Bendik S. Winsvold

  • Senior researchers; PhD

Background

Bendik S Winsvold has a medical degree from Royal College of Surgeons in Ireland (2006), and started specializing in neurology at Oslo University Hospital in 2008. His PhD (2014) was on the genetic basis of migraine, and the relationship between migraine and cardiovascular disease. He has worked as visiting scientist at the department of Human Genetics, Wellcome Trust Sanger Institute (Cambridge, UK) for two years (2011-2012), and at the Broad Institute of MIT and Harvard (Boston, USA) for six months (2014-2015). His main research focus has since been on the genetics of neurological and psychiatric disorders. He organizes the neuropsychiatric arm of a large genetic study (HUNT-MI/All-In) of 70,000 participants in the HUNT Study (https://www.ntnu.edu/huntgenes/research). Former secretary, and active member, of the International Headache Genetics Consortium. Alongside his research activity, he takes a special interest in the follow-up of patients with headache at the department of Neurology.

Research Projects

Supervision of PhD candidates

  • Main supervisor for Sigrid Børte (MD)
  • Co-supervisor for Marie Udnesseter Lie (MSc) and Ioannis Kitsos (MD)

Methodology and interests

  • Population genetics of neurological and psychiatric disorders. Epigenetics. Epidemiological studies of chronic pain disorders and headache. Organizes the neuropsychiatric arm of the HUNT-MI (All-In) study (https://www.ntnu.edu/huntgenes/research).

Publications

  1. Lane JM, Jones S, Dashti HS, Wood AR, Aragam KG, van Hees VT, Brumpton B, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont R, Bechtold DA, Cade B, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B, Tyrrell J, Winkelman J, Winkelmann J, HUNT All In Sleep, Strand LB, Zhao C, Nielsen JB, Willer CJ, Redline S, Spiegelhalder K, Kyle SD, Ray DW, Zwart J-A, Hveem K, Frayling TM, Lawlor DA, Rutter MK, Weedon MN, Saxena R. Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics 2018 (accepted).
  1. Åsberg AN, Hagen K, Stovner LJ, Heuch I, Zwart JA, Winsvold BS. Do incident musculoskeletal complaints influence mortality? The Nord-Trøndelag Health study. Plos One 2018 Sep 28;13(9):e0203925. doi: 10.1371/journal.pone.0203925.
  1. Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain I, McGuire D, Tian C [... ] Winsvold BSal. Association studies of up to 1.2 million individuals yield new insights in the genetic etiology of tobacco and alcohol use. Nature Genetics 2018 (accepted)
  1. Yang Y, Zhao H, Boomsma DI, Ligthart L, Belin AC, Smith GD, Esko T, Freilinger TM, Hansen TF, Ikram MA, Kallela M, Kubisch C, Paraskevi C, Strachan DP, Wessman M; International Headache Genetics Consortium [Winsvold B.S.], van den Maagdenberg AMJM, Terwindt GM, Nyholt DR.Molecular genetic overlap between migraine and major depressive disorder. Eur J Hum Genet 2018 [Epub ahead of print]
  1. Anttila V., Bulik-Sullivan B., Finucane H.K., Walters R.K., Bras J., Duncan L., Escott-Price V., Falcone G.J., [...] Winsvold B.al. Analysis of shared heritability in common disorders of the brain. Science 2018 Jun 22;360(6395).
  1. Johnsen M.B, Winsvold B.S., Børte S., Vie G.Å., Pedersen L.M., Storheim K., Skorpen F., Hagen K., Bjørngaard J.H., Åsvold B.O., Zwart J.-A. The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT Study. Eur J Neurology 2018 (Epub ahead of print).
  1. Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M; 23andMe Research Team; International Headache Genetics Consortium (IHGC) [Winsvold B.S.], Runz H, Daly MJ, Neale BM, Ripatti S, Kallela M, Wessman M, Palotie A. Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron 2018 May 16;98(4):743-753.e4.
  1. Hagen K., Kristoffersen E.S., Winsvold B.S., Stovner L., Zwart J.-A. Remission of chronic headache: an 11-year follow-up study. Data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008. Cephalalgia 2018 (Epub ahead of print).
  1. Kambur O., Kaunisto M.A., Winsvold B.S., Wilsgaard T., Stubhaug A., Zwart J.A., Kalso E., Nielsen C.S.. Genetic Variation in P2rx7 and Pain Tolerance. Pain 2018 Feb 20 (Epub ahead of print). 
  1. Hagen K., Åsberg A.N., Stovner L., Linde M., Zwart J.-A., Winsvold B.S., Heuch I. Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008. Cephalalgia 2018 (Epub ahead of print). 
  1. Winsvold B.S., Marvik A., Zwart J.A., Aamodt A.H. Migraine and stroke. Tidsskr Nor Laegeforen. 2018 Feb 19 (Epub ahead of print). 
  1. Winsvold B.S., Bettella F., Witoelar A., Anttila V., Gormley P., Kurth T., Terwindt G.M., Freilinger T.M., Frei O., Shadrin A., Wang Y., Dale A.M., van den Maagdenberg A., Chasman D.I., Nyholt D.R., Palotie A., Andreassen O.A., Zwart J.A., International Headache Genetics C. Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants. PLoS One 2017: Sep 28;12(9):e0185663. 
  1. Børte S., Winsvold B.S., Stensland S.Ø., Småstuen M.C., Zwart J.A. The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study. PLoS One 2017:12(4):e0175908.
  1. Winsvold B.S., Palta P., Eising E., Page C.M., International Headache Genetics C., van den Maagdenberg A.M., Palotie A., Zwart J.A. Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study. Cephalalgia 2017: doi: 10.1177/0333102417690111 (Epub ahead of print).
  1. Johnsen M.B., Vie G.A., Winsvold B.S., Bjorngaard J.H., Asvold B.O., Gabrielsen M.E., Pedersen L.M., Hellevik A.I., Langhammer A., Furnes O., Flugsrud G.B., Skorpen F., Romundstad P.R., Storheim K., Nordsletten L., Zwart J.A. The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study. Osteoarthritis Cartilage 2017 (Epub ahead of print). 
  1. Gustavsen, M.W., Celius, E.G., Winsvold, B.S., Moen, S.M., Nygaard, G.O., Berg-Hansen, P., Lie, B.A., Zwart, J.-A., Harbo, H.F. Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study. Multiple Sclerosis Journal – Experimental, Translational and Clinical 2016: 10.1177/2055217316682976.
  1. Gormley P., Winsvold B.S., Nyholt D.R., Kallela M., Chasman D.I., Palotie A. Migraine genetics: from genome-wide association studies to translational insights. Genome Medicine 2016;8:86.
  1. Gormley P., Anttila V., Winsvold B.S., Palta P., Esko T., Pers T.H., Farh K.H., Cuenca-Leon E., Muona M., Furlotte N.A., Kurth T., Ingason A., McMahon G., Ligthart L., Terwindt G.M., Kallela M., Freilinger T.M., Ran C., Gordon S.G., Stam A.H., Steinberg S., Borck G., Koiranen M., Quaye L., Adams H.H., Lehtimaki T., Sarin A.P., Wedenoja J., Hinds D.A., Buring J.E., Schurks M., Ridker P.M., Hrafnsdottir M.G., Stefansson H., Ring S.M., Hottenga J.J., Penninx B.W., Farkkila M., Artto V., Kaunisto M., Vepsalainen S., Malik R., Heath A.C., Madden P.A., Martin N.G., Montgomery G.W., Kurki M.I., Kals M., Magi R., Parn K., Hamalainen E., Huang H., Byrnes A.E., Franke L., Huang J., Stergiakouli E., Lee P.H., Sandor C., Webber C., Cader Z., Muller-Myhsok B., Schreiber S., Meitinger T., Eriksson J.G., Salomaa V., Heikkila K., Loehrer E., Uitterlinden A.G., Hofman A., van Duijn C.M., Cherkas L., Pedersen L.M., Stubhaug A., Nielsen C.S., Mannikko M., Mihailov E., Milani L., Gobel H., Esserlind A.L., Christensen A.F., Hansen T.F., Werge T., International Headache Genetics C., Kaprio J., Aromaa A.J., Raitakari O., Ikram M.A., Spector T., Jarvelin M.R., Metspalu A., Kubisch C., Strachan D.P., Ferrari M.D., Belin A.C., Dichgans M., Wessman M., van den Maagdenberg A.M., Zwart J.A., Boomsma D.I., Smith G.D., Stefansson K., Eriksson N., Daly M.J., Neale B.M., Olesen J., Chasman D.I., Nyholt D.R., Palotie A. Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics 2016;48(8): 856-866.
  1. Eising E., Huisman S.M., Mahfouz A., Vijfhuizen L.S., Anttila V., Winsvold B.S., Kurth T., Ikram M.A., Freilinger T., Kaprio J., Boomsma D.I., van Duijn C.M., Jarvelin M.R., Zwart J.A., Quaye L., Strachan D.P., Kubisch C., Dichgans M., Davey Smith G., Stefansson K., Palotie A., Chasman D.I., Ferrari M.D., Terwindt G.M., de Vries B., Nyholt D.R., Lelieveldt B.P., van den Maagdenberg A.M., Reinders M.J. Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas. Human Genetics 2016;135(4):425-439.
  1. Åsberg A.N., Stovner L., Zwart J.A., Winsvold B.S., Heuch I., Hagen K. Chronic musculoskeletal complaints as a predictor of mortality. The HUNT study. Pain 2016;157:1443-1447.
  1. Malik R., Winsvold B.S., Auffenberg E., Dichgans M., Freilinger T. The migraine–stroke connection: A genetic perspective. Cephalalgia 2016;36(7):658-668.
  1. Srinivasan S., Bettella F., Mattingsdal M., Wang Y., Witoelar A., Schork A.J., Thompson W.K., Zuber V., The Schizophrenia Working Group of the Psychiatric Genomics Consortium, International Headache Genetics Consortium, Winsvold B.S., Zwart J.A., Collier D.A. Desikan R.S., Melle I., Werge T., Dale A.M., Djurovic S., Andreassen O.A. Genetic markers of human evolution are enriched in schizophrenia.Biological Psychiatry 2015;80(4):284-92.
  1. Zhao H., Eising E., de Vries B., Anttila V., Winsvold B.S., Kurth T., Stefansson H., Kallela M., Malik R., Stam A.H., Ikram M.A., Ligthart L., Freilinger T., Alexander M., Muller-Myhsok B., Schreiber S., Meitinger T., Aromaa A., Eriksson J.G., Boomsma D.I., van Duijn C.M., Zwart J.-A., Quaye L., Kubisch C., Dichgans M., Wessman M., Stefansson K., Chasman D.I., Palotie A., Martin N.G., Montgomery G.W., Ferrari M.D., Terwindt G.M., van den Maagdenberg A.M.J.M., Nyholt D.R. Gene-based pleiotropy across migraine with aura and migraine without aura. Cephalalgia2016;36(7):648-657.
  2. Winsvold B.S., Nelson C.P., Malik R., Gormley P., Anttila V., Vander Heiden J., Elliott K.S., Jacobsen L.M., Palta P., Amin N., de Vries B., Hämäläinen E., Freilinger T., Ikram M.A., Kessler T., Koiranen M., Ligthart L., McMahon G., Pedersen L.M., Willenborg C., Won H.-H., Olesen J., Artto V., Assimes T.L., Blankenberg S., Boomsma D.I., Cherkas L., Smith G.D., Epstein S.E., Erdmann J., Ferrari M.D., Göbel H., Hall A.S., Jarvelin M.-R., Kallela M., Kaprio J., Kathiresan S., Lehtimäki T., McPherson R., März W., Nyholt D., O’Donnell C.J., Quaye L., Rader D.J., Raitakari O., Roberts R., Schunkert H., Schürks M., Stewart A.F.R., Terwindt G.M., Thorsteinsdottir U., van den Maagdenberg A.M.J.M, van Duijn C., Wessman M., Kurth T., Kubisch C., Dichgans M., Chasman D.I., Cotsapas C., Zwart J.-A., Samani N.J., Palotie A. for the CARDIoGRAM Consortium and the International Headache Genetics Consortium. Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurology: Genetics 2015; 1(1);doi:http:/​/​dx.​doi.​org/​10.​1212/​NXG.​ 00000000000010.

  3. Kvalheim S., Sandvik L., Winsvold B., Hagen K., Zwart J.A. (2016) Early menarche and chronic widespread musculoskeletal complaints- Results from the HUNT study.European Journal of Pain 2016: 20(3): 458-464.
  1. Asberg A.N., Stovner L.J., Zwart J.A., Winsvold B.S., Heuch I., Hagen K. Migraine as a predictor of mortality: The HUNT study. Cephalalgia 2016 36: 351-357.
  1. Malik R., Freilinger T., Winsvold B.S., Anttila V., Vander Heiden J., Traylor M., de Vries B., Holliday E.G., Terwindt G.M., Sturm J., Bis J.C., Hopewell J.C., Ferrari M.D., Rannikmae K., Wessman M., Kallela M., Kubisch C., Fornage M., Meschia J.F., Lehtimaki T., Sudlow C., Clarke R., Chasman D.I., Mitchell B.D., Maguire J., Kaprio J., Farrall M., Raitakari O.T., Kurth T., Ikram M.A., Reiner A.P., Longstreth W.T., Jr., Rothwell P.M., Strachan D.P., Sharma P., Seshadri S., Quaye L., Cherkas L., Schurks M., Rosand J., Ligthart L., Boncoraglio G.B., Davey Smith G., van Duijn C.M., Stefansson K., Worrall B.B., Nyholt D.R., Markus H.S., van den Maagdenberg A.M., Cotsapas C., Zwart J.A., Palotie A., Dichgans M. Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. Neurology 2015;84:2132-2145.
  1. Jacobsen K.K., Nievergelt C.M., Zayats T., Greenwood T.A., Anttila V., Akiskal H.S., Kelsoe J.R., Greenwood T.A., Nievergelt C.M., McKinney R., Shilling P.D., Smith E.N., Schork N.J., Bloss C.S., Nurnberger J.I.J., Edenberg H.J., Foroud T., Koller D.L., Gershon E.S., Badner J.A., Liu C., Scheftner W.A., Lawson W.B., Nwulia E.A., Hipolito M., Potash J., Coryell W., Rice J., Byerley W., McMahon F.J., Berrettini W.H., Zandi P.P., Mahon P.B., McInnis M.G., Zöllner S., Zhang P., Craig D.W., Szelinger S., Barrett T.B., Schulze T.G., Wedenoja J., Kaunisto M.A., Heikkilä K., Kaprio J., Wessman M., Kallela M., Färkkilä M., Artto V., Aromaa A., Eriksson J.G., Winsvold B.S., Zwart J., Gormley P., Palotie A., Kurth T., Rose L.M., Buring J.E., Ridker P.M., Chasman D.I., Bettella F., Steinberg S., Stefansson H., Stefansson K., McMahon G., Davey-Smith G., Malik R., Freilinger T., Wichmann H.E., Dichgans M., Muller-Myhsok B., Meitinger T., de Vries B., Terwindt G., Stam A.H., Frants R.R., Pelzer N., Weller C.M., Zielman R., Ferrari M.D., van den Maagdenberg A.M., Medland S.E., Montgomery G.W., Martin N.G., Nyholt D.R., Todt U., Borck G., Kubisch C., Quaye L., Williams F.M.K., Cherkas L., Koiranen M., Hartikainen A., Pouta A., Jarvelin M., Ikram M.A., van den Ende J., Uitterlinden A.G., Hofman A., Amin N., van Duijn C., Lehtimäki T., Ligthart L., Hottenga J., Vink J.M., Penninx B.W., Boomsma D.I., Schürks M., Jakobsson F., Schoenen J., Heath A.C., Madden P.A.F., Göbel H., Heinze A., Heinze-Kuhn K., Schreiber S., Anttila V., Daly M.J., Alexander M., Raitakari O., Strachan D.P., Haavik J., Fasmer O.B., Kelsoe J.R., Johansson S., Oedegaard K.J. Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder. J Affect Disord 2015;10: 453-461.
  1. Louter M.A.*, Fernandez-Morales J.*, de Vries B., Winsvold B., Anttila V., Fernandez-Cadenas I., Vila-Pueyo M., Sintas C., van Duijn C.M., Cormand B., Álvarez-Sabin J., Montaner J., Ferrari M.D., van den Maagdenberg M.J.M., Palotie A., Zwart J.A., Macaya A., Terwindt G.M., Pozo-Rosich P. Candidate gene association study searching for genetic factors involved in migraine chronification. Cephalalgia 2015;35:500-507.
  1. Nyholt D.R., Anttila V., Winsvold B.S., Kurth, T., Bettella F., Kallela MN., Malik R., de Vries B., Terwindt G., Ikram M.A., Stam A.H., Ligthart L., Freilinger T., Alexander M., Muller-Myhsok B., Schreiber S., Meitinger T., Aromaa A., Eriksson J.G., Kaprio J., Boomsma D.I., van Duijn C., Raitakari O., Jarvelin M.R., Zwart J.A., Cherkas L., Strachan D.P., Kubisch C., Ferrari M.D., van den Maagdenberg A.M., Dichgans M., Wessman M., Davey Smith G., Stefansson K., Chasman D.I. & Palotie A. Concordance of genetic risk across migraine subgroups: impact on current and future genetic association studies. Cephalalgia 2015;35:489-499.
  1. Fagernæs C.F., Heuch I., Zwart, J.A., Winsvold B., Linde M, Hagen K. Blood pressure as a risk factor for headache and migraine: A prospective population-based study. European Journal of Neurology 2015;22:156-162, e110-151.
     
  2. Chasman D.I., Anttila V., Buring J.E., Ridker P.M., Schurks M. Kurth, T., International Headache Genetics Consortium [including Winsvold, B.S.]. Selectivity in Genetic Association with Sub-classified Migraine in Women. PLoS Genet 2014;10:e1004366.
     
  3. Jacobsen L.M., Winsvold, B.S., Romundstad, S., Pripp, A.H., Holmen J., Zwart, J.A. Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway. BMJ Open 2013;3(8);doi:10.1136/bmjopen-2013-003268.
     
  4. Anttila, V.*, Winsvold, B.S.*, Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S.E., Todt, U., McArdle, W.L., Quaye, L., Koiranen, M., Ikram, M.A., Lehtimaki, T., Stam, A.H., Ligthart, L., Wedenoja, J., Dunham, I., Neale, B.M., Palta, P., Hamalainen, E., Schurks, M., Rose, L.M., Buring, J.E., Ridker, P.M., Steinberg, S., Stefansson, H., Jakobsson, F., Lawlor, D.A., Evans, D.M., Ring, S.M., Farkkila, M., Artto, V., Kaunisto, M.A., Freilinger, T., Schoenen, J., Frants, R.R., Pelzer, N., Weller, C.M., Zielman, R., Heath, A.C., Madden, P.A., Montgomery, G.W., Martin, N.G., Borck, G., Gobel, H., Heinze, A., Heinze-Kuhn, K., Williams, F.M., Hartikainen, A.L., Pouta, A., van den Ende, J., Uitterlinden, A.G., Hofman, A., Amin, N., Hottenga, J.J., Vink, J.M., Heikkila, K., Alexander, M., Muller-Myhsok, B., Schreiber, S., Meitinger, T., Wichmann, H.E., Aromaa, A., Eriksson, J.G., Traynor, B.J., Trabzuni, D., North American Brain Expression Consortium, UK Brain Expression Consortium, Rossin, E., Lage, K., Jacobs, S.B., Gibbs, J.R., Birney, E., Kaprio, J., Penninx, B.W., Boomsma, D.I., van Duijn, C., Raitakari, O., Jarvelin, M.R., Zwart, J.A., Cherkas, L., Strachan, D.P., Kubisch, C., Ferrari, M.D., van den Maagdenberg, A.M., Dichgans, M., Wessman, M., Smith, G.D., Stefansson, K., Daly, M.J., Nyholt, D.R., Chasman, D.I. & Palotie, A. , for the International Headache Genetics Consortium. Genome-wide meta-analysis identifies new susceptibility loci for migraine.Nature Genetics 2013;45(8):912-7.*The authors contributed equally.
     
  5. Winsvold B, Sandven I, Hagen K, Linde M, Midthjell K, Zwart J-A. Migraine, headache and development of metabolic syndrome: An 11 year follow-up in the HUNT Study. Pain 2013;154(8):1305-11.

  6. Freilinger T, Anttila V, de Vries B, Malik R, Kallela M, Terwindt GM, Pozo-Rosich P, Winsvold B, Nyholt D, van osterhout DPJ, Artto V, Todt U, Hämäläinen E, Fernandez-Morales J, Louter M, Kaunisto M, Schoenen J, Raitakari O, Lehtimäki T, Vila-Pueyo M, Göbel H, Wichmann E, Sintas C, Uitterlinden A, Hofman A, Rivadeneira F, Heinze A, Tronvik E, van Duijn C, Kaprio J, Cormand B, Wessman M, Frants R, Meitinger T, Müller-Myhsok B, Zwart JA, Färkkilä M, Macaya A, Ferrari M, Kubisch C, Palotie A, Dichgans M, van den Maagdenberg A for the International Headache Genetics Consortium. Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nature Genetics 2012;44(7):777-82.

  7. Boraska V, Day-Williams A, Franklin C, Elliott K, Panoutsopoulou K, Tachmazidou I, Albrecht E, Bandinelli S, Beilin L, Bochud M, Cadby G, Ernst F, Evans D, Hayward C, Hicks A, Huffman J, Huth C, James A, Klopp N, Kolcic I, Kutalik Z, Lawlor D, Musk A, Pehlic M, Pennell C, Perry J, Peters A, Polasek O, Pourcain B, Ring S, Salvi E, Schipf S, Staessen J, Teumer A, Timpson N, Vitart V, Warrington N, Yaghootkar H, Zemunik T, Zgaga L, An P, Anttila V, Borecki I, Holmen J, Ntalla J, Palotie A, Pietiläinen K, Wedenoja J, Winsvold B, Dedoussis G, Kaprio J, Province M, Zwart JA, Burnier M, Campbell, Cusi D, Davey-Smith G, Frayling T, Gieger C, Palmer L, Pramstaller P, Rudan I, Völzke H, Wichmann HE, Wright A, Zeggini E. Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. PLoS One 2012;7(3):e31369.

  8. Winsvold B, Hagen K, Aamodt AH, Stovner LJ, Holmen J, Zwart JA. Headache, migraine and cardiovascular risk factors. The HUNT study. Eur J Neurol 2011;18(3):504-11.

  9. Lian A, Karlsen PJ, Winsvold B. A re-evaluation of the phonological similarity effect in adults’ short-term memory of words and nonwords. Memory 2001;9:281-299.
 

Publications 2019

Bråten LCH, Rolfsen MP, Espeland A, Wigemyr M, Aßmus J, Froholdt A, Haugen AJ, Marchand GH, Kristoffersen PM, Lutro O, Randen S, Wilhelmsen M, Winsvold BS, Kadar TI, Holmgard TE, Vigeland MD, Vetti N, Nygaard ØP, Lie BA, Hellum C, Anke A, Grotle M, Schistad EI, Skouen JS, Grøvle L et al. (2019)
Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
BMJ, 367, l5654
DOI 10.1136/bmj.l5654, PubMed 31619437

Børte S, Zwart JA, Stensland SØ, Hagen K, Winsvold BS (2019)
Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study
Cephalalgia, 39 (7), 854-862
DOI 10.1177/0333102419828989, PubMed 30714392

Hagen K, Stovner LJ, Nilsen KB, Kristoffersen ES, Winsvold BS (2019)
The impact of C-reactive protein levels on headache frequency in the HUNT study 2006-2008
BMC Neurol, 19 (1), 229
DOI 10.1186/s12883-019-1462-8, PubMed 31558164

Kristoffersen ES, Faiz KW, Winsvold BS (2019)
Neurology residents' knowledge of the management of headache
Cephalalgia, 39 (11), 1396-1406
DOI 10.1177/0333102419847973, PubMed 31067081

Kristoffersen ES, Winsvold BS, Faiz KW (2019)
Prestige of neurological disorders among future neurologists in Norway
Acta Neurol Scand, 139 (6), 555-558
DOI 10.1111/ane.13087, PubMed 30851195

Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Cade BE, Haas M, Kathiresan S, Little MA, Luik AI, Loudon AS, Purcell S, Richmond RC, Scheer FAJL, Schormair B et al. (2019)
Biological and clinical insights from genetics of insomnia symptoms
Nat Genet, 51 (3), 387-393
DOI 10.1038/s41588-019-0361-7, PubMed 30804566

Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, Chen F, Datta G, Davila-Velderrain J, McGuire D, Tian C, Zhan X, 23andMe Research Team, HUNT All-In Psychiatry, Choquet H, Docherty AR, Faul JD, Foerster JR, Fritsche LG, Gabrielsen ME, Gordon SD, Haessler J, Hottenga JJ, Huang H, Jang SK, Jansen PR et al. (2019)
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Nat Genet, 51 (2), 237-244
DOI 10.1038/s41588-018-0307-5, PubMed 30643251

Wang H, Lane JM, Jones SE, Dashti HS, Ollila HM, Wood AR, van Hees VT, Brumpton B, Winsvold BS, Kantojärvi K, Palviainen T, Cade BE, Sofer T, Song Y, Patel K, Anderson SG, Bechtold DA, Bowden J, Emsley R, Kyle SD, Little MA, Loudon AS, Scheer FAJL, Purcell SM, Richmond RC et al. (2019)
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Nat Commun, 10 (1), 3503
DOI 10.1038/s41467-019-11456-7, PubMed 31409809

Aamodt AH, Bjork MH, Alstadhaug KB, Eldoen G, Dueland AN, Poole T, Hagen K, Vetvik KG, Ofte HK, Sonnervik J, Kristoffersen ES, Winsvold BS, Lundqvist C, Sagabraten SO (2019)
Practical management of headache
Tidsskr. Nor. Laegeforen., 139 (7), 617-620

Aamodt AH, Bjørk MH, Alstadhaug KB, Eldøen G, Dueland AN, Poole T, Hagen K, Vetvik KG, Ofte HK, Sønnervik J, Kristoffersen ES, Winsvold BS, Lundqvist C, Sagabråten SO (2019)
Practical management of headache
Tidsskr Nor Laegeforen, 139 (7)
DOI 10.4045/tidsskr.18.0837, PubMed 30969051

Publications 2018

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A et al. (2018)
Analysis of shared heritability in common disorders of the brain
Science, 360 (6395)
DOI 10.1126/science.aap8757, PubMed 29930110

Hagen K, Kristoffersen ES, Winsvold BS, Stovner LJ, Zwart JA (2018)
Remission of chronic headache: An 11-year follow-up study. Data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008
Cephalalgia, 38 (14), 2026-2034
DOI 10.1177/0333102418769940, PubMed 29629599

Hagen K, Åsberg AN, Stovner L, Linde M, Zwart JA, Winsvold BS, Heuch I (2018)
Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008
Cephalalgia, 38 (13), 1919-1926
DOI 10.1177/0333102418764888, PubMed 29517305

Johnsen MB, Winsvold BS, Børte S, Vie GÅ, Pedersen LM, Storheim K, Skorpen F, Hagen K, Bjørngaard JH, Åsvold BO, Zwart JA (2018)
The causal role of smoking on the risk of headache. A Mendelian randomization analysis in the HUNT study
Eur J Neurol, 25 (9), 1148-e102
DOI 10.1111/ene.13675, PubMed 29747220

Kambur O, Kaunisto MA, Winsvold BS, Wilsgaard T, Stubhaug A, Zwart JA, Kalso E, Nielsen CS (2018)
Genetic variation in P2RX7 and pain tolerance
Pain, 159 (6), 1064-1073
DOI 10.1097/j.pain.0000000000001188, PubMed 29470314

Winsvold BS, Marvik A, Zwart JA, Aamodt AH (2018)
Migraine and stroke
Tidsskr Nor Laegeforen, 138 (4)
DOI 10.4045/tidsskr.17.0347, PubMed 29460580

Åsberg AN, Hagen K, Stovner LJ, Heuch I, Zwart JA, Winsvold BS (2018)
Do incident musculoskeletal complaints influence mortality? The Nord-Trøndelag Health study
PLoS One, 13 (9), e0203925
DOI 10.1371/journal.pone.0203925, PubMed 30265708

Publications 2017

Børte S, Winsvold BS, Stensland SØ, Småstuen MC, Zwart JA (2017)
The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study
PLoS One, 12 (4), e0175908
DOI 10.1371/journal.pone.0175908, PubMed 28410431

Johnsen MB, Vie GÅ, Winsvold BS, Bjørngaard JH, Åsvold BO, Gabrielsen ME, Pedersen LM, Hellevik AI, Langhammer A, Furnes O, Flugsrud GB, Skorpen F, Romundstad PR, Storheim K, Nordsletten L, Zwart JA (2017)
The causal role of smoking on the risk of hip or knee replacement due to primary osteoarthritis: a Mendelian randomisation analysis of the HUNT study
Osteoarthritis Cartilage, 25 (6), 817-823
DOI 10.1016/j.joca.2016.12.021, PubMed 28049019

Winsvold BS, Bettella F, Witoelar A, Anttila V, Gormley P, Kurth T, Terwindt GM, Freilinger TM, Frei O, Shadrin A, Wang Y, Dale AM, van den Maagdenberg AMJM, Chasman DI, Nyholt DR, Palotie A, Andreassen OA, Zwart JA, International Headache Genetics Consortium (2017)
Shared genetic risk between migraine and coronary artery disease: A genome-wide analysis of common variants
PLoS One, 12 (9), e0185663
DOI 10.1371/journal.pone.0185663, PubMed 28957430

Winsvold BS, Palta P, Eising E, Page CM, International Headache Genetics Consortium, van den Maagdenberg AM, Palotie A, Zwart JA (2017)
Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study
Cephalalgia, 38 (2), 312-322
DOI 10.1177/0333102417690111, PubMed 28103696

Publications 2016

Eising E, Huisman SMH, Mahfouz A, Vijfhuizen LS, Anttila V, Winsvold BS, Kurth T, Ikram MA, Freilinger T, Kaprio J, Boomsma DI, van Duijn CM, Järvelin MR, Zwart JA, Quaye L, Strachan DP, Kubisch C, Dichgans M, Davey Smith G, Stefansson K, Palotie A, Chasman DI, Ferrari MD, Terwindt GM, de Vries B et al. (2016)
Gene co-expression analysis identifies brain regions and cell types involved in migraine pathophysiology: a GWAS-based study using the Allen Human Brain Atlas
Hum Genet, 135 (4), 425-439
DOI 10.1007/s00439-016-1638-x, PubMed 26899160

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A, McMahon G, Ligthart L, Terwindt GM, Kallela M, Freilinger TM, Ran C, Gordon SG, Stam AH, Steinberg S, Borck G, Koiranen M, Quaye L, Adams HH et al. (2016)
Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Nat Genet, 48 (10), 1296
DOI 10.1038/ng1016-1296c, PubMed 27681292

Gormley P, Anttila V, Winsvold BS, Palta P, Esko T, Pers TH, Farh KH, Cuenca-Leon E, Muona M, Furlotte NA, Kurth T, Ingason A, McMahon G, Ligthart L, Terwindt GM, Kallela M, Freilinger TM, Ran C, Gordon SG, Stam AH, Steinberg S, Borck G, Koiranen M, Quaye L, Adams HH et al. (2016)
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Nat Genet, 48 (8), 856-66
DOI 10.1038/ng.3598, PubMed 27322543

Gormley P, Winsvold BS, Nyholt DR, Kallela M, Chasman DI, Palotie A (2016)
Migraine genetics: from genome-wide association studies to translational insights
Genome Med, 8 (1), 86
DOI 10.1186/s13073-016-0346-4, PubMed 27543003

Gustavsen MW, Celius EG, Winsvold BS, Moen SM, Nygaard GO, Berg-Hansen P, Lie BA, Zwart JA, Harbo HF (2016)
Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study
Mult Scler J Exp Transl Clin, 2, 2055217316682976
DOI 10.1177/2055217316682976, PubMed 28607748

Åsberg AN, Stovner LJ, Zwart JA, Winsvold BS, Heuch I, Hagen K (2016)
Chronic musculoskeletal complaints as a predictor of mortality-The HUNT study
Pain, 157 (7), 1443-7
DOI 10.1097/j.pain.0000000000000537, PubMed 26919487

Publications 2015

Kvalheim S, Sandvik L, Winsvold B, Hagen K, Zwart JA (2015)
Early menarche and chronic widespread musculoskeletal complaints--Results from the HUNT study
Eur J Pain, 20 (3), 458-64
DOI 10.1002/ejp.747, PubMed 26132558

Malik R, Freilinger T, Winsvold BS, Anttila V, Vander Heiden J, Traylor M, de Vries B, Holliday EG, Terwindt GM, Sturm J, Bis JC, Hopewell JC, Ferrari MD, Rannikmae K, Wessman M, Kallela M, Kubisch C, Fornage M, Meschia JF, Lehtimäki T, Sudlow C, Clarke R, Chasman DI, Mitchell BD, Maguire J et al. (2015)
Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants
Neurology, 84 (21), 2132-45
DOI 10.1212/WNL.0000000000001606, PubMed 25934857

Malik R, Winsvold B, Auffenberg E, Dichgans M, Freilinger T (2015)
The migraine-stroke connection: A genetic perspective
Cephalalgia, 36 (7), 658-68
DOI 10.1177/0333102415621055, PubMed 26660850

Srinivasan S, Bettella F, Mattingsdal M, Wang Y, Witoelar A, Schork AJ, Thompson WK, Zuber V, Schizophrenia Working Group of the Psychiatric Genomics Consortium, The International Headache Genetics Consortium, Winsvold BS, Zwart JA, Collier DA, Desikan RS, Melle I, Werge T, Dale AM, Djurovic S, Andreassen OA (2015)
Genetic Markers of Human Evolution Are Enriched in Schizophrenia
Biol Psychiatry, 80 (4), 284-292
DOI 10.1016/j.biopsych.2015.10.009, PubMed 26681495

Winsvold BS, Nelson CP, Malik R, Gormley P, Anttila V, Vander Heiden J, Elliott KS, Jacobsen LM, Palta P, Amin N, de Vries B, Hämäläinen E, Freilinger T, Ikram MA, Kessler T, Koiranen M, Ligthart L, McMahon G, Pedersen LM, Willenborg C, Won HH, Olesen J, Artto V, Assimes TL, Blankenberg S et al. (2015)
Genetic analysis for a shared biological basis between migraine and coronary artery disease
Neurol Genet, 1 (1), e10
DOI 10.1212/NXG.0000000000000010, PubMed 27066539

Zhao H, Eising E, de Vries B, Vijfhuizen LS, International Headache Genetics Consortium, Anttila V, Winsvold BS, Kurth T, Stefansson H, Kallela M, Malik R, Stam AH, Ikram MA, Ligthart L, Freilinger T, Alexander M, Müller-Myhsok B, Schreiber S, Meitinger T, Aromas A, Eriksson JG, Boomsma DI, van Duijn CM, Zwart JA, Quaye L et al. (2015)
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups
Cephalalgia, 36 (7), 648-57
DOI 10.1177/0333102415591497, PubMed 26660531

Åsberg AN, Stovner LJ, Zwart JA, Winsvold BS, Heuch I, Hagen K (2015)
Migraine as a predictor of mortality: The HUNT study
Cephalalgia, 36 (4), 351-7
DOI 10.1177/0333102415593090, PubMed 26115666

Publications 2014

Fagernæs CF, Heuch I, Zwart JA, Winsvold BS, Linde M, Hagen K (2014)
Blood pressure as a risk factor for headache and migraine: a prospective population-based study
Eur J Neurol, 22 (1), 156-62, e10-1
DOI 10.1111/ene.12547, PubMed 25155744

Louter MA, Fernandez-Morales J, de Vries B, Winsvold B, Anttila V, Fernandez-Cadenas I, Vila-Pueyo M, Sintas C, van Duijn CM, Cormand B, Álvarez-Sabin J, Montaner J, Ferrari MD, van den Maagdenberg A, Palotie A, Zwart JA, Macaya A, Terwindt GM, Pozo-Rosich P (2014)
Candidate-gene association study searching for genetic factors involved in migraine chronification
Cephalalgia, 35 (6), 500-7
DOI 10.1177/0333102414547141, PubMed 25169732

Nyholt DR, International Headache Genetics Consortium, Anttila V, Winsvold BS, Kurth T, Stefansson H, Kallela M, Malik R, Vries Bd, Terwindt GM, Ikram MA, Stam AH, Ligthart L, Freilinger T, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Aromaa A, Eriksson JG, Kaprio J, Boomsma DI, Duijn Cv, Raitakari O, Järvelin MR et al. (2014)
Concordance of genetic risk across migraine subgroups: Impact on current and future genetic association studies
Cephalalgia, 35 (6), 489-99
DOI 10.1177/0333102414547784, PubMed 25179292

Publications 2013

Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimäki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schürks M et al. (2013)
Genome-wide meta-analysis identifies new susceptibility loci for migraine
Nat Genet, 45 (8), 912-917
DOI 10.1038/ng.2676, PubMed 23793025

Jacobsen LM, Winsvold BS, Romundstad S, Pripp AH, Holmen J, Zwart JA (2013)
Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway
BMJ Open, 3 (8)
DOI 10.1136/bmjopen-2013-003268, PubMed 23943777

Winsvold BS, Sandven I, Hagen K, Linde M, Midthjell K, Zwart JA (2013)
Migraine, headache and development of metabolic syndrome: an 11-year follow-up in the Nord-Trøndelag Health Study (HUNT)
Pain, 154 (8), 1305-11
DOI 10.1016/j.pain.2013.04.007, PubMed 23726372

Publications 2012

Boraska V, Day-Williams A, Franklin CS, Elliott KS, Panoutsopoulou K, Tachmazidou I, Albrecht E, Bandinelli S, Beilin LJ, Bochud M, Cadby G, Ernst F, Evans DM, Hayward C, Hicks AA, Huffman J, Huth C, James AL, Klopp N, Kolcic I, Kutalik Z, Lawlor DA, Musk AW, Pehlic M, Pennell CE et al. (2012)
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts
PLoS One, 7 (3), e31369
DOI 10.1371/journal.pone.0031369, PubMed 22479309

Freilinger T, Anttila V, de Vries B, Malik R, Kallela M, Terwindt GM, Pozo-Rosich P, Winsvold B, Nyholt DR, van Oosterhout WP, Artto V, Todt U, Hämäläinen E, Fernández-Morales J, Louter MA, Kaunisto MA, Schoenen J, Raitakari O, Lehtimäki T, Vila-Pueyo M, Göbel H, Wichmann E, Sintas C, Uitterlinden AG, Hofman A et al. (2012)
Genome-wide association analysis identifies susceptibility loci for migraine without aura
Nat Genet, 44 (7), 777-82
DOI 10.1038/ng.2307, PubMed 22683712

Johnson M, Brennecke S, Iversen AC, East C, Olsen G, Kent J, Dyer T, Said J, Roten L, Abraham L, Zwart JA, Winsvold B, Håberg A, Huentelman M, Krokan H, Gabrielsen M, Austgulen R, Blangero J, Moses E (2012)
OS046. Genome-wide association scans identify novel maternalsusceptibility loci for preeclampsia
Pregnancy Hypertens, 2 (3), 202
DOI 10.1016/j.preghy.2012.04.047, PubMed 26105260

Publications 2010

Winsvold BS, Hagen K, Aamodt AH, Stovner LJ, Holmen J, Zwart JA (2010)
Headache, migraine and cardiovascular risk factors: the HUNT study
Eur J Neurol, 18 (3), 504-11
DOI 10.1111/j.1468-1331.2010.03199.x, PubMed 20825470

Publications 2001

Lian A, Karisen PJ, Winsvold B (2001)
A re-evaluation of the phonological similarity effect in adults' short-term memory of words and nonwords
Memory, 9 (4-6), 281-99
DOI 10.1080/09658210143000074, PubMed 11594352

Lian A, Karlsen PJ, Winsvold B (2001)
A re-evaluation of the phonological similarity effect in adults' short-term memory of words and nonwords
Memory, 9 (4), 281-299
DOI 10.1080/09658210143000074, PubMed 11747583

Publications 1994

NIELSEN JL, WINSVOLD B (1994)
IMPLEMENTATION OF DIGITAL FILTERS FOR REVERBERATION ENHANCEMENT SYSTEMS
NAM '94 - NORDIC ACOUSTICAL MEETING, PROCEEDINGS, 143-148

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