Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
Click here to see hierarchical division and subunit overview
Summary of publications:
Publications (original articles or review articles) published in 2017 from OUS - Department of Medical Biochemistry
77 publications found
Establishment of a tear protein biomarker panel differentiating between Graves' disease with or without orbitopathy
PLoS One, 12 (4), e0175274
DOI 10.1371/journal.pone.0175274, PubMed 28419103
Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density
Ann Rheum Dis, 77 (3), 378-385
DOI 10.1136/annrheumdis-2017-212469, PubMed 29170203
Identification of potential saliva and tear biomarkers in primary Sjögren's syndrome, utilising the extraction of extracellular vesicles and proteomics analysis
Arthritis Res Ther, 19 (1), 14
DOI 10.1186/s13075-017-1228-x, PubMed 28122643
Assays for Infliximab Drug Levels and Antibodies: A Matter of Scales and Categories
Scand J Immunol, 86 (3), 165-170
DOI 10.1111/sji.12572, PubMed 28561325
Weight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: a cohort study
BMC Pediatr, 17 (1), 141
DOI 10.1186/s12887-017-0889-6, PubMed 28592289
NFAT-regulated cytokine gene expression during tacrolimus therapy early after renal transplantation
Br J Clin Pharmacol, 83 (11), 2494-2502
DOI 10.1111/bcp.13367, PubMed 28686294
Specific antibodies and sensitive immunoassays for the human epidermal growth factor receptors (HER2, HER3, and HER4)
Tumour Biol, 39 (6), 1010428317707436
DOI 10.1177/1010428317707436, PubMed 28653892
Traceability and distribution of Neisseria meningitidis DNA in archived post mortem tissue samples from patients with systemic meningococcal disease
BMC Clin Pathol, 17, 10
DOI 10.1186/s12907-017-0049-9, PubMed 28824331
Switching from Remicade® to Remsima® is well Tolerated and Feasible: A Prospective, Open-label Study
J Crohns Colitis, 11 (3), 297-304
DOI 10.1093/ecco-jcc/jjw166, PubMed 27660339
Medium- to Long-Term Results of Corneal Cross-Linking for Keratoconus Using Phototherapeutic Keratectomy for Epithelial Removal and Partial Stromal Ablation
J Refract Surg, 33 (7), 488-495
DOI 10.3928/1081597X-20170504-03, PubMed 28681909
Meibomian gland features in a Norwegian cohort of patients with primary Sjögren´s syndrome
PLoS One, 12 (9), e0184284
DOI 10.1371/journal.pone.0184284, PubMed 28886085
Cyst Fluid From Cystic, Malignant Brain Tumors: A Reservoir of Nutrients, Including Growth Factor-Like Nutrients, for Tumor Cells
Neurosurgery, 80 (6), 917-924
DOI 10.1093/neuros/nyw101, PubMed 28327992
PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX
Genome Res, 27 (6), 913-921
DOI 10.1101/gr.215830.116, PubMed 28341773
Anti-rheumatic treatment is not associated with reduction of pentraxin 3 in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
PLoS One, 12 (2), e0169830
DOI 10.1371/journal.pone.0169830, PubMed 28225768
Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis
Arthritis Res Ther, 19 (1), 232
DOI 10.1186/s13075-017-1439-1, PubMed 29041979
The use of CellaVision™ DM96 in the verification of the presence of blasts in samples flagged by the Sysmex XE-5000
Int J Lab Hematol, 39 (4), 423-428
DOI 10.1111/ijlh.12648, PubMed 28333407
Sham or no sham control: that is the question in trials of renal denervation for resistant hypertension. A systematic meta-analysis
Blood Press, 26 (4), 195-203
DOI 10.1080/08037051.2017.1311769, PubMed 28443356
Identification of Objective Morphometric Markers of Xerostomia in the Oral Mucosa Epithelium with In Vivo Confocal Microscopy
Microsc Microanal, 23 (1), 88-96
DOI 10.1017/S1431927617000022, PubMed 28162126
Novel Treatment with Intraperitoneal MOC31PE Immunotoxin in Colorectal Peritoneal Metastasis: Results From the ImmunoPeCa Phase 1 Trial
Ann Surg Oncol, 24 (7), 1916-1922
DOI 10.1245/s10434-017-5814-6, PubMed 28224367
Effect of multiple freeze-thaw cycles on selected biochemical serum components
Clin Chem Lab Med, 55 (7), 967-973
DOI 10.1515/cclm-2016-0892, PubMed 27987362
Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10
BMC Immunol, 18 (1), 46
DOI 10.1186/s12865-017-0229-5, PubMed 29078758
The effect of corn trypsin inhibitor, anti-tissue factor pathway inhibitor antibodies and phospholipids on microvesicle-associated thrombin generation in patients with pancreatic cancer and healthy controls
PLoS One, 12 (9), e0184579
DOI 10.1371/journal.pone.0184579, PubMed 28910348
Uptake and release of amino acids in the fetal-placental unit in human pregnancies
PLoS One, 12 (10), e0185760
DOI 10.1371/journal.pone.0185760, PubMed 28982184
Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium
Dement Geriatr Cogn Dis Extra, 7 (3), 374-385
DOI 10.1159/000481853, PubMed 29282410
Tissue Harvesting Site and Culture Medium Affect Attachment, Growth, and Phenotype of Ex Vivo Expanded Oral Mucosal Epithelial Cells
Sci Rep, 7 (1), 674
DOI 10.1038/s41598-017-00417-z, PubMed 28386069
Optimization of Storage Temperature for Retention of Undifferentiated Cell Character of Cultured Human Epidermal Cell Sheets
Sci Rep, 7 (1), 8206
DOI 10.1038/s41598-017-08586-7, PubMed 28811665
Cultured epidermal stem cells in regenerative medicine
Stem Cell Res Ther, 8 (1), 155
DOI 10.1186/s13287-017-0587-1, PubMed 28676094
Proliferative Cells Isolated from the Adult Human Peripheral Retina only Transiently Upregulate Key Retinal Markers upon Induced Differentiation
Curr Eye Res, 43 (3), 340-349
DOI 10.1080/02713683.2017.1403630, PubMed 29161152
Switching from originator infliximab to biosimilar CT-P13 compared with maintained treatment with originator infliximab (NOR-SWITCH): a 52-week, randomised, double-blind, non-inferiority trial
Lancet, 389 (10086), 2304-2316
DOI 10.1016/S0140-6736(17)30068-5, PubMed 28502609
Genetic Polymorphism of miR-196a-2 is Associated with Bone Mineral Density (BMD)
Int J Mol Sci, 18 (12)
DOI 10.3390/ijms18122529, PubMed 29186852
Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans
DNA Repair (Amst), 61, 46-55
DOI 10.1016/j.dnarep.2017.11.009, PubMed 29202295
HbA1c analysis by capillary electrophoresis - comparison with chromatography and an immunological method
Scand J Clin Lab Invest, 77 (6), 458-464
DOI 10.1080/00365513.2017.1338747, PubMed 28644050
Perioperative humoral stress response to laparoscopic versus open aortobifemoral bypass surgery
Scand J Clin Lab Invest, 77 (2), 83-92
DOI 10.1080/00365513.2016.1268264, PubMed 28067075
High-Sensitivity Troponin T vs I in Acute Coronary Syndrome: Prediction of Significant Coronary Lesions and Long-term Prognosis
Acta Bioquim. Clin. Latinoam., 51 (3), 395-407
Stage-related central corneal epithelial transformation in congenital aniridia-associated keratopathy
Ocul Surf, 16 (1), 163-172
DOI 10.1016/j.jtos.2017.11.003, PubMed 29133179
Reduced Corneal Nerve Fiber Density in Type 2 Diabetes by Wide-Area Mosaic Analysis
Invest Ophthalmol Vis Sci, 58 (14), 6318-6327
DOI 10.1167/iovs.17-22257, PubMed 29242906
The genetics of congenital aniridia-a guide for the ophthalmologist
Surv Ophthalmol, 63 (1), 105-113
DOI 10.1016/j.survophthal.2017.09.004, PubMed 28923585
Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites
Nucleus, 8 (4), 404-420
DOI 10.1080/19491034.2017.1306161, PubMed 28402725
The microINR portable coagulometer: analytical quality and user-friendliness of a PT (INR) point-of-care instrument
Scand J Clin Lab Invest, 77 (2), 115-121
DOI 10.1080/00365513.2016.1277433, PubMed 28150507
To elute or not to elute in immunocapture bottom-up LC-MS
J Chromatogr B Analyt Technol Biomed Life Sci, 1055-1056, 51-60
DOI 10.1016/j.jchromb.2017.03.044, PubMed 28445847
Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells
Sci Rep, 7 (1), 5081
DOI 10.1038/s41598-017-05086-6, PubMed 28698547
Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways
Invest Ophthalmol Vis Sci, 58 (11), 4530-4544
DOI 10.1167/iovs.17-21914, PubMed 28892824
Physical activity initiated by employer induces improvements in a novel set of biomarkers of inflammation: an 8-week follow-up study
Eur J Appl Physiol, 117 (3), 521-532
DOI 10.1007/s00421-016-3533-5, PubMed 28185008
Apparent treatment-resistant hypertension - patient-physician relationship and ethical issues
Blood Press, 26 (3), 133-138
DOI 10.1080/08037051.2016.1277129, PubMed 28078909
Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
Nat Commun, 8 (1), 121
DOI 10.1038/s41467-017-00108-3, PubMed 28743860
Precision newborn screening for lysosomal disorders
Genet Med, 20 (8), 847-854
DOI 10.1038/gim.2017.194, PubMed 29120458
An intronic variation in SLC52A1 causes exon skipping and transient riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency
Mol Genet Metab, 122 (4), 182-188
DOI 10.1016/j.ymgme.2017.10.014, PubMed 29122468
Bronchial wheezing predicts inflammation and respiratory failure in fire smoke victims
Acta Anaesthesiol Scand, 61 (9), 1142-1154
DOI 10.1111/aas.12962, PubMed 28832892
Vitamin D Deficiency Associated With Cognitive Functioning in Psychotic Disorders
J Clin Psychiatry, 78 (7), e750-e757
DOI 10.4088/JCP.16m10880, PubMed 28493652
Multicellular tumor spheroids of human uveal melanoma induce genes associated with anoikis resistance, lipogenesis, and SSXs
Mol Vis, 23, 680-694
PubMed 29033534
Circadian clock and oral cancer
Mol Clin Oncol, 8 (2), 219-226
DOI 10.3892/mco.2017.1518, PubMed 29435282
A Double-Blinded Randomized Study Investigating a Possible Anti-Inflammatory Effect of Saxagliptin versus Placebo as Add-On Therapy in Patients with Both Type 2 Diabetes And Stable Coronary Artery Disease
Mediators Inflamm, 2017, 5380638
DOI 10.1155/2017/5380638, PubMed 28596642
Lowered reference limits for hCG improve follow-up of patients with hCG-producing tumors
Clin Biochem, 52, 73-79
DOI 10.1016/j.clinbiochem.2017.11.016, PubMed 29198759
Estrogen Receptor α, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA
J Clin Endocrinol Metab, 102 (9), 3581-3590
DOI 10.1210/jc.2017-00792, PubMed 28911153
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA
Mitochondrion, 40, 16-28
DOI 10.1016/j.mito.2017.09.002, PubMed 28893634
Normal Neurological Development During Infancy Despite Massive Hyperammonemia in Early Treated NAGS Deficiency
JIMD Rep, 37, 45-47
DOI 10.1007/8904_2017_13, PubMed 28275973
Omics analysis of human bone to identify genes and molecular networks regulating skeletal remodeling in health and disease
Bone, 101, 88-95
DOI 10.1016/j.bone.2017.04.012, PubMed 28450214
Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women
Epigenetics, 12 (8), 674-687
DOI 10.1080/15592294.2017.1345832, PubMed 28650214
Bile acid profiles over 5 years after gastric bypass and duodenal switch: results from a randomized clinical trial
Surg Obes Relat Dis, 13 (9), 1544-1553
DOI 10.1016/j.soard.2017.05.024, PubMed 28756050
β-Thromboglobulin may not reflect platelet activation during haemodialysis with the HeprAN membrane
Scand J Clin Lab Invest, 77 (8), 679-684
DOI 10.1080/00365513.2017.1397288, PubMed 29117741
Estimating Glomerular Filtration Rate in Kidney Transplant Recipients: Comparing a Novel Equation With Commonly Used Equations in this Population
Transplant Direct, 3 (12), e332
DOI 10.1097/TXD.0000000000000742, PubMed 29536033
Renal Function Influences Diagnostic Markers in Serum and Urine: A Study of Guanidinoacetate, Creatine, Human Epididymis Protein 4, and Neutrophil Gelatinase-Associated Lipocalin in Children
J. Appl. Lab. Med., 2 (3), 297-308
HLA-DQ-Gluten Tetramer Blood Test Accurately Identifies Patients With and Without Celiac Disease in Absence of Gluten Consumption
Gastroenterology, 154 (4), 886-896.e6
DOI 10.1053/j.gastro.2017.11.006, PubMed 29146521
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
DNA Repair (Amst), 61, 56-62
DOI 10.1016/j.dnarep.2017.11.008, PubMed 29207315
The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor
Thromb J, 15, 6
DOI 10.1186/s12959-017-0129-1, PubMed 28239301
The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII in apixaban-treated patients in vitro
Res Pract Thromb Haemost, 1 (1), 49-56
DOI 10.1002/rth2.12015, PubMed 30046673
Bone mineral density is close to normal for age in long-term lymphoma survivors treated with high-dose therapy with autologous stem cell transplantation
Acta Oncol, 56 (4), 590-598
DOI 10.1080/0284186X.2016.1267870, PubMed 28077016
Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases
PLoS One, 12 (3), e0174577
DOI 10.1371/journal.pone.0174577, PubMed 28362874
Prednisolone and Prednisone Pharmacokinetics in Pediatric Renal Transplant Recipients-A Prospective Study
Ther Drug Monit, 39 (5), 472-482
DOI 10.1097/FTD.0000000000000439, PubMed 28749817
Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication
J Extracell Vesicles, 6 (1), 1407213
DOI 10.1080/20013078.2017.1407213, PubMed 30044885
Maternal serum calcitriol during pregnancy and risk of childhood onset type 1 diabetes
Acta Diabetol, 54 (12), 1143-1145
DOI 10.1007/s00592-017-1045-3, PubMed 28875306
Acute impairing effects of morphine related to driving: A systematic review of experimental studies to define blood morphine concentrations related to impairment in opioid-naïve subjects
Traffic Inj Prev, 18 (8), 788-794
DOI 10.1080/15389588.2017.1326595, PubMed 28481682
Interdisciplinary, Comprehensive Oral and Ocular Evaluation of Patients with Primary Sjögren's Syndrome
Sci Rep, 7 (1), 10761
DOI 10.1038/s41598-017-10809-w, PubMed 28883442
Iohexol plasma clearance in children: validation of multiple formulas and single-point sampling times
Pediatr Nephrol, 33 (4), 683-696
DOI 10.1007/s00467-017-3841-y, PubMed 29134449
Normal Vitamin Levels and Nutritional Indices in Alzheimer's Disease Patients with Mild Cognitive Impairment or Dementia with Normal Body Mass Indexes
J Alzheimers Dis, 55 (2), 717-725
DOI 10.3233/JAD-160393, PubMed 27716664
Size and concentration analyses of extracellular vesicles by nanoparticle tracking analysis: a variation study
J Extracell Vesicles, 6 (1), 1344087
DOI 10.1080/20013078.2017.1344087, PubMed 28804597
Plasma immunological markers in pregnancy and cord blood: A possible link between macrophage chemo-attractants and risk of childhood type 1 diabetes
Am J Reprod Immunol, 79 (3)
DOI 10.1111/aji.12802, PubMed 29266506