Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Geriatric Medicine

49 publications found

Aksnes M, Müller EG, Tiiman A, Edwin TH, Terenius L, Revheim ME, Vukojević V, Bogdanović N, Knapskog AB (2020)
Amyloidogenic Nanoplaques in Cerebrospinal Fluid: Relationship to Amyloid Brain Uptake and Clinical Alzheimer's Disease in a Memory Clinic Cohort
J Alzheimers Dis, 77 (2), 831-842
DOI 10.3233/JAD-200237, PubMed 32741818

Aman Y, Ryan B, Torsetnes SB, Knapskog AB, Watne LO, McEwan WA, Fang EF (2020)
Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases
Int Rev Neurobiol, 155, 169-202
DOI 10.1016/bs.irn.2020.02.008, PubMed 32854854

Araujo NB, Nielsen TR, Barca ML, Engedal K, Marinho V, Deslandes AC, Coutinho ES, Laks J (2020)
Brazilian version of the European Cross-Cultural Neuropsychological Test Battery (CNTB-BR): diagnostic accuracy across schooling levels
Braz J Psychiatry, 42 (3), 286-294
DOI 10.1590/1516-4446-2019-0539, PubMed 32130401

Bragstad LK, Hjelle EG, Zucknick M, Sveen U, Thommessen B, Bronken BA, Martinsen R, Kitzmüller G, Mangset M, Kvigne KJ, Hilari K, Lightbody CE, Kirkevold M (2020)
The effects of a dialogue-based intervention to promote psychosocial well-being after stroke: a randomized controlled trial
Clin Rehabil, 34 (8), 1056-1071
DOI 10.1177/0269215520929737, PubMed 32517513

Bragstad LK, Lerdal A, Gay CL, Kirkevold M, Lee KA, Lindberg MF, Skogestad IJ, Hjelle EG, Sveen U, Kottorp A (2020)
Psychometric properties of a short version of Lee Fatigue Scale used as a generic PROM in persons with stroke or osteoarthritis: assessment using a Rasch analysis approach
Health Qual Life Outcomes, 18 (1), 168
DOI 10.1186/s12955-020-01419-8, PubMed 32503548

Elvsåshagen T, Bahrami S, van der Meer D, Agartz I, Alnæs D, Barch DM, Baur-Streubel R, Bertolino A, Beyer MK, Blasi G, Borgwardt S, Boye B, Buitelaar J, Bøen E, Celius EG, Cervenka S, Conzelmann A, Coynel D, Di Carlo P, Djurovic S, Eisenacher S, Espeseth T, Fatouros-Bergman H, Flyckt L, Franke B et al. (2020)
The genetic architecture of human brainstem structures and their involvement in common brain disorders
Nat Commun, 11 (1), 4016
DOI 10.1038/s41467-020-17376-1, PubMed 32782260

Engedal K, Barca ML, Høgh P, Bo Andersen B, Winther Dombernowsky N, Naik M, Gudmundsson TE, Øksengaard AR, Wahlund LO, Snaedal J (2020)
The Power of EEG to Predict Conversion from Mild Cognitive Impairment and Subjective Cognitive Decline to Dementia
Dement Geriatr Cogn Disord, 49 (1), 38-47
DOI 10.1159/000508392, PubMed 32610316

Engelbak Nielsen Z, Eriksson S, Schram Harsløf LB, Petri S, Helgesson G, Mangset M, Godskesen TE (2020)
Are cancer patients better off if they participate in clinical trials? A mixed methods study
BMC Cancer, 20 (1), 401
DOI 10.1186/s12885-020-06916-z, PubMed 32384883

Ernst G, Watne LO, Rostrup M, Neerland BE (2020)
Delirium in patients with hip fracture is associated with increased heart rate variability
Aging Clin Exp Res (in press)
DOI 10.1007/s40520-019-01447-5, PubMed 31916197

Estévez-López F, Mudie K, Wang-Steverding X, Bakken IJ, Ivanovs A, Castro-Marrero J, Nacul L, Alegre J, Zalewski P, Słomko J, Strand EB, Pheby D, Shikova E, Lorusso L, Capelli E, Sekulic S, Scheibenbogen C, Sepúlveda N, Murovska M, Lacerda E (2020)
Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology
J Clin Med, 9 (5)
DOI 10.3390/jcm9051557, PubMed 32455633

Fog AF, Mdala I, Engedal K, Straand J (2020)
Variation between nursing homes in drug use and in drug-related problems
BMC Geriatr, 20 (1), 336
DOI 10.1186/s12877-020-01745-y, PubMed 32907532

Gynnild MN, Aakerøy R, Spigset O, Askim T, Beyer MK, Ihle-Hansen H, Munthe-Kaas R, Knapskog AB, Lydersen S, Naess H, Røsstad TG, Seljeseth YM, Thingstad P, Saltvedt I, Ellekjaer H (2020)
Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke
J Intern Med
DOI 10.1111/joim.13161, PubMed 32743852

Hagberg G, Ihle-Hansen H, Fure B, Thommessen B, Ihle-Hansen H, Øksengård AR, Beyer MK, Wyller TB, Müller EG, Pendlebury ST, Selnes P (2020)
No evidence for amyloid pathology as a key mediator of neurodegeneration post-stroke - a seven-year follow-up study
BMC Neurol, 20 (1), 174
DOI 10.1186/s12883-020-01753-w, PubMed 32384876

Halaas NB, Henjum K, Blennow K, Dakhil S, Idland AV, Nilsson LN, Sederevicius D, Vidal-Piñeiro D, Walhovd KB, Wyller TB, Zetterberg H, Watne LO, Fjell AM (2020)
CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults
Cereb Cortex, 30 (4), 2295-2306
DOI 10.1093/cercor/bhz240, PubMed 31812991

Hamre C, Fure B, Helbostad JL, Wyller TB, Ihle-Hansen H, Vlachos G, Ursin M, Tangen GG (2020)
Balance and Gait After First Minor Ischemic Stroke in People 70 Years of Age or Younger: A Prospective Observational Cohort Study
Phys Ther, 100 (5), 798-806
DOI 10.1093/ptj/pzaa010, PubMed 31944247

Hamre C, Fure B, Helbostad JL, Wyller TB, Ihle-Hansen H, Vlachos G, Ursin MH, Tangen GG (2020)
Impairments in spatial navigation during walking in patients 70 years or younger with mild stroke
Top Stroke Rehabil
DOI 10.1080/10749357.2020.1755814, PubMed 32316862

Hazen J, Vistnes M, Barca ML, Eldholm RS, Persson K, Brækhus A, Saltvedt I, Selbæk G, Engedal K, Knapskog AB (2020)
The Association Between Circulating Inflammatory Markers and the Progression of Alzheimer Disease in Norwegian Memory Clinic Patients With Mild Cognitive Impairment or Dementia
Alzheimer Dis Assoc Disord, 34 (1), 47-53
DOI 10.1097/WAD.0000000000000342, PubMed 31414991

Hellton KH, Cummings J, Vik-Mo AO, Nordrehaug JE, Aarsland D, Selbaek G, Giil LM (2020)
The Truth behind the Zeros: A New Approach to Principal Component Analysis of the Neuropsychiatric Inventory
Multivariate Behav Res
DOI 10.1080/00273171.2020.1736976, PubMed 32329370

Idland AV, Sala-Llonch R, Watne LO, Brækhus A, Hansson O, Blennow K, Zetterberg H, Sørensen Ø, Walhovd KB, Wyller TB, Fjell AM (2020)
Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
Neurobiol Aging, 93, 1-15
DOI 10.1016/j.neurobiolaging.2020.04.002, PubMed 32438258

Ihle-Hansen H, Sandset EC, Hagberg G, Ihle-Hansen H (2020)
Antitrombotisk behandling ved etablert cerebrovaskulær sykdom
Tidsskr Nor Laegeforen, 140 (12)
DOI 10.4045/tidsskr.20.0651, PubMed 32900163

Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK, Hägg S, Athanasiu L, Voyle N, Proitsi P, Witoelar A, Stringer S, Aarsland D, Almdahl IS, Andersen F, Bergh S, Bettella F, Bjornsson S, Brækhus A, Bråthen G, de Leeuw C, Desikan RS, Djurovic S et al. (2020)
Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk
Nat Genet, 52 (3), 354
DOI 10.1038/s41588-019-0573-x, PubMed 32029921

Janssen N, Handels RL, Köhler S, Gonçalves-Pereira M, Marques MJ, Irving K, Hopper L, Bieber A, Orrell M, Selbæk G, Michelet M, Wimo A, Zanetti O, Portolani DM, Woods B, Jelley H, Evers SMAA, Verhey FRJ, Actifcare Consortium (2020)
Profiles of Met and Unmet Needs in People with Dementia According to Caregivers' Perspective: Results from a European Multicenter Study
J Am Med Dir Assoc (in press)
DOI 10.1016/j.jamda.2020.05.009, PubMed 32674953

Kealy J, Murray C, Griffin EW, Lopez-Rodriguez AB, Healy D, Tortorelli LS, Lowry JP, Watne LO, Cunningham C (2020)
Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
J Neurosci, 40 (29), 5681-5696
DOI 10.1523/JNEUROSCI.2876-19.2020, PubMed 32513828

Kimura NRS, Simões JP, Santos RL, Baptista MAT, Portugal MDG, Johannessen A, Barca ML, Engedal K, Laks J, Rodrigues VM, Dourado MCN (2020)
Young- and Late-Onset Dementia: A Comparative Study of Quality of Life, Burden, and Depressive Symptoms in Caregivers
J Geriatr Psychiatry Neurol, 0891988720933355
DOI 10.1177/0891988720933355, PubMed 32552216

Lande A, Fluge Ø, Strand EB, Flåm ST, Sosa DD, Mella O, Egeland T, Saugstad OD, Lie BA, Viken MK (2020)
Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Sci Rep, 10 (1), 5267
DOI 10.1038/s41598-020-62157-x, PubMed 32210306

Larsen KT, Forfang E, Pennlert J, Glader EL, Kruuse C, Wester P, Ihle-Hansen H, Carlsson M, Berge E, Salman RA, Wyller TB, Ronning OM (2020)
STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage: Protocol for a randomised controlled trial
Eur. Stroke J., 2396987320954671

Lee CM, Woodward M, Batty GD, Beiser AS, Bell S, Berr C, Bjertness E, Chalmers J, Clarke R, Dartigues JF, Davis-Plourde K, Debette S, Di Angelantonio E, Feart C, Frikke-Schmidt R, Gregson J, Haan MN, Hassing LB, Hayden KM, Hoevenaar-Blom MP, Kaprio J, Kivimaki M, Lappas G, Larson EB, LeBlanc ES et al. (2020)
Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia
Obes Rev, 21 (4), e12989
DOI 10.1111/obr.12989, PubMed 31898862

Lund-Heimark H, Kjelby E, Mehlum L, Gjestad R, Selbæk G, Kroken RA, Johnsen E, Oedegaard KJ, Mellesdal LS (2020)
Elderly patients with no previous psychiatric history: suicidality and other factors relating to psychiatric acute admissions
BJPsych Open, 6 (4), e63
DOI 10.1192/bjo.2020.45, PubMed 32552924

Mehlum MH, Liestøl K, Kjeldsen SE, Wyller TB, Julius S, Rothwell PM, Mancia G, Parati G, Weber MA, Berge E (2020)
Blood Pressure-Lowering Profiles and Clinical Effects of Angiotensin Receptor Blockers Versus Calcium Channel Blockers
Hypertension, 75 (6), 1584-1592
DOI 10.1161/HYPERTENSIONAHA.119.14443, PubMed 32336236

Michelet M, Lund A, Strand BH, Engedal K, Selbaek G, Bergh S (2020)
Characteristics of patients assessed for cognitive decline in primary healthcare, compared to patients assessed in specialist healthcare
Scand J Prim Health Care, 38 (2), 107-116
DOI 10.1080/02813432.2020.1753334, PubMed 32362213

Munthe-Kaas R, Aam S, Ihle-Hansen H, Lydersen S, Knapskog AB, Wyller TB, Fure B, Thingstad P, Askim T, Beyer MK, Næss H, Seljeseth YM, Ellekjær H, Pendlebury ST, Saltvedt I (2020)
Impact of different methods defining post-stroke neurocognitive disorder: The Nor-COAST study
Alzheimers Dement (N Y), 6 (1), e12000
DOI 10.1002/trc2.12000, PubMed 32211505

Musaeus CS, Engedal K, Høgh P, Jelic V, Khanna AR, Kjaer TW, Mørup M, Naik M, Oeksengaard AR, Santarnecchi E, Snaedal J, Wahlund LO, Waldemar G, Andersen BB (2020)
Changes in the left temporal microstate are a sign of cognitive decline in patients with Alzheimer's disease
Brain Behav, 10 (6), e01630
DOI 10.1002/brb3.1630, PubMed 32338460

Neerland BE, Halaas NB, Idland AV, Henjum K, Blennow K, Zetterberg H, Watne LO (2020)
Fatty Acid-Binding Protein 3 in Cerebrospinal Fluid of Hip Fracture Patients with Delirium
J Alzheimers Dis, 77 (1), 183-190
DOI 10.3233/JAD-200364, PubMed 32804136

Nilsson MH, Tangen GG, Palmqvist S, van Westen D, Mattsson-Carlgren N, Stomrud E, Hansson O (2020)
The effects of tau, amyloid and white matter lesions on mobility, dual tasking and balance in older people
J Gerontol A Biol Sci Med Sci (in press)
DOI 10.1093/gerona/glaa143, PubMed 32506119

Petrova T, Orellana C, Jelic V, Oeksengaard AR, Snaedal J, Høgh P, Andersen BB, Naik M, Engedal K, Wahlund LO, Ferreira D (2020)
Cholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases
Psychiatry Res Neuroimaging, 302, 111099
DOI 10.1016/j.pscychresns.2020.111099, PubMed 32505903

Pålhaugen L, Sudre CH, Tecelao S, Nakling A, Almdahl IS, Kalheim LF, Cardoso MJ, Johnsen SH, Rongve A, Aarsland D, Bjørnerud A, Selnes P, Fladby T (2020)
Brain amyloid and vascular risk are related to distinct white matter hyperintensity patterns
J Cereb Blood Flow Metab, 271678X20957604 (in press)
DOI 10.1177/0271678X20957604, PubMed 32955960

Qureshi T, Bjørkmo M, Nordengen K, Gundersen V, Utheim TP, Watne LO, Storm-Mathisen J, Hassel B, Chaudhry FA (2020)
Slc38a1 Conveys Astroglia-Derived Glutamine into GABAergic Interneurons for Neurotransmitter GABA Synthesis
Cells, 9 (7)
DOI 10.3390/cells9071686, PubMed 32668809

Romskaug R, Skovlund E, Straand J, Molden E, Kersten H, Pitkala KH, Lundqvist C, Wyller TB (2020)
Effect of Clinical Geriatric Assessments and Collaborative Medication Reviews by Geriatrician and Family Physician for Improving Health-Related Quality of Life in Home-Dwelling Older Patients Receiving Polypharmacy: A Cluster Randomized Clinical Trial
JAMA Intern Med, 180 (2), 181-189
DOI 10.1001/jamainternmed.2019.5096, PubMed 31617562

Romskaug R, Wyller TB, Straand J, Kersten H, Molden E (2020)
Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy
Drugs Aging, 37 (6), 425-433
DOI 10.1007/s40266-020-00763-0, PubMed 32346827

Rostoft S, van den Bos F, Pedersen R, Hamaker ME (2020)
Shared decision-making in older patients with cancer - What does the patient want?
J Geriatr Oncol (in press)
DOI 10.1016/j.jgo.2020.08.001, PubMed 32839118

Rostoft S, van Leeuwen B (2020)
Frailty assessment tools and geriatric assessment in older patients with hepatobiliary and pancreatic malignancies
Eur J Surg Oncol (in press)
DOI 10.1016/j.ejso.2020.08.024, PubMed 32933803

Røsvik J, Rokstad AMM (2020)
What are the needs of people with dementia in acute hospital settings, and what interventions are made to meet these needs? A systematic integrative review of the literature
BMC Health Serv Res, 20 (1), 723
DOI 10.1186/s12913-020-05618-3, PubMed 32767987

Sajjad MU, Blennow K, Knapskog AB, Idland AV, Chaudhry FA, Wyller TB, Zetterberg H, Watne LO (2020)
Cerebrospinal Fluid Levels of Interleukin-8 in Delirium, Dementia, and Cognitively Healthy Patients
J Alzheimers Dis, 73 (4), 1363-1372
DOI 10.3233/JAD-190941, PubMed 31929159

Strøm BS, Engedal K, Rokstad AM (2020)
Engagement in Everyday Activities among People Living in Indian Nursing Homes: The Association with Person-Centredness
Dement Geriatr Cogn Dis Extra, 10 (1), 13-26
DOI 10.1159/000505396, PubMed 32158463

Svenøy S, Watne LO, Hestnes I, Westberg M, Madsen JE, Frihagen F (2020)
Results after introduction of a hip fracture care pathway: comparison with usual care
Acta Orthop, 91 (2), 139-145
DOI 10.1080/17453674.2019.1710804, PubMed 31928088

Sverdrup K, Bergh S, Selbæk G, Benth JŠ, Røen IM, Husebo B, Tangen GG (2020)
Trajectories of physical performance in nursing home residents with dementia
Aging Clin Exp Res
DOI 10.1007/s40520-020-01499-y, PubMed 32060802

Tonga JB, Eilertsen DE, Solem IKL, Arnevik EA, Korsnes MS, Ulstein ID (2020)
Effect of Self-Efficacy on Quality of Life in People With Mild Cognitive Impairment and Mild Dementia: The Mediating Roles of Depression and Anxiety
Am J Alzheimers Dis Other Demen, 35, 1533317519885264
DOI 10.1177/1533317519885264, PubMed 31916847

Tonga JB, Šaltytė Benth J, Arnevik EA, Werheid K, Korsnes MS, Ulstein ID (2020)
Managing depressive symptoms in people with mild cognitive impairment and mild dementia with a multicomponent psychotherapy intervention: a randomized controlled trial
Int Psychogeriatr, 1-15 (in press)
DOI 10.1017/S1041610220000216, PubMed 32131911

Aam S, Einstad MS, Munthe-Kaas R, Lydersen S, Ihle-Hansen H, Knapskog AB, Ellekjær H, Seljeseth Y, Saltvedt I (2020)
Post-stroke Cognitive Impairment-Impact of Follow-Up Time and Stroke Subtype on Severity and Cognitive Profile: The Nor-COAST Study
Front Neurol, 11, 699
DOI 10.3389/fneur.2020.00699, PubMed 32765406

 
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