Biomedical research at Oslo University Hospital
Oslo University Hospital is a merger of three former university hospitals in Oslo. Biomedical research is one of the hospital's core activities. Research at the hospital is closely interlinked with research undertaken at the University of Oslo. More than 50% of all biomedical research in Norway is published by researchers affiliated with the hospital. Research undertaken cover both basic research, translational research, and clinical research.
Oslo University Hospital has a central role in developing and supporting biomedical research within the South-Eastern Regional Health Authority. The hospital also pursues international research collaborations.
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Summary of publications:
Publications (original articles or review articles) published in 2014 from OUS - Department of Microbiology
49 publications found
Mathematical and live meningococcal models for simple sequence repeat dynamics - coherent predictions and observations
PLoS One, 9 (7), e101637
DOI 10.1371/journal.pone.0101637, PubMed 24999629
Inosine in DNA and RNA
Curr Opin Genet Dev, 26, 116-23
DOI 10.1016/j.gde.2014.07.008, PubMed 25173738
Extending serum half-life of albumin by engineering neonatal Fc receptor (FcRn) binding
J Biol Chem, 289 (19), 13492-502
DOI 10.1074/jbc.M114.549832, PubMed 24652290
Mitochondrial DNA damage and repair during ischemia-reperfusion injury of the heart
J Mol Cell Cardiol, 78, 9-22
DOI 10.1016/j.yjmcc.2014.11.010, PubMed 25446179
High frequency of enterovirus D68 in children hospitalised with respiratory illness in Norway, autumn 2014
Influenza Other Respir Viruses, 9 (2), 59-63
DOI 10.1111/irv.12300, PubMed 25534826
Comparison of PCR and serotyping of Group B Streptococcus in pregnant women: the Oslo GBS-study
J Microbiol Methods, 108, 31-5
DOI 10.1016/j.mimet.2014.11.001, PubMed 25447890
Intricacies of redoxome function demonstrated with a simple in vitro chemiluminescence method, with special reference to vitamin B12 as antioxidant
Scand J Immunol, 80 (6), 390-7
DOI 10.1111/sji.12220, PubMed 25345916
Identification and characterization of a novel evolutionarily conserved lysine-specific methyltransferase targeting eukaryotic translation elongation factor 2 (eEF2)
J Biol Chem, 289 (44), 30499-510
DOI 10.1074/jbc.M114.601658, PubMed 25231979
spa typing alone is not sufficient to demonstrate endemic establishment of meticillin-resistant Staphylococcus aureus in a low-prevalence country
J Hosp Infect, 88 (2), 72-7
DOI 10.1016/j.jhin.2014.06.008, PubMed 25085462
Tankyrases: structure, function and therapeutic implications in cancer
Curr Pharm Des, 20 (41), 6472-88
DOI 10.2174/1381612820666140630101525, PubMed 24975604
Brain infection with Staphylococcus aureus leads to high extracellular levels of glutamate, aspartate, γ-aminobutyric acid, and zinc
J Neurosci Res, 92 (12), 1792-800
DOI 10.1002/jnr.23444, PubMed 25043715
Open tubular lab-on-column/mass spectrometry for targeted proteomics of nanogram sample amounts
PLoS One, 9 (9), e106881
DOI 10.1371/journal.pone.0106881, PubMed 25222838
[Allogeneic stem-cell transplantation in adults 1985-2012: results and development]
Tidsskr Nor Laegeforen, 134 (16), 1569-75
DOI 10.4045/tidsskr.13.1415, PubMed 25178233
Genome Sequences of Corynebacterium pseudotuberculosis Strains 48252 (Human, Pneumonia), CS_10 (Lab Strain), Ft_2193/67 (Goat, Pus), and CCUG 27541
Genome Announc, 2 (5)
DOI 10.1128/genomeA.00869-14, PubMed 25189581
Dynamic RNA modifications in disease
Curr Opin Genet Dev, 26, 47-52
DOI 10.1016/j.gde.2014.05.006, PubMed 25005745
Massive parallel sequencing provides new perspectives on bacterial brain abscesses
J Clin Microbiol, 52 (6), 1990-7
DOI 10.1128/JCM.00346-14, PubMed 24671797
Comparable Cellular Immune Responses in Patients with and without Antiretroviral Treatment after Immunization with HIV-1 P24, P17 and Tat Consensus Peptides (Vacc-5q)
J AIDS Clin Res, 5 (4), 1000294
DOI 10.4172/2155-6113.1000296, PublikaID 217
The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines
MAbs, 6 (4), 1038-50
DOI 10.4161/mabs.28207, PubMed 24525727
An outbreak of enterotoxigenic Escherichia coli (ETEC) infection in Norway, 2012: a reminder to consider uncommon pathogens in outbreaks involving imported products
Epidemiol Infect, 143 (3), 486-93
DOI 10.1017/S0950268814001058, PubMed 24813906
Swarm: robust and fast clustering method for amplicon-based studies
PeerJ, 2, e593
DOI 10.7717/peerj.593, PubMed 25276506
New carbocyclic nucleosides: synthesis of carbocyclic pseudoisocytidine and its analogs
Tetrahedron Lett., 55 (27), 3713-3716
[A knot on the aquarium owner's hand]
Tidsskr Nor Laegeforen, 134 (7), 715
DOI 10.4045/tidsskr.13.1425, PubMed 24721859
A dominant STIM1 mutation causes Stormorken syndrome
Hum Mutat, 35 (5), 556-64
DOI 10.1002/humu.22544, PubMed 24619930
ALKBH4 depletion in mice leads to spermatogenic defects
PLoS One, 9 (8), e105113
DOI 10.1371/journal.pone.0105113, PubMed 25153837
Implications of targeted genomic disruption of β-catenin in BxPC-3 pancreatic adenocarcinoma cells
PLoS One, 9 (12), e115496
DOI 10.1371/journal.pone.0115496, PubMed 25536063
Promyelocytic leukemia bodies tether to early endosomes during mitosis
Cell Cycle, 13 (11), 1749-55
DOI 10.4161/cc.28653, PubMed 24675887
Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols
J Lipid Res, 55 (7), 1531-6
DOI 10.1194/jlr.D048801, PubMed 24792927
Metabolites in vertebrate Hedgehog signaling
Biochem Biophys Res Commun, 446 (3), 669-74
DOI 10.1016/j.bbrc.2014.01.087, PubMed 24486313
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination
Nucleic Acids Res, 42 (21), 13280-93
DOI 10.1093/nar/gku1032, PubMed 25355512
Interaction with both domain I and III of albumin is required for optimal pH-dependent binding to the neonatal Fc receptor (FcRn)
J Biol Chem, 289 (50), 34583-94
DOI 10.1074/jbc.M114.587675, PubMed 25344603
Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies
J Biol Chem, 289 (24), 17228-39
DOI 10.1074/jbc.M113.522565, PubMed 24764301
A metagenomic study of the microbial communities in four parallel biogas reactors
Biotechnol Biofuels, 7 (1), 146
DOI 10.1186/s13068-014-0146-2, PubMed 25328537
The distribution of DNA damage is defined by region-specific susceptibility to DNA damage formation rather than repair differences
DNA Repair (Amst), 18, 44-51
DOI 10.1016/j.dnarep.2014.03.003, PubMed 24685126
Genome instability in Maple Syrup Urine Disease correlates with impaired mitochondrial biogenesis
Metabolism, 63 (8), 1063-70
DOI 10.1016/j.metabol.2014.05.003, PubMed 24928662
PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia
Am J Hum Genet, 95 (1), 96-107
DOI 10.1016/j.ajhg.2014.05.007, PubMed 24931394
Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum
FEBS Open Bio, 4, 321-7
DOI 10.1016/j.fob.2014.03.007, PubMed 24918045
Disease mechanisms and clonidine treatment in adolescent chronic fatigue syndrome: a combined cross-sectional and randomized clinical trial
JAMA Pediatr, 168 (4), 351-60
DOI 10.1001/jamapediatrics.2013.4647, PubMed 24493300
Common variable immunodeficiency revisited: normal generation of naturally occurring dendritic cells that respond to Toll-like receptors 7 and 9
Clin Exp Immunol, 175 (3), 439-48
DOI 10.1111/cei.12239, PubMed 24237110
European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe
Eur J Clin Microbiol Infect Dis, 33 (9), 1623-30
DOI 10.1007/s10096-014-2111-1, PubMed 24791951
Viral infection in placenta relevant cells--a morphological and immunohistochemical cell culture study
APMIS, 123 (1), 60-4
DOI 10.1111/apm.12307, PubMed 25244625
Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age
PLoS One, 9 (5), e96940
DOI 10.1371/journal.pone.0096940, PubMed 24819950
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure
J Biol Chem, 289 (49), 33984-98
DOI 10.1074/jbc.M114.602581, PubMed 25336645
Time to first consultation, diagnosis and treatment of TB among patients attending a referral hospital in Northwest, Ethiopia
BMC Infect Dis, 14, 19
DOI 10.1186/1471-2334-14-19, PubMed 24410927
Tuberculosis management time: an alternative parameter for measuring the tuberculosis infectious pool
Trop Med Int Health, 19 (3), 313-320
DOI 10.1111/tmi.12246, PubMed 24393123
Uncovering the mechanism of trapping and cell orientation during Neisseria gonorrhoeae twitching motility
Biophys J, 107 (7), 1523-31
DOI 10.1016/j.bpj.2014.07.061, PubMed 25296304
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities
PLoS One, 9 (6), e98729
DOI 10.1371/journal.pone.0098729, PubMed 24914785
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4
Gut, 64 (12), 1889-97
DOI 10.1136/gutjnl-2014-308541, PubMed 25367873
Ginsenoside Rd attenuates tau protein phosphorylation via the PI3K/AKT/GSK-3β pathway after transient forebrain ischemia
Neurochem Res, 39 (7), 1363-73
DOI 10.1007/s11064-014-1321-3, PubMed 24792734
Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity
Mech Ageing Dev, 135, 1-14
DOI 10.1016/j.mad.2013.12.008, PubMed 24406253