Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Pathology

43 publications found

Abelein A, Chen G, Kitoka K, Aleksis R, Oleskovs F, Sarr M, Landreh M, Pahnke J, Nordling K, Kronqvist N, Jaudzems K, Rising A, Johansson J, Biverstål H (2020)
High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain
Sci Rep, 10 (1), 235
DOI 10.1038/s41598-019-57143-x, PubMed 31937841

Alnaes-Katjavivi P, Roald B, Staff AC (2020)
Uteroplacental acute atherosis in preeclamptic pregnancies: Rates and clinical outcomes differ by tissue collection methods
Pregnancy Hypertens, 19, 11-17
DOI 10.1016/j.preghy.2019.11.007, PubMed 31864207

Amrutkar M, Larsen EK, Aasrum M, Finstadsveen AV, Andresen PA, Verbeke CS, Gladhaug IP (2020)
Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor
Cells, 9 (1)
DOI 10.3390/cells9010227, PubMed 31963309

Autio M, Leivonen SK, Brück O, Mustjoki S, Jørgensen JM, Karjalainen-Lindsberg ML, Beiske K, Holte H, Pellinen T, Leppä S (2020)
Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma
Haematologica (in press)
DOI 10.3324/haematol.2019.243626, PubMed 32079690

Brusletto BS, Løberg EM, Hellerud BC, Goverud IL, Berg JP, Olstad OK, Gopinathan U, Brandtzaeg P, Øvstebø R (2020)
Extensive Changes in Transcriptomic "Fingerprints" and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis
Front Cell Infect Microbiol, 10, 42
DOI 10.3389/fcimb.2020.00042, PubMed 32154187

Chehover M, Reich R, Davidson B (2020)
Expression of Wnt pathway molecules is associated with disease outcome in metastatic high-grade serous carcinoma
Virchows Arch (in press)
DOI 10.1007/s00428-019-02737-z, PubMed 31900634

Dagenborg VJ, Marshall SE, Yaqub S, Grzyb K, Boye K, Lund-Iversen M, Høye E, Berstad AE, Fretland ÅA, Edwin B, Ree AH, Flatmark K (2020)
Neoadjuvant chemotherapy is associated with a transient increase of intratumoral T-cell density in microsatellite stable colorectal liver metastases
Cancer Biol Ther, 21 (5), 432-440
DOI 10.1080/15384047.2020.1721252, PubMed 32098573

Darvekar S, Juzenas P, Oksvold M, Kleinauskas A, Holien T, Christensen E, Stokke T, Sioud M, Peng Q (2020)
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020377, PubMed 32041351

Davidson B (2020)
Molecular testing on serous effusions
Diagn Cytopathol (in press)
DOI 10.1002/dc.24392, PubMed 32023012

Flem-Karlsen K, Nyakas M, Farstad IN, McFadden E, Wernhoff P, Jacobsen KD, Flørenes VA, Mælandsmo GM (2020)
Soluble AXL as a marker of disease progression and survival in melanoma
PLoS One, 15 (1), e0227187
DOI 10.1371/journal.pone.0227187, PubMed 31917795

Georgiesh T, Boye K, Bjerkehagen B (2020)
A novel risk score to predict early and late recurrence in solitary fibrous tumour
Histopathology (in press)
DOI 10.1111/his.14078, PubMed 31991494

Goeppert B, Folseraas T, Roessler S, Kloor M, Volckmar AL, Endris V, Buchhalter I, Stenzinger A, Grzyb K, Grimsrud MM, Gornicka B, von Seth E, Reynolds GM, Franke A, Gotthardt DN, Mehrabi A, Cheung A, Verheij J, Arola J, Mäkisalo H, Eide TJ, Weidemann S, Cheville JC, Mazza G, Hirschfield GM et al. (2020)
Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities
Hepatology (in press)
DOI 10.1002/hep.31110, PubMed 31925805

Hoddevik EH, Rao SB, Zahl S, Boldt HB, Ottersen OP, Amiry-Moghaddam M (2020)
Organisation of extracellular matrix proteins laminin and agrin in pericapillary basal laminae in mouse brain
Brain Struct Funct, 225 (2), 805-816
DOI 10.1007/s00429-020-02036-3, PubMed 32072250

Hoel IM, Sviland L, Syre H, Dyrhol-Riise AM, Skarstein I, Jebsen P, Jørstad MD, Wiker H, Mustafa T (2020)
Diagnosis of extrapulmonary tuberculosis using the MPT64 antigen detection test in a high-income low tuberculosis prevalence setting
BMC Infect Dis, 20 (1), 130
DOI 10.1186/s12879-020-4852-z, PubMed 32050915

Hugenschmidt H, Labori KJ, Brunborg C, Verbeke CS, Seeberg LT, Schirmer CB, Renolen A, Borgen EF, Naume B, Wiedswang G (2020)
Circulating Tumor Cells are an Independent Predictor of Shorter Survival in Patients Undergoing Resection for Pancreatic and Periampullary Adenocarcinoma
Ann Surg, 271 (3), 549-558
DOI 10.1097/SLA.0000000000003035, PubMed 30216219

Juul-Dam KL, Ommen HB, Nyvold CG, Walter C, Vålerhaugen H, Kairisto V, Abrahamsson J, Alm SJ, Jahnukainen K, Lausen B, Reinhardt D, Zeller B, von Neuhoff N, Fogelstrand L, Hasle H (2020)
Measurable residual disease assessment by qPCR in peripheral blood is an informative tool for disease surveillance in childhood acute myeloid leukaemia
Br J Haematol (in press)
DOI 10.1111/bjh.16560, PubMed 32175599

Kolnes AJ, Øystese KA, Dahlberg D, Berg-Johnsen J, Niehusmann P, Pahnke J, Bollerslev J, Jørgensen AP (2020)
Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma
Acta Neurochir (Wien), 162 (4), 845-852
DOI 10.1007/s00701-019-04068-z, PubMed 31907611

Kubach J, Muhlebner-Fahrngruber A, Soylemezoglu F, Miyata H, Niehusmann P, Honavar M, Rogerio F, Kim SH, Aronica E, Garbelli R, Vilz S, Popp A, Walcher S, Neuner C, Scholz M, Kuerten S, Schropp V, Roeder S, Eichhorn P, Eckstein M, Brehmer A, Kobow K, Coras R, Blumcke I, Jabari S (2020)
Same same but different: A Web-based deep learning application revealed classifying features for the histopathologic distinction of cortical malformations
Epilepsia, 61 (3), 421-432
DOI 10.1111/epi.16447, PubMed 32080846

Lof S, Rajak R, Vissers FLIM, Korrel M, Bateman A, Verheij J, Verbeke C, Cataldo I, Besselink MG, Abu Hilal M (2020)
DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
J Vis Exp (156)
DOI 10.3791/60343, PubMed 32065168

Lorentzen EM, Henriksen S, Kaur A, Kro GB, Hammarström C, Hirsch HH, Midtvedt K, Rinaldo CH (2020)
Early fulminant BK polyomavirus-associated nephropathy in two kidney transplant patients with low neutralizing antibody titers receiving allografts from the same donor
Virol J, 17 (1), 5
DOI 10.1186/s12985-019-1275-9, PubMed 31924245

Małecka A, Delabie J, Østlie I, Tierens A, Randen U, Berentsen S, Tjønnfjord GE, Trøen G (2020)
Cold agglutinin-associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18
Blood Adv, 4 (6), 993-996
DOI 10.1182/bloodadvances.2020001608, PubMed 32168377

Menter T, Tzankov A, Zucca E, Kimby E, Hultdin M, Sundström C, Beiske K, Cogliatti S, Banz Y, Cathomas G, Karjalainen-Lindsberg ML, Grobholz R, Mazzucchelli L, Sander B, Hawle H, Hayoz S, Dirnhofer S (2020)
Prognostic implications of the microenvironment for follicular lymphoma under immunomodulation therapy
Br J Haematol
DOI 10.1111/bjh.16414, PubMed 32012230

Ooms AHAG, Vujanić GM, D'Hooghe E, Collini P, L'Herminé-Coulomb A, Vokuhl C, Graf N, Heuvel-Eibrink MMVD, de Krijger RR (2020)
Renal Tumors of Childhood-A Histopathologic Pattern-Based Diagnostic Approach
Cancers (Basel), 12 (3)
DOI 10.3390/cancers12030729, PubMed 32204536

Panagopoulos I, Gorunova L, Johannsdottir IMR, Andersen K, Holth A, Beiske K, Heim S (2020)
Chromosome Translocation t(14;21)(q11;q22) Activates Both OLIG1 and OLIG2 in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis
Cancer Genomics Proteomics, 17 (1), 41-48
DOI 10.21873/cgp.20166, PubMed 31882550

Panagopoulos I, Gorunova L, Kostolomov I, Lobmaier I, Bjerkehagen B, Heim S (2020)
Chronic Expanding Hematoma with a t(11;19)(q13;q13) Chromosomal Translocation
Anticancer Res, 40 (1), 97-100
DOI 10.21873/anticanres.13930, PubMed 31892557

Panagopoulos I, Gorunova L, Lobmaier I, Andersen K, Kostolomov I, Lund-Iversen M, Bjerkehagen B, Heim S (2020)
FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma
Cancer Genomics Proteomics, 17 (2), 161-168
DOI 10.21873/cgp.20176, PubMed 32108038

Ree AH, Nygaard V, Boye K, Heinrich D, Dueland S, Bergheim IR, Johansen C, Beiske K, Negård A, Lund-Iversen M, Nygaard V, Hovig E, Nakken S, Nasser S, Julsrud L, Reisse CH, Ruud EA, Kristensen VN, Flørenes VA, Geitvik GA, Lingjærde OC, Børresen-Dale AL, Russnes HG, Mælandsmo GM, Flatmark K (2020)
Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study
Acta Oncol, 1-8 (in press)
DOI 10.1080/0284186X.2020.1742377, PubMed 32208873

Ryg U, Lilleby W, Hole KH, Lund-Iversen M, Switlyk MD (2020)
Local Recurrence of Prostate Cancer to the Intersphincteric Space: A Case Report
Urology (in press)
DOI 10.1016/j.urology.2020.03.009, PubMed 32199872

Saeednejad Zanjani L, Madjd Z, Axcrona U, Abolhasani M, Rasti A, Asgari M, Fodstad Ø, Andersson Y (2020)
Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma
Ann Diagn Pathol, 46, 151483 (in press)
DOI 10.1016/j.anndiagpath.2020.151483, PubMed 32143173

Serguienko A, Braadland P, Meza-Zepeda LA, Bjerkehagen B, Myklebost O (2020)
Accurate 3-gene-signature for early diagnosis of liposarcoma progression
Clin Sarcoma Res, 10, 4
DOI 10.1186/s13569-020-0126-1, PubMed 32158531

Shoemark A, Boon M, Brochhausen C, Bukowy-Bieryllo Z, Margherita De Santi M, Goggin P, Griffin P, Hegele RG, Hirst RA, Leigh MW, Lupton A, MacKenney K, Omran H, Pache JC, Pinto A, Reinholt FP, Schroeder J, Yiallouros P, Escudier E, These authors represent a larger guideline development group acknowledged below* (2020)
International consensus guideline for reporting transmission electron microscopy results in the diagnosis of Primary Ciliary Dyskinesia (BEAT PCD TEM Criteria)
Eur Respir J (in press)
DOI 10.1183/13993003.00725-2019, PubMed 32060067

Skrede OJ, De Raedt S, Kleppe A, Hveem TS, Liestøl K, Maddison J, Askautrud HA, Pradhan M, Nesheim JA, Albregtsen F, Farstad IN, Domingo E, Church DN, Nesbakken A, Shepherd NA, Tomlinson I, Kerr R, Novelli M, Kerr DJ, Danielsen HE (2020)
Deep learning for prediction of colorectal cancer outcome: a discovery and validation study
Lancet, 395 (10221), 350-360
DOI 10.1016/S0140-6736(19)32998-8, PubMed 32007170

Skaare AB, Hovden ES, Herlofson BB, Søland TM (2020)
Orofacial granulomatosis: a questionnaire study among Norwegian dental clinicians
Eur Arch Paediatr Dent
DOI 10.1007/s40368-020-00511-3, PubMed 32020549

Sonden ECB, Sebuodegard S, Korvald C, Lomo J, Schlichting E, Brandal SHB, Hofving S (2020)
Cosmetic breast implants and breast cancer
Tidsskr. Nor. Laegeforen., 140 (3), 236-241

Sondén ECB, Sebuødegård S, Korvald C, Lømo J, Schlichting E, Brandal SHB, Hofvind S (2020)
Kosmetiske brystimplantater og brystkreft
Tidsskr Nor Laegeforen, 140 (3)
DOI 10.4045/tidsskr.19.0266, PubMed 32105043

Sondén ECB, Sebuødegård S, Korvald C, Lømo J, Schlichting E, Brandal SHB, Hofvind S (2020)
Rettelse: Kosmetiske brystimplantater og brystkreft
Tidsskr Nor Laegeforen, 140 (4)
DOI 10.4045/tidsskr.20.0163, PubMed 32192257

Steigen SE, Søland TM, Nginamau ES, Laurvik H, Costea DE, Johannessen AC, Jebsen P, Bjerkli IH, Uhlin-Hansen L, Hadler-Olsen E (2020)
Grading of oral squamous cell carcinomas - Intra and interrater agreeability: Simpler is better?
J Oral Pathol Med
DOI 10.1111/jop.12990, PubMed 31899572

Thorkildsen J, Taksdal I, Bjerkehagen B, Norum OJ, Myklebust TA, Zaikova O (2020)
Risk stratification for central conventional chondrosarcoma of bone: A novel system predicting risk of metastasis and death in the Cancer Registry of Norway cohort
J Surg Oncol (in press)
DOI 10.1002/jso.25883, PubMed 32141094

Wik JA, Lundbäck P, la Cour Poulsen L, Haraldsen G, Skålhegg BS, Hol J (2020)
3PO inhibits inflammatory NFκB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3
PLoS One, 15 (3), e0229395
DOI 10.1371/journal.pone.0229395, PubMed 32130250

Wolf BJ, Brackhan M, Bascuñana P, Leiter I, Langer BLN, Ross TL, Bankstahl JP, Bankstahl M (2020)
TSPO PET Identifies Different Anti-inflammatory Minocycline Treatment Response in Two Rodent Models of Epileptogenesis
Neurotherapeutics
DOI 10.1007/s13311-020-00834-5, PubMed 31970667

Wong JJW, Berstad MB, Fremstedal ASV, Berg K, Patzke S, Sørensen V, Peng Q, Selbo PK, Weyergang A (2020)
Photochemically-Induced Release of Lysosomal Sequestered Sunitinib: Obstacles for Therapeutic Efficacy
Cancers (Basel), 12 (2)
DOI 10.3390/cancers12020417, PubMed 32053965

Zamani M, Skagen K, Scott H, Russell D, Skjelland M (2020)
Advanced ultrasound methods in assessment of carotid plaque instability: a prospective multimodal study
BMC Neurol, 20 (1), 39
DOI 10.1186/s12883-020-1620-z, PubMed 31996153

Zhao J, Li X, Liu L, Cao J, Goscinski MA, Fan H, Li H, Suo Z (2020)
Oncogenic Role of Guanylate Binding Protein 1 in Human Prostate Cancer
Front Oncol, 9, 1494
DOI 10.3389/fonc.2019.01494, PubMed 31998647

 
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