Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2014 from OUS - Section of Preventive Medicine

44 publications found

Aune D, Saugstad OD, Henriksen T, Tonstad S (2014)
Physical activity and the risk of preeclampsia: a systematic review and meta-analysis
Epidemiology, 25 (3), 331-43
DOI 10.1097/EDE.0000000000000036, PubMed 24713878

Aune D, Saugstad OD, Henriksen T, Tonstad S (2014)
Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis
JAMA, 311 (15), 1536-46
DOI 10.1001/jama.2014.2269, PubMed 24737366

Berge KE, Retterstøl K, Romeo S, Pirazzi C, Leren TP (2014)
Type 1 hyperlipoproteinemia due to a novel deletion of exons 3 and 4 in the GPIHBP1 gene
Atherosclerosis, 234 (1), 30-3
DOI 10.1016/j.atherosclerosis.2014.02.005, PubMed 24589565

Boekholdt SM, Hovingh GK, Mora S, Arsenault BJ, Amarenco P, Pedersen TR, LaRosa JC, Waters DD, DeMicco DA, Simes RJ, Keech AC, Colquhoun D, Hitman GA, Betteridge DJ, Clearfield MB, Downs JR, Colhoun HM, Gotto AM, Ridker PM, Grundy SM, Kastelein JJ (2014)
Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials
J Am Coll Cardiol, 64 (5), 485-94
DOI 10.1016/j.jacc.2014.02.615, PubMed 25082583

Chauhan A, Anand T, Kishore J, Danielsen TE, Ingle GK (2014)
Occupational hazard exposure and general health profile of welders in rural Delhi
Indian J Occup Environ Med, 18 (1), 21-6
DOI 10.4103/0019-5278.134953, PubMed 25006312

Cramariuc D, Rogge BP, Lønnebakken MT, Boman K, Bahlmann E, Gohlke-Bärwolf C, Chambers JB, Pedersen TR, Gerdts E (2014)
Sex differences in cardiovascular outcome during progression of aortic valve stenosis
Heart, 101 (3), 209-14
DOI 10.1136/heartjnl-2014-306078, PubMed 25301859

Dahle DO, Jenssen T, Holdaas H, Asberg A, Soveri I, Holme I, Mjøen G, Eide IA, Pihlstrøm H, Dörje C, Halden TA, Hartmann A (2014)
Uric acid and clinical correlates of endothelial function in kidney transplant recipients
Clin Transplant, 28 (10), 1167-76
DOI 10.1111/ctr.12435, PubMed 25124959

Fadl Elmula FE, Hoffmann P, Larstorp AC, Fossum E, Brekke M, Kjeldsen SE, Gjønnæss E, Hjørnholm U, Kjaer VN, Rostrup M, Os I, Stenehjem A, Høieggen A (2014)
Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension
Hypertension, 63 (5), 991-9
DOI 10.1161/HYPERTENSIONAHA.114.03246, PubMed 24591332

Færden K, Lund MB, Mogens Aaløkken T, Eduard W, Søstrand P, Langård S, Kongerud J (2014)
Hypersensitivity pneumonitis in a cluster of sawmill workers: a 10-year follow-up of exposure, symptoms, and lung function
Int J Occup Environ Health, 20 (2), 167-73
DOI 10.1179/2049396714Y.0000000063, PubMed 24999852

Green A, Ramey DR, Emneus M, Iachina M, Stavem K, Bolin K, McNally R, Busch-Sørensen M, Willenheimer R, Egstrup K, Kesäniemi YA, Ray S, Basta N, Kent C, Pedersen TR (2014)
Incidence of cancer and mortality in patients from the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) trial
Am J Cardiol, 114 (10), 1518-22
DOI 10.1016/j.amjcard.2014.08.016, PubMed 25267716

Holme I, Anderssen SA (2014)
[Physical activity, smoking and mortality among men who participated in the Oslo studies of 1972 and 2000]
Tidsskr Nor Laegeforen, 134 (18), 1743-8
DOI 10.4045/tidsskr.14.0073, PubMed 25273247

Holme I, Tonstad S (2014)
Increased predictive ability of BMI but not other risk factors with time in men: 39-year follow-up of total mortality in the Oslo Study
Obes Facts, 7 (5), 311-21
DOI 10.1159/000368567, PubMed 25300406

Holven KB, Narverud I, Lindvig HW, Halvorsen B, Langslet G, Nenseter MS, Ulven SM, Ose L, Aukrust P, Retterstøl K (2014)
Subjects with familial hypercholesterolemia are characterized by an inflammatory phenotype despite long-term intensive cholesterol lowering treatment
Atherosclerosis, 233 (2), 561-7
DOI 10.1016/j.atherosclerosis.2014.01.022, PubMed 24530965

Jander N, Hochholzer W, Kaufmann BA, Bahlmann E, Gerdts E, Boman K, Chambers JB, Nienaber CA, Ray S, Rossebo A, Pedersen TR, Wachtell K, Gohlke-Bärwolf C, Neumann FJ, Minners J (2014)
Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF
Heart, 100 (24), 1946-53
DOI 10.1136/heartjnl-2014-305763, PubMed 25217488

Jennings C, Kotseva K, De Bacquer D, Hoes A, de Velasco J, Brusaferro S, Mead A, Jones J, Tonstad S, Wood D, EUROACTION PLUS Study Group (2014)
Effectiveness of a preventive cardiology programme for high CVD risk persistent smokers: the EUROACTION PLUS varenicline trial
Eur Heart J, 35 (21), 1411-20
DOI 10.1093/eurheartj/ehu051, PubMed 24616337

Kastelein JJ, Robinson JG, Farnier M, Krempf M, Langslet G, Lorenzato C, Gipe DA, Baccara-Dinet MT (2014)
Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: design and rationale of the ODYSSEY FH studies
Cardiovasc Drugs Ther, 28 (3), 281-9
DOI 10.1007/s10557-014-6523-z, PubMed 24842558

Kjeldsen SE, Julius S, Dahlöf B, Weber MA (2014)
Physician (investigator) inertia in apparent treatment-resistant hypertension - insights from large randomized clinical trials. Lennart Hansson Memorial Lecture
Blood Press, 24 (1), 1-6
DOI 10.3109/08037051.2014.946787, PubMed 25162203

Langård S (2014)
Gregorius Agricola memorial lecture: Lung cancer-A work-related disease for 500 years, as predicted by Agricola
J Trace Elem Med Biol, 31, 214-8
DOI 10.1016/j.jtemb.2014.05.010, PubMed 25022333

Leiter LA, Yoon KH, Arias P, Langslet G, Xie J, Balis DA, Millington D, Vercruysse F, Canovatchel W, Meininger G (2014)
Canagliflozin provides durable glycemic improvements and body weight reduction over 104 weeks versus glimepiride in patients with type 2 diabetes on metformin: a randomized, double-blind, phase 3 study
Diabetes Care, 38 (3), 355-64
DOI 10.2337/dc13-2762, PubMed 25205142

Minners J, Gohlke-Baerwolf C, Kaufmann BA, Bahlmann E, Gerdts E, Boman K, Chambers JB, Nienaber CA, Willenheimer R, Wachtell K, Holme I, Pedersen TR, Neumann FJ, Jander N (2014)
Adjusting parameters of aortic valve stenosis severity by body size
Heart, 100 (13), 1024-30
DOI 10.1136/heartjnl-2013-305225, PubMed 24780909

Mundal L, Sarancic M, Ose L, Iversen PO, Borgan JK, Veierød MB, Leren TP, Retterstøl K (2014)
Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010
J Am Heart Assoc, 3 (6), e001236
DOI 10.1161/JAHA.114.001236, PubMed 25468658

Narverud I, Retterstøl K, Iversen PO, Halvorsen B, Ueland T, Ulven SM, Ose L, Aukrust P, Veierød MB, Holven KB (2014)
Markers of atherosclerotic development in children with familial hypercholesterolemia: a literature review
Atherosclerosis, 235 (2), 299-309
DOI 10.1016/j.atherosclerosis.2014.05.917, PubMed 24908240

Neldam S, Schumacher H, Kjeldsen SE, Neutel JM (2014)
Telmisartan in combination with hydrochlorothiazide 12.5 mg for the management of patients with hypertension
Curr Med Res Opin, 30 (9), 1715-24
DOI 10.1185/03007995.2014.924912, PubMed 24834808

Persu A, Azizi M, Jin Y, Volz S, Rosa J, Fadl Elmula FE, Pechere-Bertschi A, Burnier M, Mark PB, Elvan A, Renkin J, Sapoval M, Kahan T, Kjeldsen S, Staessen JA, European Network COordinating research on Renal Denervation (ENCOReD) consortium (2014)
Hyperresponders vs. nonresponder patients after renal denervation: do they differ?
J Hypertens, 32 (12), 2422-7; discussion 2427
DOI 10.1097/HJH.0000000000000347, PubMed 25375391

Persu A, Jin Y, Baelen M, Vink E, Verloop WL, Schmidt B, Blicher MK, Severino F, Wuerzner G, Taylor A, Pechère-Bertschi A, Jokhaji F, Fadl Elmula FE, Rosa J, Czarnecka D, Ehret G, Kahan T, Renkin J, Widimsky J, Jacobs L, Spiering W, Burnier M, Mark PB, Menne J, Olsen MH et al. (2014)
Eligibility for renal denervation: experience at 11 European expert centers
Hypertension, 63 (6), 1319-25
DOI 10.1161/HYPERTENSIONAHA.114.03194, PubMed 24664290

Persu A, Jin Y, Fadl Elmula FE, Jacobs L, Renkin J, Kjeldsen S (2014)
Renal denervation after Symplicity HTN-3: an update
Curr Hypertens Rep, 16 (8), 460
DOI 10.1007/s11906-014-0460-x, PubMed 24913923

Pihlstrøm H, Mjøen G, Dahle DO, Pilz S, Midtvedt K, März W, Abedini S, Holme I, Fellström B, Jardine A, Holdaas H (2014)
Symmetric dimethylarginine as predictor of graft loss and all-cause mortality in renal transplant recipients
Transplantation, 98 (11), 1219-25
DOI 10.1097/TP.0000000000000205, PubMed 24999963

Rogge BP, Gerdts E, Cramariuc D, Bahlmann E, Jander N, Gohlke-Bärwolf C, Pedersen TR, Lønnebakken MT (2014)
Impact of obesity and nonobesity on grading the severity of aortic valve stenosis
Am J Cardiol, 113 (9), 1532-5
DOI 10.1016/j.amjcard.2014.01.429, PubMed 24630788

Rollefstad S, Ikdahl E, Hisdal J, Kvien TK, Pedersen TR, Holme I, Semb AG (2014)
Systemic inflammation in patients with inflammatory joint diseases does not influence statin dose needed to obtain LDL cholesterol goal in cardiovascular prevention
Ann Rheum Dis, 74 (8), 1544-50
DOI 10.1136/annrheumdis-2013-204636, PubMed 24699940

Raal FJ, Giugliano RP, Sabatine MS, Koren MJ, Langslet G, Bays H, Blom D, Eriksson M, Dent R, Wasserman SM, Huang F, Xue A, Albizem M, Scott R, Stein EA (2014)
Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,300 patients in 4 phase II trials
J Am Coll Cardiol, 63 (13), 1278-1288
DOI 10.1016/j.jacc.2014.01.006, PubMed 24509273

Raal FJ, Stein EA, Dufour R, Turner T, Civeira F, Burgess L, Langslet G, Scott R, Olsson AG, Sullivan D, Hovingh GK, Cariou B, Gouni-Berthold I, Somaratne R, Bridges I, Scott R, Wasserman SM, Gaudet D, RUTHERFORD-2 Investigators (2014)
PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial
Lancet, 385 (9965), 331-40
DOI 10.1016/S0140-6736(14)61399-4, PubMed 25282519

Sandset EC, Berge E, Kjeldsen SE, Julius S, Holzhauer B, Krarup LH, Hua TA (2014)
Heart rate as a predictor of stroke in high-risk, hypertensive patients with previous stroke or transient ischemic attack
J Stroke Cerebrovasc Dis, 23 (10), 2814-8
DOI 10.1016/j.jstrokecerebrovasdis.2014.07.009, PubMed 25304725

Sandvik A, Klingen TA, Langård S (2014)
Sinonasal adenoid cystic carcinoma following formaldehyde exposure in the operating theatre
J Occup Med Toxicol, 9 (1), 43
DOI 10.1186/s12995-014-0043-4, PubMed 25550707

Sattar NA, Ginsberg H, Ray K, Chapman MJ, Arca M, Averna M, Betteridge DJ, Bhatnagar D, Bilianou E, Carmena R, Ceška R, Corsini A, Erbel R, Flynn PD, Garcia-Moll X, Gumprecht J, Ishibashi S, Jambart S, Kastelein JJ, Maher V, da Silva PM, Masana L, Odawara M, Pedersen TR, Rotella CM et al. (2014)
The use of statins in people at risk of developing diabetes mellitus: evidence and guidance for clinical practice
Atheroscler Suppl, 15 (1), 1-15
DOI 10.1016/j.atherosclerosissup.2014.04.001, PubMed 24840509

Sjouke B, Langslet G, Ceska R, Nicholls SJ, Nissen SE, Öhlander M, Ladenson PW, Olsson AG, Hovingh GK, Kastelein JJ (2014)
Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study
Lancet Diabetes Endocrinol, 2 (6), 455-63
DOI 10.1016/S2213-8587(14)70006-3, PubMed 24731671

Sletner L, Jenum AK, Mørkrid K, Vangen S, Holme IM, Birkeland KI, Nakstad B (2014)
Maternal life course socio-economic position and offspring body composition at birth in a multi-ethnic population
Paediatr Perinat Epidemiol, 28 (5), 445-54
DOI 10.1111/ppe.12137, PubMed 25060595

STABILITY Investigators, White HD, Held C, Stewart R, Tarka E, Brown R, Davies RY, Budaj A, Harrington RA, Steg PG, Ardissino D, Armstrong PW, Avezum A, Aylward PE, Bryce A, Chen H, Chen MF, Corbalan R, Dalby AJ, Danchin N, De Winter RJ, Denchev S, Diaz R, Elisaf M, Flather MD et al. (2014)
Darapladib for preventing ischemic events in stable coronary heart disease
N Engl J Med, 370 (18), 1702-11
DOI 10.1056/NEJMoa1315878, PubMed 24678955

Svendsen M, Tonstad S, Heggen E, Pedersen TR, Seljeflot I, Bøhn SK, Bastani NE, Blomhoff R, Holme IM, Klemsdal TO (2014)
The effect of kiwifruit consumption on blood pressure in subjects with moderately elevated blood pressure: a randomized, controlled study
Blood Press, 24 (1), 48-54
DOI 10.3109/08037051.2014.976979, PubMed 25483553

Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JE, Shah T, Sofat R, Stender S, Johnson PC, Scott RA, Leusink M, Verweij N, Sharp SJ, Guo Y, Giambartolomei C, Chung C, Peasey A, Amuzu A, Li K, Palmen J, Howard P, Cooper JA, Drenos F, Li YR, Lowe G et al. (2014)
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
Lancet, 385 (9965), 351-61
DOI 10.1016/S0140-6736(14)61183-1, PubMed 25262344

Sørensen H, Fadl Elmula FE, Kjeldsen SE, Brekke M, Gjønnæss E, Hjørnholm U, Kjær VN, Rostrup M, Fossum E, Os I, Stenehjem A, Høieggen A, Hoffmann P (2014)
[Renal sympathetic denervation in treatment-resistant hypertension]
Tidsskr Nor Laegeforen, 134 (1), 32-6
DOI 10.4045/tidsskr.13.0276, PubMed 24429753

Tonstad S, Gustavsson G, Kruse E, Walmsley JM, Westin Å (2014)
Symptoms of nicotine toxicity in subjects achieving high cotinine levels during nicotine replacement therapy
Nicotine Tob Res, 16 (9), 1266-71
DOI 10.1093/ntr/ntu076, PubMed 24852574

Versmissen J, Oosterveer DM, Yazdanpanah M, Dehghan A, Hólm H, Erdman J, Aulchenko YS, Thorleifsson G, Schunkert H, Huijgen R, Vongpromek R, Uitterlinden AG, Defesche JC, van Duijn CM, Mulder M, Dadd T, Karlsson HD, Ordovas J, Kindt I, Jarman A, Hofman A, van Vark-van der Zee L, Blommesteijn-Touw AC, Kwekkeboom J, Liem AH et al. (2014)
Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach
Eur J Hum Genet, 23 (3), 381-7
DOI 10.1038/ejhg.2014.101, PubMed 24916650

Voie Ø, Borander AK, Sikkeland LI, Grahnstedt S, Johnsen A, Danielsen TE, Longva K, Kongerud J (2014)
Health effects after firing small arms comparing leaded and unleaded ammunition
Inhal Toxicol, 26 (14), 873-9
DOI 10.3109/08958378.2014.970783, PubMed 25373830

Vuorio A, Kuoppala J, Kovanen PT, Humphries SE, Tonstad S, Wiegman A, Drogari E (2014)
Statins for children with familial hypercholesterolemia
Cochrane Database Syst Rev (7), CD006401
DOI 10.1002/14651858.CD006401.pub3, PubMed 25054950

 
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