Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Department of Medical Biochemistry

30 publications found

Bornstedt ME, Gjerlaugsen N, Pepaj M, Bredahl MKL, Thorsby PM (2019)
Vitamin D Increases Glucose Stimulated Insulin Secretion from Insulin Producing Beta Cells (INS1E)
Int J Endocrinol Metab, 17 (1), e74255
DOI 10.5812/ijem.74255, PubMed 30881469

Botten N, Hodges RR, Li D, Bair JA, Shatos MA, Utheim TP, Serhan CN, Dartt DA (2019)
Resolvin D2 elevates cAMP to increase intracellular [Ca2+] and stimulate secretion from conjunctival goblet cells
FASEB J, fj201802467R (in press)
DOI 10.1096/fj.201802467R, PubMed 31013438

Buer LCT, Moum BA, Cvancarova M, Warren DJ, Bolstad N, Medhus AW, Høivik ML (2019)
Real world data on effectiveness, safety and therapeutic drug monitoring of vedolizumab in patients with inflammatory bowel disease. A single center cohort
Scand J Gastroenterol, 54 (1), 41-48
DOI 10.1080/00365521.2018.1548646, PubMed 30650312

Chen X, Aqrawi LA, Utheim TP, Tashbayev B, Utheim ØA, Reppe S, Hove LH, Herlofson BB, Singh PB, Palm Ø, Galtung HK, Jensen JCL (2019)
Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations
Sci Rep, 9 (1), 7319
DOI 10.1038/s41598-019-43714-5, PubMed 31086200

Danese E, Raimondi S, Montagnana M, Tagetti A, Langaee T, Borgiani P, Ciccacci C, Carcas AJ, Borobia AM, Tong HY, Dávila-Fajardo C, Rodrigues Botton M, Bourgeois S, Deloukas P, Caldwell MD, Burmester JK, Berg RL, Cavallari LH, Drozda K, Huang M, Zhao LZ, Cen HJ, Gonzalez-Conejero R, Roldan V, Nakamura Y et al. (2019)
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals
Clin Pharmacol Ther, 105 (6), 1477-1491
DOI 10.1002/cpt.1323, PubMed 30506689

Dantas H, Warren DJ, Wendelken S, Davis T, Clark GA, Mathews VJ (2019)
Deep Learning Movement Intent Decoders Trained with Dataset Aggregation for Prosthetic Limb Control
IEEE Trans Biomed Eng (in press)
DOI 10.1109/TBME.2019.2901882, PubMed 30835207

Eilertsen H, Saether PC, Henriksson CE, Petersen AS, Hagve TA (2019)
Evaluation of the detection of blasts by Sysmex hematology instruments, CellaVision DM96, and manual microscopy using flow cytometry as the confirmatory method
Int J Lab Hematol, 41 (3), 338-344
DOI 10.1111/ijlh.12980, PubMed 30742354

Goll GL, Jørgensen KK, Sexton J, Olsen IC, Bolstad N, Haavardsholm EA, Lundin KEA, Tveit KS, Lorentzen M, Berset IP, Fevang BTS, Kalstad S, Ryggen K, Warren DJ, Klaasen RA, Asak Ø, Baigh S, Blomgren IM, Brenna Ø, Bruun TJ, Dvergsnes K, Frigstad SO, Hansen IM, Hatten ISH, Huppertz-Hauss G et al. (2019)
Long-term efficacy and safety of biosimilar infliximab (CT-P13) after switching from originator infliximab: open-label extension of the NOR-SWITCH trial
J Intern Med, 285 (6), 653-669
DOI 10.1111/joim.12880, PubMed 30762274

Gustafsson MK, Romundstad PR, Stafne SN, Helvik AS, Stunes AK, Mørkved S, Salvesen KÅ, Thorsby PM, Mosti MP, Syversen U (2019)
The effect of an exercise program in pregnancy on vitamin D status among healthy, pregnant Norwegian women: a randomized controlled trial
BMC Pregnancy Childbirth, 19 (1), 76
DOI 10.1186/s12884-019-2220-z, PubMed 30786861

Hsu YH, Estrada K, Evangelou E, Ackert-Bicknell C, Akesson K, Beck T, Brown SJ, Capellini T, Carbone L, Cauley J, Cheung CL, Cummings SR, Czerwinski S, Demissie S, Econs M, Evans D, Farber C, Gautvik K, Harris T, Kammerer C, Kemp J, Koller DL, Kung A, Lawlor D, Lee M et al. (2019)
Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry
J Bone Miner Res, e3698 (in press)
DOI 10.1002/jbmr.3698, PubMed 30888730

Jorde R, Stunes AK, Kubiak J, Joakimsen R, Grimnes G, Thorsby PM, Syversen U (2019)
Effects of vitamin D supplementation on bone turnover markers and other bone-related substances in subjects with vitamin D deficiency
Bone, 124, 7-13 (in press)
DOI 10.1016/j.bone.2019.04.002, PubMed 30959189

Juvodden HT, Alnæs D, Lund MJ, Dietrichs E, Thorsby PM, Westlye LT, Knudsen S (2019)
Hypocretin-deficient narcolepsy patients have abnormal brain activation during humor processing
Sleep (in press)
DOI 10.1093/sleep/zsz082, PubMed 30923809

Kagan ZB, Mize JT, Kosta P, Lazzi G, Normann RA, Warren DJ (2019)
Reduced Heat Generation During Magnetic Stimulation of Rat Sciatic Nerve Using Current Waveform Truncation
IEEE Trans Neural Syst Rehabil Eng, 27 (5), 937-946
DOI 10.1109/TNSRE.2019.2911054, PubMed 30990431

Klaasen RA, Egeland EJ, Chan J, Midtvedt K, Svensson M, Bolstad N, Fellström B, Holdaas H, Åsberg A, Bergan S, Vethe NT, Warren DJ (2019)
A Fully Automated Method for the Determination of Serum Belatacept and Its Application in a Pharmacokinetic Investigation in Renal Transplant Recipients
Ther Drug Monit, 41 (1), 11-18
DOI 10.1097/FTD.0000000000000580, PubMed 30633722

Lundar L, Aksnes G, Mørkrid L, Emblem R (2019)
Prenatal extravasation of urine seems to preserve renal function in boys with posterior urethral valves
J Pediatr Urol (in press)
DOI 10.1016/j.jpurol.2019.02.010, PubMed 30982696

Meuwese CL, van Diepen M, Cappola AR, Sarnak MJ, Shlipak MG, Bauer DC, Fried LP, Iacoviello M, Vaes B, Degryse J, Khaw KT, Luben RN, Åsvold BO, Bjøro T, Vatten LJ, de Craen AJM, Trompet S, Iervasi G, Molinaro S, Ceresini G, Ferrucci L, Dullaart RPF, Bakker SJL, Jukema JW, Kearney PM et al. (2019)
Low thyroid function is not associated with an accelerated deterioration in renal function
Nephrol Dial Transplant, 34 (4), 650-659
DOI 10.1093/ndt/gfy071, PubMed 29684213

Mihret W, Sletbakk Brusletto B, Øvstebø R, Siebke Troseid AM, Norheim G, Merid Y, Kassu A, Abebe W, Ayele S, Silamsaw Asres M, Yamuah L, Aseffa A, Petros B, Caugant DA, Brandtzaeg P (2019)
Molecular studies of meningococcal and pneumococcal meningitis patients in Ethiopia
Innate Immun, 25 (3), 158-167
DOI 10.1177/1753425918806363, PubMed 30894090

Myhrstad MCW, de Mello VD, Dahlman I, Kolehmainen M, Paananen J, Rundblad A, Carlberg C, Olstad OK, Pihlajamäki J, Holven KB, Hermansen K, Dragsted LO, Gunnarsdottir I, Cloetens L, Storm MU, Åkesson B, Rosqvist F, Hukkanen J, Herzig KH, Risérus U, Thorsdottir I, Poutanen KS, Savolainen MJ, Schwab U, Arner P et al. (2019)
Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome-A SYSDIET Sub-Study
Mol Nutr Food Res, e1801405 (in press)
DOI 10.1002/mnfr.201801405, PubMed 30964598

Schrader H, Bøhmer T, Aasly J (2019)
The Incidence of Diagnosis of Munchausen Syndrome, Other Factitious Disorders, and Malingering
Behav Neurol, 2019, 3891809
DOI 10.1155/2019/3891809, PubMed 30944662

Skogstad M, Mamen A, Lunde LK, Ulvestad B, Matre D, Aass HCD, Øvstebø R, Nielsen P, Samuelsen KN, Skare Ø, Sirnes PA (2019)
Shift Work Including Night Work and Long Working Hours in Industrial Plants Increases the Risk of Atherosclerosis
Int J Environ Res Public Health, 16 (3)
DOI 10.3390/ijerph16030521, PubMed 30759884

Stadnikova A, Trosan P, Skalicka P, Utheim TP, Jirsova K (2019)
Interleukin-13 maintains the stemness of conjunctival epithelial cell cultures prepared from human limbal explants
PLoS One, 14 (2), e0211861
DOI 10.1371/journal.pone.0211861, PubMed 30742646

Stiksrud B, Aass HCD, Lorvik KB, Ueland T, Trøseid M, Dyrhol-Riise AM (2019)
Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery
AIDS, 33 (7), 1117-1129
DOI 10.1097/QAD.0000000000002173, PubMed 30789356

Svanevik M, Risstad H, Hofsø D, Blom-Høgestøl IK, Kristinsson JA, Sandbu R, Småstuen MC, Thorsby PM, Mala T, Hjelmesæth J (2019)
Bone Turnover Markers After Standard and Distal Roux-en-Y Gastric Bypass: Results from a Randomized Controlled Trial
Obes Surg (in press)
DOI 10.1007/s11695-019-03909-1, PubMed 31065919

Tapia G, Mårild K, Dahl SR, Lund-Blix NA, Viken MK, Lie BA, Njølstad PR, Joner G, Skrivarhaug T, Cohen AS, Størdal K, Stene LC (2019)
Maternal and Newborn Vitamin D-Binding Protein, Vitamin D Levels, Vitamin D Receptor Genotype, and Childhood Type 1 Diabetes
Diabetes Care, 42 (4), 553-559
DOI 10.2337/dc18-2176, PubMed 30692241

Tiedemann D, Mouhammad ZA, Utheim TP, Dartt DA, Heegaard S, Petrovski G, Kolko M (2019)
Conjunctival Goblet Cells, the Overlooked Cells in Glaucoma Treatment
J Glaucoma, 28 (4), 325-333
DOI 10.1097/IJG.0000000000001168, PubMed 30585937

Tuv SS, Nordal K, Vethe NT, Bergan S (2019)
Pharmacogenetics in personalised drug therapy
Tidsskr Nor Laegeforen, 139 (8)
DOI 10.4045/tidsskr.19.0055, PubMed 31062549

Utheim OA, Pasovic L, Raeder S, Eidet JR, Fostad IG, Sehic A, Roald B, de la Paz MF, Lyberg T, Dartt DA, Utheim TP (2019)
Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells
PLoS One, 14 (3), e0212524
DOI 10.1371/journal.pone.0212524, PubMed 30861002

Vohra R, Dalgaard LM, Vibaek J, Langbøl MA, Bergersen LH, Olsen NV, Hassel B, Chaudhry FA, Kolko M (2019)
Potential metabolic markers in glaucoma and their regulation in response to hypoxia
Acta Ophthalmol (in press)
DOI 10.1111/aos.14021, PubMed 30690927

Yazdani M, Chen X, Tashbayev B, Utheim ØA, Ræder S, Hua Y, Eidet JR, Stojanovic A, Dartt DA, Utheim TP (2019)
Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients
Curr Eye Res, 1-7 (in press)
DOI 10.1080/02713683.2019.1604972, PubMed 30955380

Yazdani M, Shahdadfar A, Jackson CJ, Utheim TP (2019)
Hyaluronan-Based Hydrogel Scaffolds for Limbal Stem Cell Transplantation: A Review
Cells, 8 (3)
DOI 10.3390/cells8030245, PubMed 30875861

 
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