Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2014 from OUS - Department of Medical Biochemistry

63 publications found

Alseth I, Dalhus B, Bjørås M (2014)
Inosine in DNA and RNA
Curr Opin Genet Dev, 26, 116-23
DOI 10.1016/j.gde.2014.07.008, PubMed 25173738

Amundsen EK, Urdal P, Holthe MR, Henriksson CE (2014)
Aggregation of monocytes and platelets interferes in measurement of monocyte viability with phosphatidylserine expression but not with mitochondrial membrane potential in whole blood
Cytometry B Clin Cytom (in press)
DOI 10.1002/cytob.21189, PubMed 25178677

Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J (2014)
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
DOI 10.1074/jbc.M114.549832, PubMed 24652290

Andreassen OA, McEvoy LK, Thompson WK, Wang Y, Reppe S, Schork AJ, Zuber V, Barrett-Connor E, Gautvik K, Aukrust P, Karlsen TH, Djurovic S, Desikan RS, Dale AM, International Consortium for Blood Pressure Genome-Wide Association Studies, Genetic Factors for Osteoporosis Consortium (2014)
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes
Hypertension, 63 (4), 819-26
DOI 10.1161/HYPERTENSIONAHA.113.02077, PubMed 24396023

Aspelin T, Eriksen M, Ilebekk A, Cataliotti A, Carlson CR, Lyberg T (2014)
β-blockade abolishes the augmented cardiac tPA release induced by transactivation of heterodimerised bradykinin receptor-2 and β2-adrenergic receptor in vivo
Thromb Haemost, 112 (5), 951-9
DOI 10.1160/TH14-01-0059, PubMed 25078038

Bergersen TK, Hoffmann-Vold AM, Midtvedt Ø, Gran JT, Mørk C, Toska K, Elstad M (2014)
Dysfunctional arteriovenous anastomoses in hands of systemic sclerosis patients with digital ulcers
Clin Exp Rheumatol, 32 (6 Suppl 86), S-53-9
PubMed 24847906

Bolann BJ, Distante S, Mørkrid L, Ulvik RJ (2014)
Bloodletting therapy in hemochromatosis: Does it affect trace element homeostasis?
J Trace Elem Med Biol, 31, 225-9
DOI 10.1016/j.jtemb.2014.07.021, PubMed 25175510

Brauckhoff M, Machens A, Lorenz K, Bjøro T, Varhaug JE, Dralle H (2014)
Surgical curability of medullary thyroid cancer in multiple endocrine neoplasia 2B: a changing perspective
Ann Surg, 259 (4), 800-6
DOI 10.1097/SLA.0b013e3182a6f43a, PubMed 23979292

Capulli M, Olstad OK, Onnerfjord P, Tillgren V, Muraca M, Gautvik KM, Heinegård D, Rucci N, Teti A (2014)
The C-terminal domain of chondroadherin: a new regulator of osteoclast motility counteracting bone loss
J Bone Miner Res, 29 (8), 1833-46
DOI 10.1002/jbmr.2206, PubMed 24616121

Chen X, Stojanovic A, Hua Y, Eidet JR, Hu D, Wang J, Utheim TP (2014)
Reliability of corneal dynamic scheimpflug analyser measurements in virgin and post-PRK eyes
PLoS One, 9 (10), e109577
DOI 10.1371/journal.pone.0109577, PubMed 25302580

Dahl J, Ormstad H, Aass HC, Malt UF, Bendz LT, Sandvik L, Brundin L, Andreassen OA (2014)
The plasma levels of various cytokines are increased during ongoing depression and are reduced to normal levels after recovery
Psychoneuroendocrinology, 45, 77-86
DOI 10.1016/j.psyneuen.2014.03.019, PubMed 24845179

Dahl SR, Thorsby PM (2014)
[How to measure vitamin D status?]
Tidsskr Nor Laegeforen, 134 (7), 729-31
DOI 10.4045/tidsskr.13.0981, PubMed 24721864

Eidet JR, Pasovic L, Maria R, Jackson CJ, Utheim TP (2014)
Objective assessment of changes in nuclear morphology and cell distribution following induction of apoptosis
Diagn Pathol, 9, 92
DOI 10.1186/1746-1596-9-92, PubMed 24885713

Eidet JR, Utheim ØA, Islam R, Lyberg T, Messelt EB, Dartt DA, Utheim TP (2014)
The impact of storage temperature on the morphology, viability, cell number and metabolism of cultured human conjunctival epithelium
Curr Eye Res, 40 (1), 30-9
DOI 10.3109/02713683.2014.909497, PubMed 24750037

Fosså SD, Hess SL, Paus E, Borgen E (2014)
Circulating tumor cells in patients with metastatic castration resistant prostate cancer: exploratory findings at a tertiary referral hospital
Res Rep Urol, 6, 121-6
DOI 10.2147/RRU.S68477, PubMed 25328865

Gislefoss RE, Grimsrud TK, Mørkrid L (2014)
Stability of selected serum hormones and lipids after long-term storage in the Janus Serum Bank
Clin Biochem, 48 (6), 364-9
DOI 10.1016/j.clinbiochem.2014.12.006, PubMed 25523301

Gopinathan U, Brusletto BS, Olstad OK, Kierulf P, Berg JP, Brandtzaeg P, Øvstebø R (2014)
IL-10 immunodepletion from meningococcal sepsis plasma induces extensive changes in gene expression and cytokine release in stimulated human monocytes
Innate Immun, 21 (4), 429-49
DOI 10.1177/1753425914547743, PubMed 25233959

Grimholt RM, Urdal P, Klingenberg O, Piehler AP (2014)
Rapid and reliable detection of α-globin copy number variations by quantitative real-time PCR
BMC Hematol, 14 (1), 4
DOI 10.1186/2052-1839-14-4, PubMed 24456650

Heier MS, Skinningsrud A, Paus E, Gautvik KM (2014)
Increased cerebrospinal fluid levels of nerve cell biomarkers in narcolepsy with cataplexy
Sleep Med, 15 (6), 614-8
DOI 10.1016/j.sleep.2014.02.005, PubMed 24784789

Hereng TH, Elgstøen KB, Eide L, Rosendal KR, Skålhegg BS (2014)
Serum albumin and HCO3- regulate separate pools of ATP in human spermatozoa
Hum Reprod, 29 (5), 918-30
DOI 10.1093/humrep/deu028, PubMed 24578478

Husøy MA, Brinch L, Tjønnfjord GE, Gedde-Dahl T, Heldal D, Holme PA, Dybedal I, Kolstad A, Akkök ÇA, Rollag H, Gaustad P, Bergan S, Egeland T, Josefsen D, Kvalheim G, Fløisand Y (2014)
[Allogeneic stem-cell transplantation in adults 1985-2012: results and development]
Tidsskr Nor Laegeforen, 134 (16), 1569-75
DOI 10.4045/tidsskr.13.1415, PubMed 25178233

Høiseth G, Fjeld B, Burns ML, Strand DH, Vindenes V (2014)
Long-term stability of morphine, codeine, and 6-acetylmorphine in real-life whole blood samples, stored at -20°C
Forensic Sci Int, 239, 6-10
DOI 10.1016/j.forsciint.2014.03.008, PubMed 24709028

Jackson C, Aabel P, Eidet JR, Messelt EB, Lyberg T, von Unge M, Utheim TP (2014)
Effect of storage temperature on cultured epidermal cell sheets stored in xenobiotic-free medium
PLoS One, 9 (8), e105808
DOI 10.1371/journal.pone.0105808, PubMed 25170754

Kemp JP, Medina-Gomez C, Estrada K, St Pourcain B, Heppe DH, Warrington NM, Oei L, Ring SM, Kruithof CJ, Timpson NJ, Wolber LE, Reppe S, Gautvik K, Grundberg E, Ge B, van der Eerden B, van de Peppel J, Hibbs MA, Ackert-Bicknell CL, Choi K, Koller DL, Econs MJ, Williams FM, Foroud T, Zillikens MC et al. (2014)
Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment
PLoS Genet, 10 (6), e1004423
DOI 10.1371/journal.pgen.1004423, PubMed 24945404

Kiserud CE, Seland M, Holte H, Fosså A, Fosså SD, Bollerslev J, Bjøro T, Loge JH (2014)
Fatigue in male lymphoma survivors differs between diagnostic groups and is associated with latent hypothyroidism
Acta Oncol, 54 (1), 49-59
DOI 10.3109/0284186X.2014.948057, PubMed 25140862

Kringen MK, Piehler AP, Grimholt RM, Opdal MS, Haug KB, Urdal P (2014)
Serum bilirubin concentration in healthy adult North-Europeans is strictly controlled by the UGT1A1 TA-repeat variants
PLoS One, 9 (2), e90248
DOI 10.1371/journal.pone.0090248, PubMed 24587300

Landrø NI, Jonassen R, Clark L, Haug KB, Aker M, Bø R, Berg JP, Neumeister A, Stiles TC (2014)
Serotonin transporter polymorphisms predict response inhibition in healthy volunteers
Neurosci Lett, 584, 109-12
DOI 10.1016/j.neulet.2014.10.006, PubMed 25451724

Lund-Blix NA, Stene LC, Rasmussen T, Torjesen PA, Andersen LF, Rønningen KS (2014)
Infant feeding in relation to islet autoimmunity and type 1 diabetes in genetically susceptible children: the MIDIA Study
Diabetes Care, 38 (2), 257-63
DOI 10.2337/dc14-1130, PubMed 25422170

Lunde I, Bremer S, Midtvedt K, Mohebi B, Dahl M, Bergan S, Åsberg A, Christensen H (2014)
The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients
Eur J Clin Pharmacol, 70 (6), 685-93
DOI 10.1007/s00228-014-1656-3, PubMed 24658827

Maier L, Hylse O, Necas M, Trbusek M, Ytre-Arne M, Dalhus B, Bjoras M, Paruch K (2014)
New carbocyclic nucleosides: synthesis of carbocyclic pseudoisocytidine and its analogs
Tetrahedron Lett., 55 (27), 3713-3716

Mayorandan S, Meyer U, Gokcay G, Segarra NG, de Baulny HO, van Spronsen F, Zeman J, de Laet C, Spiekerkoetter U, Thimm E, Maiorana A, Dionisi-Vici C, Moeslinger D, Brunner-Krainz M, Lotz-Havla AS, Cocho de Juan JA, Couce Pico ML, Santer R, Scholl-Bürgi S, Mandel H, Bliksrud YT, Freisinger P, Aldamiz-Echevarria LJ, Hochuli M, Gautschi M et al. (2014)
Cross-sectional study of 168 patients with hepatorenal tyrosinaemia and implications for clinical practice
Orphanet J Rare Dis, 9, 107
DOI 10.1186/s13023-014-0107-7, PubMed 25081276

Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De Paula AM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, Tjønnfjord GE, Frengen E (2014)
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
DOI 10.1002/humu.22544, PubMed 24619930

Moltu SJ, Sachse D, Blakstad EW, Strømmen K, Nakstad B, Almaas AN, Westerberg AC, Rønnestad A, Brække K, Veierød MB, Iversen PO, Rise F, Berg JP, Drevon CA (2014)
Urinary metabolite profiles in premature infants show early postnatal metabolic adaptation and maturation
Nutrients, 6 (5), 1913-30
DOI 10.3390/nu6051913, PubMed 24824288

Nylenna M, Fagerbakk F, Kierulf P (2014)
Authorship: attitudes and practice among Norwegian researchers
BMC Med Ethics, 15, 53
DOI 10.1186/1472-6939-15-53, PubMed 24989359

Palibrk V, Lång E, Lång A, Schink KO, Rowe AD, Bøe SO (2014)
Promyelocytic leukemia bodies tether to early endosomes during mitosis
Cell Cycle, 13 (11), 1749-55
DOI 10.4161/cc.28653, PubMed 24675887

Pasovic L, Eidet JR, Lyberg T, Messelt EB, Aabel P, Utheim TP (2014)
Antioxidants Improve the Viability of Stored Adult Retinal Pigment Epithelial-19 Cultures
Ophthalmol Ther, 3 (1-2), 49-61
DOI 10.1007/s40123-014-0024-9, PubMed 25134496

Pepaj M, Gjerlaugsen N, Julien K, Thorsby PM (2014)
Tmem27 is upregulated by vitamin D in INS-1 cells and its serum concentrations are low in patients with autoimmune diabetes
Scand J Clin Lab Invest, 74 (4), 358-65
DOI 10.3109/00365513.2014.898322, PubMed 24693993

Riksen EA, Landin MA, Reppe S, Nakamura Y, Lyngstadaas SP, Reseland JE (2014)
Enamel matrix derivative promote primary human pulp cell differentiation and mineralization
Int J Mol Sci, 15 (5), 7731-49
DOI 10.3390/ijms15057731, PubMed 24857913

Robertsen I, Asberg A, Granseth T, Vethe NT, Akhlaghi F, Ghareeb M, Molden E, Reier-Nilsen M, Holdaas H, Midtvedt K (2014)
More potent lipid-lowering effect by rosuvastatin compared with fluvastatin in everolimus-treated renal transplant recipients
Transplantation, 97 (12), 1266-71
DOI 10.1097/01.TP.0000443225.66960.7e, PubMed 24521776

Rucci N, Capulli M, Olstad OK, Önnerfjord P, Tillgren V, Gautvik KM, Heinegård D, Teti A (2014)
The α2β1 binding domain of chondroadherin inhibits breast cancer-induced bone metastases and impairs primary tumour growth: a preclinical study
Cancer Lett, 358 (1), 67-75
DOI 10.1016/j.canlet.2014.12.032, PubMed 25529009

Sachse D, Bærug A, Sletner L, Birkeland KI, Nakstad B, Jenum AK, Berg JP (2014)
Urine NMR metabolomics analysis of breastfeeding biomarkers during and after pregnancy in a large prospective cohort study
Scand J Clin Lab Invest, 74 (3), 264-72
DOI 10.3109/00365513.2014.884240, PubMed 24621206

Saeland M, Wandel M, Böhmer T, Haugen M (2014)
Abscess infections and malnutrition--a cross-sectional study of polydrug addicts in Oslo, Norway
Scand J Clin Lab Invest, 74 (4), 322-8
DOI 10.3109/00365513.2014.891256, PubMed 24628456

Sand KM, Bern M, Nilsen J, Dalhus B, Gunnarsen KS, Cameron J, Grevys A, Bunting K, Sandlie I, Andersen JT (2014)
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)
J Biol Chem, 289 (50), 34583-94
DOI 10.1074/jbc.M114.587675, PubMed 25344603

Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT (2014)
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301

Sprauten M, Brydøy M, Haugnes HS, Cvancarova M, Bjøro T, Bjerner J, Fosså SD, Oldenburg J (2014)
Longitudinal serum testosterone, luteinizing hormone, and follicle-stimulating hormone levels in a population-based sample of long-term testicular cancer survivors
J Clin Oncol, 32 (6), 571-8
DOI 10.1200/JCO.2013.51.2715, PubMed 24419125

Steen NE, Methlie P, Lorentzen S, Dieset I, Aas M, Nerhus M, Haram M, Agartz I, Melle I, Berg JP, Andreassen OA (2014)
Altered systemic cortisol metabolism in bipolar disorder and schizophrenia spectrum disorders
J Psychiatr Res, 52, 57-62
DOI 10.1016/j.jpsychires.2014.01.017, PubMed 24534618

Stojanovic A, Zhou W, Utheim TP (2014)
Corneal collagen cross-linking with and without epithelial removal: a contralateral study with 0.5% hypotonic riboflavin solution
Biomed Res Int, 2014, 619398
DOI 10.1155/2014/619398, PubMed 25050368

Stormo C, Kringen MK, Lyle R, Olstad OK, Sachse D, Berg JP, Piehler AP (2014)
RNA-sequencing analysis of HepG2 cells treated with atorvastatin
PLoS One, 9 (8), e105836
DOI 10.1371/journal.pone.0105836, PubMed 25153832

Strand JM, Scheffler K, Bjørås M, Eide L (2014)
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences
DNA Repair (Amst), 18, 44-51
DOI 10.1016/j.dnarep.2014.03.003, PubMed 24685126

Strand JM, Skinnes R, Scheffler K, Rootvelt T, Woldseth B, Bjørås M, Eide L (2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis
Metabolism, 63 (8), 1063-70
DOI 10.1016/j.metabol.2014.05.003, PubMed 24928662

Stray-Pedersen A, Backe PH, Sorte HS, Mørkrid L, Chokshi NY, Erichsen HC, Gambin T, Elgstøen KB, Bjørås M, Wlodarski MW, Krüger M, Jhangiani SN, Muzny DM, Patel A, Raymond KM, Sasa GS, Krance RA, Martinez CA, Abraham SM, Speckmann C, Ehl S, Hall P, Forbes LR, Merckoll E, Westvik J et al. (2014)
PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia
Am J Hum Genet, 95 (1), 96-107
DOI 10.1016/j.ajhg.2014.05.007, PubMed 24931394

Størset E, Holford N, Hennig S, Bergmann TK, Bergan S, Bremer S, Åsberg A, Midtvedt K, Staatz CE (2014)
Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling
Br J Clin Pharmacol, 78 (3), 509-23
DOI 10.1111/bcp.12361, PubMed 25279405

Sæves I, Line PD, Bremer S, Vethe NT, Tveit RG, Meltevik TJ, Bergan S (2014)
Tacrolimus exposure and mycophenolate pharmacokinetics and pharmacodynamics early after liver transplantation
Ther Drug Monit, 36 (1), 46-53
DOI 10.1097/FTD.0b013e31829dcb66, PubMed 24081206

Torsetnes SB, Broughton MN, Paus E, Halvorsen TG, Reubsaet L (2014)
Determining ProGRP and isoforms in lung and thyroid cancer patient samples: comparing an MS method with a routine clinical immunoassay
Anal Bioanal Chem, 406 (11), 2733-8
DOI 10.1007/s00216-014-7634-x, PubMed 24518900

Torsetnes SB, Levernæs MS, Broughton MN, Paus E, Halvorsen TG, Reubsaet L (2014)
Multiplexing determination of small cell lung cancer biomarkers and their isovariants in serum by immunocapture LC-MS/MS
Anal Chem, 86 (14), 6983-92
DOI 10.1021/ac500986t, PubMed 24945626

Turgeon CT, Moser AB, Mørkrid L, Magera MJ, Gavrilov DK, Oglesbee D, Raymond K, Rinaldo P, Matern D, Tortorelli S (2014)
Streamlined determination of lysophosphatidylcholines in dried blood spots for newborn screening of X-linked adrenoleukodystrophy
Mol Genet Metab, 114 (1), 46-50
DOI 10.1016/j.ymgme.2014.11.013, PubMed 25481105

Urdal P, Amundsen EK, Toska K, Klingenberg O (2014)
Automated alarm to detect antigen excess in serum free immunoglobulin light chain kappa and lambda assays
Scand J Clin Lab Invest, 74 (7), 575-81
DOI 10.3109/00365513.2014.915426, PubMed 25007050

Vethe NT, Ali AM, Reine PA, Andersen AM, Bremer S, Line PD, Rootwelt H, Bergan S (2014)
Simultaneous quantification of IMPDH activity and purine bases in lymphocytes using LC-MS/MS: assessment of biomarker responses to mycophenolic acid
Ther Drug Monit, 36 (1), 108-18
DOI 10.1097/FTD.0b013e3182a13900, PubMed 24061448

Vikøren TB, Berg JP, Berg TJ (2014)
[Sources of error when using haemoglobin A1c]
Tidsskr Nor Laegeforen, 134 (4), 417-21
DOI 10.4045/tidsskr.13.0938, PubMed 24569741

Wang W, Scheffler K, Esbensen Y, Strand JM, Stewart JB, Bjørås M, Eide L (2014)
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age
PLoS One, 9 (5), e96940
DOI 10.1371/journal.pone.0096940, PubMed 24819950

Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR (2014)
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645

Yang M, Luna L, Sørbø JG, Alseth I, Johansen RF, Backe PH, Danbolt NC, Eide L, Bjørås M (2014)
Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21
Free Radic Biol Med, 77, 41-8
DOI 10.1016/j.freeradbiomed.2014.09.003, PubMed 25236744

Aakre I, Bjøro T, Norheim I, Strand TA, Barikmo I, Henjum S (2014)
Excessive iodine intake and thyroid dysfunction among lactating Saharawi women
J Trace Elem Med Biol, 31, 279-84
DOI 10.1016/j.jtemb.2014.09.009, PubMed 25447589

 
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