Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2018 from OUS - Psychosis Research (NORMENT)
94 publications found
Expression of TCN1 in Blood is Negatively Associated with Verbal Declarative Memory Performance
Sci Rep, 8 (1), 12654
DOI 10.1038/s41598-018-30898-5, PubMed 30139959
Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents
JAMA Psychiatry, 75 (3), 287-295
DOI 10.1001/jamapsychiatry.2017.4277, PubMed 29365026
Association of Gestational Age at Birth With Symptoms of Attention-Deficit/Hyperactivity Disorder in Children
JAMA Pediatr, 172 (8), 749-756
DOI 10.1001/jamapediatrics.2018.1315, PubMed 29946656
Trauma-related altered states of consciousness in post-traumatic stress disorder patients with or without comorbid dissociative disorders
Eur J Psychotraumatol, 9 (1), 1544025
DOI 10.1080/20008198.2018.1544025, PubMed 30455853
Recently evolved human-specific methylated regions are enriched in schizophrenia signals
BMC Evol Biol, 18 (1), 63
DOI 10.1186/s12862-018-1177-2, PubMed 29747567
Analysis of differentially methylated regions in great apes and extinct hominids provides support for the evolutionary hypothesis of schizophrenia
Schizophr Res, 206, 209-216
DOI 10.1016/j.schres.2018.11.025, PubMed 30545758
Areas of uncertainties and unmet needs in bipolar disorders: clinical and research perspectives
Lancet Psychiatry, 5 (11), 930-939
DOI 10.1016/S2215-0366(18)30253-0, PubMed 30146246
Vitamin D levels, brain volume, and genetic architecture in patients with psychosis
PLoS One, 13 (8), e0200250
DOI 10.1371/journal.pone.0200250, PubMed 30142216
Cross-tissue eQTL enrichment of associations in schizophrenia
PLoS One, 13 (9), e0202812
DOI 10.1371/journal.pone.0202812, PubMed 30188921
CXCR4 involvement in neurodegenerative diseases
Transl Psychiatry, 8 (1), 73
DOI 10.1038/s41398-017-0049-7, PubMed 29636460
Analysis of shared heritability in common disorders of the brain
Science, 360 (6395)
DOI 10.1126/science.aap8757, PubMed 29930110
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
PLoS Med, 15 (1), e1002487
DOI 10.1371/journal.pmed.1002487, PubMed 29315334
Validity of the Birchwood insight scale in patients with schizophrenia spectrum- and bipolar disorders
Psychiatry Res, 272, 715-722
DOI 10.1016/j.psychres.2018.12.072, PubMed 30832191
Reduced heart rate variability in a treatment-seeking early psychosis sample
Psychiatry Res, 269, 293-300
DOI 10.1016/j.psychres.2018.08.068, PubMed 30172186
Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories
Eur J Hum Genet, 26 (7), 1049-1059
DOI 10.1038/s41431-018-0134-2, PubMed 29700391
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Nat Commun, 9 (1), 2098
DOI 10.1038/s41467-018-04362-x, PubMed 29844566
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Nat Genet, 51 (1), 63-75
DOI 10.1038/s41588-018-0269-7, PubMed 30478444
An association between YKL-40 and type 2 diabetes in psychotic disorders
Acta Psychiatr Scand, 139 (1), 37-45
DOI 10.1111/acps.12971, PubMed 30328100
Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study
Int J Bipolar Disord, 6 (1), 19
DOI 10.1186/s40345-018-0128-6, PubMed 30198055
Cerebral blood flow changes after a day of wake, sleep, and sleep deprivation
Neuroimage, 186, 497-509
DOI 10.1016/j.neuroimage.2018.11.032, PubMed 30471387
Large social cognitive impairments characterize homicide offenders with schizophrenia
Psychiatry Res, 272, 209-215
DOI 10.1016/j.psychres.2018.12.087, PubMed 30590274
Impaired neuropsychological profile in homicide offenders with schizophrenia
Compr Psychiatry, 85, 55-60
DOI 10.1016/j.comppsych.2018.06.002, PubMed 29981505
Reliability and validity of the self-report version of the apathy evaluation scale in first-episode Psychosis: Concordance with the clinical version at baseline and 12 months follow-up
Psychiatry Res, 267, 140-147
DOI 10.1016/j.psychres.2018.05.065, PubMed 29906681
Williams Syndrome neuroanatomical score associates with GTF2IRD1 in large-scale magnetic resonance imaging cohorts: a proof of concept for multivariate endophenotypes
Transl Psychiatry, 8 (1), 114
DOI 10.1038/s41398-018-0166-y, PubMed 29884845
Beyond heritability: improving discoverability in imaging genetics
Hum Mol Genet, 27 (R1), R22-R28
DOI 10.1093/hmg/ddy082, PubMed 29522091
Imaging Violence in Schizophrenia: A Systematic Review and Critical Discussion of the MRI Literature
Front Psychiatry, 9, 333
DOI 10.3389/fpsyt.2018.00333, PubMed 30083111
Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum
Am J Hum Genet, 102 (6), 1204-1211
DOI 10.1016/j.ajhg.2018.05.002, PubMed 29861106
Depression and functioning are important to subjective quality of life after a first episode psychosis
Compr Psychiatry, 86, 107-114
DOI 10.1016/j.comppsych.2018.07.014, PubMed 30114656
Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders
Psychiatry Res Neuroimaging, 282, 55-63
DOI 10.1016/j.pscychresns.2018.10.001, PubMed 30415175
Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders
Eur Arch Psychiatry Clin Neurosci, 269 (7), 795-802
DOI 10.1007/s00406-018-0897-z, PubMed 29721726
Vitamin D, Folate and the Intracranial Volume in Schizophrenia and Bipolar Disorder and Healthy Controls
Sci Rep, 8 (1), 10817
DOI 10.1038/s41598-018-29141-y, PubMed 30018414
Chasing Animals With Split Attention: Are Animals Prioritized in Visual Tracking?
Iperception, 9 (5), 2041669518795932
DOI 10.1177/2041669518795932, PubMed 30202509
Neuroimaging hippocampal subfields in schizophrenia and bipolar disorder: A systematic review and meta-analysis
J Psychiatr Res, 104, 217-226
DOI 10.1016/j.jpsychires.2018.08.012, PubMed 30107268
Within-Network Connectivity in the Salience Network After Attention Bias Modification Training in Residual Depression: Report From a Preregistered Clinical Trial
Front Hum Neurosci, 12, 508
DOI 10.3389/fnhum.2018.00508, PubMed 30622463
Cardio-respiratory fitness is associated with a verbal factor across cognitive domains in schizophrenia
Schizophr Res, 206, 157-162
DOI 10.1016/j.schres.2018.11.033, PubMed 30528313
The right to a health-promoting diet for people with intellectual disabilities
Tidsskr Nor Laegeforen, 138 (2)
DOI 10.4045/tidsskr.17.0985, PubMed 29357630
Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder
Transl Psychiatry, 8 (1), 55
DOI 10.1038/s41398-018-0102-1, PubMed 29507296
Attenuated Notch signaling in schizophrenia and bipolar disorder
Sci Rep, 8 (1), 5349
DOI 10.1038/s41598-018-23703-w, PubMed 29593239
Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder
Transl Psychiatry, 8 (1), 210
DOI 10.1038/s41398-018-0175-x, PubMed 30297702
Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives
Sleep, 41 (10)
DOI 10.1093/sleep/zsy145, PubMed 30016530
Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum
JAMA Neurol, 75 (7), 860-875
DOI 10.1001/jamaneurol.2018.0372, PubMed 29630712
Combining Polygenic Hazard Score With Volumetric MRI and Cognitive Measures Improves Prediction of Progression From Mild Cognitive Impairment to Alzheimer's Disease
Front Neurosci, 12, 260
DOI 10.3389/fnins.2018.00260, PubMed 29760643
Revisiting Antipsychotic Drug Actions Through Gene Networks Associated With Schizophrenia
Am J Psychiatry, 175 (7), 674-682
DOI 10.1176/appi.ajp.2017.17040410, PubMed 29495895
Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence
eNeuro, 5 (4)
DOI 10.1523/ENEURO.0092-18.2018, PubMed 30073200
An augmented aging process in brain white matter in HIV
Hum Brain Mapp, 39 (6), 2532-2540
DOI 10.1002/hbm.24019, PubMed 29488278
In Vivo Two-Photon Voltage Imaging with Sulfonated Rhodamine Dyes
ACS Cent Sci, 4 (10), 1371-1378
DOI 10.1021/acscentsci.8b00422, PubMed 30410975
Psychedelic drugs in the treatment of anxiety, depression and addiction
Tidsskr Nor Laegeforen, 138 (18)
DOI 10.4045/tidsskr.17.1110, PubMed 30421744
A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework
BMC Genomics, 19 (1), 494
DOI 10.1186/s12864-018-4859-7, PubMed 29940862
A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia
Am J Med Genet B Neuropsychiatr Genet, 177 (4), 454-467
DOI 10.1002/ajmg.b.32634, PubMed 29704319
Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex
Sci Rep, 8 (1), 13373
DOI 10.1038/s41598-018-31075-4, PubMed 30190613
Protocol for the Individual Placement and Support (IPS) in Pain Trial: A randomized controlled trial investigating the effectiveness of IPS for patients with chronic pain
BMC Musculoskelet Disord, 19 (1), 47
DOI 10.1186/s12891-018-1962-5, PubMed 29433493
Use of an Alzheimer's disease polygenic risk score to identify mild cognitive impairment in adults in their 50s
Mol Psychiatry, 24 (3), 421-430
DOI 10.1038/s41380-018-0030-8, PubMed 29487403
Consequences of persistent depression and apathy in first-episode psychosis - A one-year follow-up study
Compr Psychiatry, 86, 60-66
DOI 10.1016/j.comppsych.2018.07.015, PubMed 30081208
Data-Driven Clustering Reveals a Link Between Symptoms and Functional Brain Connectivity in Depression
Biol Psychiatry Cogn Neurosci Neuroimaging, 4 (1), 16-26
DOI 10.1016/j.bpsc.2018.05.005, PubMed 29980494
Ocular signatures of proactive versus reactive cognitive control in young adults
Cogn Affect Behav Neurosci, 18 (5), 1049-1063
DOI 10.3758/s13415-018-0621-5, PubMed 29992484
Isotropically weighted intravoxel incoherent motion brain imaging at 7T
Magn Reson Imaging, 57, 124-132
DOI 10.1016/j.mri.2018.11.007, PubMed 30472300
Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations
Bipolar Disord, 20 (7), 647-657
DOI 10.1111/bdi.12627, PubMed 29441665
Treatment outcomes for anorexia nervosa: a systematic review and meta-analysis of randomized controlled trials
Psychol Med, 49 (4), 535-544
DOI 10.1017/S0033291718002088, PubMed 30101734
Probing Brain Developmental Patterns of Myelination and Associations With Psychopathology in Youths Using Gray/White Matter Contrast
Biol Psychiatry, 85 (5), 389-398
DOI 10.1016/j.biopsych.2018.09.027, PubMed 30447910
Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group
Mol Psychiatry, 25 (9), 2130-2143
DOI 10.1038/s41380-018-0228-9, PubMed 30171211
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Nat Genet, 50 (3), 381-389
DOI 10.1038/s41588-018-0059-2, PubMed 29483656
Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectives
Ther Deliv, 9 (7), 515-525
DOI 10.4155/tde-2018-0002, PubMed 29943688
Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study
Neuropsychopharmacology, 44 (2), 306-313
DOI 10.1038/s41386-018-0241-3, PubMed 30323359
Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men
Horm Behav, 102, 85-92
DOI 10.1016/j.yhbeh.2018.05.004, PubMed 29750971
Bayesian alternatives for common null-hypothesis significance tests in psychiatry: a non-technical guide using JASP
BMC Psychiatry, 18 (1), 178
DOI 10.1186/s12888-018-1761-4, PubMed 29879931
Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry
PeerJ, 6, e5908
DOI 10.7717/peerj.5908, PubMed 30533290
Cardiometabolic risk factors, physical activity and psychiatric status in patients in long-term psychiatric inpatient departments
Nord J Psychiatry, 72 (4), 296-302
DOI 10.1080/08039488.2018.1449012, PubMed 29523041
Using motivational techniques to reduce cardiometabolic risk factors in long term psychiatric inpatients: a naturalistic interventional study
BMC Psychiatry, 18 (1), 255
DOI 10.1186/s12888-018-1832-6, PubMed 30111298
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Nat Genet, 50 (7), 912-919
DOI 10.1038/s41588-018-0152-6, PubMed 29942086
Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts
BMJ, 360, j5757
DOI 10.1136/bmj.j5757, PubMed 29321194
Self-rated disability in first treated episode of psychosis: A 1-year follow-up study
Compr Psychiatry, 85, 48-54
DOI 10.1016/j.comppsych.2018.06.004, PubMed 29981504
Thalamo-cortical functional connectivity in schizophrenia and bipolar disorder
Brain Imaging Behav, 12 (3), 640-652
DOI 10.1007/s11682-017-9714-y, PubMed 28444556
How can genetics help understand the relationship between cognitive dysfunction and schizophrenia?
Scand J Psychol, 59 (1), 26-31
DOI 10.1111/sjop.12407, PubMed 29356008
Genetic Overlap Between Schizophrenia and Volumes of Hippocampus, Putamen, and Intracranial Volume Indicates Shared Molecular Genetic Mechanisms
Schizophr Bull, 44 (4), 854-864
DOI 10.1093/schbul/sbx148, PubMed 29136250
Psychiatric genetics and the structure of psychopathology
Mol Psychiatry, 24 (3), 409-420
DOI 10.1038/s41380-017-0010-4, PubMed 29317742
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia
Mol Psychiatry, 25 (3), 584-602
DOI 10.1038/s41380-018-0118-1, PubMed 30283035
Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis
Mult Scler, 25 (5), 687-698
DOI 10.1177/1352458518765671, PubMed 29542336
Enrichment of genetic markers of recent human evolution in educational and cognitive traits
Sci Rep, 8 (1), 12585
DOI 10.1038/s41598-018-30387-9, PubMed 30135563
Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes
Sci Rep, 8 (1), 6915
DOI 10.1038/s41598-018-25280-4, PubMed 29720671
Stability in basic self-disturbances and diagnosis in a first treated psychosis: A seven year follow-up study
Schizophr Res, 202, 274-280
DOI 10.1016/j.schres.2018.07.011, PubMed 30007869
Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays
Nat Commun, 9 (1), 2035
DOI 10.1038/s41467-018-04457-5, PubMed 29789548
White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging
Sci Rep, 8 (1), 14129
DOI 10.1038/s41598-018-32355-9, PubMed 30237410
Metacognitive Aspects of Executive Function Are Highly Associated with Social Functioning on Parent-Rated Measures in Children with Autism Spectrum Disorder
Front Behav Neurosci, 11, 258
DOI 10.3389/fnbeh.2017.00258, PubMed 29375332
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes
Mol Psychiatry, 25 (11), 3053-3065
DOI 10.1038/s41380-018-0262-7, PubMed 30279459
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
Biol Psychiatry, 84 (9), 644-654
DOI 10.1016/j.biopsych.2018.04.023, PubMed 29960671
The interactive effect of autism and psychosis severity on theory of mind and functioning in schizophrenia
Neuropsychology, 33 (2), 195-202
DOI 10.1037/neu0000499, PubMed 30346197
Emotion perception, non-social cognition and symptoms as predictors of theory of mind in schizophrenia
Compr Psychiatry, 85, 1-7
DOI 10.1016/j.comppsych.2018.05.002, PubMed 29906670
Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication
J Psychiatr Res, 106, 74-81
DOI 10.1016/j.jpsychires.2018.09.014, PubMed 30292780
Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort
Hum Mol Genet, 27 (4), 732-741
DOI 10.1093/hmg/ddx424, PubMed 29228364
Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Sci Rep, 8 (1), 18088
DOI 10.1038/s41598-018-36429-6, PubMed 30591712
Mapping the Heterogeneous Phenotype of Schizophrenia and Bipolar Disorder Using Normative Models
JAMA Psychiatry, 75 (11), 1146-1155
DOI 10.1001/jamapsychiatry.2018.2467, PubMed 30304337
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Nat Genet, 50 (5), 668-681
DOI 10.1038/s41588-018-0090-3, PubMed 29700475
Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals
Transl Psychiatry, 8 (1), 103
DOI 10.1038/s41398-018-0151-5, PubMed 29795193
Identification of shared genetic variants between schizophrenia and lung cancer
Sci Rep, 8 (1), 674
DOI 10.1038/s41598-017-16481-4, PubMed 29330379