Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2020 from OUS - Department of Immunology (Div LabMed)

48 publications found

Berg LK, Goll R, Fagerli E, Ludviksen JK, Fure H, Moen OS, Sørbye SW, Mollnes TE, Florholmen J (2020)
Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome
Scand J Gastroenterol, 55 (5), 537-542
DOI 10.1080/00365521.2020.1754455, PubMed 32329383

Bjerre A, Mjøen G, Line PD, Naper C, Reisaeter AV, Åsberg A (2020)
Five decades with grandparent donors: The Norwegian strategy and experience
Pediatr Transplant, e13751
DOI 10.1111/petr.13751, PubMed 32485019

Briand N, Collas P (2020)
Lamina-associated domains: peripheral matters and internal affairs
Genome Biol, 21 (1), 85
DOI 10.1186/s13059-020-02003-5, PubMed 32241294

Brusletto BS, Løberg EM, Hellerud BC, Goverud IL, Berg JP, Olstad OK, Gopinathan U, Brandtzaeg P, Øvstebø R (2020)
Extensive Changes in Transcriptomic "Fingerprints" and Immunological Cells in the Large Organs of Patients Dying of Acute Septic Shock and Multiple Organ Failure Caused by Neisseria meningitidis
Front Cell Infect Microbiol, 10, 42
DOI 10.3389/fcimb.2020.00042, PubMed 32154187

Braathen R, Spång HCL, Hinke DM, Blazevski J, Bobic S, Fossum E, Bogen B (2020)
A DNA Vaccine That Encodes an Antigen-Presenting Cell-Specific Heterodimeric Protein Protects against Cancer and Influenza
Mol Ther Methods Clin Dev, 17, 378-392
DOI 10.1016/j.omtm.2020.01.007, PubMed 32128342

Chaban V, Clarke GJB, Skandsen T, Islam R, Einarsen CE, Vik A, Damås JK, Mollnes TE, Håberg AK, Pischke SE (2020)
Systemic Inflammation Persists the First Year after Mild Traumatic Brain Injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study
J Neurotrauma
DOI 10.1089/neu.2019.6963, PubMed 32326805

du Pré MF, Blazevski J, Dewan AE, Stamnaes J, Kanduri C, Sandve GK, Johannesen MK, Lindstad CB, Hnida K, Fugger L, Melino G, Qiao SW, Sollid LM (2020)
B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2
J Exp Med, 217 (2)
DOI 10.1084/jem.20190860, PubMed 31727780

Ehrnström B, Kojen JF, Giambelluca M, Ryan L, Moen SH, Hu Z, Yin H, Mollnes TE, Damås JK, Espevik T, Stenvik J (2020)
TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria
J Leukoc Biol, 107 (4), 673-683
DOI 10.1002/JLB.3A0120-114R, PubMed 32083344

Fagerhol MK, Johnson E, Tangen JM, Hollan I, Mirlashari MR, Nissen-Meyer LSH, Hetland G (2020)
NETs analysed by novel calprotectin-based assays in blood donors and patients with multiple myeloma or rheumatoid arthritis: A pilot study
Scand J Immunol, 91 (5), e12870
DOI 10.1111/sji.12870, PubMed 32034957

Fossum E, Tesfaye DY, Bobic S, Gudjonsson A, Braathen R, Lahoud MH, Caminschi I, Bogen B (2020)
Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response
J Immunol (in press)
DOI 10.4049/jimmunol.1901119, PubMed 32591401

Fretheim H, Chung BK, Didriksen H, Bækkevold ES, Midtvedt Ø, Brunborg C, Holm K, Valeur J, Tennøe AH, Garen T, Midtvedt T, Trøseid M, Zarè H, Lund MB, Hov JR, Lundin KEA, Molberg Ø, Hoffmann-Vold AM (2020)
Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial
PLoS One, 15 (5), e0232739
DOI 10.1371/journal.pone.0232739, PubMed 32437393

Grinde D, Øverland T, Lima K, Schjalm C, Mollnes TE, Abrahamsen TG (2020)
Complement Activation in 22q11.2 Deletion Syndrome
J Clin Immunol, 40 (3), 515-523
DOI 10.1007/s10875-020-00766-x, PubMed 32152940

Grødeland G, Baranowska-Hustad M, Abadejos J, Blane TR, Teijaro J, Nemazee D, Bogen B (2020)
Induction of Cross-Reactive and Protective Antibody Responses After DNA Vaccination With MHCII-Targeted Stem Domain From Influenza Hemagglutinin
Front Immunol, 11, 431
DOI 10.3389/fimmu.2020.00431, PubMed 32269566

Gustavsen A, Njerve IU, Sitras V, Haugen G, Tollofsrud PA, Akkok CA (2020)
A young woman with a transfusion-related pregnancy complication
Tidsskr. Nor. Laegeforen., 140 (1), 58-61

Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E (2020)
Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifolafrondosa: A Review of Preclinical and Clinical Studies
Nutrients, 12 (5)
DOI 10.3390/nu12051339, PubMed 32397163

Hovland A, Retterstøl K, Mollnes TE, Halvorsen B, Aukrust P, Lappegård KT (2020)
Anti-inflammatory effects of non-statin low-density lipoprotein cholesterol-lowering drugs: an unused potential?
Scand Cardiovasc J, 1-6 (in press)
DOI 10.1080/14017431.2020.1775878, PubMed 32500743

Haabeth OAW, Hennig K, Fauskanger M, Løset GÅ, Bogen B, Tveita A (2020)
CD4+ T-cell killing of multiple myeloma cells is mediated by resident bone marrow macrophages
Blood Adv, 4 (12), 2595-2605
DOI 10.1182/bloodadvances.2020001434, PubMed 32544236

Ihle-Hansen H, Berge T, Tveita A, Rønning EJ, Ernø PE, Andersen EL, Wang CH, Tveit A, Myrstad M (2020)
COVID-19: Symptoms, course of illness and use of clinical scoring systems for the first 42 patients admitted to a Norwegian local hospital
Tidsskr Nor Laegeforen, 140 (7)
DOI 10.4045/tidsskr.20.0301, PubMed 32378844

Iversen R, Amundsen SF, Kleppa L, Fleur du Pré M, Stamnaes J, Sollid LM (2020)
Evidence that pathogenic transglutaminase 2 in celiac disease derives from enterocytes
Gastroenterology (in press)
DOI 10.1053/j.gastro.2020.04.018, PubMed 32302613

Juvodden HT, Viken MK, Nordstrand SEH, Viste R, Westlye LT, Thorsby PM, Lie BA, Knudsen-Heier S (2020)
HLA and sleep parameter associations in post-H1N1 narcolepsy type 1 patients and first-degree relatives
Sleep, 43 (3)
DOI 10.1093/sleep/zsz239, PubMed 31606740

Kierulf-Vieira KS, Sandberg CJ, Waaler J, Lund K, Skaga E, Saberniak BM, Panagopoulos I, Brandal P, Krauss S, Langmoen IA, Vik-Mo EO (2020)
A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation
Cancers (Basel), 12 (6)
DOI 10.3390/cancers12061630, PubMed 32575464

Krapf SA, Lund J, Lundkvist M, Dale MG, Nyman TA, Thoresen GH, Kase ET (2020)
Pancreatic cancer cells show lower oleic acid oxidation and their conditioned medium inhibits oleic acid oxidation in human myotubes
Pancreatology, 20 (4), 676-682
DOI 10.1016/j.pan.2020.04.014, PubMed 32360002

Kräutler NJ, Yermanos A, Pedrioli A, Welten SPM, Lorgé D, Greczmiel U, Bartsch I, Scheuermann J, Kiefer JD, Eyer K, Menzel U, Greiff V, Neri D, Stadler T, Reddy ST, Oxenius A (2020)
Quantitative and Qualitative Analysis of Humoral Immunity Reveals Continued and Personalized Evolution in Chronic Viral Infection
Cell Rep, 30 (4), 997-1012.e6
DOI 10.1016/j.celrep.2019.12.088, PubMed 31995768

Kwon M, Kim CG, Lee H, Cho H, Kim Y, Lee EC, Choi SJ, Park J, Seo IH, Bogen B, Song IC, Jo DY, Kim JS, Park SH, Choi I, Choi YS, Shin EC (2020)
PD-1 Blockade Reinvigorates Bone Marrow CD8+ T Cells from Patients with Multiple Myeloma in the Presence of TGFβ Inhibitors
Clin Cancer Res, 26 (7), 1644-1655
DOI 10.1158/1078-0432.CCR-19-0267, PubMed 31941832

Kåresen R, Gisvold SE, Heier HE (2020)
Regjeringens «koronakommisjon» er lite representativ og har inhabil leder
Tidsskr Nor Laegeforen, 140 (10)
DOI 10.4045/tidsskr.20.0446, PubMed 32602330

Kåresen R, Gisvold SE, Heier HE (2020)
Beredskap og sykehusbygging: Hva bør vi lære av covid-19?
Tidsskr Nor Laegeforen, 140 (10)
DOI 10.4045/tidsskr.20.0286, PubMed 32602334

Lande A, Fluge Ø, Strand EB, Flåm ST, Sosa DD, Mella O, Egeland T, Saugstad OD, Lie BA, Viken MK (2020)
Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Sci Rep, 10 (1), 5267
DOI 10.1038/s41598-020-62157-x, PubMed 32210306

Lau C, McAdam MB, Bergseth G, Grevys A, Bruun JA, Ludviksen JK, Fure H, Espevik T, Moen A, Andersen JT, Mollnes TE (2020)
NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies
MAbs, 12 (1), 1686319
DOI 10.1080/19420862.2019.1686319, PubMed 31671278

Matikainen S, Nyman TA, Cypryk W (2020)
Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome
J Immunol, 204 (12), 3063-3069
DOI 10.4049/jimmunol.2000373, PubMed 32513874

Mikocziova I, Gidoni M, Lindeman I, Peres A, Snir O, Yaari G, Sollid LM (2020)
Polymorphisms in human immunoglobulin heavy chain variable genes and their upstream regions
Nucleic Acids Res, 48 (10), 5499-5510
DOI 10.1093/nar/gkaa310, PubMed 32365177

Munthe LA (2020)
Koronaviruset – kryssimmunitet, flokkimmunitet og vaksineutvikling
Tidsskr Nor Laegeforen, 140 (7)
DOI 10.4045/tidsskr.20.0298, PubMed 32378847

Nilsen J, Trabjerg E, Grevys A, Azevedo C, Brennan SO, Stensland M, Wilson J, Sand KMK, Bern M, Dalhus B, Roopenian DC, Sandlie I, Rand KD, Andersen JT (2020)
An intact C-terminal end of albumin is required for its long half-life in humans
Commun Biol, 3 (1), 181
DOI 10.1038/s42003-020-0903-7, PubMed 32313072

Perdreau-Dahl H, Progida C, Barfeld SJ, Guldsten H, Thiede B, Arntzen M, Bakke O, Mills IG, Krauss S, Morth JP (2020)
Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells
Commun Biol, 3 (1), 123
DOI 10.1038/s42003-020-0851-2, PubMed 32170109

Rekeland IG, Fosså A, Lande A, Ktoridou-Valen I, Sørland K, Holsen M, Tronstad KJ, Risa K, Alme K, Viken MK, Lie BA, Dahl O, Mella O, Fluge Ø (2020)
Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study
Front Med (Lausanne), 7, 162
DOI 10.3389/fmed.2020.00162, PubMed 32411717

Savijoki K, Miettinen I, Nyman TA, Kortesoja M, Hanski L, Varmanen P, Fallarero A (2020)
Growth Mode and Physiological State of Cells Prior to Biofilm Formation Affect Immune Evasion and Persistence of Staphylococcus aureus
Microorganisms, 8 (1)
DOI 10.3390/microorganisms8010106, PubMed 31940921

Shahini N, Schjalm C, Nilsson PH, Holt MF, Øgaard JDS, Lien E, Ahmed MS, Attramadal H, Aukrust P, Yndestad A, Mollnes TE, Louwe MC (2020)
Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling
Biochem Biophys Res Commun, 523 (4), 867-873
DOI 10.1016/j.bbrc.2020.01.018, PubMed 31955888

Storjord E, Hennø LT, Mollnes TE, Brekke OL (2020)
Analysis of cytokines
Tidsskr Nor Laegeforen, 140 (1)
DOI 10.4045/tidsskr.18.0961, PubMed 31948201

Szekanecz Z, Gomez I, Soós B, Bodoki L, Szamosi S, András C, Juhász B, Váróczy L, Antal-Szalmás P, Szodoray P, Bittner N, Árkosy P, Illés Á, Szűcs G, Dankó K, Bender T, Tamási L, Szekanecz É (2020)
Oncorheumatology: relationship between malignancies and musculoskeletal diseases
Orv Hetil, 161 (28), 1151-1165
DOI 10.1556/650.2020.31800, PubMed 32609623

Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gärtner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlüter KD, Jacobs HT (2020)
Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia
J Cell Mol Med, 24 (6), 3534-3548
DOI 10.1111/jcmm.15043, PubMed 32040259

Ting YT, Dahal-Koirala S, Kim HSK, Qiao SW, Neumann RS, Lundin KEA, Petersen J, Reid HH, Sollid LM, Rossjohn J (2020)
A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease
Proc Natl Acad Sci U S A, 117 (6), 3063-3073
DOI 10.1073/pnas.1914308117, PubMed 31974305

Toch M, Harris A, Schakman O, Kondratskaya E, Boulland JL, Dauguet N, Debrulle S, Baudouin C, Hidalgo-Figueroa M, Gow A, Glover JC, Tissir F, Clotman F (2020)
Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits
Sci Rep, 10 (1), 996
DOI 10.1038/s41598-020-57945-4, PubMed 31969659

Tveita A, Hestenes S, Sporastøyl ER, Pettersen SA, Neple BL, Myrstad M, Tveit A, Frøen H, Svendsen J, Rønning EJ (2020)
Pulmonary embolism in cases of COVID-19
Tidsskr Nor Laegeforen, 140 (8)
DOI 10.4045/tidsskr.20.0366, PubMed 32463186

Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C (2020)
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation
Nat Cell Biol (in press)
DOI 10.1038/s41556-020-0537-5, PubMed 32601372

Wang H, Kuusela S, Rinnankoski-Tuikka R, Dumont V, Bouslama R, Ramadan UA, Waaler J, Linden AM, Chi NW, Krauss S, Pirinen E, Lehtonen S (2020)
Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
Int J Obes (Lond)
DOI 10.1038/s41366-020-0573-z, PubMed 32317752

Waaler J, Leenders RGG, Sowa ST, Alam Brinch S, Lycke M, Nieczypor P, Aertssen S, Murthy S, Galera-Prat A, Damen E, Wegert A, Nazaré M, Lehtiö L, Krauss S (2020)
Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor
J Med Chem (in press)
DOI 10.1021/acs.jmedchem.0c00208, PubMed 32511917

Waaler J, Mygland L, Tveita A, Strand MF, Solberg NT, Olsen PA, Aizenshtadt A, Fauskanger M, Lund K, Brinch SA, Lycke M, Dybing E, Nygaard V, Bøe SL, Heintz KM, Hovig E, Hammarström C, Corthay A, Krauss S (2020)
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models
Commun Biol, 3 (1), 196
DOI 10.1038/s42003-020-0916-2, PubMed 32332858

Østvik AE, Svendsen TD, Granlund AVB, Doseth B, Skovdahl HK, Bakke I, Thorsvik S, Afroz W, Walaas GA, Mollnes TE, Gustafsson BI, Sandvik AK, Bruland T (2020)
Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease
J Crohns Colitis (in press)
DOI 10.1093/ecco-jcc/jjaa022, PubMed 32020185

Aamodt AH, Flinstad Harbo H, Eldøen G, Barratt-Due A, Aukrust P (2020)
How does COVID-19 affect the brain?
Tidsskr Nor Laegeforen, 140 (10)
DOI 10.4045/tidsskr.20.0444, PubMed 32602331

 
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