Tone Berge

  • Researcher at the Neuroscience Research Unit and Associate Professor at OsloMEt - Oslo metropolitan University; PhD, MSc
  • +47 230 79027

Background:

Tone Berge has a Master and PhD degree in Biochemistry from the Institute of Biosciences, University of Oslo, where she studied the hematopoietic transcription factor c-Myb. She used in vitro techniques as well as yeast and mammalian cells to define the optimal DNA binding sites for c-Myb. At the Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, she has performed postdoctoral research on T cells signaling, studying the adapter protein TSAd, encoded by the SH2D2A gene. Her main task was to characterize SH2D2A-deficient mice.

Project/Research interest:

Tone Berges main focus is to use molecular immunology technology to get mechanistic insight into disease mechanisms behind multiple sclerosis (MS). Berge and her students are performing molecular studies in order to understand the biological significance behind MS susceptibility gene variants identified through genome-wide approaches. In addition, how MS susceptibility genes interact with common environmental risk factors is under study in the lab. Berge is also collaborating on genome-wide approaches comparing epigenetics, transcriptomics and proteomics between samples from MS patients and healthy controls, and a co-worker in two EU funded projects (Sys4MS and MultipleMS), where Harbo is the Norwegian PI. Berge is currently the main supervisor of PhD student Anna Erikson and co-supervisor of PhD student Ina S. Brorson. She is also supervising several Bachelor projects.

Research interest:

  • Autoimmunity
  • Vitamin D and MS
  • Molecular immunology
  • T cell activation
  • Transcriptional reulation

Methodology:

  • Transfection of cell lines
  • Isolation and cultivation of primary, human T cells
  • Western blotting
  • Flow cytometri
  • Quantitative real-time PCR
  • Vector design and sub-cloning
  • Chromatin immunoprecipitation

Previous students (as main supervisor):

PhD student Pankaj Kumar Keshari, thesis defense 23.05.17 - Genetic and molecular studies of multiple sclerosis associated genes.
PhD student Ingvild Sørum Leikfoss, thesis defense: 30.10.15 - Characterization of multiple sclerosis susceptibility genes, genetic and molecular studies in T cells.

Master students: Ingrid Mo, master exam: 09.11.17; Fernanda Kropf Correia, master exam: 07.11.17; Ina Skaara Brorson, master exam: 14.01.15; Anna Eriksson, master exam: 18.12.14

Previous students (as co supervisor):

PhD student Marte Wendel Gustavsen (main supervisor Hanne F. Harbo), thesis defence: 13.12.15 - Genetic, clinical and environmental aspects of multiple sclerosis.

 

 
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