Developing novel complement activation assays for application in basic and clinical research
Studying the cross-talk between complement and TLRs, in particular to the co-receptor CD14
Investigating the effect on inflammation by inhibiting complement activation and CD14 using human whole blood in vitro models and in vivo animal models of human diseases
Studying the “Thromboinflammation” and new complex whole blood models to reveal cross-talk between biological systems ex vivo
Studying complement activation in patients with diseases being tentative candidates for future complement intervention
Develop tools for evaluation of the effect of complement therapy in the clinic
Recent publications
Storm BS, Halvorsen PS, Skulstad H, Dybwik K, Schjalm C, Christiansen D, Wisløff-Aase K, Fosse E, Braaten T, Nielsen EW, Mollnes TE(2021) Open chest and pericardium facilitate transpulmonary passage of venous air emboli Acta Anaesthesiol Scand(in press) DOI 10.1111/aas.13796, PubMed 33595102
Debler L, Palmer A, Braumüller S, Klohs B, Mollnes TE, Holzmann K, Huber-Lang M, Halbgebauer R(2021) Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury Mediators Inflamm, 2021, 6654318 DOI 10.1155/2021/6654318, PubMed 33574730
Macpherson A, Laabei M, Ahdash Z, Graewert MA, Birtley JR, Schulze ME, Crennell S, Robinson SA, Holmes B, Oleinikovas V, Nilsson PH, Snowden J, Ellis V, Mollnes TE, Deane CM, Svergun D, Lawson AD, van den Elsen JM(2021) The allosteric modulation of Complement C5 by knob domain peptides Elife, 10(in press) DOI 10.7554/eLife.63586, PubMed 33570492