Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2016 from OUS - Department of Pharmacology

38 publications found

Baftiu A, Johannessen Landmark C, Rusten IR, Feet SA, Johannessen SI, Larsson PG (2016)
Changes in utilisation of antiepileptic drugs in epilepsy and non-epilepsy disorders-a pharmacoepidemiological study and clinical implications
Eur J Clin Pharmacol, 72 (10), 1245-1254
DOI 10.1007/s00228-016-2092-3, PubMed 27411937

Bjørnebekk A, Walhovd KB, Jørstad ML, Due-Tønnessen P, Hullstein IR, Fjell AM (2016)
Structural Brain Imaging of Long-Term Anabolic-Androgenic Steroid Users and Nonusing Weightlifters
Biol Psychiatry, 82 (4), 294-302
DOI 10.1016/j.biopsych.2016.06.017, PubMed 27616036

Brunet M, Shipkova M, van Gelder T, Wieland E, Sommerer C, Budde K, Haufroid V, Christians U, López-Hoyos M, Barten MJ, Bergan S, Picard N, Millán López O, Marquet P, Hesselink DA, Noceti O, Pawinski T, Wallemacq P, Oellerich M (2016)
Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation
Ther Drug Monit, 38 Suppl 1, S1-20
DOI 10.1097/FTD.0000000000000287, PubMed 26977997

Braadland PR, Grytli HH, Ramberg H, Katz B, Kellman R, Gauthier-Landry L, Fazli L, Krobert KA, Wang W, Levy FO, Bjartell A, Berge V, Rennie PS, Mellgren G, Mælandsmo GM, Svindland A, Barbier O, Taskén KA (2016)
Low β₂-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism
Oncotarget, 7 (2), 1878-94
DOI 10.18632/oncotarget.6479, PubMed 26646591

Burns ML, Baftiu A, Opdal MS, Johannessen SI, Landmark CJ (2016)
Therapeutic Drug Monitoring of Clobazam and Its Metabolite-Impact of Age and Comedication on Pharmacokinetic Variability
Ther Drug Monit, 38 (3), 350-7
DOI 10.1097/FTD.0000000000000272, PubMed 26751267

Burns ML, Stensvold HJ, Risnes K, Guthe HJ, Astrup H, Nordhov SM, Selberg TR, Rønnestad A, Lang AM, Norwegian Neonatal Network (2016)
Inotropic Therapy in Newborns, A Population-Based National Registry Study
Pediatr Crit Care Med, 17 (10), 948-956
DOI 10.1097/PCC.0000000000000898, PubMed 27500723

Dyreborg A, Krogh N, Backer V, Rzeppa S, Hemmersbach P, Hostrup M (2016)
Pharmacokinetics of Oral and Inhaled Terbutaline after Exercise in Trained Men
Front Pharmacol, 7, 150
DOI 10.3389/fphar.2016.00150, PubMed 27375484

Eikemo H, Moltzau LR, Hussain RI, Nguyen CH, Qvigstad E, Levy FO, Skomedal T, Osnes JB (2016)
CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes
Biochem Biophys Res Commun, 471 (1), 219-25
DOI 10.1016/j.bbrc.2016.01.132, PubMed 26809094

Eikemo H, Moltzau LR, Nguyen CH, Levy FO, Skomedal T, Osnes JB (2016)
CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes
Biochem Biophys Res Commun, 477 (1), 14-9
DOI 10.1016/j.bbrc.2016.05.138, PubMed 27237977

Gottås A, Arnestad M, Halvorsen PS, Bachs LC, Høiseth G (2016)
Pharmacokinetics of heroin and its metabolites in vitreous humor and blood in a living pig model
Forensic Toxicol, 34 (2), 277-285
DOI 10.1007/s11419-016-0315-z, PubMed 27660664

Haga C, Opdal MS, Tuv SS, Zahl PH, Stenberg-Nilsen H (2016)
[Drug safety associated with the change of digitalis drug in Norway]
Tidsskr Nor Laegeforen, 136 (20), 1714-1718
DOI 10.4045/tidsskr.15.0161, PubMed 27830905

Halden TA, Egeland EJ, Åsberg A, Hartmann A, Midtvedt K, Khiabani HZ, Holst JJ, Knop FK, Hornum M, Feldt-Rasmussen B, Jenssen T (2016)
GLP-1 Restores Altered Insulin and Glucagon Secretion in Posttransplantation Diabetes
Diabetes Care, 39 (4), 617-24
DOI 10.2337/dc15-2383, PubMed 26908914

Henjum K, Almdahl IS, Årskog V, Minthon L, Hansson O, Fladby T, Nilsson LN (2016)
Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease
Alzheimers Res Ther, 8 (1), 17
DOI 10.1186/s13195-016-0182-1, PubMed 27121148

Johannessen Landmark C, Henning O, Johannessen SI (2016)
Proconvulsant effects of antidepressants - What is the current evidence?
Epilepsy Behav, 61, 287-291
DOI 10.1016/j.yebeh.2016.01.029, PubMed 26926001

Johannessen Landmark C, Svendsen T, Dinarevic J, Kufaas RF, Reimers A, Brodtkorb E, Baftiu A, Burns ML, Johannessen SI (2016)
The Impact of Pharmacokinetic Interactions With Eslicarbazepine Acetate Versus Oxcarbazepine and Carbamazepine in Clinical Practice
Ther Drug Monit, 38 (4), 499-505
DOI 10.1097/FTD.0000000000000306, PubMed 27414974

Kloster-Jensen K, Sahraoui A, Vethe NT, Korsgren O, Bergan S, Foss A, Scholz H (2016)
Treatment with Tacrolimus and Sirolimus Reveals No Additional Adverse Effects on Human Islets In Vitro Compared to Each Drug Alone but They Are Reduced by Adding Glucocorticoids
J Diabetes Res, 2016, 4196460
DOI 10.1155/2016/4196460, PubMed 26885529

Kong XY, Feng YZ, Eftestøl E, Kase ET, Haugum H, Eskild W, Rustan AC, Thoresen GH (2016)
Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmp(gt/gt) mice
Arch Physiol Biochem, 122 (1), 36-45
DOI 10.3109/13813455.2015.1120752, PubMed 26707125

Kreiberg M, Becker V, Jessen S, Rzeppa S, Hemmersbach P, Backer V, Hostrup M (2016)
Influence of exercise in normal and hot ambient conditions on the pharmacokinetics of inhaled terbutaline in trained men
Scand J Med Sci Sports, 27 (7), 692-703
DOI 10.1111/sms.12697, PubMed 27167471

Krogh N, Backer V, Rzeppa S, Hemmersbach P, Hostrup M (2016)
Pharmacokinetics of nebulized and oral procaterol in asthmatic and non-asthmatic subjects in relation to doping analysis
Drug Test Anal, 8 (10), 1056-1064
DOI 10.1002/dta.1935, PubMed 26990656

Landmark CJ, Johannessen SI, Tomson T (2016)
Dosing strategies for antiepileptic drugs: from a standard dose for all to individualised treatment by implementation of therapeutic drug monitoring
Epileptic Disord, 18 (4), 367-383
DOI 10.1684/epd.2016.0880, PubMed 27965183

Lund J, Stensrud C, Rajender, Bohov P, Thoresen GH, Berge RK, Wright M, Kamal A, Rustan AC, Miller AD, Skorve J (2016)
The molecular structure of thio-ether fatty acids influences PPAR-dependent regulation of lipid metabolism
Bioorg Med Chem, 24 (6), 1191-203
DOI 10.1016/j.bmc.2016.01.045, PubMed 26874397

Mevaag M, Henning O, Baftiu A, Granas AG, Johannessen SI, Nakken KO, Johannessen Landmark C (2016)
Discrepancies between physicians' prescriptions and patients' use of antiepileptic drugs
Acta Neurol Scand, 135 (1), 80-87
DOI 10.1111/ane.12578, PubMed 26923477

Moen B, Henjum K, Måge I, Knutsen SH, Rud I, Hetland RB, Paulsen JE (2016)
Effect of Dietary Fibers on Cecal Microbiota and Intestinal Tumorigenesis in Azoxymethane Treated A/J Min/+ Mice
PLoS One, 11 (5), e0155402
DOI 10.1371/journal.pone.0155402, PubMed 27196124

Narum S, Brørs O, Stokland O, Kringen MK (2016)
Mortality among head trauma patients taking preinjury antithrombotic agents: a retrospective cohort analysis from a Level 1 trauma centre
BMC Emerg Med, 16 (1), 29
DOI 10.1186/s12873-016-0094-1, PubMed 27485307

Norum HM, Kolberg ES, Solhaug V, Nordal K, Aukrust P (2016)
Rhabdomyolysis and capillary leak syndrome in a patient treated with topical imiquimod
Int J Dermatol, 55 (9), 1030-2
DOI 10.1111/ijd.13255, PubMed 27061736

Olberg DE, Bauer N, Andressen KW, Hjørnevik T, Cumming P, Levy FO, Klaveness J, Haraldsen I, Sutcliffe JL (2016)
Brain penetrant small molecule (18)F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats
Nucl Med Biol, 43 (8), 478-89
DOI 10.1016/j.nucmedbio.2016.05.003, PubMed 27236283

Picard N, Bergan S, Marquet P, van Gelder T, Wallemacq P, Hesselink DA, Haufroid V (2016)
Pharmacogenetic Biomarkers Predictive of the Pharmacokinetics and Pharmacodynamics of Immunosuppressive Drugs
Ther Drug Monit, 38 Suppl 1, S57-69
DOI 10.1097/FTD.0000000000000255, PubMed 26469711

Rzeppa S, Viet L (2016)
Analysis of sulfate metabolites of the doping agents oxandrolone and danazol using high performance liquid chromatography coupled to tandem mass spectrometry
J Chromatogr B Analyt Technol Biomed Life Sci, 1029-1030, 1-9
DOI 10.1016/j.jchromb.2016.06.028, PubMed 27394004

Rzeppa S, Viet LN (2016)
Analysis of tolvaptan and its metabolites in sports drug testing by high-performance liquid chromatography coupled to tandem mass spectrometry
Drug Test Anal, 8 (10), 1090-1094
DOI 10.1002/dta.1933, PubMed 26768215

Sakshaug S, Handal M, Hjellvik V, Berg C, Ripel Å, Gustavsen I, Mørland J, Skurtveit S (2016)
Long-term Use of Z-Hypnotics and Co-medication with Benzodiazepines and Opioids
Basic Clin Pharmacol Toxicol, 120 (3), 292-298
DOI 10.1111/bcpt.12684, PubMed 27717229

Størset E, von Düring ME, Godang K, Bergan S, Midtvedt K, Åsberg A (2016)
Prediction of Fat-Free Mass in Kidney Transplant Recipients
Ther Drug Monit, 38 (4), 439-46
DOI 10.1097/FTD.0000000000000305, PubMed 27019101

Størset E, Åsberg A, Hartmann A, Reisaeter AV, Holdaas H, Skauby M, Bergan S, Midtvedt K (2016)
Low-target tacrolimus in de novo standard risk renal transplant recipients: A single-centre experience
Nephrology (Carlton), 21 (10), 821-7
DOI 10.1111/nep.12738, PubMed 26854648

Svendsen T, Brodtkorb E, Reimers A, Molden E, Sætre E, Johannessen SI, Johannessen Landmark C (2016)
Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate-A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome
Epilepsy Res, 129, 125-131
DOI 10.1016/j.eplepsyres.2016.12.001, PubMed 28043062

Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J (2016)
Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells
Epigenetics Chromatin, 9, 21
DOI 10.1186/s13072-016-0070-8, PubMed 27252783

Villar IC, Bubb KJ, Moyes AJ, Steiness E, Gulbrandsen T, Levy FO, Hobbs AJ (2016)
Functional pharmacological characterization of SER100 in cardiovascular health and disease
Br J Pharmacol, 173 (23), 3386-3401
DOI 10.1111/bph.13634, PubMed 27667485

Westlye LT, Kaufmann T, Alnæs D, Hullstein IR, Bjørnebekk A (2016)
Brain connectivity aberrations in anabolic-androgenic steroid users
Neuroimage Clin, 13, 62-69
DOI 10.1016/j.nicl.2016.11.014, PubMed 27942448

Aasrum M, Brusevold IJ, Christoffersen T, Thoresen GH (2016)
HGF-induced DNA synthesis in hepatocytes is suppressed by p38
Growth Factors, 34 (5-6), 217-223
DOI 10.1080/08977194.2017.1285765, PubMed 28209091

Åstrand OAH, Viktorsson EÖ, Kristensen AL, Ekeberg D, Røberg-Larsen H, Wilson SR, Gabrielsen M, Sylte I, Rustan AC, Thoresen GH, Rongved P, Kase ET (2016)
Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors
J Steroid Biochem Mol Biol, 165 (Pt B), 323-330
DOI 10.1016/j.jsbmb.2016.07.010, PubMed 27471149

 
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