Trond Paul Leren
Position: Group leader
Phone: +47 23026389
Email:
 

Author network for Trond Paul Leren by COREMINE medical


Publications 2017

Hovland A, Mundal LJ, Igland J, Veierød MB, Holven KB, Bogsrud MP, Tell GS, Leren TP, Retterstøl K (2017)
Increased risk of heart failure and atrial fibrillation in heterozygous familial hypercholesterolemia
Atherosclerosis, 266, 69-73 (in press)
PubMed 28992466

Strøm TB, Laerdahl JK, Leren TP (2017)
Mutations affecting the transmembrane domain of the LDL receptor: impact of charged residues on the membrane insertion
Hum Mol Genet, 26 (9), 1634-1642
PubMed 28334946

Subasinghe CJ, Sirisena ND, Herath C, Berge KE, Leren TP, Bulugahapitiya U, Dissanayake VHW (2017)
Novel mutation in the SLC12A3 gene in a Sri Lankan family with Gitelman syndrome & coexistent diabetes: a case report
BMC Nephrol, 18 (1), 140
PubMed 28446151

Ørstavik K, Garfelt B, Leren TP, Saberniak J, Haugaa K, Jonsrud C (2017)
[No title available]
Tidsskr Nor Laegeforen, 137 (16)
PubMed 28871726

Publications 2016

Leren TP, Strøm TB, Berge KE (2016)
Variable phenotypic expression of nonsense mutation p.Thr5* in the APOE gene
Mol Genet Metab Rep, 9, 67-70
PubMed 27830118

Mundal L, Igland J, Ose L, Holven KB, Veierød MB, Leren TP, Retterstøl K (2016)
Cardiovascular disease mortality in patients with genetically verified familial hypercholesterolemia in Norway during 1992-2013
Eur J Prev Cardiol, 24 (2), 137-144
PubMed 27794106

Mundal L, Veierød MB, Halvorsen T, Holven KB, Ose L, Iversen PO, Tell GS, Leren TP, Retterstøl K (2016)
Cardiovascular disease in patients with genotyped familial hypercholesterolemia in Norway during 1994-2009, a registry study
Eur J Prev Cardiol, 23 (18), 1962-1969
PubMed 27558979

Pingitore P, Lepore SM, Pirazzi C, Mancina RM, Motta BM, Valenti L, Berge KE, Retterstøl K, Leren TP, Wiklund O, Romeo S (2016)
Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia
J Clin Lipidol, 10 (4), 816-823
PubMed 27578112

Wierød L, Cameron J, Strøm TB, Leren TP (2016)
Studies of the autoinhibitory segment comprising residues 31-60 of the prodomain of PCSK9: Possible implications for the mechanism underlying gain-of-function mutations
Mol Genet Metab Rep, 9, 86-93
PubMed 27896130

Publications 2015

Broch K, Andreassen AK, Hopp E, Leren TP, Scott H, Müller F, Aakhus S, Gullestad L (2015)
Results of comprehensive diagnostic work-up in 'idiopathic' dilated cardiomyopathy
Open Heart, 2 (1), e000271
PubMed 26468400

Hopkins PN, Defesche J, Fouchier SW, Bruckert E, Luc G, Cariou B, Sjouke B, Leren TP, Harada-Shiba M, Mabuchi H, Rabès JP, Carrié A, van Heyningen C, Carreau V, Farnier M, Teoh YP, Bourbon M, Kawashiri MA, Nohara A, Soran H, Marais AD, Tada H, Abifadel M, Boileau C, Chanu B et al. (2015)
Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody
Circ Cardiovasc Genet, 8 (6), 823-31
PubMed 26374825

Mundal L, Sarancic M, Ose L, Iversen PO, Borgan JK, Veierød MB, Leren TP, Retterstøl K (2015)
[Increased mortality in familial hypercholesterolemia]
Tidsskr Nor Laegeforen, 135 (11), 1024-5
PubMed 26080775

Strøm TB, Laerdahl JK, Leren TP (2015)
Mutation p.L799R in the LDLR, which affects the transmembrane domain of the LDLR, prevents membrane insertion and causes secretion of the mutant LDLR
Hum Mol Genet, 24 (20), 5836-44
PubMed 26220972

Publications 2014

Berge KE, Retterstøl K, Romeo S, Pirazzi C, Leren TP (2014)
Type 1 hyperlipoproteinemia due to a novel deletion of exons 3 and 4 in the GPIHBP1 gene
Atherosclerosis, 234 (1), 30-3
PubMed 24589565

Christiansen M, Hedley PL, Theilade J, Stoevring B, Leren TP, Eschen O, Sørensen KM, Tybjærg-Hansen A, Ousager LB, Pedersen LN, Frikke-Schmidt R, Aidt FH, Hansen MG, Hansen J, Bloch Thomsen PE, Toft E, Henriksen FL, Bundgaard H, Jensen HK, Kanters JK (2014)
Mutations in Danish patients with long QT syndrome and the identification of a large founder family with p.F29L in KCNH2
BMC Med Genet, 15, 31
PubMed 24606995

Leren TP (2014)
Sorting an LDL receptor with bound PCSK9 to intracellular degradation
Atherosclerosis, 237 (1), 76-81
PubMed 25222343

Mundal L, Sarancic M, Ose L, Iversen PO, Borgan JK, Veierød MB, Leren TP, Retterstøl K (2014)
Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010
J Am Heart Assoc, 3 (6), e001236
PubMed 25468658

Strøm TB, Tveten K, Laerdahl JK, Leren TP (2014)
Mutation G805R in the transmembrane domain of the LDL receptor gene causes familial hypercholesterolemia by inducing ectodomain cleavage of the LDL receptor in the endoplasmic reticulum
FEBS Open Bio, 4, 321-7
PubMed 24918045

Strøm TB, Tveten K, Leren TP (2014)
PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum
Biochem J, 457 (1), 99-105
PubMed 24144304

Publications 2013

Almaas VM, Haugaa KH, Strøm EH, Scott H, Dahl CP, Leren TP, Geiran OR, Endresen K, Edvardsen T, Aakhus S, Amlie JP (2013)
Increased amount of interstitial fibrosis predicts ventricular arrhythmias, and is associated with reduced myocardial septal function in patients with obstructive hypertrophic cardiomyopathy
Europace, 15 (9), 1319-27
PubMed 23426552

Berge KE, Leren TP (2013)
Genetics of hypertrophic cardiomyopathy in Norway
Clin Genet, 86 (4), 355-60
PubMed 24111713

Hasselberg NE, Edvardsen T, Petri H, Berge KE, Leren TP, Bundgaard H, Haugaa KH (2013)
Risk prediction of ventricular arrhythmias and myocardial function in Lamin A/C mutation positive subjects
Europace, 16 (4), 563-71
PubMed 24058181

Pareek M, Pedersen RL, Leren TP, Jensen HK (2013)
[Weight loss pills purchased on the internet as the cause of ventricular fibrillation]
Ugeskr Laeger, 175 (11), 739-40
PubMed 23480888

Tveten K, Strøm TB, Berge KE, Leren TP (2013)
PCSK9-mediated degradation of the LDL receptor generates a 17 kDa C-terminal LDL receptor fragment
J Lipid Res, 54 (6), 1560-6
PubMed 23509406

Publications 2012

Cameron J, Bogsrud MP, Tveten K, Strøm TB, Holven K, Berge KE, Leren TP (2012)
Serum levels of proprotein convertase subtilisin/kexin type 9 in subjects with familial hypercholesterolemia indicate that proprotein convertase subtilisin/kexin type 9 is cleared from plasma by low-density lipoprotein receptor-independent pathways
Transl Res, 160 (2), 125-30
PubMed 22683370

Larsen MK, Berge KE, Leren TP, Nissen PH, Hansen J, Kristensen IB, Banner J, Jensen HK (2012)
Postmortem genetic testing of the ryanodine receptor 2 (RYR2) gene in a cohort of sudden unexplained death cases
Int J Legal Med, 127 (1), 139-44
PubMed 22222782

Marduel M, Ouguerram K, Serre V, Bonnefont-Rousselot D, Marques-Pinheiro A, Erik Berge K, Devillers M, Luc G, Lecerf JM, Tosolini L, Erlich D, Peloso GM, Stitziel N, Nitchké P, Jaïs JP, French Research Network on ADH, Abifadel M, Kathiresan S, Leren TP, Rabès JP, Boileau C, Varret M (2012)
Description of a large family with autosomal dominant hypercholesterolemia associated with the APOE p.Leu167del mutation
Hum Mutat, 34 (1), 83-7
PubMed 22949395

Tveten K, Strøm TB, Cameron J, Berge KE, Leren TP (2012)
Mutations in the SORT1 gene are unlikely to cause autosomal dominant hypercholesterolemia
Atherosclerosis, 225 (2), 370-5
PubMed 23102784

Winkel BG, Larsen MK, Berge KE, Leren TP, Nissen PH, Olesen MS, Hollegaard MV, Jespersen T, Yuan L, Nielsen N, Haunsø S, Svendsen JH, Wang Y, Kristensen IB, Jensen HK, Tfelt-Hansen J, Banner J (2012)
The prevalence of mutations in KCNQ1, KCNH2, and SCN5A in an unselected national cohort of young sudden unexplained death cases
J Cardiovasc Electrophysiol, 23 (10), 1092-8
PubMed 22882672

Publications 2011

Holla ØL, Cameron J, Tveten K, Strøm TB, Berge KE, Laerdahl JK, Leren TP (2011)
Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors
J Lipid Res, 52 (10), 1787-94
PubMed 21771976

Holla ØL, Laerdahl JK, Strøm TB, Tveten K, Cameron J, Berge KE, Leren TP (2011)
Removal of acidic residues of the prodomain of PCSK9 increases its activity towards the LDL receptor
Biochem Biophys Res Commun, 406 (2), 234-8
PubMed 21324305

Larsen MK, Nissen PH, Berge KE, Leren TP, Kristensen IB, Jensen HK, Banner J (2011)
Molecular autopsy in young sudden cardiac death victims with suspected cardiomyopathy
Forensic Sci Int, 219 (1-3), 33-8
PubMed 22177269

Leren TP, Berge KE (2011)
Subjects with molecularly defined familial hypercholesterolemia or familial defective apoB-100 are not being adequately treated
PLoS One, 6 (2), e16721
PubMed 21364743

Mousavi SA, Berge KE, Berg T, Leren TP (2011)
Affinity and kinetics of proprotein convertase subtilisin/kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells
FEBS J, 278 (16), 2938-50
PubMed 21692990

Sarvari SI, Haugaa KH, Anfinsen OG, Leren TP, Smiseth OA, Kongsgaard E, Amlie JP, Edvardsen T (2011)
Right ventricular mechanical dispersion is related to malignant arrhythmias: a study of patients with arrhythmogenic right ventricular cardiomyopathy and subclinical right ventricular dysfunction
Eur Heart J, 32 (9), 1089-96
PubMed 21406439

Strøm EH, Sund S, Reier-Nilsen M, Dørje C, Leren TP (2011)
Lecithin: Cholesterol Acyltransferase (LCAT) Deficiency: renal lesions with early graft recurrence
Ultrastruct Pathol, 35 (3), 139-45
PubMed 21323422

Strøm TB, Tveten K, Holla ØL, Cameron J, Berge KE, Leren TP (2011)
The cytoplasmic domain is not involved in directing Class 5 mutant LDL receptors to lysosomal degradation
Biochem Biophys Res Commun, 408 (4), 642-6
PubMed 21531209

Strøm TB, Tveten K, Holla ØL, Cameron J, Berge KE, Leren TP (2011)
Characterization of residues in the cytoplasmic domain of the LDL receptor required for exit from the endoplasmic reticulum
Biochem Biophys Res Commun, 415 (4), 642-5
PubMed 22079632

Toleikyte I, Retterstøl K, Leren TP, Iversen PO (2011)
Pregnancy outcomes in familial hypercholesterolemia: a registry-based study
Circulation, 124 (15), 1606-14
PubMed 21911783

Tveten K, Holla ØL, Cameron J, Strøm TB, Berge KE, Laerdahl JK, Leren TP (2011)
Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification
Hum Mol Genet, 21 (6), 1402-9
PubMed 22156580

Tveten K, Strøm TB, Cameron J, Holla ØL, Berge KE, Leren TP (2011)
Characterization of a naturally occurring degradation product of the LDL receptor
Mol Genet Metab, 105 (1), 149-54
PubMed 22078455

Publications 2010

Berge KE, Leren TP (2010)
Mutations in APOA-I and ABCA1 in Norwegians with low levels of HDL cholesterol
Clin Chim Acta, 411 (23-24), 2019-23
PubMed 20800056

Haugaa KH, Amlie JP, Berge KE, Leren TP, Smiseth OA, Edvardsen T (2010)
Transmural differences in myocardial contraction in long-QT syndrome: mechanical consequences of ion channel dysfunction
Circulation, 122 (14), 1355-63
PubMed 20855658

Haugaa KH, Leren IS, Berge KE, Bathen J, Loennechen JP, Anfinsen OG, Früh A, Edvardsen T, Kongsgård E, Leren TP, Amlie JP (2010)
High prevalence of exercise-induced arrhythmias in catecholaminergic polymorphic ventricular tachycardia mutation-positive family members diagnosed by cascade genetic screening
Europace, 12 (3), 417-23
PubMed 20106799

Kulseth MA, Berge KE, Bogsrud MP, Leren TP (2010)
Analysis of LDLR mRNA in patients with familial hypercholesterolemia revealed a novel mutation in intron 14, which activates a cryptic splice site
J Hum Genet, 55 (10), 676-80
PubMed 20703241

Leren IS, Haugaa KH, Edvardsen T, Anfinsen OG, Kongsgård E, Berge KE, Leren TP, Amlie JP (2010)
[Catecholaminergic polymorphic ventricular tachycardia]
Tidsskr Nor Laegeforen, 130 (2), 139-42
PubMed 20125202

Möller T, Leren TP, Eiklid KL, Holmstrøm H, Fredriksen PM, Thaulow E (2010)
A novel BMPR2 gene mutation associated with exercise-induced pulmonary hypertension in septal defects
Scand Cardiovasc J, 44 (6), 331-6
PubMed 21070126

Siem G, Fagerheim T, Jonsrud C, Laurent C, Teig E, Harris S, Leren TP, Früh A, Heimdal K (2010)
Causes of hearing impairment in the Norwegian paediatric cochlear implant program
Int J Audiol, 49 (8), 596-605
PubMed 20553101

Skinner JR, Crawford J, Smith W, Aitken A, Heaven D, Evans CA, Hayes I, Neas KR, Stables S, Koelmeyer T, Denmark L, Vuletic J, Maxwell F, White K, Yang T, Roden DM, Leren TP, Shelling A, Love DR, Cardiac Inherited Disease Group New Zealand (2010)
Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds
Heart Rhythm, 8 (3), 412-9
PubMed 21070882

Strøm TB, Holla ØL, Tveten K, Cameron J, Berge KE, Leren TP (2010)
Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain
Mol Genet Metab, 101 (1), 76-80
PubMed 20659812

Publications 2009

Cameron J, Holla ØL, Kulseth MA, Leren TP, Berge KE (2009)
Splice-site mutation c.313+1, G>A in intron 3 of the LDL receptor gene results in transcripts with skipping of exon 3 and inclusion of intron 3
Clin Chim Acta, 403 (1-2), 131-5
PubMed 19361455

Cameron J, Ranheim T, Halvorsen B, Kulseth MA, Leren TP, Berge KE (2009)
Tangier disease caused by compound heterozygosity for ABCA1 mutations R282X and Y1532C
Atherosclerosis, 209 (1), 163-6
PubMed 19765707

Haugaa KH, Edvardsen T, Leren TP, Smiseth OA, Amlie JP (2009)
Abnormal left ventricular relaxation in patients with long QT syndrome: reply
Eur. Heart J., 30 (22), 2814-2815

Haugaa KH, Leren TP, Amlie JP (2009)
Genetic testing in specific cardiomyopathies
F1000 Med Rep, 1
PubMed 20948728

Holla ØL, Kulseth MA, Berge KE, Leren TP, Ranheim T (2009)
Nonsense-mediated decay of human LDL receptor mRNA
Scand J Clin Lab Invest, 69 (3), 409-17
PubMed 19148831

Holla ØL, Nakken S, Mattingsdal M, Ranheim T, Berge KE, Defesche JC, Leren TP (2009)
Effects of intronic mutations in the LDLR gene on pre-mRNA splicing: Comparison of wet-lab and bioinformatics analyses
Mol Genet Metab, 96 (4), 245-52
PubMed 19208450

Holla ØL, Strøm TB, Cameron J, Berge KE, Leren TP (2009)
A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9
Mol Genet Metab, 99 (2), 149-56
PubMed 19828345

Holst AG, Calloe K, Jespersen T, Cedergreen P, Winkel BG, Jensen HK, Leren TP, Haunso S, Svendsen JH, Tfelt-Hansen J (2009)
A Novel SCN5A Mutation in a Patient with Coexistence of Brugada Syndrome Traits and Ischaemic Heart Disease
Case Rep Med, 2009, 963645
PubMed 19829766

Leigh SE, Leren TP, Humphries SE (2009)
Commentary PCSK9 variants: A new database
Atherosclerosis, 203 (1), 32-3
PubMed 19249440

Leren TP, Berge KE (2009)
Comparison of clinical and molecular genetic criteria for diagnosing familial hypercholesterolemia
Clin. Lipidol., 4 (3), 303-310

Mousavi SA, Berge KE, Leren TP (2009)
The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis
J Intern Med, 266 (6), 507-19
PubMed 19930098

Strøm TB, Holla ØL, Cameron J, Berge KE, Leren TP (2009)
Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial hypercholesterolemia heterozygotes
Clin Chim Acta, 411 (3-4), 229-33
PubMed 19917273

Tajsharghi H, Leren TP, Abdul-Hussein S, Tulinius M, Brunvand L, Dahl HM, Oldfors A (2009)
Unexpected myopathy associated with a mutation in MYBPC3 and misplacement of the cardiac myosin binding protein C
J Med Genet, 47 (8), 575-7
PubMed 19858127

Tveten K, Khoo KL, Berge KE, Leren TP, Kulseth MA (2009)
Functional analysis of the synonymous R385R mutation in the low-density lipoprotein receptor gene
Genet Test Mol Biomarkers, 13 (2), 243-8
PubMed 19371225

Tveten K, Ranheim T, Berge KE, Leren TP, Kulseth MA (2009)
The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR
Acta Biochim Biophys Sin (Shanghai), 41 (3), 246-55
PubMed 19280064

Publications 2008

Aurlien D, Leren TP, Taubøll E, Gjerstad L (2008)
New SCN5A mutation in a SUDEP victim with idiopathic epilepsy
Seizure, 18 (2), 158-60
PubMed 18752973

Berge KE, Haugaa KH, Früh A, Anfinsen OG, Gjesdal K, Siem G, Oyen N, Greve G, Carlsson A, Rognum TO, Hallerud M, Kongsgård E, Amlie JP, Leren TP (2008)
Molecular genetic analysis of long QT syndrome in Norway indicating a high prevalence of heterozygous mutation carriers
Scand J Clin Lab Invest, 68 (5), 362-8
PubMed 18752142

Bjørnstad PG, Leren TP (2008)
Familial atrial septal defect in the oval fossa with progressive prolongation of the atrioventricular conduction caused by mutations in the NKX2.5 gene
Cardiol Young, 19 (1), 40-4
PubMed 19049681

Cameron J, Holla OL, Laerdahl JK, Kulseth MA, Ranheim T, Rognes T, Berge KE, Leren TP (2008)
Characterization of novel mutations in the catalytic domain of the PCSK9 gene
J Intern Med, 263 (4), 420-31
PubMed 18266662

Cameron J, Holla ØL, Berge KE, Kulseth MA, Ranheim T, Leren TP, Laerdahl JK (2008)
Investigations on the evolutionary conservation of PCSK9 reveal a functionally important protrusion
FEBS J, 275 (16), 4121-33
PubMed 18631360

Cameron J, Holla ØL, Laerdahl JK, Kulseth MA, Berge KE, Leren TP (2008)
Mutation S462P in the PCSK9 gene reduces secretion of mutant PCSK9 without affecting the autocatalytic cleavage
Atherosclerosis, 203 (1), 161-5
PubMed 19022446

Cameron J, Ranheim T, Kulseth MA, Leren TP, Berge KE (2008)
Berberine decreases PCSK9 expression in HepG2 cells
Atherosclerosis, 201 (2), 266-73
PubMed 18355829

Graven T, Loennechen JP, Leren TP (2008)
[Brugada syndrome]
Tidsskr Nor Laegeforen, 128 (24), 2828-31
PubMed 19092950

Haugaa KH, Edvardsen T, Leren TP, Gran JM, Smiseth OA, Amlie JP (2008)
Left ventricular mechanical dispersion by tissue Doppler imaging: a novel approach for identifying high-risk individuals with long QT syndrome
Eur Heart J, 30 (3), 330-7
PubMed 18940888

Leren TP, Berge KE (2008)
Identification of mutations in the apolipoprotein B-100 gene and in the PCSK9 gene as the cause of hypocholesterolemia
Clin Chim Acta, 397 (1-2), 92-5
PubMed 18710658

Leren TP, Finborud TH, Manshaus TE, Ose L, Berge KE (2008)
Diagnosis of familial hypercholesterolemia in general practice using clinical diagnostic criteria or genetic testing as part of cascade genetic screening
Community Genet, 11 (1), 26-35
PubMed 18196915

Mulatinho M, Llerena J, Leren TP, Rao PN, Quintero-Rivera F (2008)
Deletion (1)(p32.2-p32.3) detected by array-CGH in a patient with developmental delay/mental retardation, dysmorphic features and low cholesterol: A new microdeletion syndrome?
Am J Med Genet A, 146A (17), 2284-90
PubMed 18680192

Ranheim T, Mattingsdal M, Lindvall JM, Holla OL, Berge KE, Kulseth MA, Leren TP (2008)
Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9
J Cell Physiol, 217 (2), 459-67
PubMed 18570182

Siem G, Früh A, Leren TP, Heimdal K, Teig E, Harris S (2008)
Jervell and Lange-Nielsen syndrome in Norwegian children: aspects around cochlear implantation, hearing, and balance
Ear Hear, 29 (2), 261-9
PubMed 18595190

Starr B, Hadfield SG, Hutten BA, Lansberg PJ, Leren TP, Damgaard D, Neil HA, Humphries SE (2008)
Development of sensitive and specific age- and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial hypercholesterolaemia in cascade testing
Clin Chem Lab Med, 46 (6), 791-803
PubMed 18601600

Publications 2007

García-Pavía P, Segovia J, Molano J, Mora R, Kontny F, Erik Berge K, Leren TP, Alonso-Pulpón L (2007)
[High-risk hypertrophic cardiomyopathy associated with a novel mutation in cardiac Myosin-binding protein C]
Rev Esp Cardiol, 60 (3), 311-4
PubMed 17394878

Grøndahl J, Riise R, Heiberg A, Leren T, Christoffersen T, Bragadottir R (2007)
Autosomal dominant retinitis pigmentosa in Norway: a 20-year clinical follow-up study with molecular genetic analysis. Two novel rhodopsin mutations: 1003delG and I179F
Acta Ophthalmol Scand, 85 (3), 287-97
PubMed 17488458

Holla ØL, Cameron J, Berge KE, Ranheim T, Leren TP (2007)
Degradation of the LDL receptors by PCSK9 is not mediated by a secreted protein acted upon by PCSK9 extracellularly
BMC Cell Biol, 8, 9
PubMed 17328821

Leren TP, Manshaus TE, Ose L, Berge KE (2007)
[Lipid profile in children and adolescents with familial hypercholesterolemia]
Tidsskr Nor Laegeforen, 127 (18), 2363-6
PubMed 17895939

Tveten K, Holla ØL, Ranheim T, Berge KE, Leren TP, Kulseth MA (2007)
4-Phenylbutyrate restores the functionality of a misfolded mutant low-density lipoprotein receptor
FEBS J, 274 (8), 1881-93
PubMed 17408384

Publications 2006

Berge KE, Ose L, Leren TP (2006)
Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
Arterioscler Thromb Vasc Biol, 26 (5), 1094-100
PubMed 16424354

Cameron J, Holla ØL, Ranheim T, Kulseth MA, Berge KE, Leren TP (2006)
Effect of mutations in the PCSK9 gene on the cell surface LDL receptors
Hum Mol Genet, 15 (9), 1551-8
PubMed 16571601

Holla ØL, Cameron J, Berge KE, Kulseth MA, Ranheim T, Leren TP (2006)
Low-density lipoprotein receptor activity in Epstein-Barr virus-transformed lymphocytes from heterozygotes for the D374Y mutation in the PCSK9 gene
Scand J Clin Lab Invest, 66 (4), 317-28
PubMed 16777760

Ranheim T, Kulseth MA, Berge KE, Leren TP (2006)
Model system for phenotypic characterization of sequence variations in the LDL receptor gene
Clin Chem, 52 (8), 1469-79
PubMed 16740646

Tveten K, Ranheim T, Berge KE, Leren TP, Kulseth MA (2006)
Analysis of alternatively spliced isoforms of human LDL receptor mRNA
Clin Chim Acta, 373 (1-2), 151-7
PubMed 16828075

Publications 2005

Berge KE, Haugaa KH, Anfinsen OG, Früh A, Hallerud M, Jonsrud C, Øyen N, Gjesdal K, Amlie JP, Leren TP (2005)
[DNA-based diagnostics of long QT syndrome]
Tidsskr Nor Laegeforen, 125 (20), 2783-6
PubMed 16244680

Haugaa KH, Berge KE, Früh A, Anfinsen OG, Arnestad M, Hallerud M, Gjesdal K, Leren TP, Amlie JP (2005)
[Cardiac ion channel disorders--diagnosis and treatment]
Tidsskr Nor Laegeforen, 125 (20), 2778-81
PubMed 16244679

Holla Ø, Teie C, Berge KE, Leren TP (2005)
Identification of deletions and duplications in the low density lipoprotein receptor gene by MLPA
Clin Chim Acta, 356 (1-2), 164-71
PubMed 15936313

Sørensen S, Ranheim T, Bakken KS, Leren TP, Kulseth MA (2005)
Retention of mutant low density lipoprotein receptor in endoplasmic reticulum (ER) leads to ER stress
J Biol Chem, 281 (1), 468-76
PubMed 16257961

Publications 2004

Hovland A, Bjørbaek E, Leren TP (2004)
[Gitelman's syndrome--a differential diagnosis in hypokalemia]
Tidsskr Nor Laegeforen, 124 (8), 1093-4
PubMed 15114386

Leren TP (2004)
Mutations in the PCSK9 gene in Norwegian subjects with autosomal dominant hypercholesterolemia
Clin Genet, 65 (5), 419-22
PubMed 15099351

Leren TP (2004)
Cascade genetic screening for familial hypercholesterolemia
Clin Genet, 66 (6), 483-7
PubMed 15521974

Leren TP, Manshaus T, Ose L (2004)
[A family-based strategy for diagnosing familial hypercholesterolemia]
Tidsskr Nor Laegeforen, 124 (9), 1228-9
PubMed 15131703

Leren TP, Manshaus T, Skovholt U, Skodje T, Nossen IE, Teie C, Sørensen S, Bakken KS (2004)
Application of molecular genetics for diagnosing familial hypercholesterolemia in Norway: results from a family-based screening program
Semin Vasc Med, 4 (1), 75-85
PubMed 15199436

Pasalić D, Jurcić Z, Stipancić G, Ferencak G, Leren TP, Djurovic S, Stavljenić-Rukavina A (2004)
Missense mutation W86R in exon 3 of the lipoprotein lipase gene in a boy with chylomicronemia
Clin Chim Acta, 343 (1-2), 179-84
PubMed 15115692

Publications 2002

Leren TP (2002)
[How common is familial hypercholesterolemia?]
Tidsskr Nor Laegeforen, 122 (25), 2484
PubMed 12448123

Publications 2001

Leren TP, Tonstad S, Ose L (2001)
[Familial hypercholesterolemia--prognosis and treatment]
Tidsskr Nor Laegeforen, 121 (13), 1635
PubMed 11446054

Leren TP, Tonstad S, Ose L (2001)
[Genetic screening and treatment in familial hypercholesterolemia]
Tidsskr Nor Laegeforen, 121 (13), 1635-6
PubMed 11446055

Publications 2000

Björn Lundahl, Leren TP, Ose L, Hamsten A, Karpe F (2000)
A functional polymorphism in the promoter region of the microsomal triglyceride transfer protein (MTP -493G/T) influences lipoprotein phenotype in familial hypercholesterolemia
Arterioscler Thromb Vasc Biol, 20 (7), 1784-8
PubMed 10894817

Braaten O, Rødningen OK, Nordal I, Leren TP (2000)
The genetic algorithm applied to haplotype data at the LDL receptor locus
Comput Methods Programs Biomed, 61 (1), 1-9
PubMed 10660265

Tonstad S, Joakimsen O, Leren TP, Ose L (2000)
Does maternal or paternal heredity affect carotid atherosclerosis in children with familial hypercholesterolaemia?
Acta Paediatr, 89 (12), 1490-2
PubMed 11195242

Tranebjaerg L, Leren T (2000)
[Medical genetics--knowledge with many challenges in the new century]
Tidsskr Nor Laegeforen, 120 (7), 852-3
PubMed 10806912

Publications 1999

Daum U, Leren TP, Langer C, Chirazi A, Cullen P, Pritchard PH, Assmann G, von Eckardstein A (1999)
Multiple dysfunctions of two apolipoprotein A-I variants, apoA-I(R160L)Oslo and apoA-I(P165R), that are associated with hypoalphalipoproteinemia in heterozygous carriers
J Lipid Res, 40 (3), 486-94
PubMed 10064737

Rødningen OK, Tonstad S, Medh JD, Chappell DA, Ose L, Leren TP (1999)
Phenotypic consequences of a deletion of exons 2 and 3 of the LDL receptor gene
J Lipid Res, 40 (2), 213-20
PubMed 9925649

Rødningen OK, Tonstad S, Saugstad OD, Ose L, Leren TP (1999)
Mutant transcripts of the LDL receptor gene: mRNA structure and quantity
Hum Mutat, 13 (3), 186-96
PubMed 10090473

Publications 1998

Leren TP, Bakken KS, Hoel V, Hjermann I, Berg K (1998)
Screening for mutations of the apolipoprotein B gene causing hypocholesterolemia
Hum Genet, 102 (1), 44-9
PubMed 9490296

Rødningen OK, Tonstad S, Ose L, Berg K, Leren TP (1998)
Effects of a 9.6-kb deletion of the LDL receptor gene (FH Helsinki) on structure and levels of mRNA
Hum Mutat, 12 (2), 95-102
PubMed 9671270

Tonstad S, Joakimsen O, Stensland-Bugge E, Ose L, Bønaa KH, Leren TP (1998)
Carotid intima-media thickness and plaque in patients with familial hypercholesterolaemia mutations and control subjects
Eur J Clin Invest, 28 (12), 971-9
PubMed 9893006

Publications 1997

Leren TP, Bakken KS, Daum U, Ose L, Berg K, Assmann G, von Eckardstein A (1997)
Heterozygosity for apolipoprotein A-I(R160L)Oslo is associated with low levels of high density lipoprotein cholesterol and HDL-subclass LpA-I/A-II but normal levels of HDL-subclass LpA-I
J Lipid Res, 38 (1), 121-31
PubMed 9034206

Leren TP, Bakken KS, Rødningen OK, Gundersen KE, Sundvold H, Berg K, Tonstad S, Ose L (1997)
[Application of gene technology in the diagnosis of familial hypercholesterolemia]
Tidsskr Nor Laegeforen, 117 (5), 678-81
PubMed 9102960

Leren TP, Ose L (1997)
[Is there a need for genetic/molecular diagnosis of familial hypercholesterolemia?]
Tidsskr Nor Laegeforen, 117 (5), 681-3
PubMed 9102961

Leren TP, Tonstad S, Gundersen KE, Bakken KS, Rødningen OK, Sundvold H, Ose L, Berg K (1997)
Molecular genetics of familial hypercholesterolaemia in Norway
J Intern Med, 241 (3), 185-94
PubMed 9104431

Tonstad S, Leren TP, Ose L (1997)
[Diagnosis and treatment of severe hyperlipidemia]
Tidsskr Nor Laegeforen, 117 (29), 4241-4
PubMed 9441469

Urdal P, Leren TP, Tonstad S, Lund PK, Ose L (1997)
Flow cytometric measurement of low density lipoprotein receptor activity validated by DNA analysis in diagnosing heterozygous familial hypercholesterolemia
Cytometry, 30 (5), 264-8
PubMed 9383100

Publications 1996

Gundersen KE, Solberg K, Rødningen OK, Tonstad S, Ose L, Berg K, Leren TP (1996)
Two novel missense mutations in the LDL receptor gene causing familial hypercholesterolemia
Clin Genet, 49 (2), 85-7
PubMed 8740918

Rødningen OK, Leren TP (1996)
Application of long polymerase chain reaction in the study of the LDL receptor gene
Scand J Clin Lab Invest, 56 (1), 93-6
PubMed 8850178

Sundvold H, Solberg K, Tonstad S, Rødningen OK, Ose L, Berg K, Leren TP (1996)
A common missense mutation (C210G) in the LDL receptor gene among Norwegian familial hypercholesterolemia subjects
Hum Mutat, 7 (1), 70-1
PubMed 8664907

Tonstad S, Joakimsen O, Stensland-Bugge E, Leren TP, Ose L, Russell D, Bønaa KH (1996)
Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects
Arterioscler Thromb Vasc Biol, 16 (8), 984-91
PubMed 8696963

Publications 1995

Jo DW, Leren TP, Yang ZY, Chung YH, Taylor JM, Paik YK (1995)
Characterization of an upstream regulatory element of the human apolipoprotein E gene, and purification of its binding protein from the human placenta
J Biochem, 117 (4), 915-22
PubMed 7592559

Leren TP, Hjermann I (1995)
Is responsiveness to lovastatin in familial hypercholesterolaemia heterozygotes influenced by the specific mutation in the low-density lipoprotein receptor gene?
Eur J Clin Invest, 25 (12), 967-73
PubMed 8719939

Leren TP, Rødningen OK, Tonstad S, Røsby O, Urdal P, Ose L (1995)
Identification of the apo B-3500 mutation in the Norwegian population
Scand J Clin Lab Invest, 55 (3), 217-21
PubMed 7638555

Leren TP, Solberg K, Rødningen OK, Tonstad S, Ose L (1995)
Two novel point mutations in the EGF precursor homology domain of the LDL receptor gene causing familial hypercholesterolemia
Hum Genet, 96 (2), 241-2
PubMed 7635482

Leren TP, Sundvold H, Rødningen OK, Tonstad S, Solberg K, Ose L, Berg K (1995)
Screening for known mutations in the LDL receptor gene causing familial hypercholesterolemia
Hum Genet, 95 (6), 671-6
PubMed 7789953

Løhne K, Urdal P, Leren TP, Tonstad S, Ose L (1995)
Standardization of a flow cytometric method for measurement of low-density lipoprotein receptor activity on blood mononuclear cells
Cytometry, 20 (4), 290-5
PubMed 7587716

Tonstad S, Leren TP, Sivertsen M, Ose L (1995)
Determinants of lipid levels among children with heterozygous familial hypercholesterolemia in Norway
Arterioscler Thromb Vasc Biol, 15 (8), 1009-14
PubMed 7627689

Publications 1994

Leren TP, Solberg K, Rødningen OK, Tonstad S, Ose L (1994)
Two founder mutations in the LDL receptor gene in Norwegian familial hypercholesterolemia subjects
Atherosclerosis, 111 (2), 175-82
PubMed 7718019

Solberg K, Rødningen OK, Tonstad S, Ose L, Leren TP (1994)
Familial hypercholesterolaemia caused by a non-sense mutation in codon 329 of the LDL receptor gene
Scand J Clin Lab Invest, 54 (8), 605-9
PubMed 7709162

Publications 1993

Eiklid K, Leren TP (1993)
[Genotyping of apolipoprotein E]
Tidsskr Nor Laegeforen, 113 (15), 1885
PubMed 8322337

Leren TP (1993)
[Molecular genetic causes of familial hypercholesterolemia]
Tidsskr Nor Laegeforen, 113 (26), 3251-4
PubMed 8236220

Leren TP, Fagerhol MK, Leren P (1993)
Sixteen years of plasma exchange in a homozygote for familial hypercholesterolaemia
J Intern Med, 233 (2), 195-200
PubMed 8433081

Leren TP, Rødningen OK, Røsby O, Solberg K, Berg K (1993)
Screening for point mutations by semi-automated DNA sequencing using sequenase and magnetic beads
Biotechniques, 14 (4), 618-23
PubMed 8476605

Leren TP, Solberg K, Rødningen OK, Ose L, Tonstad S, Berg K (1993)
Evaluation of running conditions for SSCP analysis: application of SSCP for detection of point mutations in the LDL receptor gene
PCR Methods Appl, 3 (3), 159-62
PubMed 8118396

Leren TP, Solberg K, Rødningen OK, Røsby O, Tonstad S, Ose L, Berg K (1993)
Screening for point mutations in exon 10 of the low density lipoprotein receptor gene by analysis of single-strand conformation polymorphisms: detection of a nonsense mutation-FH469-->Stop
Hum Genet, 92 (1), 6-10
PubMed 8103503

Rødningen OK, Leren TP, Røsby O, Tonstad S, Ose L, Berg K (1993)
Haplotype analysis at the low density lipoprotein receptor locus in normal and familial hypercholesterolemia Norwegian subjects
Clin Genet, 44 (4), 214-20
PubMed 7903228

Solberg K, Rødningen OK, Tonstad S, Ose L, Berg K, Leren TP (1993)
Short report on DNA marker at candidate locus
Clin Genet, 44 (2), 111
PubMed 8275559

Tuveng JM, Eik-Nes SH, Sviggum O, Isaksen C, Berg K, Leren TP, van der Hagen CB (1993)
[Karyotyping of fetuses with developmental disorders. A 5-year material 1985-89]
Tidsskr Nor Laegeforen, 113 (3), 339-42
PubMed 8441983

Publications 1992

Leren TP, Hjermann I, Foss OP, Leren P, Berg K (1992)
Long-term effect of lovastatin alone and in combination with cholestyramine on lipoprotein (a) level in familial hypercholesterolemic subjects
Clin Investig, 70 (8), 711-8
PubMed 1392453

Leren TP, Solberg K, Røsby O, Rødningen OK, Tonstad S, Ose L, Berg K (1992)
A new polymorphism in exon 11 of the LDL receptor gene in healthy people and in familial hypercholesterolemia subjects
Clin Genet, 42 (5), 224-8
PubMed 1486698

Rødningen OK, Røsby O, Tonstad S, Ose L, Berg K, Leren TP (1992)
A 9.6 kilobase deletion in the low density lipoprotein receptor gene in Norwegian familial hypercholesterolemia subjects
Clin Genet, 42 (6), 288-95
PubMed 1362925

Røsby O, Poledne R, Hjermann I, Tonstad S, Berg K, Leren TP (1992)
StyI polymorphism in an enhancer region of the second intron of the apolipoprotein B gene in hyper- and hypocholesterolemic subjects
Clin Genet, 42 (5), 217-23
PubMed 1362528

Publications 1990

Chang DJ, Paik YK, Leren TP, Walker DW, Howlett GJ, Taylor JM (1990)
Characterization of a human apolipoprotein E gene enhancer element and its associated protein factors
J Biol Chem, 265 (16), 9496-504
PubMed 2188976

Publications 1989

Berg K, Leren TP (1989)
Unchanged serum lipoprotein (a) concentrations with lovastatin
Lancet, 2 (8666), 812
PubMed 2571057

Publications 1988

Hjermann I, Leren T, Berg K, Leren P, Foss OP (1988)
[At last, an effective treatment of familial hypercholesterolemia?]
Tidsskr Nor Laegeforen, 108 (6), 493-6
PubMed 3281324

Leren TP, Berg K (1988)
Studies of serum lipids in hypercholesterolaemic rabbits treated with doxazosin
Scand J Clin Lab Invest, 48 (4), 313-7
PubMed 2907180

Leren TP, Berg K, Hjermann I, Leren P (1988)
Further evidence for an association between the XbaI polymorphism at the apolipoprotein B locus and lipoprotein level
Clin Genet, 34 (6), 347-51
PubMed 2906824

Leren TP, Blomhoff R, Berg K (1988)
Metabolism of low density lipoprotein after storage
J Oslo City Hosp, 38 (2), 21-6
PubMed 3361378

Leren TP, Hjermann I, Berg K, Leren P, Foss OP, Viksmoen L (1988)
Effects of lovastatin alone and in combination with cholestyramine on serum lipids and apolipoproteins in heterozygotes for familial hypercholesterolemia
Atherosclerosis, 73 (2-3), 135-41
PubMed 3056429

Publications 1987

Børresen AL, Leren T, Berg K, Solaas MH (1987)
Effect of haptoglobin subtypes on serum lipid levels
Hum Hered, 37 (3), 150-6
PubMed 3583295

Leren TP, Tolleshaug H (1987)
[Biochemical defects in familial hypercholesterolemia]
Tidsskr Nor Laegeforen, 107 (32), 2855-7, 2848
PubMed 3321551

Publications 1986

Leren TP (1986)
[Total cholesterol. Reference values and criteria for treatment]
Tidsskr Nor Laegeforen, 106 (22), 1716-7
PubMed 3775706

Leren TP, Blomhoff R, Berg K (1986)
Low density lipoprotein receptor determination in peripheral blood mononuclear cells: influence of differences in cell concentration
Scand J Clin Lab Invest, 46 (5), 477-88
PubMed 3749791

Publications 1985

Leren TP (1985)
Doxazosin increases low density lipoprotein receptor activity
Acta Pharmacol Toxicol (Copenh), 56 (3), 269-72
PubMed 2861710

Leren TP, Berg K (1985)
Cell-released substances interfere with low density lipoprotein receptor determination in fibroblasts
Scand J Clin Lab Invest, 45 (4), 379-85
PubMed 4012217

Leren TP, Berg K (1985)
Low density lipoprotein receptor determination in peripheral blood mononuclear cells (PBMCs). I. Influence of differences in cell concentration
J Oslo City Hosp, 35 (11-12), 119-27
PubMed 4087061

Leren TP, Blomhoff R, Berg K (1985)
Low density lipoprotein (LDL) receptor determination in peripheral blood mononuclear cells. III. Cell membrane constituents bind to LDL and interfere with LDL receptor analyses
J Oslo City Hosp, 35 (11-12), 141-50
PubMed 4087063

Leren TP, Blomhoff R, Berg K (1985)
Low density lipoprotein (LDL) receptor determination in peripheral blood mononuclear cells. II. Characteristics of cell released substances that interfere with binding of LDL
J Oslo City Hosp, 35 (11-12), 129-39
PubMed 4087062

Leren TP, Børresen AL, Berg K, Hjermann I, Leren P (1985)
Increased frequency of the apolipoprotein E-4 isoform in male subjects with multifactorial hypercholesterolemia
Clin Genet, 27 (5), 458-62
PubMed 4006269

Leren TP, Hjermann I, Børresen AL, Berg K, Leren P (1985)
Maximal low density lipoprotein receptor activity and the effect of lipid lowering diet on total serum cholesterol
Clin Genet, 27 (6), 543-9
PubMed 4017275

Leren TP, Hjermann I, Maartmann-Moe K, Beckmann SL, Leren P, Berg K (1985)
Effect of lipid lowering diet on low density lipoprotein receptor activity in freshly isolated peripheral blood mononuclear cells
Acta Med Scand, 218 (1), 41-9
PubMed 2996310

Leren TP, Maartmann-Moe K, Berg K (1985)
Low density lipoprotein receptor activity in cultured skin fibroblasts from octa- and nonagenarians
Clin Genet, 27 (5), 433-42
PubMed 4006267

Publications 1984

Leren TP, Maartmann-Moe K, Thune P, Berg K (1984)
Low density lipoprotein receptors in cultured skin fibroblasts from psoriasis patients
Clin Genet, 25 (3), 230-41
PubMed 6323070

Publications 1983

Bruserud O, Leren TP (1983)
[Hyperosmolar nonketotic diabetic coma]
Tidsskr Nor Laegeforen, 103 (5), 519-21
PubMed 6868026