Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2019 from OUS - Department of Pathology

44 publications found

Bains SJ, Niehusmann PF, Meling TR, Saxhaug C, Züchner M, Brandal P (2019)
Disseminated central nervous system hemangioblastoma in a patient with no clinical or genetic evidence of von Hippel-Lindau disease-a case report and literature review
Acta Neurochir (Wien), 161 (2), 343-349
DOI 10.1007/s00701-019-03800-z, PubMed 30652202

Batmanov K, Delabie J, Wang J (2019)
BayesPI-BAR2: A New Python Package for Predicting Functional Non-coding Mutations in Cancer Patient Cohorts
Front Genet, 10, 282
DOI 10.3389/fgene.2019.00282, PubMed 31001324

Binzer-Panchal A, Hardell E, Viklund B, Ghaderi M, Bosse T, Nucci MR, Lee CH, Hollfelder N, Corcoran P, Gonzalez-Molina J, Moyano-Galceran L, Bell DA, Schoolmeester JK, Måsbäck A, Kristensen GB, Davidson B, Lehti K, Isaksson A, Carlson JW (2019)
Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes
Clin Cancer Res, 25 (7), 2155-2165
DOI 10.1158/1078-0432.CCR-18-2792, PubMed 30617134

Bowitz Lothe IM, Kleive D, Pomianowska E, Cvancarova M, Kure E, Dueland S, Gladhaug IP, Labori KJ (2019)
Clinical relevance of pancreatobiliary and intestinal subtypes of ampullary and duodenal adenocarcinoma: Pattern of recurrence, chemotherapy, and survival after pancreatoduodenectomy
Pancreatology, 19 (2), 316-324
DOI 10.1016/j.pan.2019.01.019, PubMed 30713128

Carling U, Barkhatov L, Reims HM, Storås T, Courivaud F, Kazaryan AM, Halvorsen PS, Dorenberg E, Edwin B, Hol PK (2019)
Can we ablate liver lesions close to large portal and hepatic veins with MR-guided HIFU? An experimental study in a porcine model
Eur Radiol (in press)
DOI 10.1007/s00330-018-5996-8, PubMed 30737565

Carpino G, Cardinale V, Folseraas T, Overi D, Grzyb K, Costantini D, Berloco PB, Di Matteo S, Karlsen TH, Alvaro D, Gaudio E (2019)
Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis
Hepatology, 69 (2), 622-638
DOI 10.1002/hep.30210, PubMed 30102768

Cassetta L, Baekkevold ES, Brandau S, Bujko A, Cassatella MA, Dorhoi A, Krieg C, Lin A, Loré K, Marini O, Pollard JW, Roussel M, Scapini P, Umansky V, Adema GJ (2019)
Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates
Cancer Immunol Immunother, 68 (4), 687-697
DOI 10.1007/s00262-019-02302-2, PubMed 30684003

Davidson B (2019)
Biomarkers of drug resistance in ovarian cancer - an update
Expert Rev Mol Diagn, 1-8 (in press)
DOI 10.1080/14737159.2019.1618187, PubMed 31075061

Del Risco Kollerud R, Ruud E, Haugnes HS, Cannon-Albright LA, Thoresen M, Nafstad P, Vlatkovic L, Blaasaas KG, Næss Ø, Claussen B (2019)
Family history of cancer and risk of paediatric and young adult's testicular cancer: A Norwegian cohort study
Br J Cancer, 120 (10), 1007-1014
DOI 10.1038/s41416-019-0445-2, PubMed 30967648

Fan Z, Li L, Li X, Zhang M, Dou M, Zhao J, Cao J, Deng X, Zhang M, Li H, Suo Z (2019)
Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro
Aging (Albany NY), 11 (2), 573-589
DOI 10.18632/aging.101761, PubMed 30668541

Flem-Karlsen K, Tekle C, Øyjord T, Flørenes VA, Mælandsmo GM, Fodstad Ø, Nunes-Xavier CE (2019)
p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance
Sci Rep, 9 (1), 5839
DOI 10.1038/s41598-019-42303-w, PubMed 30967582

Flørenes VA, Flem-Karlsen K, McFadden E, Bergheim IR, Nygaard V, Nygård V, Farstad IN, Øy GF, Emilsen E, Giller-Fleten K, Ree AH, Flatmark K, Gullestad HP, Hermann R, Ryder T, Wernhoff P, Mælandsmo GM (2019)
A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases
Transl Oncol, 12 (7), 951-958 (in press)
DOI 10.1016/j.tranon.2019.04.001, PubMed 31096111

Frøysnes IS, Andersson Y, Larsen SG, Davidson B, Øien JT, Julsrud L, Fodstad Ø, Dueland S, Flatmark K (2019)
ImmunoPeCa trial: Long-term outcome following intraperitoneal MOC31PE immunotoxin treatment in colorectal peritoneal metastasis
Eur J Surg Oncol (in press)
DOI 10.1016/j.ejso.2019.04.014, PubMed 31036394

Haram K, Mortensen JH, Myking O, Roald B, Magann EF, Morrison JC (2019)
Early development of the human placenta and pregnancy complications
J Matern Fetal Neonatal Med, 1-8 (in press)
DOI 10.1080/14767058.2019.1578745, PubMed 30810433

Johansson HJ, Socciarelli F, Vacanti NM, Haugen MH, Zhu Y, Siavelis I, Fernandez-Woodbridge A, Aure MR, Sennblad B, Vesterlund M, Branca RM, Orre LM, Huss M, Fredlund E, Beraki E, Garred Ø, Boekel J, Sauer T, Zhao W, Nord S, Höglander EK, Jans DC, Brismar H, Haukaas TH, Bathen TF et al. (2019)
Breast cancer quantitative proteome and proteogenomic landscape
Nat Commun, 10 (1), 1600
DOI 10.1038/s41467-019-09018-y, PubMed 30962452

Johnsen GM, Størvold GL, Alnaes-Katjavivi PH, Roald B, Golic M, Dechend R, Redman CWG, Staff AC (2019)
Lymphocyte characterization of decidua basalis spiral arteries with acute atherosis in preeclamptic and normotensive pregnancies
J Reprod Immunol, 132, 42-48
DOI 10.1016/j.jri.2019.03.003, PubMed 30928772

Jonsson M, Fjeldbo CS, Holm R, Stokke T, Kristensen GB, Lyng H (2019)
Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer
Neoplasia, 21 (4), 353-362
DOI 10.1016/j.neo.2019.01.002, PubMed 30856376

Josefsson SE, Beiske K, Blaker YN, Førsund MS, Holte H, Østenstad B, Kimby E, Köksal H, Wälchli S, Bai B, Smeland EB, Levy R, Kolstad A, Huse K, Myklebust JH (2019)
TIGIT and PD-1 Mark Intratumoral T Cells with Reduced Effector Function in B-cell Non-Hodgkin Lymphoma
Cancer Immunol Res, 7 (3), 355-362
DOI 10.1158/2326-6066.CIR-18-0351, PubMed 30659053

Kraby MR, Opdahl S, Russnes HG, Bofin AM (2019)
Microvessel density in breast cancer: the impact of field area on prognostic informativeness
J Clin Pathol, 72 (4), 304-310
DOI 10.1136/jclinpath-2018-205536, PubMed 30630872

Köksal H, Dillard P, Josefsson SE, Maggadottir SM, Pollmann S, Fåne A, Blaker YN, Beiske K, Huse K, Kolstad A, Holte H, Kvalheim G, Smeland EB, Myklebust JH, Inderberg EM, Wälchli S (2019)
Preclinical development of CD37CAR T-cell therapy for treatment of B-cell lymphoma
Blood Adv, 3 (8), 1230-1243
DOI 10.1182/bloodadvances.2018029678, PubMed 30979721

Latysheva A, Emblem KE, Brandal P, Vik-Mo EO, Pahnke J, Røysland K, Hald JK, Server A (2019)
Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach
Neuroradiology, 61 (5), 545-555
DOI 10.1007/s00234-019-02173-5, PubMed 30712139

Lenggenhager D, Amrutkar M, Sántha P, Aasrum M, Löhr JM, Gladhaug IP, Verbeke CS (2019)
Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells
Cells, 8 (1)
DOI 10.3390/cells8010023, PubMed 30621293

Lund-Andersen C, Nakken S, Nygård S, Fromm B, Aasheim LB, Davidson B, Julsrud L, Abrahamsen TW, Kristensen AT, Dybdahl B, Larsen SG, Hovig E, Flatmark K (2019)
Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response
Cold Spring Harb Mol Case Stud, 5 (2)
DOI 10.1101/mcs.a003566, PubMed 30862609

Lundar T, Due-Tønnessen BJ, Frič R, Krossnes B, Brandal P, Stensvold E, Due-Tønnessen P (2019)
Neurosurgical treatment of pediatric pleomorphic xanthoastrocytomas: long-term follow-up of a single-institution, consecutive series of 12 patients
J Neurosurg Pediatr, 23 (4), 512-516
DOI 10.3171/2018.11.PEDS18449, PubMed 30738389

Løvvik Juul-Dam K, Guldborg Nyvold C, Vålerhaugen H, Zeller B, Lausen B, Hasle H, Beier Ommen H (2019)
Measurable residual disease monitoring using Wilms tumor gene 1 expression in childhood acute myeloid leukemia based on child-specific reference values
Pediatr Blood Cancer, 66 (6), e27671
DOI 10.1002/pbc.27671, PubMed 30900388

Misra S, Moro CF, Del Chiaro M, Pouso S, Sebestyén A, Löhr M, Björnstedt M, Verbeke CS (2019)
Ex vivo organotypic culture system of precision-cut slices of human pancreatic ductal adenocarcinoma
Sci Rep, 9 (1), 2133
DOI 10.1038/s41598-019-38603-w, PubMed 30765891

Murali R, Davidson B, Fadare O, Carlson JA, Crum CP, Gilks CB, Irving JA, Malpica A, Matias-Guiu X, McCluggage WG, Mittal K, Oliva E, Parkash V, Rutgers JKL, Staats PN, Stewart CJR, Tornos C, Soslow RA (2019)
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations
Int J Gynecol Pathol, 38 Suppl 1, S40-S63
DOI 10.1097/PGP.0000000000000491, PubMed 30550483

Petersen JK, Scheie D, Boldt HB, Ulhøi BP, Ettrup MS, Kristensen BW (2019)
[Integrated diagnostics of brain tumours based on histological and molecular features]
Ugeskr Laeger, 181 (6)
PubMed 30729918

Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC et al. (2019)
Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1
Leukemia (in press)
DOI 10.1038/s41375-019-0413-0, PubMed 30858550

Ree AH, Nygaard V, Russnes HG, Heinrich D, Nygaard V, Johansen C, Bergheim IR, Hovig E, Beiske K, Negård A, Børresen-Dale AL, Flatmark K, Mælandsmo GM (2019)
Responsiveness to PD-1 Blockade in End-Stage Colon Cancer with Gene Locus 9p24.1 Copy-Number Gain
Cancer Immunol Res, 7 (5), 701-706
DOI 10.1158/2326-6066.CIR-18-0777, PubMed 30804006

Reppe Moe SE, Molberg Ø, Strøm EH, Lerang K (2019)
Assessing the relative impact of lupus nephritis on mortality in a population-based systemic lupus erythematosus cohort
Lupus, 961203319847275 (in press)
DOI 10.1177/0961203319847275, PubMed 31072277

Schäfer N, Gielen GH, Rauschenbach L, Kebir S, Till A, Reinartz R, Simon M, Niehusmann P, Kleinschnitz C, Herrlinger U, Pietsch T, Scheffler B, Glas M (2019)
Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors
J Transl Med, 17 (1), 96
DOI 10.1186/s12967-019-1846-y, PubMed 30894200

Sherman-Samis M, Onallah H, Holth A, Reich R, Davidson B (2019)
SOX2 and SOX9 are markers of clinically aggressive disease in metastatic high-grade serous carcinoma
Gynecol Oncol (in press)
DOI 10.1016/j.ygyno.2019.03.099, PubMed 30904337

Switlyk MD, Salberg UB, Geier OM, Vlatkovic L, Lilleby W, Lyng H, Seierstad T (2019)
PTEN Expression in Prostate Cancer: Relationship With Clinicopathologic Features and Multiparametric MRI Findings
AJR Am J Roentgenol, 1-9 (in press)
DOI 10.2214/AJR.18.20743, PubMed 30888866

Taylor-King JP, Baratchart E, Dhawan A, Coker EA, Rye IH, Russnes H, Chapman SJ, Basanta D, Marusyk A (2019)
Simulated ablation for detection of cells impacting paracrine signalling in histology analysis
Math Med Biol, 36 (1), 93-112
DOI 10.1093/imammb/dqx022, PubMed 29452382

Tellum T, Qvigstad E, Skovholt EK, Lieng M (2019)
In Vivo Adenomyosis Tissue Sampling Using a Transvaginal Ultrasound-guided Core Biopsy Technique for Research Purposes: Safety, Feasibility, and Effectiveness
J Minim Invasive Gynecol (in press)
DOI 10.1016/j.jmig.2019.02.002, PubMed 30738919

Theodossiou TA, Ali M, Grigalavicius M, Grallert B, Dillard P, Schink KO, Olsen CE, Wälchli S, Inderberg EM, Kubin A, Peng Q, Berg K (2019)
Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
NPJ Breast Cancer, 5, 13
DOI 10.1038/s41523-019-0108-8, PubMed 30993194

Thorkildsen J, Taksdal I, Bjerkehagen B, Haugland HK, Børge Johannesen T, Viset T, Norum OJ, Bruland Ø, Zaikova O (2019)
Chondrosarcoma in Norway 1990-2013; an epidemiological and prognostic observational study of a complete national cohort
Acta Oncol, 58 (3), 273-282
DOI 10.1080/0284186X.2018.1554260, PubMed 30632866

Udjus C, Cero FT, Halvorsen B, Behmen D, Carlson CR, Bendiksen BA, Espe EKS, Sjaastad I, Løberg EM, Yndestad A, Aukrust P, Christensen G, Skjønsberg OH, Larsen KO (2019)
Caspase-1 induces smooth muscle cell growth in hypoxia-induced pulmonary hypertension
Am J Physiol Lung Cell Mol Physiol, 316 (6), L999-L1012
DOI 10.1152/ajplung.00322.2018, PubMed 30908936

Utheim OA, Pasovic L, Raeder S, Eidet JR, Fostad IG, Sehic A, Roald B, de la Paz MF, Lyberg T, Dartt DA, Utheim TP (2019)
Effects of explant size on epithelial outgrowth, thickness, stratification, ultrastructure and phenotype of cultured limbal epithelial cells
PLoS One, 14 (3), e0212524
DOI 10.1371/journal.pone.0212524, PubMed 30861002

Vujasinovic M, Pozzi Mucelli RM, Valente R, Verbeke CS, Haas SL, Löhr JM (2019)
Kidney Involvement in Patients with Type 1 Autoimmune Pancreatitis
J Clin Med, 8 (2)
DOI 10.3390/jcm8020258, PubMed 30781677

Zhou Y, Gerrard DL, Wang J, Li T, Yang Y, Fritz AJ, Rajendran M, Fu X, Schiff R, Lin S, Frietze S, Jin VX (2019)
Temporal dynamic reorganization of 3D chromatin architecture in hormone-induced breast cancer and endocrine resistance
Nat Commun, 10 (1), 1522
DOI 10.1038/s41467-019-09320-9, PubMed 30944316

Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Traxl A, Schuetz JD, Kuntner C, Pahnke J, Langer O (2019)
Influence of Multidrug Resistance-Associated Proteins on the Excretion of the ABCC1 Imaging Probe 6-Bromo-7-[11C]Methylpurine in Mice
Mol Imaging Biol, 21 (2), 306-316
DOI 10.1007/s11307-018-1230-y, PubMed 29942989

Öjlert ÅK, Halvorsen AR, Nebdal D, Lund-Iversen M, Solberg S, Brustugun OT, Lingjaerde OC, Helland Å (2019)
The immune microenvironment in non-small cell lung cancer is predictive of prognosis after surgery
Mol Oncol, 13 (5), 1166-1179
DOI 10.1002/1878-0261.12475, PubMed 30854794

 
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