Genetic studies

Circos plot showing primary association analysis of 161,311 autosomal variants in the discovery phase (14,498 cases and 24,091 healthy controls). The outermost track shows the numbered autosomal chromosomes. The second track indicates the gene closest to the most associated SNP meeting all replication criteria. Previously identified associations are indicated in gray. The third track indicates the physical position of the 184 fine-mapping intervals (green). The innermost track indicates −log(P) (two-sided) for each SNP (scaled from 0–12, which truncates the signal in several regions). Additionally, contour lines are given at the a priori discovery (−log(P) = 4) and genome-wide significance (−log(P) = 7.3) thresholds. Orange indicates −log(P) ≥ 4 and <7.3, and red indicates −log(P) ≥ 7.3.

Image reference: Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis, International Multiple Sclerosis Genetics Consortium (IMSGC), Nature genetics 2013.


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