Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
Click here to see hierarchical division and subunit overview
Summary of publications:
Publications (original articles or review articles) published in 2016 from OUS - Department of Immunology (Div LabMed)
97 publications found
Norwegican Cartilage Project - a study protocol for a double-blinded randomized controlled trial comparing arthroscopic microfracture with arthroscopic debridement in focal cartilage defects in the knee
BMC Musculoskelet Disord, 17, 292
DOI 10.1186/s12891-016-1156-y, PubMed 27422025
Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits
Cell Rep, 17 (9), 2474-2487
DOI 10.1016/j.celrep.2016.10.053, PubMed 27818087
Coupling of HIV-1 Antigen to the Selective Autophagy Receptor SQSTM1/p62 Promotes T-Cell-Mediated Immunity
Front Immunol, 7, 167
DOI 10.3389/fimmu.2016.00167, PubMed 27242780
Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery
Immunity, 45 (2), 305-18
DOI 10.1016/j.immuni.2016.07.019, PubMed 27533013
Increased Levels of Interferon-Inducible Protein 10 (IP-10) in 22q11.2 Deletion Syndrome
Scand J Immunol, 83 (3), 188-94
DOI 10.1111/sji.12406, PubMed 26708691
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets
J Leukoc Biol, 101 (1), 193-204
DOI 10.1189/jlb.3VMR0316-132R, PubMed 27581539
Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice
Mol Ther Oncolytics, 3, 16032
DOI 10.1038/mto.2016.32, PubMed 27933316
Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency
Oncogene, 36 (4), 570-584
DOI 10.1038/onc.2016.230, PubMed 27345406
Ultrasonic Surgical Aspirate is a Reliable Source For Culturing Glioblastoma Stem Cells
Sci Rep, 6, 32788
DOI 10.1038/srep32788, PubMed 27605047
Hampered Lung Maturation in Methimazole-Induced Hypothyroidism in Fetal Chicken: Morphological and Molecular Correlates to Human Fetal Development
Neonatology, 110 (2), 83-92
DOI 10.1159/000444656, PubMed 27070722
The Role of Animal Models in the Study of Hematopoietic Stem Cell Transplantation and GvHD: A Historical Overview
Front Immunol, 7, 333
DOI 10.3389/fimmu.2016.00333, PubMed 27625651
Antibody-antigen kinetics constrain intracellular humoral immunity
Sci Rep, 6, 37457
DOI 10.1038/srep37457, PubMed 27881870
A Longitudinal Follow-up of Autoimmune Polyendocrine Syndrome Type 1
J Clin Endocrinol Metab, 101 (8), 2975-83
DOI 10.1210/jc.2016-1821, PubMed 27253668
Dissecting the interaction between transglutaminase 2 and fibronectin
Amino Acids, 49 (3), 489-500
DOI 10.1007/s00726-016-2296-y, PubMed 27394141
The role of microRNAs in the pathogenesis of autoimmune diseases
Autoimmun Rev, 15 (12), 1171-1180
DOI 10.1016/j.autrev.2016.09.003, PubMed 27639156
Toll-Like Receptor Pathways in Autoimmune Diseases
Clin Rev Allergy Immunol, 50 (1), 1-17
DOI 10.1007/s12016-015-8473-z, PubMed 25687121
Altered leukocyte distribution under hypercholesterolemia: A cross-sectional study in children with familial hypercholesterolemia
Atherosclerosis, 256, 67-74
DOI 10.1016/j.atherosclerosis.2016.11.031, PubMed 28024183
Healthy HLA-DQ2.5+ Subjects Lack Regulatory and Memory T Cells Specific for Immunodominant Gluten Epitopes of Celiac Disease
J Immunol, 196 (6), 2819-26
DOI 10.4049/jimmunol.1501152, PubMed 26895834
TCR sequencing of single cells reactive to DQ2.5-glia-α2 and DQ2.5-glia-ω2 reveals clonal expansion and epitope-specific V-gene usage
Mucosal Immunol, 9 (3), 587-96
DOI 10.1038/mi.2015.147, PubMed 26838051
Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1
Dev Comp Immunol, 65, 31-40
DOI 10.1016/j.dci.2016.06.015, PubMed 27345169
Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients
Cancer Res, 76 (18), 5326-36
DOI 10.1158/0008-5472.CAN-16-1162, PubMed 27406829
Gluten-specific antibodies of celiac disease gut plasma cells recognize long proteolytic fragments that typically harbor T-cell epitopes
Sci Rep, 6, 25565
DOI 10.1038/srep25565, PubMed 27146306
Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects
J Allergy Clin Immunol, 137 (6), 1872-1881.e12
DOI 10.1016/j.jaci.2015.11.025, PubMed 26851967
Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients
J Ren Nutr, 27 (3), 161-168
DOI 10.1053/j.jrn.2016.09.008, PubMed 27838193
Modeling psychiatric disorders: from genomic findings to cellular phenotypes
Mol Psychiatry, 21 (9), 1167-79
DOI 10.1038/mp.2016.89, PubMed 27240529
Variants in CXCR4 associate with juvenile idiopathic arthritis susceptibility
BMC Med Genet, 17, 24
DOI 10.1186/s12881-016-0285-3, PubMed 27005825
Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease
Biol Blood Marrow Transplant, 23 (1), 172-175
DOI 10.1016/j.bbmt.2016.10.009, PubMed 27777142
TRIM21 Immune Signaling Is More Sensitive to Antibody Affinity Than Its Neutralization Activity
J Immunol, 196 (8), 3452-3459
DOI 10.4049/jimmunol.1502601, PubMed 26962230
Genetic risk variants for autoimmune diseases that influence gene expression in thymus
Hum Mol Genet, 25 (14), 3117-3124
DOI 10.1093/hmg/ddw152, PubMed 27199374
Autoimmune risk variants in ERAP2 are associated with gene-expression levels in thymus
Genes Immun, 17 (7), 406-411
DOI 10.1038/gene.2016.39, PubMed 27829666
Antiphospholipid Antibodies are Associated with Low Levels of Complement C3 and C4 in Patients with Systemic Lupus Erythematosus
Scand J Immunol, 84 (2), 95-9
DOI 10.1111/sji.12445, PubMed 27135178
Antigen Targeting to Human HLA Class II Molecules Increases Efficacy of DNA Vaccination
J Immunol, 197 (9), 3575-3585
DOI 10.4049/jimmunol.1600893, PubMed 27671110
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species
Immunity, 45 (3), 669-684
DOI 10.1016/j.immuni.2016.08.015, PubMed 27637149
Long-term mucosal recovery and healing in celiac disease is the rule - not the exception
Scand J Gastroenterol, 51 (12), 1439-1446
DOI 10.1080/00365521.2016.1218540, PubMed 27534885
Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport
J Proteome Res, 15 (10), 3841-3855
DOI 10.1021/acs.jproteome.6b00652, PubMed 27615514
Patients with depression display cytokine levels in serum and cerebrospinal fluid similar to patients with diffuse neurological symptoms without a defined diagnosis
Neuropsychiatr Dis Treat, 12, 817-22
DOI 10.2147/NDT.S101925, PubMed 27110115
The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse
PLoS One, 11 (12), e0167754
DOI 10.1371/journal.pone.0167754, PubMed 28002446
Epitope-dependent Functional Effects of Celiac Disease Autoantibodies on Transglutaminase 2
J Biol Chem, 291 (49), 25542-25552
DOI 10.1074/jbc.M116.738161, PubMed 27784785
Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis
Liver Int, 37 (3), 458-465
DOI 10.1111/liv.13238, PubMed 27558072
Multivalent pIX phage display selects for distinct and improved antibody properties
Sci Rep, 6, 39066
DOI 10.1038/srep39066, PubMed 27966617
Tissue-Specific Expression Patterns of MicroRNA during Acute Graft-versus-Host Disease in the Rat
Front Immunol, 7, 361
DOI 10.3389/fimmu.2016.00361, PubMed 27695455
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency
Am J Gastroenterol, 111 (10), 1467-1475
DOI 10.1038/ajg.2016.329, PubMed 27527747
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation
Mucosal Immunol, 9 (6), 1455-1465
DOI 10.1038/mi.2016.18, PubMed 26982597
High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells
Mol Cell Proteomics, 15 (4), 1246-61
DOI 10.1074/mcp.M115.054593, PubMed 26785729
Early postnatal maturation in vestibulospinal pathways involved in neck and forelimb motor control
Dev Neurobiol, 76 (10), 1061-77
DOI 10.1002/dneu.22375, PubMed 26724676
DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8(+) T Cell Responses, Enabling Faster Resolution of Influenza Disease
Front Immunol, 7, 321
DOI 10.3389/fimmu.2016.00321, PubMed 27602032
C1-inhibitor efficiently delays clot development in normal human whole blood and inhibits Escherichia coli-induced coagulation measured by thromboelastometry
Thromb Res, 143, 63-70
DOI 10.1016/j.thromres.2016.04.024, PubMed 27197075
LDL apheresis activates the complement system and the cytokine network, whereas PCSK9 inhibition with evolocumab induces no inflammatory response
J Clin Lipidol, 10 (6), 1481-1487
DOI 10.1016/j.jacl.2016.09.001, PubMed 27919366
A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans
Cell, 167 (4), 1099-1110.e14
DOI 10.1016/j.cell.2016.10.017, PubMed 27814507
Ex Vivo Oncolytic Virotherapy with Myxoma Virus Arms Multiple Allogeneic Bone Marrow Transplant Leukocytes to Enhance Graft versus Tumor
Mol Ther Oncolytics, 4, 31-40
DOI 10.1016/j.omto.2016.12.002, PubMed 28345022
Adoptive Transfer of Tumor-Specific Th2 Cells Eradicates Tumors by Triggering an In Situ Inflammatory Immune Response
Cancer Res, 76 (23), 6864-6876
DOI 10.1158/0008-5472.CAN-16-1219, PubMed 27634753
High-throughput sequencing of immune repertoires in multiple sclerosis
Ann Clin Transl Neurol, 3 (4), 295-306
DOI 10.1002/acn3.295, PubMed 27081660
IRF8 Transcription-Factor-Dependent Classical Dendritic Cells Are Essential for Intestinal T Cell Homeostasis
Immunity, 44 (4), 860-74
DOI 10.1016/j.immuni.2016.02.008, PubMed 27067057
Transition from childhood to adulthood in coeliac disease: the Prague consensus report
Gut, 65 (8), 1242-51
DOI 10.1136/gutjnl-2016-311574, PubMed 27196596
MetaMass, a tool for meta-analysis of subcellular proteomics data
Nat Methods, 13 (10), 837-40
DOI 10.1038/nmeth.3967, PubMed 27571551
Functional Effects of Schizophrenia-Linked Genetic Variants on Intrinsic Single-Neuron Excitability: A Modeling Study
Biol Psychiatry Cogn Neurosci Neuroimaging, 1 (1), 49-59
DOI 10.1016/j.bpsc.2015.09.002, PubMed 26949748
A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis
FEBS J, 283 (4), 757-70
DOI 10.1111/febs.13630, PubMed 26683827
Immunomodulation Induced by Stem Cell Mobilization and Harvesting in Healthy Donors: Increased Systemic Osteopontin Levels after Treatment with Granulocyte Colony-Stimulating Factor
Int J Mol Sci, 17 (7)
DOI 10.3390/ijms17071158, PubMed 27447610
Complement activation by cholesterol crystals triggers a subsequent cytokine response
Mol Immunol, 84, 43-50
DOI 10.1016/j.molimm.2016.09.019, PubMed 27692470
Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood
J Immunol, 196 (5), 2293-9
DOI 10.4049/jimmunol.1502220, PubMed 26800874
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
J Control Release, 229, 58-69
DOI 10.1016/j.jconrel.2016.03.021, PubMed 26993426
High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation
Cytokine, 83, 269-274
DOI 10.1016/j.cyto.2016.05.006, PubMed 27180202
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo
Clin Microbiol Infect, 22 (8), 734.e1-6
DOI 10.1016/j.cmi.2016.05.010, PubMed 27217049
Label-free Proteomic Reveals that Cowpea Severe Mosaic Virus Transiently Suppresses the Host Leaf Protein Accumulation During the Compatible Interaction with Cowpea (Vigna unguiculata [L.] Walp.)
J Proteome Res, 15 (12), 4208-4220
DOI 10.1021/acs.jproteome.6b00211, PubMed 27934294
The assessment of immune-regulatory effects of extracorporeal photopheresis in systemic sclerosis: a long-term follow-up study
Immunol Res, 64 (2), 404-11
DOI 10.1007/s12026-015-8678-5, PubMed 26168768
Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society December 7-10, 2015, San Diego, CA, USA
MAbs, 8 (3), 617-52
DOI 10.1080/19420862.2016.1153211, PubMed 26909869
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis
J Immunol, 196 (12), 5064-74
DOI 10.4049/jimmunol.1502595, PubMed 27183610
Focal cartilage defects in the knee - a randomized controlled trial comparing autologous chondrocyte implantation with arthroscopic debridement
BMC Musculoskelet Disord, 17, 117
DOI 10.1186/s12891-016-0969-z, PubMed 26956476
Membrane array and multiplex bead analysis of tear cytokines in systemic sclerosis
Immunol Res, 64 (2), 619-26
DOI 10.1007/s12026-015-8763-9, PubMed 26687127
Mass spectrometric detection of 27-hydroxycholesterol in breast cancer exosomes
J Steroid Biochem Mol Biol, 169, 22-28
DOI 10.1016/j.jsbmb.2016.02.006, PubMed 26877254
Effect of high-dose vitamin D3 supplementation on antibody responses against Epstein-Barr virus in relapsing-remitting multiple sclerosis
Mult Scler, 23 (3), 395-402
DOI 10.1177/1352458516654310, PubMed 27325604
Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein
Kidney Int Rep, 2 (3), 461-469
DOI 10.1016/j.ekir.2016.11.005, PubMed 29142973
Dynamics of the Escherichia coli proteome in response to nitrogen starvation and entry into the stationary phase
Biochim Biophys Acta Proteins Proteom, 1865 (3), 344-352
DOI 10.1016/j.bbapap.2016.12.002, PubMed 27939605
Development of a rapid screen for the endodermal differentiation potential of human pluripotent stem cell lines
Sci Rep, 6, 37178
DOI 10.1038/srep37178, PubMed 27872482
Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients
BMC Nephrol, 17 (1), 148
DOI 10.1186/s12882-016-0373-9, PubMed 27760523
Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation
Am J Transplant, 17 (1), 265-271
DOI 10.1111/ajt.13933, PubMed 27341702
The human intestinal B-cell response
Mucosal Immunol, 9 (5), 1113-24
DOI 10.1038/mi.2016.59, PubMed 27461177
Transglutaminase 2 strongly binds to an extracellular matrix component other than fibronectin via its second C-terminal beta-barrel domain
FEBS J, 283 (21), 3994-4010
DOI 10.1111/febs.13907, PubMed 27685605
Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts
J Acquir Immune Defic Syndr, 73 (2), 138-48
DOI 10.1097/QAI.0000000000001080, PubMed 27632144
Systemic inflammation in acute intermittent porphyria: a case-control study
Clin Exp Immunol, 187 (3), 466-479
DOI 10.1111/cei.12899, PubMed 27859020
Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Science, 352 (6291), 1337-41
DOI 10.1126/science.aaf2288, PubMed 27198675
Specific allergen immunotherapy: effect on IgE, IgG4 and chemokines in patients with allergic rhinitis
Scand J Clin Lab Invest, 76 (2), 118-27
DOI 10.3109/00365513.2015.1110856, PubMed 26878875
Degranulation Response in Cytotoxic Rat Lymphocytes Measured with a Novel CD107a Antibody
Front Immunol, 7, 572
DOI 10.3389/fimmu.2016.00572, PubMed 28003815
T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity
J Allergy Clin Immunol, 138 (3), 839-851.e8
DOI 10.1016/j.jaci.2016.01.035, PubMed 27056269
Host and Environmental Factors Influencing Individual Human Cytokine Responses
Cell, 167 (4), 1111-1124.e13
DOI 10.1016/j.cell.2016.10.018, PubMed 27814508
Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study
PLoS One, 11 (3), e0150191
DOI 10.1371/journal.pone.0150191, PubMed 26933886
Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study
PLoS One, 11 (7), e0159288
DOI 10.1371/journal.pone.0159288, PubMed 27415795
Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™ , in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study
Scand J Immunol, 84 (6), 323-331
DOI 10.1111/sji.12476, PubMed 27588816
Deep Pelvic Surgical Site Infection After Radiotherapy and Surgery for Locally Advanced Rectal Cancer
Ann Surg Oncol, 24 (3), 721-728
DOI 10.1245/s10434-016-5621-5, PubMed 27766561
Genetic Evidence for a Contribution of Native Americans to the Early Settlement of Rapa Nui (Easter Island)
Front. Ecol. Evol., 4, 118
Tumor-specific CD4+ T cells eradicate myeloma cells genetically deficient in MHC class II display
Oncotarget, 7 (41), 67175-67182
DOI 10.18632/oncotarget.11946, PubMed 27626487
Macrophage-mediated gliadin degradation and concomitant IL-27 production drive IL-10- and IFN-γ-secreting Tr1-like-cell differentiation in a murine model for gluten tolerance
Mucosal Immunol, 10 (3), 635-649
DOI 10.1038/mi.2016.76, PubMed 27579860
Versatile, sensitive liquid chromatography mass spectrometry - Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins
Sci Rep, 6, 37507
DOI 10.1038/srep37507, PubMed 27897190
Comparison of commercial nanoliquid chromatography columns for fast, targeted mass spectrometry-based proteomics
Future Sci OA, 2 (2), FSO119
DOI 10.4155/fsoa-2016-0014, PubMed 28031966
Expression of prophage-encoded endolysins contributes to autolysis of Lactococcus lactis
Appl Microbiol Biotechnol, 101 (3), 1099-1110
DOI 10.1007/s00253-016-7822-z, PubMed 27660179
Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages
Sci Rep, 6, 38597
DOI 10.1038/srep38597, PubMed 27934903
A Neonatal Mouse Spinal Cord Compression Injury Model
J Vis Exp (109), e53498
DOI 10.3791/53498, PubMed 27078037