Biomedical research at Oslo University Hospital

Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.

Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.

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Summary of publications:

Publications (original articles or review articles) published in 2014 from OUS - Department of Microbiology

49 publications found

Alfsnes K, Raynaud X, Tønjum T, Ambur OH (2014)
Mathematical and live meningococcal models for simple sequence repeat dynamics - coherent predictions and observations
PLoS One, 9 (7), e101637
DOI 10.1371/journal.pone.0101637, PubMed 24999629

Alseth I, Dalhus B, Bjørås M (2014)
Inosine in DNA and RNA
Curr Opin Genet Dev, 26, 116-23
DOI 10.1016/j.gde.2014.07.008, PubMed 25173738

Andersen JT, Dalhus B, Viuff D, Ravn BT, Gunnarsen KS, Plumridge A, Bunting K, Antunes F, Williamson R, Athwal S, Allan E, Evans L, Bjørås M, Kjærulff S, Sleep D, Sandlie I, Cameron J (2014)
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
DOI 10.1074/jbc.M114.549832, PubMed 24652290

Bliksøen M, Baysa A, Eide L, Bjørås M, Suganthan R, Vaage J, Stensløkken KO, Valen G (2014)
Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart
J Mol Cell Cardiol, 78, 9-22
DOI 10.1016/j.yjmcc.2014.11.010, PubMed 25446179

Bragstad K, Jakobsen K, Rojahn AE, Skram MK, Vainio K, Holberg-Petersen M, Hungnes O, Dudman SG, Kran AM (2014)
High frequency of enterovirus D68 in children hospitalised with respiratory illness in Norway, autumn 2014
Influenza Other Respir Viruses, 9 (2), 59-63
DOI 10.1111/irv.12300, PubMed 25534826

Brigtsen AK, Dedi L, Melby KK, Holberg-Petersen M, Radtke A, Lyng RV, Andresen LL, Jacobsen AF, Fugelseth D, Whitelaw A (2014)
Comparison of PCR and serotyping of Group B Streptococcus in pregnant women: the Oslo GBS-study
J Microbiol Methods, 108, 31-5
DOI 10.1016/j.mimet.2014.11.001, PubMed 25447890

Bøyum A, Forstrøm RJ, Sefland I, Sand KL, Benestad HB (2014)
Intricacies of redoxome function demonstrated with a simple in vitro chemiluminescence method, with special reference to vitamin B12 as antioxidant
Scand J Immunol, 80 (6), 390-7
DOI 10.1111/sji.12220, PubMed 25345916

Davydova E, Ho AY, Malecki J, Moen A, Enserink JM, Jakobsson ME, Loenarz C, Falnes PØ (2014)
Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)
J Biol Chem, 289 (44), 30499-510
DOI 10.1074/jbc.M114.601658, PubMed 25231979

Fossum Moen AE, Holberg-Petersen M, Andresen LL, Blomfeldt A (2014)
spa typing alone is not sufficient to demonstrate endemic establishment of meticillin-resistant Staphylococcus aureus in a low-prevalence country
J Hosp Infect, 88 (2), 72-7
DOI 10.1016/j.jhin.2014.06.008, PubMed 25085462

Haikarainen T, Krauss S, Lehtio L (2014)
Tankyrases: structure, function and therapeutic implications in cancer
Curr Pharm Des, 20 (41), 6472-88
DOI 10.2174/1381612820666140630101525, PubMed 24975604

Hassel B, Dahlberg D, Mariussen E, Goverud IL, Antal EA, Tønjum T, Maehlen J (2014)
Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc
J Neurosci Res, 92 (12), 1792-800
DOI 10.1002/jnr.23444, PubMed 25043715

Hustoft HK, Vehus T, Brandtzaeg OK, Krauss S, Greibrokk T, Wilson SR, Lundanes E (2014)
Open tubular lab-on-column/mass spectrometry for targeted proteomics of nanogram sample amounts
PLoS One, 9 (9), e106881
DOI 10.1371/journal.pone.0106881, PubMed 25222838

Husøy MA, Brinch L, Tjønnfjord GE, Gedde-Dahl T, Heldal D, Holme PA, Dybedal I, Kolstad A, Akkök ÇA, Rollag H, Gaustad P, Bergan S, Egeland T, Josefsen D, Kvalheim G, Fløisand Y (2014)
[Allogeneic stem-cell transplantation in adults 1985-2012: results and development]
Tidsskr Nor Laegeforen, 134 (16), 1569-75
DOI 10.4045/tidsskr.13.1415, PubMed 25178233

Håvelsrud OE, Sørum H, Gaustad P (2014)
Genome Sequences of Corynebacterium pseudotuberculosis Strains 48252 (Human, Pneumonia), CS_10 (Lab Strain), Ft_2193/67 (Goat, Pus), and CCUG 27541
Genome Announc, 2 (5)
DOI 10.1128/genomeA.00869-14, PubMed 25189581

Klungland A, Dahl JA (2014)
Dynamic RNA modifications in disease
Curr Opin Genet Dev, 26, 47-52
DOI 10.1016/j.gde.2014.05.006, PubMed 25005745

Kommedal Ø, Wilhelmsen MT, Skrede S, Meisal R, Jakovljev A, Gaustad P, Hermansen NO, Vik-Mo E, Solheim O, Ambur OH, Sæbø Ø, Høstmælingen CT, Helland C (2014)
Massive parallel sequencing provides new perspectives on bacterial brain abscesses
J Clin Microbiol, 52 (6), 1990-7
DOI 10.1128/JCM.00346-14, PubMed 24671797

Kran AMB, Lind A, Sommerfelt MM, Baksaas I, Sørensen B, Kvale D (2014)
Comparable Cellular Immune Responses in Patients with and without Antiretroviral Treatment after Immunization with HIV-1 P24, P17 and Tat Consensus Peptides (Vacc-5q)
J AIDS Clin Res, 5 (4), 1000294
DOI 10.4172/2155-6113.1000296, PublikaID 217

Lund K, Bostad M, Skarpen E, Braunagel M, Kiprijanov S, Krauss S, Duncan A, Høgset A, Selbo PK (2014)
The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
MAbs, 6 (4), 1038-50
DOI 10.4161/mabs.28207, PubMed 24525727

MacDonald E, Møller KE, Wester AL, Dahle UR, Hermansen NO, Jenum PA, Thoresen L, Vold L (2014)
An outbreak of enterotoxigenic Escherichia coli (ETEC) infection in Norway, 2012: a reminder to consider uncommon pathogens in outbreaks involving imported products
Epidemiol Infect, 143 (3), 486-93
DOI 10.1017/S0950268814001058, PubMed 24813906

Mahé F, Rognes T, Quince C, de Vargas C, Dunthorn M (2014)
Swarm: robust and fast clustering method for amplicon-based studies
PeerJ, 2, e593
DOI 10.7717/peerj.593, PubMed 25276506

Maier L, Hylse O, Necas M, Trbusek M, Ytre-Arne M, Dalhus B, Bjoras M, Paruch K (2014)
New carbocyclic nucleosides: synthesis of carbocyclic pseudoisocytidine and its analogs
Tetrahedron Lett., 55 (27), 3713-3716

Mantaka P, Tønjum T, Gjersvik P (2014)
[A knot on the aquarium owner's hand]
Tidsskr Nor Laegeforen, 134 (7), 715
DOI 10.4045/tidsskr.13.1425, PubMed 24721859

Misceo D, Holmgren A, Louch WE, Holme PA, Mizobuchi M, Morales RJ, De Paula AM, Stray-Pedersen A, Lyle R, Dalhus B, Christensen G, Stormorken H, Tjønnfjord GE, Frengen E (2014)
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
DOI 10.1002/humu.22544, PubMed 24619930

Nilsen A, Fusser M, Greggains G, Fedorcsak P, Klungland A (2014)
ALKBH4 depletion in mice leads to spermatogenic defects
PLoS One, 9 (8), e105113
DOI 10.1371/journal.pone.0105113, PubMed 25153837

Olsen PA, Solberg NT, Lund K, Vehus T, Gelazauskaite M, Wilson SR, Krauss S (2014)
Implications of targeted genomic disruption of β-catenin in BxPC-3 pancreatic adenocarcinoma cells
PLoS One, 9 (12), e115496
DOI 10.1371/journal.pone.0115496, PubMed 25536063

Palibrk V, Lång E, Lång A, Schink KO, Rowe AD, Bøe SO (2014)
Promyelocytic leukemia bodies tether to early endosomes during mitosis
Cell Cycle, 13 (11), 1749-55
DOI 10.4161/cc.28653, PubMed 24675887

Roberg-Larsen H, Lund K, Vehus T, Solberg N, Vesterdal C, Misaghian D, Olsen PA, Krauss S, Wilson SR, Lundanes E (2014)
Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols
J Lipid Res, 55 (7), 1531-6
DOI 10.1194/jlr.D048801, PubMed 24792927

Roberg-Larsen H, Strand MF, Krauss S, Wilson SR (2014)
Metabolites in vertebrate Hedgehog signaling
Biochem Biophys Res Commun, 446 (3), 669-74
DOI 10.1016/j.bbrc.2014.01.087, PubMed 24486313

Robertson AB, Robertson J, Fusser M, Klungland A (2014)
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination
Nucleic Acids Res, 42 (21), 13280-93
DOI 10.1093/nar/gku1032, PubMed 25355512

Sand KM, Bern M, Nilsen J, Dalhus B, Gunnarsen KS, Cameron J, Grevys A, Bunting K, Sandlie I, Andersen JT (2014)
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)
J Biol Chem, 289 (50), 34583-94
DOI 10.1074/jbc.M114.587675, PubMed 25344603

Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT (2014)
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301

Solli L, Håvelsrud OE, Horn SJ, Rike AG (2014)
A metagenomic study of the microbial communities in four parallel biogas reactors
Biotechnol Biofuels, 7 (1), 146
DOI 10.1186/s13068-014-0146-2, PubMed 25328537

Strand JM, Scheffler K, Bjørås M, Eide L (2014)
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences
DNA Repair (Amst), 18, 44-51
DOI 10.1016/j.dnarep.2014.03.003, PubMed 24685126

Strand JM, Skinnes R, Scheffler K, Rootvelt T, Woldseth B, Bjørås M, Eide L (2014)
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis
Metabolism, 63 (8), 1063-70
DOI 10.1016/j.metabol.2014.05.003, PubMed 24928662

Stray-Pedersen A, Backe PH, Sorte HS, Mørkrid L, Chokshi NY, Erichsen HC, Gambin T, Elgstøen KB, Bjørås M, Wlodarski MW, Krüger M, Jhangiani SN, Muzny DM, Patel A, Raymond KM, Sasa GS, Krance RA, Martinez CA, Abraham SM, Speckmann C, Ehl S, Hall P, Forbes LR, Merckoll E, Westvik J et al. (2014)
PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia
Am J Hum Genet, 95 (1), 96-107
DOI 10.1016/j.ajhg.2014.05.007, PubMed 24931394

Strøm TB, Tveten K, Laerdahl JK, Leren TP (2014)
Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum
FEBS Open Bio, 4, 321-7
DOI 10.1016/j.fob.2014.03.007, PubMed 24918045

Sulheim D, Fagermoen E, Winger A, Andersen AM, Godang K, Müller F, Rowe PC, Saul JP, Skovlund E, Øie MG, Wyller VB (2014)
Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized clinical trial
JAMA Pediatr, 168 (4), 351-60
DOI 10.1001/jamapediatrics.2013.4647, PubMed 24493300

Taraldsrud E, Fevang B, Aukrust P, Beiske KH, Fløisand Y, Frøland S, Rollag H, Olweus J (2014)
Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9
Clin Exp Immunol, 175 (3), 439-48
DOI 10.1111/cei.12239, PubMed 24237110

Tortorano AM, Prigitano A, Esposto MC, Arsic Arsenijevic V, Kolarovic J, Ivanovic D, Paripovic L, Klingspor L, Nordøy I, Hamal P, Arikan Akdagli S, Ossi C, Grancini A, Cavanna C, Lo Cascio G, Scarparo C, Candoni A, Caira M, Drogari Apiranthitou M, ECMM Working Group (2014)
European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe
Eur J Clin Microbiol Infect Dis, 33 (9), 1623-30
DOI 10.1007/s10096-014-2111-1, PubMed 24791951

Turowski G, Rollag H, Roald B (2014)
Viral infection in placenta relevant cells--a morphological and immunohistochemical cell culture study
APMIS, 123 (1), 60-4
DOI 10.1111/apm.12307, PubMed 25244625

Wang W, Scheffler K, Esbensen Y, Strand JM, Stewart JB, Bjørås M, Eide L (2014)
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age
PLoS One, 9 (5), e96940
DOI 10.1371/journal.pone.0096940, PubMed 24819950

Wanichawan P, Hafver TL, Hodne K, Aronsen JM, Lunde IG, Dalhus B, Lunde M, Kvaløy H, Louch WE, Tønnessen T, Sjaastad I, Sejersted OM, Carlson CR (2014)
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645

Yimer SA, Bjune GA, Holm-Hansen C (2014)
Time to first consultation, diagnosis and treatment of TB among patients attending a referral hospital in Northwest, Ethiopia
BMC Infect Dis, 14, 19
DOI 10.1186/1471-2334-14-19, PubMed 24410927

Yimer SA, Holm-Hansen C, Storla DG, Bjune GA (2014)
Tuberculosis management time: an alternative parameter for measuring the tuberculosis infectious pool
Trop Med Int Health, 19 (3), 313-320
DOI 10.1111/tmi.12246, PubMed 24393123

Zaburdaev V, Biais N, Schmiedeberg M, Eriksson J, Jonsson AB, Sheetz MP, Weitz DA (2014)
Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility
Biophys J, 107 (7), 1523-31
DOI 10.1016/j.bpj.2014.07.061, PubMed 25296304

Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ (2014)
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities
PLoS One, 9 (6), e98729
DOI 10.1371/journal.pone.0098729, PubMed 24914785

Zeissig S, Petersen BS, Tomczak M, Melum E, Huc-Claustre E, Dougan SK, Laerdahl JK, Stade B, Forster M, Schreiber S, Weir D, Leichtner AM, Franke A, Blumberg RS (2014)
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4
Gut, 64 (12), 1889-97
DOI 10.1136/gutjnl-2014-308541, PubMed 25367873

Zhang X, Shi M, Ye R, Wang W, Liu X, Zhang G, Han J, Zhang Y, Wang B, Zhao J, Hui J, Xiong L, Zhao G (2014)
Ginsenoside Rd attenuates tau protein phosphorylation via the PI3K/AKT/GSK-3β pathway after transient forebrain ischemia
Neurochem Res, 39 (7), 1363-73
DOI 10.1007/s11064-014-1321-3, PubMed 24792734

Aamann MD, Hvitby C, Popuri V, Muftuoglu M, Lemminger L, Skeby CK, Keijzers G, Ahn B, Bjørås M, Bohr VA, Stevnsner T (2014)
Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity
Mech Ageing Dev, 135, 1-14
DOI 10.1016/j.mad.2013.12.008, PubMed 24406253

 
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