Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Dept. of Microbiology, Lab for genome repair and regulation (Klungland)

13 publications found

Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A (2019)
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells
Nat Genet, 52 (1), 48-55
DOI 10.1038/s41588-019-0549-x, PubMed 31844323

Alexeeva M, Moen MN, Grøsvik K, Tesfahun AN, Xu XM, Muruzábal-Lecumberri I, Olsen KM, Rasmussen A, Ruoff P, Kirpekar F, Klungland A, Bjelland S (2019)
Excision of uracil from DNA by hSMUG1 includes strand incision and processing
Nucleic Acids Res, 47 (2), 779-793
DOI 10.1093/nar/gky1184, PubMed 30496516

Berges N, Nawaz MS, Børresdatter Dahl T, Hagen L, Bjørås M, Laerdahl JK, Alseth I (2019)
Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
PLoS One, 14 (11), e0225081
DOI 10.1371/journal.pone.0225081, PubMed 31703097

Fosslie M, Manaf A, Lerdrup M, Hansen K, Gilfillan GD, Dahl JA (2019)
Going low to reach high: Small-scale ChIP-seq maps new terrain
Wiley Interdiscip Rev Syst Biol Med, 12 (1), e1465
DOI 10.1002/wsbm.1465, PubMed 31478357

Jaroy EG, Acosta-Jimenez L, Hotta R, Goldstein AM, Emblem R, Klungland A, Ougland R (2019)
"Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review
Clin Epigenetics, 11 (1), 135
DOI 10.1186/s13148-019-0718-x, PubMed 31519213

Lie-Jensen A, Ivanauskiene K, Malerød L, Jain A, Tan KW, Laerdahl JK, Liestøl K, Stenmark H, Haglund K (2019)
Centralspindlin Recruits ALIX to the Midbody during Cytokinetic Abscission in Drosophila via a Mechanism Analogous to Virus Budding
Curr Biol, 29 (20), 3538-3548.e7
DOI 10.1016/j.cub.2019.09.025, PubMed 31607533

Pilžys T, Marcinkowski M, Kukwa W, Garbicz D, Dylewska M, Ferenc K, Mieczkowski A, Kukwa A, Migacz E, Wołosz D, Mielecki D, Klungland A, Piwowarski J, Poznański J, Grzesiuk E (2019)
ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy
Sci Rep, 9 (1), 13249
DOI 10.1038/s41598-019-49550-x, PubMed 31519943

Prikrylova T, Robertson J, Ferrucci F, Konorska D, Aanes H, Manaf A, Zhang B, Vågbø CB, Kuśnierczyk A, Gilljam KM, Løvkvam-Køster C, Otterlei M, Dahl JA, Enserink J, Klungland A, Robertson AB (2019)
5-hydroxymethylcytosine Marks Mammalian Origins Acting as a Barrier to Replication
Sci Rep, 9 (1), 11065
DOI 10.1038/s41598-019-47528-3, PubMed 31363131

Segala G, Bennesch MA, Ghahhari NM, Pandey DP, Echeverria PC, Karch F, Maeda RK, Picard D (2019)
Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
Nat Commun, 10 (1), 1833
DOI 10.1038/s41467-019-09800-y, PubMed 31015428

Strøm TB, Vinje T, Bjune K, da Costa LT, Laerdahl JK, Leren TP (2019)
Lysosomal acid lipase does not have a propeptide and should not be considered being a proprotein
Proteins, 88 (3), 440-448
DOI 10.1002/prot.25821, PubMed 31587363

Søraas A, Matsuyama M, de Lima M, Wald D, Buechner J, Gedde-Dahl T, Søraas CL, Chen B, Ferrucci L, Dahl JA, Horvath S, Matsuyama S (2019)
Epigenetic age is a cell-intrinsic property in transplanted human hematopoietic cells
Aging Cell, 18 (2), e12897
DOI 10.1111/acel.12897, PubMed 30712319

Vinje T, Laerdahl JK, Bjune K, Leren TP, Strøm TB (2019)
Characterization of the mechanisms by which missense mutations in the lysosomal acid lipase gene disrupt enzymatic activity
Hum Mol Genet, 28 (18), 3043-3052
DOI 10.1093/hmg/ddz114, PubMed 31131398

Zhang Z, Manaf A, Li Y, Perez SP, Suganthan R, Dahl JA, Bjørås M, Klungland A (2019)
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone
Mol Neurobiol, 57 (2), 997-1008
DOI 10.1007/s12035-019-01777-5, PubMed 31654318

 
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