Eur Heart J, 37 (21), 1671-80
DOI 10.1093/eurheartj/ehw022, PubMed 26903532
Marker of Endothelial Dysfunction Asymmetric Dimethylarginine Is Elevated in HIV Infection but Not Associated With Subclinical Atherosclerosis
J Acquir Immune Defic Syndr, 73 (5), 507-513
DOI 10.1097/QAI.0000000000001148, PubMed 27509250
A nationwide registry study to compare bleeding rates in patients with atrial fibrillation being prescribed oral anticoagulants
Eur Heart J Cardiovasc Pharmacother, 3 (1), 28-36
DOI 10.1093/ehjcvp/pvw031, PubMed 27680880
Initiation of and long-term adherence to secondary preventive drugs after acute myocardial infarction
BMC Cardiovasc Disord, 16, 115
DOI 10.1186/s12872-016-0283-6, PubMed 27246583
Association Between Paradoxical HDL Cholesterol Decrease and Risk of Major Adverse Cardiovascular Events in Patients Initiated on Statin Treatment in a Primary Care Setting
Clin Drug Investig, 36 (3), 225-33
DOI 10.1007/s40261-015-0372-9, PubMed 26718960
Tertiary work-up of apparent treatment-resistant hypertension
Blood Press, 25 (5), 312-8
DOI 10.3109/08037051.2016.1172865, PubMed 27124769
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Tidsskr Nor Laegeforen, 136 (10), 945
DOI 10.4045/tidsskr.16.0318, PubMed 27272379
The Time Course of Markers of Neutrophil Extracellular Traps in Patients Undergoing Revascularisation for Acute Myocardial Infarction or Stable Angina Pectoris
Mediators Inflamm, 2016, 2182358
DOI 10.1155/2016/2182358, PubMed 28074081
Assessment of Right Ventricular Afterload in COPD
COPD, 13 (2), 176-85
DOI 10.3109/15412555.2015.1057275, PubMed 26914261
Comorbidities in Heart Failure: Are There Gender Differences?
Curr Heart Fail Rep, 13 (1), 1-12
DOI 10.1007/s11897-016-0280-1, PubMed 26829930
Troponin I levels in permanent atrial fibrillation-impact of rate control and exercise testing
BMC Cardiovasc Disord, 16, 79
DOI 10.1186/s12872-016-0255-x, PubMed 27142292
Gender differences in the assessment and treatment of myocardial infarction
Tidsskr Nor Laegeforen, 136 (14-15), 1215-22
DOI 10.4045/tidsskr.16.0224, PubMed 27554562
Nifedipine GITS/Candesartan Combination Therapy Lowers Blood Pressure Across Different Baseline Systolic and Diastolic Blood Pressure Categories: DISTINCT Study Subanalyses
J Clin Pharmacol, 56 (9), 1120-9
DOI 10.1002/jcph.712, PubMed 26829251
Fixed-dose combination of nifedipine gastrointestinal therapeutic system and candesartan cilexetil in patients with moderate-to-severe essential hypertension: an open-label, long-term safety and efficacy study
J Clin Pharm Ther, 41 (6), 695-702
DOI 10.1111/jcpt.12451, PubMed 27670639
Unattended Blood Pressure Measurements in the Systolic Blood Pressure Intervention Trial: Implications for Entry and Achieved Blood Pressure Values Compared With Other Trials
Hypertension, 67 (5), 808-12
DOI 10.1161/HYPERTENSIONAHA.116.07257, PubMed 27001295
Treatment of high blood pressure in elderly and octogenarians: European Society of Hypertension statement on blood pressure targets
Blood Press, 25 (6), 333-336
DOI 10.1080/08037051.2016.1236329, PubMed 27644446
Effect of age and sex on efficacy and tolerability of β blockers in patients with heart failure with reduced ejection fraction: individual patient data meta-analysis
BMJ, 353, i1855
DOI 10.1136/bmj.i1855, PubMed 27098105
Serum Fatty Acids, Traditional Risk Factors, and Comorbidity as Related to Myocardial Injury in an Elderly Population with Acute Myocardial Infarction
J Lipids, 2016, 4945720
DOI 10.1155/2016/4945720, PubMed 26989512
Blood pressure-lowering effects of nifedipine/candesartan combinations in high-risk individuals: subgroup analysis of the DISTINCT randomised trial
J Hum Hypertens, 31 (3), 178-188
DOI 10.1038/jhh.2016.54, PubMed 27511476
A Case for Less Intensive Blood Pressure Control: It Matters to Achieve Target Blood Pressure Early and Sustained Below 140/90mmHg
Prog Cardiovasc Dis, 59 (3), 209-218
DOI 10.1016/j.pcad.2016.09.002, PubMed 27619341
Recommendations to improve smoking cessation outcomes from people with lung conditions who smoke
ERJ Open Res, 2 (2)
DOI 10.1183/23120541.00009-2016, PubMed 27730185
Association Between Sitagliptin Use and Heart Failure Hospitalization and Related Outcomes in Type 2 Diabetes Mellitus: Secondary Analysis of a Randomized Clinical Trial
JAMA Cardiol, 1 (2), 126-35
DOI 10.1001/jamacardio.2016.0103, PubMed 27437883
Prognostic Value of Secretoneurin in Patients with Acute Respiratory Failure: Data from the FINNALI Study
Clin Chem, 62 (10), 1380-9
DOI 10.1373/clinchem.2016.258764, PubMed 27540029
NT-proBNP in patients with out-of-hospital cardiac arrest: Results from the FINNRESUSCI Study
Resuscitation, 104, 12-8
DOI 10.1016/j.resuscitation.2016.04.007, PubMed 27109503
Minimal invasive treatment of life-threatening bleeding caused by cardiopulmonary resuscitation-associated liver injury: a case report
J Med Case Rep, 10 (1), 132
DOI 10.1186/s13256-016-0926-3, PubMed 27236329
Associations Between Delirium and Preoperative Cerebrospinal Fluid C-Reactive Protein, Interleukin-6, and Interleukin-6 Receptor in Individuals with Acute Hip Fracture
J Am Geriatr Soc, 64 (7), 1456-63
DOI 10.1111/jgs.14238, PubMed 27341529
The role of levosimendan in acute heart failure complicating acute coronary syndrome: A review and expert consensus opinion
Int J Cardiol, 218, 150-157
DOI 10.1016/j.ijcard.2016.05.009, PubMed 27232927
Effects of long-term exercise training on adipose tissue expression of fractalkine and MCP-1 in patients with type 2 diabetes and stable coronary artery disease: a substudy of a randomized controlled trial
Diabetes Metab Syndr Obes, 9, 55-62
DOI 10.2147/DMSO.S96299, PubMed 27042130
Extent of Myocardium at Risk for Left Anterior Descending Artery, Right Coronary Artery, and Left Circumflex Artery Occlusion Depicted by Contrast-Enhanced Steady State Free Precession and T2-Weighted Short Tau Inversion Recovery Magnetic Resonance Imaging
Circ Cardiovasc Imaging, 9 (7)
DOI 10.1161/CIRCIMAGING.115.004376, PubMed 27412659
Multi-vendor, multicentre comparison of contrast-enhanced SSFP and T2-STIR CMR for determining myocardium at risk in ST-elevation myocardial infarction
Eur Heart J Cardiovasc Imaging, 17 (7), 744-53
DOI 10.1093/ehjci/jew027, PubMed 27002140
Electrocardiographic left atrial abnormalities and risk of incident stroke in hypertensive patients with electrocardiographic left ventricular hypertrophy
J Hypertens, 34 (9), 1831-7
DOI 10.1097/HJH.0000000000000989, PubMed 27254312
Combined Elevated Levels of the Proinflammatory Cytokines IL-18 and IL-12 Are Associated with Clinical Events in Patients with Coronary Artery Disease: An Observational Study
Metab Syndr Relat Disord, 14 (5), 242-8
DOI 10.1089/met.2015.0130, PubMed 27058587
Cigarette smoking represses expression of cytokine IL-12 and its regulator miR-21-An observational study in patients with coronary artery disease
Immunobiology, 222 (2), 169-175
DOI 10.1016/j.imbio.2016.10.007, PubMed 27765464
Management of the hypertensive patient with elevated heart rate: Statement of the Second Consensus Conference endorsed by the European Society of Hypertension
J Hypertens, 34 (5), 813-21
DOI 10.1097/HJH.0000000000000865, PubMed 26982382
Renal Denervation for Treatment of Hypertension: a Second Start and New Challenges
Curr Hypertens Rep, 18 (1), 6
DOI 10.1007/s11906-015-0610-9, PubMed 26739586
Circulating Levels of IL-6 Receptor and gp130 and Long-Term Clinical Outcomes in ST-Elevation Myocardial Infarction
J Am Heart Assoc, 5 (6)
DOI 10.1161/JAHA.115.003014, PubMed 27412895
The 'obesity paradox' in atrial fibrillation: observations from the ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial
Eur Heart J, 37 (38), 2869-2878
DOI 10.1093/eurheartj/ehw124, PubMed 27071819
Sphingosine-1-Phosphate Receptor Agonist Fingolimod Increases Myocardial Salvage and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Porcine Model of Ischemia/Reperfusion
Circulation, 133 (10), 954-66
DOI 10.1161/CIRCULATIONAHA.115.012427, PubMed 26826180
Cardiovascular safety of non-aspirin non-steroidal anti-inflammatory drugs: review and position paper by the working group for Cardiovascular Pharmacotherapy of the European Society of Cardiology
Eur Heart J, 37 (13), 1015-23
DOI 10.1093/eurheartj/ehv505, PubMed 26984863
Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies
RMD Open, 2 (2), e000291
DOI 10.1136/rmdopen-2016-000291, PubMed 27752355
Relationship Between Arterial Access and Outcomes in ST-Elevation Myocardial Infarction With a Pharmacoinvasive Versus Primary Percutaneous Coronary Intervention Strategy: Insights From the STrategic Reperfusion Early After Myocardial Infarction (STREAM) Study
J Am Heart Assoc, 5 (6)
DOI 10.1161/JAHA.116.003559, PubMed 28525886
Relationship of diastolic function to new or persistent electrocardiographic left ventricular hypertrophy
Blood Press, 25 (6), 364-372
DOI 10.1080/08037051.2016.1179514, PubMed 27146272
Relationship between abnormal P-wave terminal force in lead V1 and left ventricular diastolic dysfunction in hypertensive patients: the LIFE study
Blood Press, 26 (2), 94-101
DOI 10.1080/08037051.2016.1215765, PubMed 27601135
Invasive versus conservative strategy in patients aged 80 years or older with non-ST-elevation myocardial infarction or unstable angina pectoris (After Eighty study): an open-label randomised controlled trial
Lancet, 387 (10023), 1057-1065
DOI 10.1016/S0140-6736(15)01166-6, PubMed 26794722
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy
J Clin Invest, 127 (1), 335-348
DOI 10.1172/JCI88353, PubMed 27893464
Automatic segmentation of myocardium at risk from contrast enhanced SSFP CMR: validation against expert readers and SPECT
BMC Med Imaging, 16, 19
DOI 10.1186/s12880-016-0124-1, PubMed 26946139
D-Dimer and prothrombin fragment 1 + 2 in urine and plasma in patients with clinically suspected venous thromboembolism
Blood Coagul Fibrinolysis, 27 (4), 396-400
DOI 10.1097/MBC.0000000000000461, PubMed 26595215
Cost-effectiveness of antiplatelet drugs after percutaneous coronary intervention
Eur Heart J Qual Care Clin Outcomes, 2 (1), 52-57
DOI 10.1093/ehjqcco/qcv023, PubMed 29474586