Bjørn Steen Skålhegg

  • Head of Division of Molecular Nutrition, Department of Nutrition.; Professor, PhD

Publications 2023

Clauss M, Skattebo Ø, Dæhli MR, Valsdottir D, Bastani NE, Johansen EI, Kolnes KJ, Skålhegg BS, Jensen J (2023)
Carbohydrate Ingestion during Prolonged Cycling Improves Next-Day Time Trial Performance and Alters Amino Acid Concentrations
Med Sci Sports Exerc (in press)
DOI 10.1249/MSS.0000000000003264, PubMed 37535337

Gjølberg TT, Wik JA, Johannessen H, Krüger S, Bassi N, Christopoulos PF, Bern M, Foss S, Petrovski G, Moe MC, Haraldsen G, Fosse JH, Skålhegg BS, Andersen JT, Sundlisæter E (2023)
Antibody blockade of Jagged1 attenuates choroidal neovascularization
Nat Commun, 14 (1), 3109
DOI 10.1038/s41467-023-38563-w, PubMed 37253747

Nordsletten M, Saeed U, Myklebust TÅ, Robsahm TE, Møller B, Skålhegg BS, Mala T, Yaqub S (2023)
Body mass index and its association with 22 cancer types: a Norwegian cohort study of 481 202 cancer cases
Acta Oncol, 1-6 (in press)
DOI 10.1080/0284186X.2023.2258443, PubMed 37713274

Pfabigan DM, Frogner ER, Schéle E, Thorsby PM, Skålhegg BS, Dickson SL, Sailer U (2023)
Ghrelin is related to lower brain reward activation during touch
Psychophysiology, e14443 (in press)
DOI 10.1111/psyp.14443, PubMed 37737514

Saeed U, Nordsletten M, Myklebust TÅ, Robsahm TE, Møller B, Skålhegg BS, Mala T, Yaqub S (2023)
Cancer risk and survival according to body mass index in hepatobiliary malignancies: a nationwide registry-based cohort study
HPB (Oxford) (in press)
DOI 10.1016/j.hpb.2023.07.882, PubMed 37544854

Sollie O, Clauss M, Jeppesen PB, Tangen DS, Johansen EI, Skålhegg BS, Ivy JL, Jensen J (2023)
Similar performance after intake of carbohydrate plus whey protein and carbohydrate only in the early phase after non-exhaustive cycling
Scand J Med Sci Sports, 33 (7), 1091-1103
DOI 10.1111/sms.14364, PubMed 37010270

Publications 2022

Kolan SS, Li G, Grimolizzi F, Sexton J, Goll G, Kvien TK, Sundlisæter NP, Zucknick M, Lillegraven S, Haavardsholm EA, Skålhegg BS (2022)
Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis
Front Pharmacol, 13, 1075603
DOI 10.3389/fphar.2022.1075603, PubMed 36467057

Richartz N, Pietka W, Gilljam KM, Skah S, Skålhegg BS, Bhagwat S, Naderi EH, Ruud E, Blomhoff HK (2022)
cAMP-Mediated Autophagy Promotes Cell Survival via ROS-Induced Activation of PARP1: Implications for Treatment of Acute Lymphoblastic Leukemia
Mol Cancer Res, 20 (3), 400-411
DOI 10.1158/1541-7786.MCR-21-0652, PubMed 34880123

Saeed U, Myklebust TÅ, Robsahm TE, Kielland MF, Møller B, Skålhegg BS, Mala T, Yaqub S (2022)
Risk and survival in colorectal cancer with increasing body mass index: A nationwide population-based cohort study
Colorectal Dis, 25 (3), 375-385
DOI 10.1111/codi.16367, PubMed 36222384

Saeed U, Myklebust TÅ, Robsahm TE, Møller B, Mala T, Skålhegg BS, Yaqub S (2022)
Body mass index and pancreatic adenocarcinoma: A nationwide registry-based cohort study
Scand J Surg, 112 (1), 11-21
DOI 10.1177/14574969221127530, PubMed 36173093

Silwal-Pandit L, Stålberg SM, Henrik J. Johansson, Georgios Mermelekas, Lothe IMB, Skrede ML, Dalsgaard AM, Nebdal D, Helland, Lingjærde OC, Labori KJ, Skålhegg BS, Janne Lehtiö, Kure EH (2022)
Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome
Cancer Res Commun, 2 (6), 434-446
DOI 10.1158/2767-9764.CRC-21-0100, PublikaID 411

Silwal-Pandit L, Stålberg SM, Johansson HJ, Mermelekas G, Lothe IMB, Skrede ML, Dalsgaard AM, Nebdal DJH, Helland Å, Lingjærde OC, Labori KJ, Skålhegg BS, Lehtiö J, Kure EH (2022)
Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome
Cancer Res Commun, 2 (6), 434-446
DOI 10.1158/2767-9764.CRC-21-0100, PubMed 36923555

Wik JA, Chowdhury A, Kolan S, Bastani NE, Li G, Alam K, Grimolizzi F, Skålhegg BS (2022)
Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4+ T-cell proliferation and glycolytic activity under hypoxia and normoxia
Biochem J, 479 (11), 1221-1235
DOI 10.1042/BCJ20220144, PubMed 35695514

Wik JA, Skålhegg BS (2022)
T Cell Metabolism in Infection
Front Immunol, 13, 840610
DOI 10.3389/fimmu.2022.840610, PubMed 35359994

Publications 2021

Cederkvist H, Kolan SS, Wik JA, Sener Z, Skålhegg BS (2021)
Identification and characterization of a novel glutaminase inhibitor
FEBS Open Bio, 12 (1), 163-174
DOI 10.1002/2211-5463.13319, PubMed 34698439

Li G, Kolan SS, Guo S, Marciniak K, Kolan P, Malachin G, Grimolizzi F, Haraldsen G, Skålhegg BS (2021)
Activated, Pro-Inflammatory Th1, Th17, and Memory CD4+ T Cells and B Cells Are Involved in Delayed-Type Hypersensitivity Arthritis (DTHA) Inflammation and Paw Swelling in Mice
Front Immunol, 12, 689057
DOI 10.3389/fimmu.2021.689057, PubMed 34408746

Taylor SS, Søberg K, Kobori E, Wu J, Pautz S, Herberg FW, Skålhegg BS (2021)
The Tails of Protein Kinase A
Mol Pharmacol, 101 (4), 219-225
DOI 10.1124/molpharm.121.000315, PubMed 34330820

Taylor SS, Wallbott M, Machal EMF, Søberg K, Ahmed F, Bruystens J, Vu L, Baker B, Wu J, Raimondi F, Ongeri EM, Herberg FW, Skålhegg BS (2021)
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies
Biochem J, 478 (11), 2101-2119
DOI 10.1042/BCJ20200867, PubMed 34115095

Wendel K, Pfeiffer HCV, Fugelseth DM, Nestaas E, Domellöf M, Skålhegg BS, Elgstøen KBP, Rootwelt H, Pettersen RD, Pripp AH, Stiris T, Moltu SJ, ImNuT Collaboration Group (2021)
Effects of nutrition therapy on growth, inflammation and metabolism in immature infants: a study protocol of a double-blind randomized controlled trial (ImNuT)
BMC Pediatr, 21 (1), 19
DOI 10.1186/s12887-020-02425-x, PubMed 33407269

Wik JA, Phung D, Kolan S, Haraldsen G, Skålhegg BS, Hol Fosse J (2021)
Inflammatory activation of endothelial cells increases glycolysis and oxygen consumption despite inhibiting cell proliferation
FEBS Open Bio, 11 (6), 1719-1730
DOI 10.1002/2211-5463.13174, PubMed 33979025

Publications 2020

Dahl MA, Areta JL, Jeppesen PB, Birk JB, Johansen EI, Ingemann-Hansen T, Hansen M, Skålhegg BS, Ivy JL, Wojtaszewski JFP, Overgaard K, Jensen J (2020)
Coingestion of protein and carbohydrate in the early recovery phase, compared with carbohydrate only, improves endurance performance despite similar glycogen degradation and AMPK phosphorylation
J Appl Physiol (1985), 129 (2), 297-310
DOI 10.1152/japplphysiol.00817.2019, PubMed 32584664

Kolan SS, Li G, Wik JA, Malachin G, Guo S, Kolan P, Skålhegg BS (2020)
Cellular metabolism dictates T cell effector function in health and disease
Scand J Immunol, 92 (5), e12956
DOI 10.1111/sji.12956, PubMed 32767795

Palencia-Campos A, Aoto PC, Machal EMF, Rivera-Barahona A, Soto-Bielicka P, Bertinetti D, Baker B, Vu L, Piceci-Sparascio F, Torrente I, Boudin E, Peeters S, Van Hul W, Huber C, Bonneau D, Hildebrand MS, Coleman M, Bahlo M, Bennett MF, Schneider AL, Scheffer IE, Kibæk M, Kristiansen BS, Issa MY, Mehrez MI et al. (2020)
Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome
Am J Hum Genet, 107 (5), 977-988
DOI 10.1016/j.ajhg.2020.09.005, PubMed 33058759

Wik JA, Lundbäck P, la Cour Poulsen L, Haraldsen G, Skålhegg BS, Hol J (2020)
3PO inhibits inflammatory NFκB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3
PLoS One, 15 (3), e0229395
DOI 10.1371/journal.pone.0229395, PubMed 32130250

Publications 2019

Volchenkov R, Matthews J, Zucknick M, Skålhegg BS (2019)
Shared epitope is associated with the reactivity of Th17 cells to cigarette smoke extract regardless of smoking history
Cell Mol Immunol, 16 (7), 674-675
DOI 10.1038/s41423-019-0230-4, PubMed 31076726

Publications 2018

Sollie O, Jeppesen PB, Tangen DS, Jernerén F, Nellemann B, Valsdottir D, Madsen K, Turner C, Refsum H, Skålhegg BS, Ivy JL, Jensen J (2018)
Protein intake in the early recovery period after exhaustive exercise improves performance the following day
J Appl Physiol (1985), 125 (6), 1731-1742
DOI 10.1152/japplphysiol.01132.2017, PubMed 30212306

Søberg K, Skålhegg BS (2018)
The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit
Front Endocrinol (Lausanne), 9, 538
DOI 10.3389/fendo.2018.00538, PubMed 30258407

Publications 2017

Gjevestad GO, Ottestad I, Biong AS, Iversen PO, Retterstøl K, Raastad T, Skålhegg BS, Ulven SM, Holven KB (2017)
Consumption of protein-enriched milk has minor effects on inflammation in older adults-A 12-week double-blind randomized controlled trial
Mech Ageing Dev, 162, 1-8
DOI 10.1016/j.mad.2017.01.011, PubMed 28163108

Moen LV, Sener Z, Volchenkov R, Svarstad AC, Eriksen AM, Holen HL, Skålhegg BS (2017)
Ablation of the Cβ2 subunit of PKA in immune cells leads to increased susceptibility to systemic inflammation in mice
Eur J Immunol, 47 (11), 1880-1889
DOI 10.1002/eji.201646809, PubMed 28837222

Stakkestad Ø, Lyngstadaas SP, Thiede B, Vondrasek J, Skålhegg BS, Reseland JE (2017)
Phosphorylation Modulates Ameloblastin Self-assembly and Ca 2+ Binding
Front Physiol, 8, 531
DOI 10.3389/fphys.2017.00531, PubMed 28798693

Søberg K, Moen LV, Skålhegg BS, Laerdahl JK (2017)
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms
PLoS One, 12 (7), e0181091
DOI 10.1371/journal.pone.0181091, PubMed 28742821

Volchenkov R, Nygaard V, Sener Z, Skålhegg BS (2017)
Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner
Front Immunol, 8, 698
DOI 10.3389/fimmu.2017.00698, PubMed 28674533

Publications 2016

Moen LV, Ramberg H, Zhao S, Grytli HH, Sveen A, Berge V, Skotheim RI, Taskén KA, Skålhegg BS (2016)
Observed correlation between the expression levels of catalytic subunit, Cβ2, of cyclic adenosine monophosphate-dependent protein kinase and prostate cancer aggressiveness
Urol Oncol, 35 (3), 111.e1-111.e8
DOI 10.1016/j.urolonc.2016.10.002, PubMed 27838142

Sener Z, Cederkvist FH, Volchenkov R, Holen HL, Skålhegg BS (2016)
T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions
PLoS One, 11 (7), e0160291
DOI 10.1371/journal.pone.0160291, PubMed 27467144

Volchenkov R, Dung Cao M, Elgstøen KB, Goll GL, Eikvar K, Bjørneboe O, Bathen TF, Holen HL, Kvien TK, Skålhegg BS (2016)
Metabolic profiling of synovial tissue shows altered glucose and choline metabolism in rheumatoid arthritis samples
Scand J Rheumatol, 46 (2), 160-161
DOI 10.3109/03009742.2016.1164242, PubMed 27098118

Publications 2014

Hereng TH, Elgstøen KB, Eide L, Rosendal KR, Skålhegg BS (2014)
Serum albumin and HCO3- regulate separate pools of ATP in human spermatozoa
Hum Reprod, 29 (5), 918-30
DOI 10.1093/humrep/deu028, PubMed 24578478

Publications 2013

Søberg K, Jahnsen T, Rognes T, Skålhegg BS, Laerdahl JK (2013)
Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits
PLoS One, 8 (4), e60935
DOI 10.1371/journal.pone.0060935, PubMed 23593352

Publications 2012

Hereng TH, Backe PH, Kahmann J, Scheich C, Bjørås M, Skålhegg BS, Rosendal KR (2012)
Structure and function of the human sperm-specific isoform of protein kinase A (PKA) catalytic subunit Cα2
J Struct Biol, 178 (3), 300-10
DOI 10.1016/j.jsb.2012.03.013, PubMed 22504716

Søberg K, Larsen AC, Diskar M, Backe PH, Bjørås M, Jahnsen T, Laerdahl JK, Rognes T, Herberg FW, Skålhegg BS (2012)
Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA)
PLoS One, 7 (4), e34838
DOI 10.1371/journal.pone.0034838, PubMed 22514673

Törmänen Persson H, Aksaas AK, Kvissel AK, Punga T, Engström Å, Skålhegg BS, Akusjärvi G (2012)
Two cellular protein kinases, DNA-PK and PKA, phosphorylate the adenoviral L4-33K protein and have opposite effects on L1 alternative RNA splicing
PLoS One, 7 (2), e31871
DOI 10.1371/journal.pone.0031871, PubMed 22363758

Publications 2011

Aksaas AK, Eikvar S, Akusjärvi G, Skålhegg BS, Kvissel AK (2011)
Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein
Genes Cancer, 2 (8), 841-51
DOI 10.1177/1947601911430226, PubMed 22393468

Aksaas AK, Larsen AC, Rogne M, Rosendal K, Kvissel AK, Skålhegg BS (2011)
G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A
J Mol Signal, 6, 10
DOI 10.1186/1750-2187-6-10, PubMed 21880142

Hereng TH, Elgstøen KB, Cederkvist FH, Eide L, Jahnsen T, Skålhegg BS, Rosendal KR (2011)
Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa
Hum Reprod, 26 (12), 3249-63
DOI 10.1093/humrep/der317, PubMed 21946930

Stakkestad Ø, Larsen AC, Kvissel AK, Eikvar S, Ørstavik S, Skålhegg BS (2011)
Protein kinase A type I activates a CRE-element more efficiently than protein kinase A type II regardless of C subunit isoform
BMC Biochem, 12, 7
DOI 10.1186/1471-2091-12-7, PubMed 21303506

Vetter MM, Zenn HM, Méndez E, van den Boom H, Herberg FW, Skålhegg BS (2011)
The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA
BMC Biochem, 12, 40
DOI 10.1186/1471-2091-12-40, PubMed 21812984

Publications 2010

Haugen F, Norheim F, Lian H, Wensaas AJ, Dueland S, Berg O, Funderud A, Skålhegg BS, Raastad T, Drevon CA (2010)
IL-7 is expressed and secreted by human skeletal muscle cells
Am J Physiol Cell Physiol, 298 (4), C807-16
DOI 10.1152/ajpcell.00094.2009, PubMed 20089933

Publications 2009

Jarnaess E, Stokka AJ, Kvissel AK, Skålhegg BS, Torgersen KM, Scott JD, Carlson CR, Taskén K (2009)
Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments
J Biol Chem, 284 (50), 35154-64
DOI 10.1074/jbc.M109.056465, PubMed 19840947

Publications 2008

Funderud A, Aas-Hanssen K, Aksaas AK, Hafte TT, Corthay A, Munthe LA, Orstavik S, Skålhegg BS (2008)
Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA)
Cell Signal, 21 (2), 274-81
DOI 10.1016/j.cellsig.2008.10.013, PubMed 19000925

Kloster MM, Hafte TT, Moltzau LR, Naderi EH, Dahle MK, Skålhegg BS, Gaudernack G, Levy FO, Naderi S, Blomhoff HK (2008)
EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase
Cell Signal, 20 (6), 1169-78
DOI 10.1016/j.cellsig.2008.02.007, PubMed 18406106

Oksvold MP, Funderud A, Kvissel AK, Skarpen E, Henanger H, Huitfeldt HS, Skålhegg BS, Ørstavik S (2008)
Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit
BMC Cell Biol, 9, 16
DOI 10.1186/1471-2121-9-16, PubMed 18380891

Publications 2007

Kvissel AK, Ørstavik S, Eikvar S, Brede G, Jahnsen T, Collas P, Akusjärvi G, Skålhegg BS (2007)
Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing
Exp Cell Res, 313 (13), 2795-809
DOI 10.1016/j.yexcr.2007.05.014, PubMed 17594903

Larsen AC, Kvissel AK, Hafte TT, Avellan CI, Eikvar S, Rootwelt T, Ørstavik S, Skålhegg BS (2007)
Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates
FEBS J, 275 (2), 250-62
DOI 10.1111/j.1742-4658.2007.06195.x, PubMed 18070107

Skarpen E, Flinder LI, Rosseland CM, Orstavik S, Wierød L, Oksvold MP, Skålhegg BS, Huitfeldt HS (2007)
MEK1 and MEK2 regulate distinct functions by sorting ERK2 to different intracellular compartments
FASEB J, 22 (2), 466-76
DOI 10.1096/fj.07-8650com, PubMed 17928366

Publications 2006

Frøyland E, Pedersen ED, Kvissel AK, Almaas R, Pharo A, Skålhegg BS, Mollnes TE, Rootwelt T (2006)
Effect of acidosis on IL-8 and MCP-1 during hypoxia and reoxygenation in human NT2-N neurons
Brain Res, 1113 (1), 64-73
DOI 10.1016/j.brainres.2006.07.051, PubMed 16919250

Funderud A, Henanger HH, Hafte TT, Amieux PS, Orstavik S, Skålhegg BS (2006)
Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cbeta2
BMC Biochem, 7, 20
DOI 10.1186/1471-2091-7-20, PubMed 16889664

Kvissel AK, Ramberg H, Eide T, Svindland A, Skålhegg BS, Taskén KA (2006)
Androgen dependent regulation of protein kinase A subunits in prostate cancer cells
Cell Signal, 19 (2), 401-9
DOI 10.1016/j.cellsig.2006.07.011, PubMed 16949795

Pedersen ED, Frøyland E, Kvissel AK, Pharo AM, Skålhegg BS, Rootwelt T, Mollnes TE (2006)
Expression of complement regulators and receptors on human NT2-N neurons--effect of hypoxia and reoxygenation
Mol Immunol, 44 (9), 2459-68
DOI 10.1016/j.molimm.2006.10.022, PubMed 17116331

Publications 2005

Håkelien AM, Gaustad KG, Taranger CK, Skålhegg BS, Küntziger T, Collas P (2005)
Long-term in vitro, cell-type-specific genome-wide reprogramming of gene expression
Exp Cell Res, 309 (1), 32-47
DOI 10.1016/j.yexcr.2005.06.001, PubMed 16005866

Orstavik S, Funderud A, Hafte TT, Eikvar S, Jahnsen T, Skålhegg BS (2005)
Identification and characterization of novel PKA holoenzymes in human T lymphocytes
FEBS J, 272 (7), 1559-67
DOI 10.1111/j.1742-4658.2005.04568.x, PubMed 15794744

Skålhegg BS, Funderud A, Henanger HH, Hafte TT, Larsen AC, Kvissel AK, Eikvar S, Ørstavik S (2005)
Protein kinase A (PKA)--a potential target for therapeutic intervention of dysfunctional immune cells
Curr Drug Targets, 6 (6), 655-64
DOI 10.2174/1389450054863644, PubMed 16178799

Publications 2004

Fredriksen J, Ueland T, Dyrøy E, Halvorsen B, Melby K, Melbye L, Skalhegg BS, Bohov P, Skorve J, Berge RK, Aukrust P, Frøland SS (2004)
Lipid-lowering and anti-inflammatory effects of tetradecylthioacetic acid in HIV-infected patients on highly active antiretroviral therapy
Eur J Clin Invest, 34 (10), 709-15
DOI 10.1111/j.1365-2362.2004.01410.x, PubMed 15473896

Kvissel AK, Ørstavik S, Øistad P, Rootwelt T, Jahnsen T, Skålhegg BS (2004)
Induction of Cbeta splice variants and formation of novel forms of protein kinase A type II holoenzymes during retinoic acid-induced differentiation of human NT2 cells
Cell Signal, 16 (5), 577-87
DOI 10.1016/j.cellsig.2003.08.014, PubMed 14751543

Publications 2003

Gutzkow KB, Låhne HU, Naderi S, Torgersen KM, Skålhegg B, Koketsu M, Uehara Y, Blomhoff HK (2003)
Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation
Cell Signal, 15 (9), 871-81
DOI 10.1016/s0898-6568(03)00038-x, PubMed 12834812

Méndez E, Maeland M, Skålhegg BS, Planas JV (2003)
Activation of the cAMP-dependent protein kinase signaling pathway by luteinizing hormone in trout theca layers
Mol Cell Endocrinol, 205 (1-2), 11-20
DOI 10.1016/s0303-7207(03)00208-9, PubMed 12890563

Publications 2002

Han I, Xue Y, Harada S, Orstavik S, Skalhegg B, Kieff E (2002)
Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins
Mol Cell Biol, 22 (7), 2136-46
DOI 10.1128/MCB.22.7.2136-2146.2002, PubMed 11884601

Hoover F, Kalhovde JM, Dahle MK, Skålhegg B, Taskén K, Lømo T (2002)
Electrical muscle activity pattern and transcriptional and posttranscriptional mechanisms regulate PKA subunit expression in rat skeletal muscle
Mol Cell Neurosci, 19 (2), 125-37
DOI 10.1006/mcne.2001.1053, PubMed 11860267

Håkelien AM, Landsverk HB, Robl JM, Skålhegg BS, Collas P (2002)
Reprogramming fibroblasts to express T-cell functions using cell extracts
Nat Biotechnol, 20 (5), 460-6
DOI 10.1038/nbt0502-460, PubMed 11981558

Landsverk HB, Håkelien AM, Küntziger T, Robl JM, Skålhegg BS, Collas P (2002)
Reprogrammed gene expression in a somatic cell-free extract
EMBO Rep, 3 (4), 384-9
DOI 10.1093/embo-reports/kvf064, PubMed 11897658

Skålhegg BS, Huang Y, Su T, Idzerda RL, McKnight GS, Burton KA (2002)
Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction
Mol Endocrinol, 16 (3), 630-9
DOI 10.1210/mend.16.3.0793, PubMed 11875122

Publications 2001

Carlson CR, Witczak O, Vossebein L, Labbé JC, Skålhegg BS, Keryer G, Herberg FW, Collas P, Taskén K (2001)
CDK1-mediated phosphorylation of the RIIalpha regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIalpha from centrosomes at mitosis
J Cell Sci, 114 (Pt 18), 3243-54
DOI 10.1242/jcs.114.18.3243, PubMed 11591813

Han I, Harada S, Weaver D, Xue Y, Lane W, Orstavik S, Skalhegg B, Kieff E (2001)
EBNA-LP associates with cellular proteins including DNA-PK and HA95
J Virol, 75 (5), 2475-81
DOI 10.1128/JVI.75.5.2475-2481.2001, PubMed 11160753

Hoover F, Mathiesen I, Skålhegg BS, Lømo T, Taskén K (2001)
Differential expression and regulation of the PKA signalling pathway in fast and slow skeletal muscle
Anat Embryol (Berl), 203 (3), 193-201
DOI 10.1007/s004290000155, PubMed 11303905

Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, Hansson V, Mustelin T, Taskén K (2001)
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor
J Exp Med, 193 (4), 497-507
DOI 10.1084/jem.193.4.497, PubMed 11181701

Ørstavik S, Reinton N, Frengen E, Langeland BT, Jahnsen T, Skålhegg BS (2001)
Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase
Eur J Biochem, 268 (19), 5066-73
DOI 10.1046/j.0014-2956.2001.02429.x, PubMed 11589697

Publications 2000

Hansson V, Skålhegg BS, Taskén K (2000)
Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
J Steroid Biochem Mol Biol, 73 (1-2), 81-92
PubMed 10905822

Orstavik S, Eide T, Collas P, Han IO, Taskén K, Kieff E, Jahnsen T, Skålhegg BS (2000)
Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95
Biol Cell, 92 (1), 27-37
DOI 10.1016/s0248-4900(00)88761-4, PubMed 10761695

Reinton N, Collas P, Haugen TB, Skâlhegg BS, Hansson V, Jahnsen T, Taskén K (2000)
Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis
Dev Biol, 223 (1), 194-204
DOI 10.1006/dbio.2000.9725, PubMed 10864471

Reinton N, Orstavik S, Haugen TB, Jahnsen T, Taskén K, Skålhegg BS (2000)
A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece
Biol Reprod, 63 (2), 607-11
DOI 10.1095/biolreprod63.2.607, PubMed 10906071

Skalhegg BS, Tasken K (2000)
Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA
Front Biosci, 5, D678-93
DOI 10.2741/skalhegg, PubMed 10922298

Taskén K, Hansson V, Aukrust P, Frøland S, Skålhegg BS, Müller F, Tobin D, Vang T, Torgersen KM, Aandahl EM (2000)
PKAI as a potential target for therapeutic intervention
Drug News Perspect, 13 (1), 12-8
PubMed 12937648

Publications 1999

Aukrust P, Aandahl EM, Skålhegg BS, Nordøy I, Hansson V, Taskén K, Frøland SS, Müller F (1999)
Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency
J Immunol, 162 (2), 1178-85
PubMed 9916750

Hansson V, Skålhegg BS, Taskén K (1999)
Cyclic-AMP-dependent protein kinase (PKA) in testicular cells. Cell specific expression, differential regulation and targeting of subunits of PKA
J Steroid Biochem Mol Biol, 69 (1-6), 367-78
DOI 10.1016/s0960-0760(99)00077-1, PubMed 10419014

Keryer G, Skålhegg BS, Landmark BF, Hansson V, Jahnsen T, Taskén K (1999)
Differential localization of protein kinase A type II isozymes in the Golgi-centrosomal area
Exp Cell Res, 249 (1), 131-46
DOI 10.1006/excr.1999.4447, PubMed 10328961

Witczak O, Skålhegg BS, Keryer G, Bornens M, Taskén K, Jahnsen T, Orstavik S (1999)
Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450
EMBO J, 18 (7), 1858-68
DOI 10.1093/emboj/18.7.1858, PubMed 10202149

Publications 1998

Andersson KB, Skålhegg BS (1998)
[Genetic modification of the mouse]
Tidsskr Nor Laegeforen, 118 (25), 3952-7
PubMed 9830341

Eide T, Coghlan V, Orstavik S, Holsve C, Solberg R, Skâlhegg BS, Lamb NJ, Langeberg L, Fernandez A, Scott JD, Jahnsen T, Taskén K (1998)
Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95
Exp Cell Res, 238 (2), 305-16
DOI 10.1006/excr.1997.3855, PubMed 9473338

Reinton N, Haugen TB, Orstavik S, Skålhegg BS, Hansson V, Jahnsen T, Taskén K (1998)
The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon
Genomics, 49 (2), 290-7
DOI 10.1006/geno.1998.5240, PubMed 9598317

Skålhegg BS, Johansen AK, Levy FO, Andersson KB, Aandahl EM, Blomhoff HK, Hansson V, Taskén K (1998)
Isozymes of cyclic AMP-dependent protein kinases (PKA) in human lymphoid cell lines: levels of endogenous cAMP influence levels of PKA subunits and growth in lymphoid cell lines
J Cell Physiol, 177 (1), 85-93
DOI 10.1002/(SICI)1097-4652(199810)177:1<85::AID-JCP9>3.0.CO;2-A, PubMed 9731748

Vang T, Taskén K, Skålhegg BS, Hansson V, Levy FO (1998)
Kinetic properties of the C-terminal Src kinase, p50csk
Biochim Biophys Acta, 1384 (2), 285-93
DOI 10.1016/s0167-4838(97)00202-1, PubMed 9659389

Aandahl EM, Aukrust P, Skålhegg BS, Müller F, Frøland SS, Hansson V, Taskén K (1998)
Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients
FASEB J, 12 (10), 855-62
DOI 10.1096/fasebj.12.10.855, PubMed 9657525

Publications 1997

Guthrie CR, Skâlhegg BS, McKnight GS (1997)
Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase
J Biol Chem, 272 (47), 29560-5
DOI 10.1074/jbc.272.47.29560, PubMed 9368018

Maghazachi AA, Skalhegg BS, Rolstad B, Al-Aoukaty A (1997)
Interferon-inducible protein-10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin-sensitive and -insensitive heterotrimeric G-proteins
FASEB J, 11 (10), 765-74
DOI 10.1096/fasebj.11.10.9271361, PubMed 9271361

Skålhegg BS, Taskén K (1997)
Specificity in the cAMP/PKA signaling pathway. differential expression, regulation, and subcellular localization of subunits of PKA
Front Biosci, 2, d331-42
DOI 10.2741/a195, PubMed 9236186

Taskén K, Skålhegg BS, Taskén KA, Solberg R, Knutsen HK, Levy FO, Sandberg M, Orstavik S, Larsen T, Johansen AK, Vang T, Schrader HP, Reinton NT, Torgersen KM, Hansson V, Jahnsen T (1997)
Structure, function, and regulation of human cAMP-dependent protein kinases
Adv Second Messenger Phosphoprotein Res, 31, 191-204
DOI 10.1016/s1040-7952(97)80019-5, PubMed 9344252

Publications 1996

Hansson V, Skålhegg BS, Taskén K (1996)
Is basic endocrinology disappearing?
Eur J Endocrinol, 134 (1), 7-8
DOI 10.1530/eje.0.1340007, PubMed 8590959

Levy FO, Rasmussen AM, Taskén K, Skålhegg BS, Huitfeldt HS, Funderud S, Smeland EB, Hansson V (1996)
Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation
Eur J Immunol, 26 (6), 1290-6
DOI 10.1002/eji.1830260617, PubMed 8647207

Qi M, Zhuo M, Skålhegg BS, Brandon EP, Kandel ER, McKnight GS, Idzerda RL (1996)
Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase
Proc Natl Acad Sci U S A, 93 (4), 1571-6
DOI 10.1073/pnas.93.4.1571, PubMed 8643673

Publications 1995

La Spada AR, Skålhegg BS, Henderson R, Schmer G, Pierce R, Chandler W (1995)
Brief report: fatal hemorrhage in a patient with an acquired inhibitor of human thrombin
N Engl J Med, 333 (8), 494-7
DOI 10.1056/NEJM199508243330805, PubMed 7623881

Publications 1994

Foss KB, Landmark B, Skålhegg BS, Taskén K, Jellum E, Hansson V, Jahnsen T (1994)
Characterization of in-vitro-translated human regulatory and catalytic subunits of cAMP-dependent protein kinases
Eur J Biochem, 220 (1), 217-23
DOI 10.1111/j.1432-1033.1994.tb18617.x, PubMed 8119290

Pepe S, Ruggiero A, Tortora G, Ciardiello F, Garbi C, Yokozaki H, Cho-Chung YS, Clair T, Skalhegg BS, Bianco AR (1994)
Flow-cytometric detection of the RI alpha subunit of type I cAMP-dependent protein kinase in human cells
Cytometry, 15 (1), 73-9
DOI 10.1002/cyto.990150112, PubMed 8162827

Skålhegg BS, Rasmussen AM, Taskén K, Hansson V, Jahnsen T, Lea T (1994)
Cyclic AMP sensitive signalling by the CD28 marker requires concomitant stimulation by the T-cell antigen receptor (TCR/CD3) complex
Scand J Immunol, 40 (2), 201-8
DOI 10.1111/j.1365-3083.1994.tb03451.x, PubMed 8047842

Skålhegg BS, Taskén K, Hansson V, Huitfeldt HS, Jahnsen T, Lea T (1994)
Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex
Science, 263 (5143), 84-7
DOI 10.1126/science.8272870, PubMed 8272870

Publications 1993

I C S S, 3, 29-33

Keryer G, Rios RM, Landmark BF, Skalhegg B, Lohmann SM, Bornens M (1993)
A high-affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II in the centrosome of human cells
Exp Cell Res, 204 (2), 230-40
DOI 10.1006/excr.1993.1029, PubMed 8440320

Kjeldsen-Kragh J, Quayle AJ, Skålhegg BS, Sioud M, Førre O (1993)
Selective activation of resting human gamma delta T lymphocytes by interleukin-2
Eur J Immunol, 23 (9), 2092-9
DOI 10.1002/eji.1830230908, PubMed 8370391

Landmark BF, Oyen O, Skålhegg BS, Fauske B, Jahnsen T, Hansson V (1993)
Cellular location and age-dependent changes of the regulatory subunits of cAMP-dependent protein kinase in rat testis
J Reprod Fertil, 99 (2), 323-34
DOI 10.1530/jrf.0.0990323, PubMed 8107013

Taskén K, Andersson KB, Skålhegg BS, Taskén KA, Hansson V, Jahnsen T, Blomhoff HK (1993)
Reciprocal regulation of mRNA and protein for subunits of cAMP-dependent protein kinase (RI alpha and C alpha) by cAMP in a neoplastic B cell line (Reh)
J Biol Chem, 268 (31), 23483-9
PubMed 8226875

Taskén K, Skålhegg BS, Solberg R, Andersson KB, Taylor SS, Lea T, Blomhoff HK, Jahnsen T, Hansson V (1993)
Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes
J Biol Chem, 268 (28), 21276-83
PubMed 8407966

Publications 1992

Skålhegg BS, Landmark B, Foss KB, Lohmann SM, Hansson V, Lea T, Jahnsen T (1992)
Identification, purification, and characterization of subunits of cAMP-dependent protein kinase in human testis. Reverse mobilities of human RII alpha and RII beta on sodium dodecyl sulfate-polyacrylamide gel electrophoresis compared with rat and bovine RIIs
J Biol Chem, 267 (8), 5374-9
PubMed 1544918

Skålhegg BS, Landmark BF, Døskeland SO, Hansson V, Lea T, Jahnsen T (1992)
Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes
J Biol Chem, 267 (22), 15707-14
PubMed 1379235

Publications 1991

Landmark BF, Fauske B, Eskild W, Skålhegg B, Lohmann SM, Hansson V, Jahnsen T, Beebe SJ (1991)
Identification, characterization, and hormonal regulation of 3', 5'-cyclic adenosine monophosphate-dependent protein kinases in rat Sertoli cells
Endocrinology, 129 (5), 2345-54
DOI 10.1210/endo-129-5-2345, PubMed 1657573

Publications 1990

Sandberg M, Skålhegg B, Jahnsen T (1990)
The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals
Biochem Biophys Res Commun, 167 (1), 323-30
DOI 10.1016/0006-291x(90)91768-n, PubMed 2310396

Publications 1987

Lund T, Skålhegg BS, Holtlund J, Blomhoff HK, Laland SG (1987)
Fractionation and identification of metaphase-specific phosphorylated forms of high-mobility-group proteins
Eur J Biochem, 166 (1), 21-6
DOI 10.1111/j.1432-1033.1987.tb13477.x, PubMed 3595612

Publications 1986

Lund T, Holtlund J, Skålhegg B, Laland SG (1986)
Method for complete separation of the high mobility group (HMG) proteins HMG I and HMG Y from HMG 14 and HMG 17 and a procedure for purification of HMG I and HMG Y
J Chromatogr, 369 (2), 341-8
DOI 10.1016/s0021-9673(00)90140-7, PubMed 3805203

Publications 1977

Grimmer O, Andersen I, Dale S, Oseid S, Thorsdalen N, Skålhegg B, Aas K (1977)
A new well-characterized, purified allergen preparation from timothy pollen. I. Chemical properties
Int Arch Allergy Appl Immunol, 55 (1-6), 29-34
DOI 10.1159/000231904, PubMed 591096

Publications 1970

Sander S, Skålhegg B (1970)
A possible discriminant test for hormone-responsive breast cancers. Estradiol--17 beta sensitive dehydrogenase activity
Acta Pathol Microbiol Scand A, 78 (6), 735-6
DOI 10.1111/j.1699-0463.1970.tb03527.x, PubMed 5499393

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