Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2014 from OUS - Psychosis Research (NORMENT & KG Jebsen)

57 publications found

Alnæs D, Sneve MH, Espeseth T, Endestad T, van de Pavert SH, Laeng B (2014)
Pupil size signals mental effort deployed during multiple object tracking and predicts brain activity in the dorsal attention network and the locus coeruleus
J Vis, 14 (4)
DOI 10.1167/14.4.1, PubMed 24692319

Andreassen OA, Harbo HF, Wang Y, Thompson WK, Schork AJ, Mattingsdal M, Zuber V, Bettella F, Ripke S, Kelsoe JR, Kendler KS, O'Donovan MC, Sklar P, Psychiatric Genomics Consortium (PGC) Bipolar Disorder and Schizophrenia Work Groups, International Multiple Sclerosis Genetics Consortium (IMSGC), McEvoy LK, Desikan RS, Lie BA, Djurovic S, Dale AM (2014)
Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci
Mol Psychiatry, 20 (2), 207-14
DOI 10.1038/mp.2013.195, PubMed 24468824

Andreassen OA, McEvoy LK, Thompson WK, Wang Y, Reppe S, Schork AJ, Zuber V, Barrett-Connor E, Gautvik K, Aukrust P, Karlsen TH, Djurovic S, Desikan RS, Dale AM, International Consortium for Blood Pressure Genome-Wide Association Studies, Genetic Factors for Osteoporosis Consortium (2014)
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes
Hypertension, 63 (4), 819-26
DOI 10.1161/HYPERTENSIONAHA.113.02077, PubMed 24396023

Barder HE, Sundet K, Rund BR, Evensen J, Haahr U, ten Velden Hegelstad W, Joa I, Johannessen JO, Langeveld J, Larsen TK, Melle I, Opjordsmoen S, Røssberg JI, Simonsen E, Vaglum P, McGlashan T, Friis SP (2014)
10 year course of IQ in first-episode psychosis: relationship between duration of psychosis and long-term intellectual trajectories
Psychiatry Res, 225 (3), 515-21
DOI 10.1016/j.psychres.2014.11.054, PubMed 25535007

Bauer M, Glenn T, Alda M, Andreassen OA, Angelopoulos E, Ardau R, Baethge C, Bauer R, Bellivier F, Belmaker RH, Berk M, Bjella TD, Bossini L, Bersudsky Y, Cheung EY, Conell J, Del Zompo M, Dodd S, Etain B, Fagiolini A, Frye MA, Fountoulakis KN, Garneau-Fournier J, Gonzalez-Pinto A, Harima H et al. (2014)
Influence of birth cohort on age of onset cluster analysis in bipolar I disorder
Eur Psychiatry, 30 (1), 99-105
DOI 10.1016/j.eurpsy.2014.10.005, PubMed 25498240

Bauer M, Glenn T, Alda M, Andreassen OA, Angelopoulos E, Ardau R, Baethge C, Bauer R, Bellivier F, Belmaker RH, Berk M, Bjella TD, Bossini L, Bersudsky Y, Cheung EY, Conell J, Del Zompo M, Dodd S, Etain B, Fagiolini A, Frye MA, Fountoulakis KN, Garneau-Fournier J, González-Pinto A, Harima H et al. (2014)
Relationship between sunlight and the age of onset of bipolar disorder: an international multisite study
J Affect Disord, 167, 104-11
DOI 10.1016/j.jad.2014.05.032, PubMed 24953482

Berg AO, Andreassen OA, Aminoff SR, Romm KL, Hauff E, Melle I (2014)
The impact of immigration and visible minority status on psychosis symptom profile
Soc Psychiatry Psychiatr Epidemiol, 49 (11), 1747-57
DOI 10.1007/s00127-014-0897-x, PubMed 24927946

Berg AO, Aas M, Larsson S, Nerhus M, Hauff E, Andreassen OA, Melle I (2014)
Childhood trauma mediates the association between ethnic minority status and more severe hallucinations in psychotic disorder
Psychol Med, 45 (1), 133-42
DOI 10.1017/S0033291714001135, PubMed 25065296

Boraska V, Franklin CS, Floyd JA, Thornton LM, Huckins LM, Southam L, Rayner NW, Tachmazidou I, Klump KL, Treasure J, Lewis CM, Schmidt U, Tozzi F, Kiezebrink K, Hebebrand J, Gorwood P, Adan RA, Kas MJ, Favaro A, Santonastaso P, Fernández-Aranda F, Gratacos M, Rybakowski F, Dmitrzak-Weglarz M, Kaprio J et al. (2014)
A genome-wide association study of anorexia nervosa
Mol Psychiatry, 19 (10), 1085-94
DOI 10.1038/mp.2013.187, PubMed 24514567

Brandt CL, Eichele T, Melle I, Sundet K, Server A, Agartz I, Hugdahl K, Jensen J, Andreassen OA (2014)
Working memory networks and activation patterns in schizophrenia and bipolar disorder: comparison with healthy controls
Br J Psychiatry, 204, 290-8
DOI 10.1192/bjp.bp.113.129254, PubMed 24434074

Bratlien U, Øie M, Haug E, Møller P, Andreassen OA, Lien L, Melle I (2014)
Environmental factors during adolescence associated with later development of psychotic disorders - a nested case-control study
Psychiatry Res, 215 (3), 579-85
DOI 10.1016/j.psychres.2013.12.048, PubMed 24495574

Buil A, Brown AA, Lappalainen T, Viñuela A, Davies MN, Zheng HF, Richards JB, Glass D, Small KS, Durbin R, Spector TD, Dermitzakis ET (2014)
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
Nat Genet, 47 (1), 88-91
DOI 10.1038/ng.3162, PubMed 25436857

Bull H, Ueland T, Lystad JU, Evensen S, Friis S, Martinsen EW, Falkum E (2014)
Validation of the work behavior inventory
Nord J Psychiatry, 69 (4), 300-6
DOI 10.3109/08039488.2014.973902, PubMed 25393653

Bøen E, Westlye LT, Elvsåshagen T, Hummelen B, Hol PK, Boye B, Andersson S, Karterud S, Malt UF (2014)
Smaller stress-sensitive hippocampal subfields in women with borderline personality disorder without posttraumatic stress disorder
J Psychiatry Neurosci, 39 (2), 127-34
DOI 10.1503/jpn.130070, PubMed 24309162

Christoforou A, Espeseth T, Davies G, Fernandes CP, Giddaluru S, Mattheisen M, Tenesa A, Harris SE, Liewald DC, Payton A, Ollier W, Horan M, Pendleton N, Haggarty P, Djurovic S, Herms S, Hoffman P, Cichon S, Starr JM, Lundervold A, Reinvang I, Steen VM, Deary IJ, Le Hellard S (2014)
GWAS-based pathway analysis differentiates between fluid and crystallized intelligence
Genes Brain Behav, 13 (7), 663-74
DOI 10.1111/gbb.12152, PubMed 24975275

Dahl J, Ormstad H, Aass HC, Malt UF, Bendz LT, Sandvik L, Brundin L, Andreassen OA (2014)
The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery
Psychoneuroendocrinology, 45, 77-86
DOI 10.1016/j.psyneuen.2014.03.019, PubMed 24845179

Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM, Alzheimer’s Disease Neuroimaging Initiative Group (2014)
The role of clusterin in amyloid-β-associated neurodegeneration
JAMA Neurol, 71 (2), 180-7
DOI 10.1001/jamaneurol.2013.4560, PubMed 24378367

Dieset I, Haukvik UK, Melle I, Røssberg JI, Ueland T, Hope S, Dale AM, Djurovic S, Aukrust P, Agartz I, Andreassen OA (2014)
Association between altered brain morphology and elevated peripheral endothelial markers--implications for psychotic disorders
Schizophr Res, 161 (2-3), 222-8
DOI 10.1016/j.schres.2014.11.006, PubMed 25433965

Douaud G, Groves AR, Tamnes CK, Westlye LT, Duff EP, Engvig A, Walhovd KB, James A, Gass A, Monsch AU, Matthews PM, Fjell AM, Smith SM, Johansen-Berg H (2014)
A common brain network links development, aging, and vulnerability to disease
Proc Natl Acad Sci U S A, 111 (49), 17648-53
DOI 10.1073/pnas.1410378111, PubMed 25422429

Elvsåshagen T, Moberget T, Bøen E, Hol PK, Malt UF, Andersson S, Westlye LT (2014)
The surface area of early visual cortex predicts the amplitude of the visual evoked potential
Brain Struct Funct, 220 (2), 1229-36
DOI 10.1007/s00429-013-0703-7, PubMed 24415060

Engvig A, Fjell AM, Westlye LT, Skaane NV, Dale AM, Holland D, Due-Tønnessen P, Sundseth O, Walhovd KB (2014)
Effects of cognitive training on gray matter volumes in memory clinic patients with subjective memory impairment
J Alzheimers Dis, 41 (3), 779-91
DOI 10.3233/JAD-131889, PubMed 24685630

Espeseth T, Vangkilde SA, Petersen A, Dyrholm M, Westlye LT (2014)
TVA-based assessment of attentional capacities-associations with age and indices of brain white matter microstructure
Front Psychol, 5, 1177
DOI 10.3389/fpsyg.2014.01177, PubMed 25374549

Fernandes CP, Westlye LT, Giddaluru S, Christoforou A, Kauppi K, Adolfsson R, Nilsson LG, Nyberg L, Lundervold AJ, Reinvang I, Steen VM, Le Hellard S, Espeseth T (2014)
Lack of association of the rs1344706 ZNF804A variant with cognitive functions and DTI indices of white matter microstructure in two independent healthy populations
Psychiatry Res, 222 (1-2), 60-6
DOI 10.1016/j.pscychresns.2014.02.009, PubMed 24636489

Finseth PI, Morken G, Malt UF, Andreassen OA, Vaaler AE (2014)
Risk factors of cycle acceleration in acutely admitted patients with bipolar disorder
Acta Psychiatr Scand, 130 (5), 388-96
DOI 10.1111/acps.12308, PubMed 24962060

Fountoulakis KN, Kawohl W, Theodorakis PN, Kerkhof AJ, Navickas A, Höschl C, Lecic-Tosevski D, Sorel E, Rancans E, Palova E, Juckel G, Isacsson G, Jagodic HK, Botezat-Antonescu I, Warnke I, Rybakowski J, Azorin JM, Cookson J, Waddington J, Pregelj P, Demyttenaere K, Hranov LG, Stevovic LI, Pezawas L, Adida M et al. (2014)
Relationship of suicide rates to economic variables in Europe: 2000-2011
Br J Psychiatry, 205 (6), 486-96
DOI 10.1192/bjp.bp.114.147454, PubMed 25359926

Gjevik E, Sandstad B, Andreassen OA, Myhre AM, Sponheim E (2014)
Exploring the agreement between questionnaire information and DSM-IV diagnoses of comorbid psychopathology in children with autism spectrum disorders
Autism, 19 (4), 433-42
DOI 10.1177/1362361314526003, PubMed 24637430

Grellmann C, Bitzer S, Neumann J, Westlye LT, Andreassen OA, Villringer A, Horstmann A (2014)
Comparison of variants of canonical correlation analysis and partial least squares for combined analysis of MRI and genetic data
Neuroimage, 107, 289-310
DOI 10.1016/j.neuroimage.2014.12.025, PubMed 25527238

Haram M, Tesli M, Dieset I, Steen NE, Røssberg JI, Djurovic S, Andreassen OA, Melle I (2014)
An attempt to identify single nucleotide polymorphisms contributing to possible relationships between personality traits and oxytocin-related genes
Neuropsychobiology, 69 (1), 25-30
DOI 10.1159/000356965, PubMed 24458227

Haug E, Øie M, Andreassen OA, Bratlien U, Nelson B, Aas M, Møller P, Melle I (2014)
Anomalous self-experience and childhood trauma in first-episode schizophrenia
Compr Psychiatry, 56, 35-41
DOI 10.1016/j.comppsych.2014.10.005, PubMed 25458477

Haukvik UK, Westlye LT, Mørch-Johnsen L, Jørgensen KN, Lange EH, Dale AM, Melle I, Andreassen OA, Agartz I (2014)
In vivo hippocampal subfield volumes in schizophrenia and bipolar disorder
Biol Psychiatry, 77 (6), 581-8
DOI 10.1016/j.biopsych.2014.06.020, PubMed 25127742

Hill WD, Davies G, van de Lagemaat LN, Christoforou A, Marioni RE, Fernandes CP, Liewald DC, Croning MD, Payton A, Craig LC, Whalley LJ, Horan M, Ollier W, Hansell NK, Wright MJ, Martin NG, Montgomery GW, Steen VM, Le Hellard S, Espeseth T, Lundervold AJ, Reinvang I, Starr JM, Pendleton N, Grant SG et al. (2014)
Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins
Transl Psychiatry, 4, e341
DOI 10.1038/tp.2013.114, PubMed 24399044

Hugdahl K, Craven AR, Nygård M, Løberg EM, Berle JØ, Johnsen E, Kroken R, Specht K, Andreassen OA, Ersland L (2014)
Glutamate as a mediating transmitter for auditory hallucinations in schizophrenia: a (1)H MRS study
Schizophr Res, 161 (2-3), 252-60
DOI 10.1016/j.schres.2014.11.015, PubMed 25542859

Kauppi K, Westlye LT, Tesli M, Bettella F, Brandt CL, Mattingsdal M, Ueland T, Espeseth T, Agartz I, Melle I, Djurovic S, Andreassen OA (2014)
Polygenic risk for schizophrenia associated with working memory-related prefrontal brain activation in patients with schizophrenia and healthy controls
Schizophr Bull, 41 (3), 736-43
DOI 10.1093/schbul/sbu152, PubMed 25392519

Kvitland LR, Melle I, Aminoff SR, Lagerberg TV, Andreassen OA, Ringen PA (2014)
Cannabis use in first-treatment bipolar I disorder: relations to clinical characteristics
Early Interv Psychiatry, 10 (1), 36-44
DOI 10.1111/eip.12138, PubMed 24739233

Langeveld J, Bjørkly S, Auestad B, Barder H, Evensen J, Ten Velden Hegelstad W, Joa I, Johannessen JO, Larsen TK, Melle I, Opjordsmoen S, Røssberg JI, Rund BR, Simonsen E, Vaglum P, McGlashan T, Friis S (2014)
Treatment and violent behavior in persons with first episode psychosis during a 10-year prospective follow-up study
Schizophr Res, 156 (2-3), 272-6
DOI 10.1016/j.schres.2014.04.010, PubMed 24837683

Lystad JU, Falkum E, Mohn C, Haaland VØ, Bull H, Evensen S, Rund BR, Ueland T (2014)
The MATRICS Consensus Cognitive Battery (MCCB): performance and functional correlates
Psychiatry Res, 220 (3), 1094-101
DOI 10.1016/j.psychres.2014.08.060, PubMed 25242432

Nilsen L, Frich JC, Friis S, Norheim I, Røssberg JI (2014)
Participants' perceived benefits of family intervention following a first episode of psychosis: a qualitative study
Early Interv Psychiatry, 10 (2), 152-9
DOI 10.1111/eip.12153, PubMed 24861325

Nilsen L, Frich JC, Friis S, Røssberg JI (2014)
Patients' and family members' experiences of a psychoeducational family intervention after a first episode psychosis: a qualitative study
Issues Ment Health Nurs, 35 (1), 58-68
DOI 10.3109/01612840.2013.837992, PubMed 24350752

Nordvik JE, Walle KM, Nyberg CK, Fjell AM, Walhovd KB, Westlye LT, Tornas S (2014)
Bridging the gap between clinical neuroscience and cognitive rehabilitation: the role of cognitive training, models of neuroplasticity and advanced neuroimaging in future brain injury rehabilitation
NeuroRehabilitation, 34 (1), 81-5
DOI 10.3233/NRE-131017, PubMed 24284460

Ousdal OT, Andreassen OA, Server A, Jensen J (2014)
Increased amygdala and visual cortex activity and functional connectivity towards stimulus novelty is associated with state anxiety
PLoS One, 9 (4), e96146
DOI 10.1371/journal.pone.0096146, PubMed 24755617

Ousdal OT, Specht K, Server A, Andreassen OA, Dolan RJ, Jensen J (2014)
The human amygdala encodes value and space during decision making
Neuroimage, 101, 712-9
DOI 10.1016/j.neuroimage.2014.07.055, PubMed 25094017

Reckless GE, Ousdal OT, Server A, Walter H, Andreassen OA, Jensen J (2014)
The left inferior frontal gyrus is involved in adjusting response bias during a perceptual decision-making task
Brain Behav, 4 (3), 398-407
DOI 10.1002/brb3.223, PubMed 24944869

Ringen PA, Engh JA, Birkenaes AB, Dieset I, Andreassen OA (2014)
Increased mortality in schizophrenia due to cardiovascular disease - a non-systematic review of epidemiology, possible causes, and interventions
Front Psychiatry, 5, 137
DOI 10.3389/fpsyt.2014.00137, PubMed 25309466

Schoeyen HK, Kessler U, Andreassen OA, Auestad BH, Bergsholm P, Malt UF, Morken G, Oedegaard KJ, Vaaler A (2014)
Treatment-resistant bipolar depression: a randomized controlled trial of electroconvulsive therapy versus algorithm-based pharmacological treatment
Am J Psychiatry, 172 (1), 41-51
DOI 10.1176/appi.ajp.2014.13111517, PubMed 25219389

Sexton CE, Walhovd KB, Storsve AB, Tamnes CK, Westlye LT, Johansen-Berg H, Fjell AM (2014)
Accelerated changes in white matter microstructure during aging: a longitudinal diffusion tensor imaging study
J Neurosci, 34 (46), 15425-36
DOI 10.1523/JNEUROSCI.0203-14.2014, PubMed 25392509

Sonmez N, Hagen R, Andreassen OA, Romm KL, Grande M, Jensen LH, Morrison AP, Melle I, Rossberg JI (2014)
Cognitive Behavior Therapy in First-Episode Psychosis With a Focus on Depression, Anxiety, and Self-Esteem
Cogn. Behav. Pract., 21 (1), 43-54

Steen NE, Methlie P, Lorentzen S, Dieset I, Aas M, Nerhus M, Haram M, Agartz I, Melle I, Berg JP, Andreassen OA (2014)
Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders
J Psychiatr Res, 52, 57-62
DOI 10.1016/j.jpsychires.2014.01.017, PubMed 24534618

Sönmez N, Røssberg JI, Evensen J, Barder HE, Haahr U, Ten Velden Hegelstad W, Joa I, Johannessen JO, Langeveld H, Larsen TK, Melle I, Opjordsmoen S, Rund BR, Simonsen E, Vaglum P, McGlashan T, Friis S (2014)
Depressive symptoms in first-episode psychosis: a 10-year follow-up study
Early Interv Psychiatry, 10 (3), 227-33
DOI 10.1111/eip.12163, PubMed 24956976

Tesli M, Espeseth T, Bettella F, Mattingsdal M, Aas M, Melle I, Djurovic S, Andreassen OA (2014)
Polygenic risk score and the psychosis continuum model
Acta Psychiatr Scand, 130 (4), 311-7
DOI 10.1111/acps.12307, PubMed 24961959

Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, Toro R, Jahanshad N, Schumann G, Franke B, Wright MJ, Martin NG, Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J, Alpert K, Andreasen NC, Andreassen OA, Apostolova LG, Appel K, Armstrong NJ, Aribisala B, Bastin ME et al. (2014)
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Brain Imaging Behav, 8 (2), 153-82
DOI 10.1007/s11682-013-9269-5, PubMed 24399358

Vaskinn A, Ueland T, Melle I, Agartz I, Andreassen OA, Sundet K (2014)
Neurocognitive Decrements are Present in Intellectually Superior Schizophrenia
Front Psychiatry, 5, 45
DOI 10.3389/fpsyt.2014.00045, PubMed 24847284

Walhovd KB, Fjell AM, Espeseth T (2014)
Cognitive decline and brain pathology in aging--need for a dimensional, lifespan and systems vulnerability view
Scand J Psychol, 55 (3), 244-54
DOI 10.1111/sjop.12120, PubMed 24730622

Zai CC, Manchia M, Sønderby IE, Yilmaz Z, De Luca V, Tiwari AK, Squassina A, Zai GC, Shaikh SA, Strauss J, King N, Le Foll B, Kaplan AS, Finseth PI, Vaaler AE, Djurovic S, Andreassen OA, Vincent JB, Kennedy JL (2014)
Investigation of the genetic interaction between BDNF and DRD3 genes in suicidical behaviour in psychiatric disorders
World J Biol Psychiatry, 16 (3), 171-9
DOI 10.3109/15622975.2014.953011, PubMed 25264289

Aas M, Aminoff SR, Vik Lagerberg T, Etain B, Agartz I, Andreassen OA, Melle I (2014)
Affective lability in patients with bipolar disorders is associated with high levels of childhood trauma
Psychiatry Res, 218 (1-2), 252-5
DOI 10.1016/j.psychres.2014.03.046, PubMed 24803185

Aas M, Dazzan P, Mondelli V, Melle I, Murray RM, Pariante CM (2014)
A systematic review of cognitive function in first-episode psychosis, including a discussion on childhood trauma, stress, and inflammation
Front Psychiatry, 4, 182
DOI 10.3389/fpsyt.2013.00182, PubMed 24409157

Aas M, Haukvik UK, Djurovic S, Tesli M, Athanasiu L, Bjella T, Hansson L, Cattaneo A, Agartz I, Andreassen OA, Melle I (2014)
Interplay between childhood trauma and BDNF val66met variants on blood BDNF mRNA levels and on hippocampus subfields volumes in schizophrenia spectrum and bipolar disorders
J Psychiatr Res, 59, 14-21
DOI 10.1016/j.jpsychires.2014.08.011, PubMed 25246365

Aas M, Pedersen G, Henry C, Bjella T, Bellivier F, Leboyer M, Kahn JP, Cohen RF, Gard S, Aminoff SR, Lagerberg TV, Andreassen OA, Melle I, Etain B (2014)
Psychometric properties of the Affective Lability Scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls
J Affect Disord, 172, 375-80
DOI 10.1016/j.jad.2014.10.028, PubMed 25451440

 
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