Mariaserena Giliberto

  • PhD student; MSc
  • +47 2278 1755

Related imageRoom: K04.061

  italy

Projects

The primary objective of the PhD project is to develop a new approach to personalized cancer therapy. Differently from other approaches, a transdisciplinary strategy will be applied to implement today’s cancer therapy. The project aims to establish a new pipeline to identify drugs and drug combinations effective in personalized therapy of individual cancer patients, in whom other treatment options are exhausted or ineffective. Novel in-silico mathematical models and simulations will also be applied to investigate the current challenges of tumor heterogeneity and drug resistance mechanisms.
To date, ex vivo drug sensitivity and resistance testing are performed in our lab, with patient cancer cells and patient-derived cell lines for multiple myeloma (MM) and chronic lymphatic leukemia (CLL). The drug sensitivity responses are measured by cell viability and death readouts along with relevant cell signaling analysis.

 

Figure: Drug sensitivity screen pipeline

 

 

Publications 2018

Thimiri Govinda Raj DB, Giliberto M, Cremaschi A, Skånland SS, Gade A, Tjønnfjord GE, Schjesvold FH, Munthe LA, Tasken K (2018)
Drug Sensitivity Screening on Multiple Myeloma for Precision Cancer Therapy
Blood, 132, 4677
DOI 10.1182/blood-2018-99-110669, PublikaID 303

Publications 2017

Zahoor M, Westhrin M, Aass KR, Moen SH, Misund K, Psonka-Antonczyk KM, Giliberto M, Buene G, Sundan A, Waage A, Sponaas AM, Standal T (2017)
Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss
Blood Adv, 1 (27), 2656-2666
DOI 10.1182/bloodadvances.2017010801, PubMed 29296919

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