Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Department of Medical Biochemistry

47 publications found

Aqrawi LA, Galtung HK, Guerreiro EM, Øvstebø R, Thiede B, Utheim TP, Chen X, Utheim ØA, Palm Ø, Skarstein K, Jensen JL (2019)
Proteomic and histopathological characterisation of sicca subjects and primary Sjögren's syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers
Arthritis Res Ther, 21 (1), 181
DOI 10.1186/s13075-019-1961-4, PubMed 31366407

Beitland S, Nakstad ER, Berg JP, Trøseid AS, Brusletto BS, Brunborg C, Lundqvist C, Sunde K (2019)
Urine β-2-Microglobulin, Osteopontin, and Trefoil Factor 3 May Early Predict Acute Kidney Injury and Outcome after Cardiac Arrest
Crit Care Res Pract, 2019, 4384796
DOI 10.1155/2019/4384796, PubMed 31205786

Bornstedt ME, Gjerlaugsen N, Pepaj M, Bredahl MKL, Thorsby PM (2019)
Vitamin D Increases Glucose Stimulated Insulin Secretion from Insulin Producing Beta Cells (INS1E)
Int J Endocrinol Metab, 17 (1), e74255
DOI 10.5812/ijem.74255, PubMed 30881469

Botten N, Hodges RR, Li D, Bair JA, Shatos MA, Utheim TP, Serhan CN, Dartt DA (2019)
Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells
FASEB J, 33 (7), 8468-8478
DOI 10.1096/fj.201802467R, PubMed 31013438

Buer LCT, Moum BA, Cvancarova M, Warren DJ, Bolstad N, Medhus AW, Høivik ML (2019)
Real world data on effectiveness, safety and therapeutic drug monitoring of vedolizumab in patients with inflammatory bowel disease. A single center cohort
Scand J Gastroenterol, 54 (1), 41-48
DOI 10.1080/00365521.2018.1548646, PubMed 30650312

Chen X, Aqrawi LA, Utheim TP, Tashbayev B, Utheim ØA, Reppe S, Hove LH, Herlofson BB, Singh PB, Palm Ø, Galtung HK, Jensen JCL (2019)
Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations
Sci Rep, 9 (1), 7319
DOI 10.1038/s41598-019-43714-5, PubMed 31086200

Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, Ciccacci C, Carcas AJ, Borobia AM, Tong HY, Dávila-Fajardo C, Rodrigues Botton M, Bourgeois S, Deloukas P, Caldwell MD, Burmester JK, Berg RL, Cavallari LH, Drozda K, Huang M, Zhao LZ, Cen HJ, Gonzalez-Conejero R, Roldan V, Nakamura Y et al. (2019)
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals
Clin Pharmacol Ther, 105 (6), 1477-1491
DOI 10.1002/cpt.1323, PubMed 30506689

Dantas H, Warren DJ, Wendelken S, Davis T, Clark GA, Mathews VJ (2019)
Deep Learning Movement Intent Decoders Trained with Dataset Aggregation for Prosthetic Limb Control
IEEE Trans Biomed Eng (in press)
DOI 10.1109/TBME.2019.2901882, PubMed 30835207

Eidet JR, Biernat D, Dahlberg D, Wiedmann MKH, Jorstad OK (2019)
Foster Kennedy syndrome
Tidsskr. Nor. Laegeforen., 139 (10), 941-943

Eidet JR, Biernat D, Dahlberg D, Wiedmann MKH, Jørstad ØK (2019)
Foster Kennedys syndrom
Tidsskr Nor Laegeforen, 139 (10)
DOI 10.4045/tidsskr.18.0719, PubMed 31238653

Eilertsen H, Saether PC, Henriksson CE, Petersen AS, Hagve TA (2019)
Evaluation of the detection of blasts by Sysmex hematology instruments, CellaVision DM96, and manual microscopy using flow cytometry as the confirmatory method
Int J Lab Hematol, 41 (3), 338-344
DOI 10.1111/ijlh.12980, PubMed 30742354

Gabrielsen ISM, Helgeland H, Akselsen H, D Aass HC, Sundaram AYM, Snowhite IV, Pugliese A, Flåm ST, Lie BA (2019)
Transcriptomes of antigen presenting cells in human thymus
PLoS One, 14 (7), e0218858
DOI 10.1371/journal.pone.0218858, PubMed 31261375

Goll GL, Jørgensen KK, Sexton J, Olsen IC, Bolstad N, Haavardsholm EA, Lundin KEA, Tveit KS, Lorentzen M, Berset IP, Fevang BTS, Kalstad S, Ryggen K, Warren DJ, Klaasen RA, Asak Ø, Baigh S, Blomgren IM, Brenna Ø, Bruun TJ, Dvergsnes K, Frigstad SO, Hansen IM, Hatten ISH, Huppertz-Hauss G et al. (2019)
Long-term efficacy and safety of biosimilar infliximab (CT-P13) after switching from originator infliximab: open-label extension of the NOR-SWITCH trial
J Intern Med, 285 (6), 653-669
DOI 10.1111/joim.12880, PubMed 30762274

Grimholt RM, Fjeld B, Selsås H, Schwettmann L, Klingenberg O (2019)
Hb Aalesund (HBA2: c.400_406delAGCACCG), an Unstable α-Globin Variant Found in a Norwegian Patient Causing Moderate Hemolytic Anemia and Falsely High Hb A1c Using Ion Exchange High Performance Liquid Chromatography
Hemoglobin, 43 (2), 122-125
DOI 10.1080/03630269.2019.1614048, PubMed 31145010

Gustafsson MK, Romundstad PR, Stafne SN, Helvik AS, Stunes AK, Mørkved S, Salvesen KÅ, Thorsby PM, Mosti MP, Syversen U (2019)
The effect of an exercise program in pregnancy on vitamin D status among healthy, pregnant Norwegian women: a randomized controlled trial
BMC Pregnancy Childbirth, 19 (1), 76
DOI 10.1186/s12884-019-2220-z, PubMed 30786861

Hokstad I, Deyab G, Wang Fagerland M, Lyberg T, Hjeltnes G, Førre Ø, Agewall S, Mollnes TE, Hollan I (2019)
Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study
PLoS One, 14 (7), e0220079
DOI 10.1371/journal.pone.0220079, PubMed 31335881

Holmberg A, Ho AV, Fernand D, Toska K, Wester T, Klaastad Ø, Draegni T, Sauter AR (2019)
Microcirculation and haemodynamics after infraclavicular brachial plexus block using adrenaline as an adjuvant to lidocaine: a randomised, double-blind, crossover study in healthy volunteers
Anaesthesia (in press)
DOI 10.1111/anae.14795, PubMed 31389614

Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M et al. (2019)
Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry
J Bone Miner Res, 34 (7), 1284-1296
DOI 10.1002/jbmr.3698, PubMed 30888730

Jorde R, Stunes AK, Kubiak J, Joakimsen R, Grimnes G, Thorsby PM, Syversen U (2019)
Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency
Bone, 124, 7-13
DOI 10.1016/j.bone.2019.04.002, PubMed 30959189

Juvodden HT, Alnæs D, Lund MJ, Dietrichs E, Thorsby PM, Westlye LT, Knudsen S (2019)
Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing
Sleep, 42 (7)
DOI 10.1093/sleep/zsz082, PubMed 30923809

Kagan ZB, Mize JT, Kosta P, Lazzi G, Normann RA, Warren DJ (2019)
Reduced Heat Generation During Magnetic Stimulation of Rat Sciatic Nerve Using Current Waveform Truncation
IEEE Trans Neural Syst Rehabil Eng, 27 (5), 937-946
DOI 10.1109/TNSRE.2019.2911054, PubMed 30990431

Klaasen RA, Egeland EJ, Chan J, Midtvedt K, Svensson M, Bolstad N, Fellström B, Holdaas H, Åsberg A, Bergan S, Vethe NT, Warren DJ (2019)
A Fully Automated Method for the Determination of Serum Belatacept and Its Application in a Pharmacokinetic Investigation in Renal Transplant Recipients
Ther Drug Monit, 41 (1), 11-18
DOI 10.1097/FTD.0000000000000580, PubMed 30633722

Kvisvik B, Aagaard EN, Mørkrid L, Røsjø H, Lyngbakken M, Smedsrud MK, Eek C, Bendz B, Haugaa KH, Edvardsen T, Gravning J (2019)
Mechanical dispersion as a marker of left ventricular dysfunction and prognosis in stable coronary artery disease
Int J Cardiovasc Imaging, 35 (7), 1265-1275
DOI 10.1007/s10554-019-01583-z, PubMed 31165941

Lundar L, Aksnes G, Mørkrid L, Emblem R (2019)
Prenatal extravasation of urine seems to preserve renal function in boys with posterior urethral valves
J Pediatr Urol, 15 (3), 241.e1-241.e7
DOI 10.1016/j.jpurol.2019.02.010, PubMed 30982696

Meuwese CL, van Diepen M, Cappola AR, Sarnak MJ, Shlipak MG, Bauer DC, Fried LP, Iacoviello M, Vaes B, Degryse J, Khaw KT, Luben RN, Åsvold BO, Bjøro T, Vatten LJ, de Craen AJM, Trompet S, Iervasi G, Molinaro S, Ceresini G, Ferrucci L, Dullaart RPF, Bakker SJL, Jukema JW, Kearney PM et al. (2019)
Low thyroid function is not associated with an accelerated deterioration in renal function
Nephrol Dial Transplant, 34 (4), 650-659
DOI 10.1093/ndt/gfy071, PubMed 29684213

Mihret W, Sletbakk Brusletto B, Øvstebø R, Siebke Troseid AM, Norheim G, Merid Y, Kassu A, Abebe W, Ayele S, Silamsaw Asres M, Yamuah L, Aseffa A, Petros B, Caugant DA, Brandtzaeg P (2019)
Molecular studies of meningococcal and pneumococcal meningitis patients in Ethiopia
Innate Immun, 25 (3), 158-167
DOI 10.1177/1753425918806363, PubMed 30894090

Morthen MK, Tellefsen S, Richards SM, Lieberman SM, Rahimi Darabad R, Kam WR, Sullivan DA (2019)
Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome
Invest Ophthalmol Vis Sci, 60 (6), 2181-2197
DOI 10.1167/iovs.19-26815, PubMed 31108549

Myhrstad MCW, de Mello VD, Dahlman I, Kolehmainen M, Paananen J, Rundblad A, Carlberg C, Olstad OK, Pihlajamäki J, Holven KB, Hermansen K, Dragsted LO, Gunnarsdottir I, Cloetens L, Storm MU, Åkesson B, Rosqvist F, Hukkanen J, Herzig KH, Risérus U, Thorsdottir I, Poutanen KS, Savolainen MJ, Schwab U, Arner P et al. (2019)
Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome-A SYSDIET Sub-Study
Mol Nutr Food Res, 63 (13), 1801405
DOI 10.1002/mnfr.201801405, PubMed 30964598

Opsahl EM, Akslen LA, Schlichting E, Aas T, Brauckhoff K, Hagen AI, Rosenlund AF, Sigstad E, Grøholt KK, Jørgensen LH, Bjøro T (2019)
The Role of Calcitonin in Predicting the Extent of Surgery in Medullary Thyroid Carcinoma: A Nationwide Population-Based Study in Norway
Eur Thyroid J, 8 (3), 159-166
DOI 10.1159/000499018, PubMed 31259158

Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019)
Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease
Dis Model Mech, 12 (7)
DOI 10.1242/dmm.038737, PubMed 31278192

Ræder S, Klyve P, Utheim TP (2019)
Tørre øyne – diagnostikk og behandling
Tidsskr Nor Laegeforen, 139 (11)
DOI 10.4045/tidsskr.18.0752, PubMed 31429248

Schrader H, Bøhmer T, Aasly J (2019)
The Incidence of Diagnosis of Munchausen Syndrome, Other Factitious Disorders, and Malingering
Behav Neurol, 2019, 3891809
DOI 10.1155/2019/3891809, PubMed 30944662

Skogstad M, Mamen A, Lunde LK, Ulvestad B, Matre D, Aass HCD, Øvstebø R, Nielsen P, Samuelsen KN, Skare Ø, Sirnes PA (2019)
Shift Work Including Night Work and Long Working Hours in Industrial Plants Increases the Risk of Atherosclerosis
Int J Environ Res Public Health, 16 (3)
DOI 10.3390/ijerph16030521, PubMed 30759884

Smatlikova P, Askeland G, Vaskovicova M, Klima J, Motlik J, Eide L, Ellederová Z (2019)
Age-Related Oxidative Changes in Primary Porcine Fibroblasts Expressing Mutated Huntingtin
Neurodegener Dis, 19 (1), 22-34
DOI 10.1159/000500091, PubMed 31167196

Stadnikova A, Trosan P, Skalicka P, Utheim TP, Jirsova K (2019)
Interleukin-13 maintains the stemness of conjunctival epithelial cell cultures prepared from human limbal explants
PLoS One, 14 (2), e0211861
DOI 10.1371/journal.pone.0211861, PubMed 30742646

Stiksrud B, Aass HCD, Lorvik KB, Ueland T, Trøseid M, Dyrhol-Riise AM (2019)
Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery
AIDS, 33 (7), 1117-1129
DOI 10.1097/QAD.0000000000002173, PubMed 30789356

Svanevik M, Risstad H, Hofsø D, Blom-Høgestøl IK, Kristinsson JA, Sandbu R, Småstuen MC, Thorsby PM, Mala T, Hjelmesæth J (2019)
Bone Turnover Markers After Standard and Distal Roux-en-Y Gastric Bypass: Results from a Randomized Controlled Trial
Obes Surg (in press)
DOI 10.1007/s11695-019-03909-1, PubMed 31065919

Tapia G, Mårild K, Dahl SR, Lund-Blix NA, Viken MK, Lie BA, Njølstad PR, Joner G, Skrivarhaug T, Cohen AS, Størdal K, Stene LC (2019)
Maternal and Newborn Vitamin D-Binding Protein, Vitamin D Levels, Vitamin D Receptor Genotype, and Childhood Type 1 Diabetes
Diabetes Care, 42 (4), 553-559
DOI 10.2337/dc18-2176, PubMed 30692241

Tiedemann D, Mouhammad ZA, Utheim TP, Dartt DA, Heegaard S, Petrovski G, Kolko M (2019)
Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment
J Glaucoma, 28 (4), 325-333
DOI 10.1097/IJG.0000000000001168, PubMed 30585937

Tuv SS, Nordal K, Vethe NT, Bergan S (2019)
Pharmacogenetics in personalised drug therapy
Tidsskr Nor Laegeforen, 139 (8)
DOI 10.4045/tidsskr.19.0055, PubMed 31062549

Utheim OA, Pasovic L, Raeder S, Eidet JR, Fostad IG, Sehic A, Roald B, de la Paz MF, Lyberg T, Dartt DA, Utheim TP (2019)
Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells
PLoS One, 14 (3), e0212524
DOI 10.1371/journal.pone.0212524, PubMed 30861002

Vohra R, Dalgaard LM, Vibaek J, Langbøl MA, Bergersen LH, Olsen NV, Hassel B, Chaudhry FA, Kolko M (2019)
Potential metabolic markers in glaucoma and their regulation in response to hypoxia
Acta Ophthalmol, 97 (6), 567-576
DOI 10.1111/aos.14021, PubMed 30690927

Yazdani M, Elgstøen KBP, Rootwelt H, Shahdadfar A, Utheim ØA, Utheim TP (2019)
Tear Metabolomics in Dry Eye Disease: A Review
Int J Mol Sci, 20 (15)
DOI 10.3390/ijms20153755, PubMed 31374809

Yazdani M, Shahdadfar A, Jackson CJ, Utheim TP (2019)
Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review
Cells, 8 (3)
DOI 10.3390/cells8030245, PubMed 30875861

Zheng J, Maerz W, Gergei I, Kleber M, Drechsler C, Wanner C, Brandenburg V, Reppe S, Gautvik KM, Medina-Gomez C, Shevroja E, Gilly A, Park YC, Dedoussis G, Zeggini E, Lorentzon M, Henning P, Lerner UH, Nilsson KH, Movérare-Skrtic S, Baird D, Elsworth B, Falk L, Groom A, Capellini TD et al. (2019)
Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures
J Bone Miner Res (in press)
DOI 10.1002/jbmr.3803, PubMed 31170332

Zhou W, Reinstein DZ, Chen X, Chen S, Xu Y, Utheim TP, Stojanovic A (2019)
Transepithelial Topography-Guided Ablation Assisted by Epithelial Thickness Mapping for Treatment of Regression After Myopic Refractive Surgery
J Refract Surg, 35 (8), 525-533
DOI 10.3928/1081597X-20190730-01, PubMed 31393991

Øya E, Solhaug A, Bølling AK, Øvstebø R, Steensen TB, Afanou AKJ, Holme JA (2019)
Pro-inflammatory responses induced by A. fumigatus and A. versicolor in various human macrophage models
J Toxicol Environ Health A, 82 (8), 483-501
DOI 10.1080/15287394.2019.1619114, PubMed 31116698

 
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