Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

Click here to see hierarchical division and subunit overview

Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Medical Biochemistry

55 publications found

Atukunda P, Muhoozi GK, Diep LM, Berg JP, Westerberg AC, Iversen PO (2020)
The association of urine markers of iodine intake with development and growth among children in rural Uganda: a secondary analysis of a randomised education trial
Public Health Nutr, 1-10 (in press)
DOI 10.1017/S1368980020001603, PubMed 32654677

Backe PH, Laerdahl JK, Kittelsen LS, Dalhus B, Mørkrid L, Bjørås M (2020)
Structural basis for substrate and product recognition in human phosphoglucomutase-1 (PGM1) isoform 2, a member of the α-D-phosphohexomutase superfamily
Sci Rep, 10 (1), 5656
DOI 10.1038/s41598-020-62548-0, PubMed 32221390

Badian RA, Utheim TP, Lagali N (2020)
Region of interest and directional analysis of subbasal nerves in wide-area corneal nerve plexus mosaics in type 2 diabetes mellitus
Sci Rep, 10 (1), 10802
DOI 10.1038/s41598-020-67737-5, PubMed 32612112

Barone H, Bliksrud YT, Elgen IB, Szigetvari PD, Kleppe R, Ghorbani S, Hansen EV, Haavik J (2020)
Tyrosinemia Type 1 and symptoms of ADHD: Biochemical mechanisms and implications for treatment and prognosis
Am. J. Med. Genet. B, 183 (2), 95-105

Berg JP, Gladhaug IP (2020)
Disputasen er en del av doktorgradsprøven
Tidsskr Nor Laegeforen, 140 (9)
DOI 10.4045/tidsskr.20.0328, PubMed 32549008

Bergo KK, Larstorp AC, Hoffmann P, Hjørnholm U, Cataliotti A, Høieggen A, Rostrup M, Fadl Elmula FEM (2020)
Renal sympathetic denervation lowers systemic vascular resistance in true treatment-resistant hypertension
Blood Press
DOI 10.1080/08037051.2020.1789446, PubMed 32633141

Bornstedt ME, Gjerlaugsen N, Olstad OK, Berg JP, Bredahl MK, Thorsby PM (2020)
Vitamin D metabolites influence expression of genes concerning cellular viability and function in insulin producing β-cells (INS1E)
Gene, 746, 144649
DOI 10.1016/j.gene.2020.144649, PubMed 32251702

Brusletto BS, Løberg EM, Hellerud BC, Goverud IL, Berg JP, Olstad OK, Gopinathan U, Brandtzaeg P, Øvstebø R (2020)
Extensive Changes in Transcriptomic "Fingerprints" and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis
Front Cell Infect Microbiol, 10, 42
DOI 10.3389/fcimb.2020.00042, PubMed 32154187

Buhl S, Dorn-Rasmussen M, Brynskov J, Ainsworth MA, Bendtzen K, Klausen PH, Bolstad N, Warren DJ, Steenholdt C (2020)
Therapeutic thresholds and mechanisms for primary non-response to infliximab in inflammatory bowel disease
Scand J Gastroenterol
DOI 10.1080/00365521.2020.1786852, PubMed 32631131

Bøhmer T, Bachtyari Z, Sommer C, Hammerstad SS (2020)
Auto regulatory capacity of the thyroid gland after numerous iodinated contrast media investigations
Scand J Clin Lab Invest, 80 (3), 191-195
DOI 10.1080/00365513.2019.1709658, PubMed 31990217

Cabral JV, Jackson CJ, Utheim TP, Jirsova K (2020)
Ex vivo cultivated oral mucosal epithelial cell transplantation for limbal stem cell deficiency: a review
Stem Cell Res Ther, 11 (1), 301
DOI 10.1186/s13287-020-01783-8, PubMed 32693830

Eidet JR, Jørstad ØK, Fostad IG, Olstad OK, Sørland RØ, Moe MC, Petrovski G, Pepaj M (2020)
Unilateral acute anterior uveitis is associated with ipsilateral changes in the tear fluid proteome that involves the LXR/RXR pathway
J Ophthalmic Inflamm Infect, 10 (1), 13
DOI 10.1186/s12348-020-00204-4, PubMed 32458144

Enayati S, Chang K, Achour H, Cho KS, Xu F, Guo S, Z Enayati K, Xie J, Zhao E, Turunen T, Sehic A, Lu L, Utheim TP, Chen DF (2020)
Electrical Stimulation Induces Retinal Müller Cell Proliferation and Their Progenitor Cell Potential
Cells, 9 (3)
DOI 10.3390/cells9030781, PubMed 32210151

Farup PG, Rootwelt H, Hestad K (2020)
APOE - a genetic marker of comorbidity in subjects with morbid obesity
BMC Med Genet, 21 (1), 146
DOI 10.1186/s12881-020-01082-2, PubMed 32646381

Fineide F, Arita R, Utheim TP (2020)
The role of meibography in ocular surface diagnostics: A review
Ocul Surf (in press)
DOI 10.1016/j.jtos.2020.05.004, PubMed 32416235

Fosså SD, Dahl AA, Myklebust TÅ, Kiserud CE, Nome R, Klepp OH, Brydøy M, Haugnes HS (2020)
Risk of positive selection bias in longitudinal surveys among cancer survivors: Lessons learnt from the national Norwegian Testicular Cancer Survivor Study
Cancer Epidemiol, 67, 101744
DOI 10.1016/j.canep.2020.101744, PubMed 32652337

García-Posadas L, Hodges RR, Utheim TP, Olstad OK, Delcroix V, Makarenkova H, Dartt DA (2020)
Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease
Am J Pathol (in press)
DOI 10.1016/j.ajpath.2020.06.013, PubMed 32679229

Gautvik KM, Günther CC, Prijatelj V, Medina-Gomez C, Shevroja E, Rad LH, Yazdani M, Lindalen E, Valland H, Gautvik VT, Olstad OK, Holden M, Rivadeneira F, Utheim TP, Reppe S (2020)
Distinct Subsets of Noncoding RNAs Are Strongly Associated With BMD and Fracture, Studied in Weight-Bearing and Non-Weight-Bearing Human Bone
J Bone Miner Res, 35 (6), 1065-1076
DOI 10.1002/jbmr.3974, PubMed 32017184

Ho AVT, Toska K, Wesche J (2020)
Rapid, Large, and Synchronous Sweat and Cardiovascular Responses Upon Minor Stimuli in Healthy Subjects. Dynamics and Reproducibility
Front Neurol, 11, 51
DOI 10.3389/fneur.2020.00051, PubMed 32117014

Holm AM, Andreassen SL, Christensen VL, Kongerud J, Almås Ø, Auråen H, Henriksen AH, Aaberge IS, Klingenberg O, Rustøen T (2020)
Hypogammaglobulinemia and Risk of Exacerbation and Mortality in Patients with COPD
Int J Chron Obstruct Pulmon Dis, 15, 799-807
DOI 10.2147/COPD.S236656, PubMed 32368026

Hope S, Naerland T, Høiland AL, Torske T, Malt E, Abrahamsen T, Nerhus M, Wedervang-Resell K, Lonning V, Johannessen J, Steen NE, Agartz I, Stenberg N, Hundhausen T, Mørkrid L, Andreassen OA (2020)
Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia: A comparison among participants between 2 and 53 years
FASEB J, 34 (6), 8114-8124
DOI 10.1096/fj.201900855RRR, PubMed 32323402

Jackson CJ, Pasovic L, Raeder S, Sehic A, Roald B, de la Paz MF, Tønseth KA, Utheim TP (2020)
Optisol-GS Storage of Cultured Human Limbal Epithelial Cells at Ambient Temperature Is Superior to Hypothermic Storage
Curr Eye Res
DOI 10.1080/02713683.2020.1770295, PubMed 32578462

Jansen A, Berg JP, Klungsøyr O, Müller MHB, Lyche JL, Aaseth JO (2020)
The Influence of Persistent Organic Pollutants on Thyroidal, Reproductive and Adrenal Hormones After Bariatric Surgery
Obes Surg, 30 (4), 1368-1378
DOI 10.1007/s11695-019-04273-w, PubMed 31721064

Jirsova K, Seidler Stangova P, Palos M, Mahelkova G, Kalasova S, Rybickova I, Utheim TP, Vesela V (2020)
Aberrant HLA-DR expression in the conjunctival epithelium after autologous serum treatment in patients with graft-versus-host disease or Sjögren's syndrome
PLoS One, 15 (4), e0231473
DOI 10.1371/journal.pone.0231473, PubMed 32315325

Johannessen TR, Vallersnes OM, Halvorsen S, Larstorp ACK, Mdala I, Atar D (2020)
Pre-hospital One-Hour Troponin in a Low-Prevalence Population of Acute Coronary Syndrome: OUT-ACS study
Open Heart, 7 (2)
DOI 10.1136/openhrt-2020-001296, PubMed 32719074

Juvodden HT, Viken MK, Nordstrand SEH, Viste R, Westlye LT, Thorsby PM, Lie BA, Knudsen-Heier S (2020)
HLA and sleep parameter associations in post-H1N1 narcolepsy type 1 patients and first-degree relatives
Sleep, 43 (3)
DOI 10.1093/sleep/zsz239, PubMed 31606740

Khan AZ, Utheim TP, Moe MC, Aass HCD, Sapkota D, Vallenari EM, Eidet JR (2020)
The Silk Protein Sericin Promotes Viability of ARPE-19 and Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells In Vitro
Curr Eye Res (in press)
DOI 10.1080/02713683.2020.1809001, PubMed 32777180

Klaasen RA, Bergan S, Bremer S, Hole K, Nordahl CB, Andersen AM, Midtvedt K, Skauby MH, Vethe NT (2020)
Pharmacodynamic assessment of mycophenolic acid in resting and activated target cell population during the first year after renal transplantation
Br J Clin Pharmacol, 86 (6), 1100-1112
DOI 10.1111/bcp.14218, PubMed 31925806

Lavelle TJ, Alver TN, Heintz KM, Wernhoff P, Nygaard V, Nakken S, Øy GF, Bøe SL, Urbanucci A, Hovig E (2020)
Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes
Cancers (Basel), 12 (7)
DOI 10.3390/cancers12071719, PubMed 32605315

Lunde LK, Skare Ø, Mamen A, Sirnes PA, Aass HCD, Øvstebø R, Goffeng E, Matre D, Nielsen P, Heglum HSA, Hammer SE, Skogstad M (2020)
Cardiovascular Health Effects of Shift Work with Long Working Hours and Night Shifts: Study Protocol for a Three-Year Prospective Follow-Up Study on Industrial Workers
Int J Environ Res Public Health, 17 (2)
DOI 10.3390/ijerph17020589, PubMed 31963313

Mamen A, Øvstebø R, Sirnes PA, Nielsen P, Skogstad M (2020)
High-Intensity Training Reduces CVD Risk Factors among Rotating Shift Workers: An Eight-Week Intervention in Industry
Int J Environ Res Public Health, 17 (11)
DOI 10.3390/ijerph17113943, PubMed 32498373

Molteberg E, Thorsby PM, Kverneland M, Iversen PO, Selmer KK, Nakken KO, Taubøll E (2020)
Effects of modified Atkins diet on thyroid function in adult patients with pharmacoresistant epilepsy
Epilepsy Behav, 111, 107285 (in press)
DOI 10.1016/j.yebeh.2020.107285, PubMed 32698106

Nedal A, Ræder SB, Dalhus B, Helgesen E, Forstrøm RJ, Lindland K, Sumabe BK, Martinsen JH, Kragelund BB, Skarstad K, Bjørås M, Otterlei M (2020)
Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis
Nucleic Acids Res, 48 (10), 5540-5554
DOI 10.1093/nar/gkaa278, PubMed 32347931

Nilsen J, Trabjerg E, Grevys A, Azevedo C, Brennan SO, Stensland M, Wilson J, Sand KMK, Bern M, Dalhus B, Roopenian DC, Sandlie I, Rand KD, Andersen JT (2020)
An intact C-terminal end of albumin is required for its long half-life in humans
Commun Biol, 3 (1), 181
DOI 10.1038/s42003-020-0903-7, PubMed 32313072

Nome RV, Cvancarova Småstuen M, Bjøro T, Kiserud CE, Fosså SD (2020)
Longitudinal kidney function outcome in aging testicular cancer survivors
Acta Oncol, 59 (4), 467-474
DOI 10.1080/0284186X.2020.1724328, PubMed 32043400

Nordstrand SEH, Juvodden HT, Viste R, Rootwelt T, Karlsen TI, Thorsby PM, Swanson D, Nilsen KB, Hansen BH, Knudsen-Heier S (2020)
Obesity and other medical comorbidities among NT1 patients after the Norwegian H1N1 influenza epidemic and vaccination campaign
Sleep, 43 (5)
DOI 10.1093/sleep/zsz277, PubMed 31724727

Olsen MV, Lyngstadaas AV, Bair JA, Hodges RR, Utheim TP, Serhan CN, Dartt DA (2020)
Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+ ] and secretion in conjunctival goblet cells
J Cell Physiol
DOI 10.1002/jcp.29846, PubMed 32510663

Olstad OK, Gautvik VT, LeBlanc M, Kvernevik KJ, Utheim TP, Runningen A, Wiig H, Kirkegaard C, Raastad T, Reppe S, Gautvik KM (2020)
Postmenopausal osteoporosis is a musculoskeletal disease with a common genetic trait which responds to strength training: a translational intervention study
Ther Adv Musculoskelet Dis, 12, 1759720X20929443
DOI 10.1177/1759720X20929443, PubMed 32536985

Ringstad H, Reppe S, Schøyen TH, Tønseth KA, Utheim TP, Jackson CJ (2020)
Stem cell function is conserved during short-term storage of cultured epidermal cell sheets at 12°C
PLoS One, 15 (5), e0232270
DOI 10.1371/journal.pone.0232270, PubMed 32433698

Salminen L, Nadeem N, Rolfsen AL, Dørum A, Laajala TD, Grènman S, Hietanen S, Heinosalo T, Perheentupa A, Poutanen M, Bolstad N, Carpén O, Lamminmäki U, Pettersson K, Gidwani K, Hynninen J, Huhtinen K (2020)
Exploratory Analysis of CA125-MGL and -STn Glycoforms in the Differential Diagnostics of Pelvic Masses
J Appl Lab Med, 5 (2), 263-272
DOI 10.1093/jalm/jfz012, PubMed 32445385

Shabestari M, Shabestari YR, Landin MA, Pepaj M, Cleland TP, Reseland JE, Eriksen EF (2020)
Altered protein levels in bone marrow lesions of hip osteoarthritis: Analysis by proteomics and multiplex immunoassays
Int J Rheum Dis, 23 (6), 788-799
DOI 10.1111/1756-185X.13843, PubMed 32383346

Strand J, Gul KA, Erichsen HC, Lundman E, Berge MC, Trømborg AK, Sørgjerd LK, Ytre-Arne M, Hogner S, Halsne R, Gaup HJ, Osnes LT, Kro GAB, Sorte HS, Mørkrid L, Rowe AD, Tangeraas T, Jørgensen JV, Alme C, Bjørndalen TEH, Rønnestad AE, Lang AM, Rootwelt T, Buechner J, Øverland T et al. (2020)
Second-Tier Next Generation Sequencing Integrated in Nationwide Newborn Screening Provides Rapid Molecular Diagnostics of Severe Combined Immunodeficiency
Front Immunol, 11, 1417
DOI 10.3389/fimmu.2020.01417, PubMed 32754152

Syversen SW, Goll GL, Jørgensen KK, Olsen IC, Sandanger Ø, Gehin JE, Warren DJ, Sexton J, Mørk C, Jahnsen J, Kvien TK, Bolstad N, Haavardsholm EA (2020)
Therapeutic drug monitoring of infliximab compared to standard clinical treatment with infliximab: study protocol for a randomised, controlled, open, parallel-group, phase IV study (the NOR-DRUM study)
Trials, 21 (1), 13
DOI 10.1186/s13063-019-3734-4, PubMed 31907007

Tashbayev B, Garen T, Palm Ø, Chen X, Herlofson BB, Young A, Hove LH, Rykke M, Singh PB, Aqrawi LA, Utheim ØA, Utheim TP, Jensen JL (2020)
Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study
Sci Rep, 10 (1), 2063
DOI 10.1038/s41598-020-59078-0, PubMed 32034249

Tashbayev B, Utheim TP, Utheim ØA, Ræder S, Jensen JL, Yazdani M, Lagali N, Vitelli V, Dartt DA, Chen X (2020)
Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease
Sci Rep, 10 (1), 5542
DOI 10.1038/s41598-020-62583-x, PubMed 32218518

Tashbayev B, Yazdani M, Arita R, Fineide F, Utheim TP (2020)
Intense pulsed light treatment in meibomian gland dysfunction: A concise review
Ocul Surf (in press)
DOI 10.1016/j.jtos.2020.06.002, PubMed 32629039

Thomassen RA, Kvammen JA, Sæland C, Kjeserud C, Eikeland J, Juliusson PB, Bentsen BS, Henriksen C (2020)
Micronutrients in paediatric Intestinal Failure Patients receiving home parenteral nutrition
Clin Nutr (in press)
DOI 10.1016/j.clnu.2020.02.039, PubMed 32204976

Thorsen L, Haugnes HS, Fosså SD, Brydøy M, Tandstad T, Wisløff T, Gjerset GM, Edvardsen E, Larsen KO, Sandset PM, Henriksson CE, Raastad T, Negaard HFS (2020)
Thromboembolic events after high-intensity training during cisplatin-based chemotherapy for testicular cancer: Case reports and review of the literature
Int J Cancer
DOI 10.1002/ijc.33151, PubMed 32525564

Thorsteinsdottir H, Salvador CL, Mjøen G, Lie A, Sugulle M, Tøndel C, Brun A, Almaas R, Bjerre A (2020)
Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation
Dis Markers, 2020, 6162892
DOI 10.1155/2020/6162892, PubMed 32089755

Tulek A, Mulic A, Refsholt Stenhagen K, Galtung HK, Saeed M, Utheim TP, Khuu C, Galteland P, Sehic A (2020)
Dental erosion in mice with impaired salivary gland function
Acta Odontol Scand, 78 (5), 390-400
DOI 10.1080/00016357.2020.1734234, PubMed 32141357

Waaler J, Mygland L, Tveita A, Strand MF, Solberg NT, Olsen PA, Aizenshtadt A, Fauskanger M, Lund K, Brinch SA, Lycke M, Dybing E, Nygaard V, Bøe SL, Heintz KM, Hovig E, Hammarström C, Corthay A, Krauss S (2020)
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
Commun Biol, 3 (1), 196
DOI 10.1038/s42003-020-0916-2, PubMed 32332858

Yang M, Bair JA, Hodges RR, Serhan CN, Dartt DA (2020)
Resolvin E1 Reduces Leukotriene B4-Induced Intracellular Calcium Increase and Mucin Secretion in Rat Conjunctival Goblet Cells
Am J Pathol (in press)
DOI 10.1016/j.ajpath.2020.06.001, PubMed 32561135

Yang M, Lin X, Segers F, Suganthan R, Hildrestrand GA, Rinholm JE, Aas PA, Sousa MML, Holm S, Bolstad N, Warren D, Berge RK, Johansen RF, Yndestad A, Kristiansen E, Klungland A, Luna L, Eide L, Halvorsen B, Aukrust P, Bjørås M (2020)
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
Cell Rep, 30 (12), 4165-4178.e7
DOI 10.1016/j.celrep.2020.02.063, PubMed 32209476

Yang M, Lippestad M, Hodges RR, Fjærvoll HK, Fjærvoll KA, Bair JA, Utheim TP, Serhan CN, Dartt DA (2020)
RvE1 uses the LTB4 receptor BLT1 to increase [Ca2+]i and stimulate mucin secretion in cultured rat and human conjunctival goblet cells
Ocul Surf, 18 (3), 470-482
DOI 10.1016/j.jtos.2020.04.011, PubMed 32361084

Yu H, Enayati S, Chang K, Cho K, Lee SW, Talib M, Zihlavnikova K, Xie J, Achour H, Fried SI, Utheim TP, Chen DF (2020)
Noninvasive Electrical Stimulation Improves Photoreceptor Survival and Retinal Function in Mice with Inherited Photoreceptor Degeneration
Invest Ophthalmol Vis Sci, 61 (4), 5
DOI 10.1167/iovs.61.4.5, PubMed 32271885

 
Page visits: 423963