Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2014 from OUS - Department of Pharmacology

32 publications found

Brudeli B, Navaratnarajah M, Andressen KW, Manfra O, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2014)
Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists
Bioorg Med Chem Lett, 24 (18), 4598-4602
DOI 10.1016/j.bmcl.2014.06.083, PubMed 25149506

Brusevold IJ, Tveteraas IH, Aasrum M, Ødegård J, Sandnes DL, Christoffersen T (2014)
Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells
BMC Cancer, 14, 432
DOI 10.1186/1471-2407-14-432, PubMed 24928086

Dehnes Y, Myrvold L, Ström H, Ericsson M, Hemmersbach P (2014)
MAIIA EPO SeLect-a rapid screening kit for the detection of recombinant EPO analogues in doping control: inter-laboratory prevalidation and normative study of athlete urine and plasma samples
Drug Test Anal, 6 (11-12), 1144-50
DOI 10.1002/dta.1752, PubMed 25421537

Haug JB, Berild D, Walberg M, Reikvam Å (2014)
Hospital- and patient-related factors associated with differences in hospital antibiotic use: analysis of national surveillance results
Antimicrob Resist Infect Control, 3 (1), 40
DOI 10.1186/s13756-014-0040-5, PubMed 25598971

Hostrup M, Kalsen A, Bangsbo J, Hemmersbach P, Karlsson S, Backer V (2014)
High-dose inhaled terbutaline increases muscle strength and enhances maximal sprint performance in trained men
Eur J Appl Physiol, 114 (12), 2499-508
DOI 10.1007/s00421-014-2970-2, PubMed 25113095

Hostrup M, Kalsen A, Ortenblad N, Juel C, Mørch K, Rzeppa S, Karlsson S, Backer V, Bangsbo J (2014)
β2-adrenergic stimulation enhances Ca2+ release and contractile properties of skeletal muscles, and counteracts exercise-induced reductions in Na+-K+-ATPase Vmax in trained men
J Physiol, 592 (24), 5445-59
DOI 10.1113/jphysiol.2014.277095, PubMed 25344552

Hullstein I, Sagredo C, Hemmersbach P (2014)
Carbon isotope ratios of nandrolone, boldenone, and testosterone preparations seized in Norway compared to those of endogenously produced steroids in a Nordic reference population
Drug Test Anal, 6 (11-12), 1163-9
DOI 10.1002/dta.1745, PubMed 25388436

Husøy MA, Brinch L, Tjønnfjord GE, Gedde-Dahl T, Heldal D, Holme PA, Dybedal I, Kolstad A, Akkök ÇA, Rollag H, Gaustad P, Bergan S, Egeland T, Josefsen D, Kvalheim G, Fløisand Y (2014)
[Allogeneic stem-cell transplantation in adults 1985-2012: results and development]
Tidsskr Nor Laegeforen, 134 (16), 1569-75
DOI 10.4045/tidsskr.13.1415, PubMed 25178233

Høgmoen Åstrand OA, Gikling I, Sylte I, Rustan AC, Thoresen GH, Rongved P, Kase ET (2014)
Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models
Eur J Med Chem, 74, 258-63
DOI 10.1016/j.ejmech.2014.01.003, PubMed 24480357

Høiseth G, Fjeld B, Burns ML, Strand DH, Vindenes V (2014)
Long-term stability of morphine, codeine, and 6-acetylmorphine in real-life whole blood samples, stored at -20°C
Forensic Sci Int, 239, 6-10
DOI 10.1016/j.forsciint.2014.03.008, PubMed 24709028

Jendresen CB, Cui H, Zhang X, Vlodavsky I, Nilsson LN, Li JP (2014)
Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor protein transgenic mice
J Biol Chem, 290 (8), 5053-64
DOI 10.1074/jbc.M114.600569, PubMed 25548284

Kalsen A, Hostrup M, Karlsson S, Hemmersbach P, Bangsbo J, Backer V (2014)
Effect of inhaled terbutaline on substrate utilization and 300-kcal time trial performance
J Appl Physiol (1985), 117 (10), 1180-7
DOI 10.1152/japplphysiol.00635.2014, PubMed 25257871

Kilander MB, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G (2014)
Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6
FASEB J, 28 (5), 2293-305
DOI 10.1096/fj.13-246363, PubMed 24500924

Kringen MK, Piehler AP, Grimholt RM, Opdal MS, Haug KB, Urdal P (2014)
Serum bilirubin concentration in healthy adult North-Europeans is strictly controlled by the UGT1A1 TA-repeat variants
PLoS One, 9 (2), e90248
DOI 10.1371/journal.pone.0090248, PubMed 24587300

Levinsen M, Rotevatn EØ, Rosthøj S, Nersting J, Abrahamsson J, Appell ML, Bergan S, Bechensteen AG, Harila-Saari A, Heyman M, Jonsson OG, Maxild JB, Niemi M, Söderhäll S, Schmiegelow K, Nordic Society of Paediatric Haematology, Oncology (2014)
Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: influence on cure rates and risk of second cancer
Pediatr Blood Cancer, 61 (5), 797-802
DOI 10.1002/pbc.24921, PubMed 24395436

Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L, Morigen (2014)
AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle
PLoS One, 9 (3), e92229
DOI 10.1371/journal.pone.0092229, PubMed 24670900

Lunde I, Bremer S, Midtvedt K, Mohebi B, Dahl M, Bergan S, Åsberg A, Christensen H (2014)
The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients
Eur J Clin Pharmacol, 70 (6), 685-93
DOI 10.1007/s00228-014-1656-3, PubMed 24658827

Melsom CB, Hussain RI, Ørstavik Ø, Aronsen JM, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Krobert KA (2014)
Non-classical regulation of β1- and β 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi
Naunyn Schmiedebergs Arch Pharmacol, 387 (12), 1177-86
DOI 10.1007/s00210-014-1036-7, PubMed 25216690

Melsom CB, Ørstavik Ø, Osnes JB, Skomedal T, Levy FO, Krobert KA (2014)
Gi proteins regulate adenylyl cyclase activity independent of receptor activation
PLoS One, 9 (9), e106608
DOI 10.1371/journal.pone.0106608, PubMed 25203113

Moltzau LR, Aronsen JM, Meier S, Skogestad J, Ørstavik Ø, Lothe GB, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle
J Pharmacol Exp Ther, 350 (3), 681-90
DOI 10.1124/jpet.114.214882, PubMed 25022512

Moltzau LR, Meier S, Aronsen JM, Afzal F, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E (2014)
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium
Naunyn Schmiedebergs Arch Pharmacol, 387 (5), 407-17
DOI 10.1007/s00210-013-0953-1, PubMed 24424715

Narum S, Westergren T, Klemp M (2014)
Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis
BMJ Open, 4 (5), e004587
DOI 10.1136/bmjopen-2013-004587, PubMed 24833682

Nuruddin S, Syverstad GH, Lillehaug S, Leergaard TB, Nilsson LN, Ropstad E, Krogenæs A, Haraldsen IR, Torp R (2014)
Elevated mRNA-levels of gonadotropin-releasing hormone and its receptor in plaque-bearing Alzheimer's disease transgenic mice
PLoS One, 9 (8), e103607
DOI 10.1371/journal.pone.0103607, PubMed 25089901

Orstavik O, Ata SH, Riise J, Dahl CP, Andersen GØ, Levy FO, Skomedal T, Osnes JB, Qvigstad E (2014)
Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart
Br J Pharmacol, 171 (23), 5169-81
DOI 10.1111/bph.12647, PubMed 24547784

Robertsen I, Asberg A, Granseth T, Vethe NT, Akhlaghi F, Ghareeb M, Molden E, Reier-Nilsen M, Holdaas H, Midtvedt K (2014)
More potent lipid-lowering effect by rosuvastatin compared with fluvastatin in everolimus-treated renal transplant recipients
Transplantation, 97 (12), 1266-71
DOI 10.1097/01.TP.0000443225.66960.7e, PubMed 24521776

Smith R, Solberg R, Jacobsen LL, Voreland AL, Rustan AC, Thoresen GH, Johansen HT (2014)
Simvastatin inhibits glucose metabolism and legumain activity in human myotubes
PLoS One, 9 (1), e85721
DOI 10.1371/journal.pone.0085721, PubMed 24416446

Stormo C, Kringen MK, Lyle R, Olstad OK, Sachse D, Berg JP, Piehler AP (2014)
RNA-sequencing analysis of HepG2 cells treated with atorvastatin
PLoS One, 9 (8), e105836
DOI 10.1371/journal.pone.0105836, PubMed 25153832

Størset E, Holford N, Hennig S, Bergmann TK, Bergan S, Bremer S, Åsberg A, Midtvedt K, Staatz CE (2014)
Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling
Br J Clin Pharmacol, 78 (3), 509-23
DOI 10.1111/bcp.12361, PubMed 25279405

Sulheim D, Fagermoen E, Winger A, Andersen AM, Godang K, Müller F, Rowe PC, Saul JP, Skovlund E, Øie MG, Wyller VB (2014)
Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized clinical trial
JAMA Pediatr, 168 (4), 351-60
DOI 10.1001/jamapediatrics.2013.4647, PubMed 24493300

Sæves I, Line PD, Bremer S, Vethe NT, Tveit RG, Meltevik TJ, Bergan S (2014)
Tacrolimus exposure and mycophenolate pharmacokinetics and pharmacodynamics early after liver transplantation
Ther Drug Monit, 36 (1), 46-53
DOI 10.1097/FTD.0b013e31829dcb66, PubMed 24081206

Vethe NT, Ali AM, Reine PA, Andersen AM, Bremer S, Line PD, Rootwelt H, Bergan S (2014)
Simultaneous quantification of IMPDH activity and purine bases in lymphocytes using LC-MS/MS: assessment of biomarker responses to mycophenolic acid
Ther Drug Monit, 36 (1), 108-18
DOI 10.1097/FTD.0b013e3182a13900, PubMed 24061448

Westergren T, Hjelmeland K, Kristoffersen B, Johannessen SI, Kalikstad B (2014)
Probable topiramate-induced diarrhea in a 2-month-old breast-fed child - A case report
Epilepsy Behav Case Rep, 2, 22-3
DOI 10.1016/j.ebcr.2013.12.006, PubMed 25667861

 
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