Preclinical testing

Preclinical testing Candidate sarcoma targets

One of the concepts of NCGC, taken further in NoSarC, is the sequencing of all available cell lines representing the various tumour types. Although the xenografts and cell lines established as part of NoSarC are the best to use, since we know the genetic status, many candidate target mutations can be identified also in the older lines by bioinformatic analysis. Over the years we have characterised these lines extensively, and we have initially pursued some of the most interesting ones in preclinical studies.

Our main ongoing preclinical studies are: