Kjetil Wessel Andressen

  • Researcher
  • +47 22 84 03 72
 

Author network for Kjetil Wessel Andressen by COREMINE medical


Publications 2018

Andressen KW, Ulsund AH, Krobert KA, Lohse MJ, Bünemann M, Levy FO (2018)
Related GPCRs couple differently to G<sub>s</sub>: preassociation between G protein and 5-HT<sub>7</sub>serotonin receptor reveals movement of Gα<sub>s</sub>upon receptor activation
FASEB J, 32 (2), 1059-1069
PubMed 29079700

Publications 2017

Meier S, Andressen KW, Aronsen JM, Sjaastad I, Hougen K, Skomedal T, Osnes JB, Qvigstad E, Levy FO, Moltzau LR (2017)
PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts
Eur J Pharmacol, 812, 174-183
PubMed 28697992

Publications 2016

Olberg DE, Bauer N, Andressen KW, Hjørnevik T, Cumming P, Levy FO, Klaveness J, Haraldsen I, Sutcliffe JL (2016)
Brain penetrant small molecule (18)F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats
Nucl Med Biol, 43 (8), 478-89
PubMed 27236283

Publications 2015

Andressen KW, Manfra O, Brevik CH, Ulsund AH, Vanhoenacker P, Levy FO, Krobert KA (2015)
The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors
Br J Pharmacol, 172 (15), 3846-60
PubMed 25884989

Impellizzeri AA, Pappalardo M, Basile L, Manfra O, Andressen KW, Krobert KA, Messina A, Levy FO, Guccione S (2015)
Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis
Front Behav Neurosci, 9, 92
PubMed 26005408

Manfra O, Van Craenenbroeck K, Skieterska K, Frimurer T, Schwartz TW, Levy FO, Andressen KW (2015)
Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1
ACS Chem Neurosci, 6 (7), 1206-18
PubMed 25706089

Olberg DE, Hausner SH, Bauer N, Klaveness J, Indrevoll B, Andressen KW, Dahl M, Levy FO, Sutcliffe JL, Haraldsen I (2015)
Radiosynthesis of high affinity fluorine-18 labeled GnRH peptide analogues: in vitro studies and in vivo assessment of brain uptake in rats
MedChemComm, 6 (4), 708-714

Ørstavik Ø, Manfra O, Andressen KW, Andersen GØ, Skomedal T, Osnes JB, Levy FO, Krobert KA (2015)
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium
PLoS One, 10 (3), e0115547
PubMed 25738589

Publications 2014

Brudeli B, Navaratnarajah M, Andressen KW, Manfra O, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2014)
Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists
Bioorg Med Chem Lett, 24 (18), 4598-4602
PubMed 25149506

Kilander MB, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G (2014)
Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6
FASEB J, 28 (5), 2293-305
PubMed 24500924

Olberg DE, Andressen KW, Levy FO, Klaveness J, Haraldsen I, Sutcliffe JL (2014)
Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression
Bioorg Med Chem Lett, 24 (7), 1846-50
PubMed 24613701

Publications 2013

Brudeli B, Andressen KW, Moltzau LR, Nilsen NO, Levy FO, Klaveness J (2013)
Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists
Bioorg Med Chem, 21 (22), 7134-45
PubMed 24113240

Brudeli B, Moltzau LR, Nguyen CH, Andressen KW, Nilsen NO, Levy FO, Klaveness J (2013)
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist
Eur J Med Chem, 64, 629-37
PubMed 23711770

Gellynck E, Heyninck K, Andressen KW, Haegeman G, Levy FO, Vanhoenacker P, Van Craenenbroeck K (2013)
The serotonin 5-HT7 receptors: two decades of research
Exp Brain Res, 230 (4), 555-68
PubMed 24042216

Publications 2012

Gellynck E, Andressen KW, Lintermans B, Haegeman G, Levy FO, Vanhoenacker P, Van Craenenbroeck K (2012)
Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT₇a receptor
FEBS J, 279 (11), 1994-2003
PubMed 22448645

Publications 2010

Brudeli B, Moltzau LR, Andressen KW, Krobert KA, Klaveness J, Levy FO (2010)
Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists
Bioorg Med Chem, 18 (24), 8600-13
PubMed 21075638

Publications 2008

Afzal F, Andressen KW, Mørk HK, Aronsen JM, Sjaastad I, Dahl CP, Skomedal T, Levy FO, Osnes JB, Qvigstad E (2008)
5-HT4-elicited positive inotropic response is mediated by cAMP and regulated by PDE3 in failing rat and human cardiac ventricles
Br J Pharmacol, 155 (7), 1005-14
PubMed 18846035

Gellynck E, Laenen K, Andressen KW, Lintermans B, De Martelaere K, Matthys A, Levy FO, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (2008)
Cloning, genomic organization and functionality of 5-HT(7) receptor splice variants from mouse brain
Gene, 426 (1-2), 23-31
PubMed 18793707

Ngai J, Methi T, Andressen KW, Levy FO, Torgersen KM, Vang T, Wettschureck N, Taskén K (2008)
The heterotrimeric G-protein alpha-subunit Galphaq regulates TCR-mediated immune responses through an Lck-dependent pathway
Eur J Immunol, 38 (11), 3208-18
PubMed 18991294

Publications 2007

Vinge LE, Andressen KW, Attramadal T, Andersen GØ, Ahmed MS, Peppel K, Koch WJ, Freedman NJ, Levy FO, Skomedal T, Osnes JB, Attramadal H (2007)
Substrate specificities of g protein-coupled receptor kinase-2 and -3 at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function
Mol Pharmacol, 72 (3), 582-91
PubMed 17573483

Publications 2006

Krobert KA, Andressen KW, Levy FO (2006)
Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT(7) serotonin receptor
Eur J Pharmacol, 532 (1-2), 1-10
PubMed 16487959

Publications 2005

Andressen KW, Norum JH, Levy FO, Krobert KA (2005)
Activation of adenylyl cyclase by endogenous G(s)-coupled receptors in human embryonic kidney 293 cells is attenuated by 5-HT(7) receptor expression
Mol Pharmacol, 69 (1), 207-15
PubMed 16189297

Qvigstad E, Brattelid T, Sjaastad I, Andressen KW, Krobert KA, Birkeland JA, Sejersted OM, Kaumann AJ, Skomedal T, Osnes JB, Levy FO (2005)
Appearance of a ventricular 5-HT4 receptor-mediated inotropic response to serotonin in heart failure
Cardiovasc Res, 65 (4), 869-78
PubMed 15721867

Publications 2004

Brattelid T, Kvingedal AM, Krobert KA, Andressen KW, Bach T, Hystad ME, Kaumann AJ, Levy FO (2004)
Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i)
Naunyn Schmiedebergs Arch Pharmacol, 369 (6), 616-28
PubMed 15118808

Publications 2003

Bruheim S, Krobert KA, Andressen KW, Levy FO (2003)
Unaltered agonist potency upon inducible 5-HT7(a) but not 5-HT4(b) receptor expression indicates agonist-independent association of 5-HT7(a) receptor and Gs
Receptors Channels, 9 (2), 107-16
PubMed 12916471

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