Oslo University Hospital (OUH) Multiple Sclerosis (MS) research group
Multiple Sclerosis (MS) research group at Department of Neurology at Oslo University Hospital (OUH) aims to identify characteristics and susceptibility factors of MS, to contribute to a better understanding of the disease and development of better treatments.
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system that may lead to severe neurological deficits. The cause of MS is not fully known, but a combination of common and rare genetic variants and environmental factors may lead to disease development.
We perform genetic, immunological, clinical, epidemiological, environmental, MRI and translational studies of MS in collaboration with national and international research partners and networks. We have approvals for studies of approximately 800 MS patients collected in the Oslo MS Registry and Biobank, as well as access to several thousands of additional samples through collaborations with the Norwegian MS Registry and Biobank and the Nordic Network of MS Genetics. We also have active collaborations internationally, especially with the International MS Genetics consortium (IMSGC).
Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system (CNS) that causes relapsing-remitting attacks (RR-MS) or a progressive disease (primary or secondary progressive MS) leading to different degrees of physical and cognitive disability. There is a global, latitudinal gradient of MS prevalence, with lower disease prevalence near the equator and an increasing prevalence in the Northern and Southern hemisphere. MS typically appears in young adults and affects females more than twice as often as males. Genetic susceptibility studies show that MS is a complex, multifactorial genetic disease, where several common genetic variants each exert a relatively small effect. The disease develops in genetic susceptible individuals, triggered by common environmental factors, e.g. reduced access to vitamin D, virus infection and smoking.
Figure: The prevalence of MS is associated with latitude, with an icreasing risk with distance from equator in the Southern and Northern hemisphere. The prevalence also follows the emigration routes of Western Europeans to North-America and Canada (Figure by A. Langdalen).